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Results for "

IMR-32

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Apoptosis (8) Aurora Kinase (2) Calcium Channel (3) Caspase (1) Endogenous Metabolite (4) Enterovirus (1) Ferroptosis (4) Formyl Peptide Receptor (FPR) (1) HSP (2) HSV (1) iGluR (4) Influenza Virus (1) Ligands for Target Protein for PROTAC (1) MCHR1 (GPR24) (1) nAChR (1) Phosphatase (1) Polo-like Kinase (PLK) (1) Potassium Channel (1) PROTACs (1) Quinone Reductase (1) Reference Standards (4) RSV (1) Sirtuin (1)
By Research Areas:	Cancer (14) Endocrinology (1) Infection (3) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (12)

By Targets:

Amyloid-β (1)

Apoptosis (8)

Aurora Kinase (2)

Calcium Channel (3)

Caspase (1)

Endogenous Metabolite (4)

Enterovirus (1)

Ferroptosis (4)

Formyl Peptide Receptor (FPR) (1)

HSP (2)

HSV (1)

iGluR (4)

Influenza Virus (1)

Ligands for Target Protein for PROTAC (1)

MCHR1 (GPR24) (1)

nAChR (1)

Phosphatase (1)

Polo-like Kinase (PLK) (1)

Potassium Channel (1)

PROTACs (1)

Quinone Reductase (1)

Reference Standards (4)

RSV (1)

Sirtuin (1)

By Research Areas:

Cancer (14)

Endocrinology (1)

Infection (3)

Inflammation/Immunology (1)

Metabolic Disease (1)

Neurological Disease (12)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100321

MCHR1 antagonist 2	MCHR1 (GPR24) Potassium Channel	Metabolic Disease Endocrinology
MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC₅₀ of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC₅₀ of 4.0 nM in IMR-32 cells .

HY-103318

PD173212 2 Publications Verification	Calcium Channel	Neurological Disease
PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC₅₀ of 36 nM in IMR-32 assays.

HY-W011762

VK3-OCH3	Apoptosis	Cancer
VK3-OCH3 is a potent antitumor agent. VK3-OCH3 shows cytotoxicity for neuroblastoma cell lines and low cytotoxicity for normal cell lines. VK3-OCH3 induces apoptosis and cell cycle arrest at G2/M phase in IMR-32 cells. VK3-OCH3 shows antitumor activity .

HY-P3275

β-Amyloid (17-40) Aβ(17-40)	Amyloid-β	Neurological Disease
β-Amyloid (17-40) (Aβ(17-40)) is a fragment of Amyloid-β peptide that has shown neurotoxic activities in SH-SY5Y and IMR-32 cells. β-Amyloid (17-40) can be used for the research of neurological disease .

HY-N15215

Antiviral agent 64	Enterovirus Influenza Virus RSV HSV	Infection Cancer
Antiviral agent 64 (Compound 12) is a diarylheptanoid that can be isolated from Alpinia officinarum. Antiviral agent 64 exhibits cytotoxicity in human neuroblastoma cell IMR-32 with an IC₅₀ of 0.23 μM. Antiviral agent 64 exhibits antiviral efficacy, that inhibits RSV, poliovirus, measles virus, HSV-1, and influenza virus H1N1, with EC₅₀ of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively .

HY-N10890

Alpinoid D	Others	Cancer
Alpinoid D, a diarylheptanoid, can be isolated from the MeOH extract from the rhizomes of Alpinia officinarum Hance. Alpinoid D shows cytotoxic effect against IMR-32 human neuroblastoma cell line .

HY-111839

ATRA-hydroxyimino CRABP-II ligand 1	Ligands for Target Protein for PROTAC	Cancer
ATRA-hydroxyimino (CRABP-II ligand 1), the Retinoic acid (ATRA)-based moiety, binds to cIAP1 ligand (Bestatin) via a linker to form SNIPER to degrade CRABP-II in IMR-32 cells .

HY-118974

PD-151307	Calcium Channel	Neurological Disease Cancer
PD-151307 is an N-type calcium channel antagonist with significant inhibitory effects in IMR-32 human neuroblastoma cells, exhibiting an IC₅₀ of 0.32 µM. PD-151307 can be used in research related to cancer therapy, anticonvulsants, and neuropathic pain .

HY-100310

N-type calcium channel blocker-1	Calcium Channel	Neurological Disease
N-type calcium channel blocker-1 is an orally active compound which shows high affinity to functionally block N-type calcium channels with an IC₅₀ of 0.7 μM in the IMR32 assay.

HY-176734

CZL-S092	Polo-like Kinase (PLK)	Cancer
CZL-S092 is a PLK4 inhibitor with an IC₅₀ value of 0.9 nM and excellent selectivity over other PLK4 family members (PLK1, PLK2, and PLK3).CZL-S092 exhibits anti-neuroblastoma activity in vitro (IMR-32 cells, IC₅₀ = 1.143 μM) and acceptable oral bioavailability in vivo (SD rats, F = 22.1%). CZL-S092 can be used in studies of various cancers including neuroblastoma cancer .

HY-133011

nAChR agonist 1	nAChR	Neurological Disease
nAChR agonist 1 is a potent, brain-permeable, and orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR). nAChR agonist 1 has the EC₅₀ of 0.32 µM in a Ca ²⁺ mobilization assay (PNU-282987-induced, FLIPR based) in human IMR-32 neuroblastoma cells that endogenously express α7 nAChR. nAChR agonist 1 can be develpoped for the treatment of Alzheimer’s disease .

HY-136479

F0911-7667	Sirtuin	Cancer
F0911-7667 is a SIRT1 activator that induces autophagic cell death in U87MG and T98G cells by activating the AMPK-mTOR-ULK complex. CWR tripeptide was also identified as a SIRT1 activator that reduced p53 acetylation in IMR32 neuroblastoma cells and protected cells from cell death induced by Aβ fragments .

HY-171769

dAurAB2	PROTACs Aurora Kinase	Cancer
dAurAB2 is a dual-degrading PROTAC that potently degrades Aurora-A and Aurora-B with DC₅₀s of 59 nM and 39 nM, respectively. dAurAB2 reduces N-Myc levels in MYCN-amplified IMR32 neuroblastoma cells. dAurAB2 can be used for the study of neuroblastoma. (Pink, Aurora ligand (HY-10804); Blue, E3 ligand: (HY-103597); Black, linker (HY-W105740)) .

HY-157396

JAB-2485	Aurora Kinase Apoptosis Caspase	Cancer
JAB-2485 is an orally active and selective Aurora kinase A (AURKA) inhibitor with an IC₅₀ value of 0.327 nM. JAB-2485 exhibits inhibitory activity against various tumor cell lines such as neuroblastoma, triple-negative breast cancer, small cell lung cancer, and epithelial ovarian cancer. JAB-2485 can induce cell cycle arrest and apoptosis in tumor cells. JAB-2485 has antitumor activity .

HY-14608AR

L-Glutamic acid monosodium salt (Standard)	Reference Standards iGluR Apoptosis Ferroptosis Endogenous Metabolite	Neurological Disease
L-Glutamic acid (monosodium salt) (Standard) is the analytical standard of L-Glutamic acid (monosodium salt). This product is intended for research and analytical applications. L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases .

HY-14608R

L-Glutamic acid (Standard)	Reference Standards Endogenous Metabolite iGluR Ferroptosis Apoptosis	Neurological Disease
L-Glutamic acid (Standard) is the analytical standard of L-Glutamic acid. This product is intended for research and analytical applications. L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases . IC₅₀ & Target:DA . In Vitro: L-Glutamic acid (120, 500, 750, 1000 mg/dL) can reduce the harmful effect of lithium on the embryonic development of Xenopus Xenopus . L-Glutamic acid (2, 5, 10, 20 mM, 24-48 h) can induce neuroexcitotoxicity in neuroblastoma . In Vivo: L-Glutamic acid (3 g/kg, subcutaneous injection) can promote excitotoxic degeneration of retinal ganglion cells in mice . L-Glutamic acid (750 mg/kg, intraperitoneal injection) can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats .

HY-W011762R

VK3-OCH3 (Standard)	Apoptosis Reference Standards	Cancer
Fluoxetine (hydrochloride) (Standard) is the analytical standard of Fluoxetine (hydrochloride). This product is intended for research and analytical applications. Fluoxetine hydrochloride (LY 110140) is an antidepressant and a selective serotonin reuptake inhibitor.

HY-14608

L-Glutamic acid 10+ Cited Publications	Endogenous Metabolite iGluR Ferroptosis Apoptosis	Neurological Disease
L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors .

HY-14608A

L-Glutamic acid monosodium salt 10+ Cited Publications	iGluR Apoptosis Ferroptosis Endogenous Metabolite	Neurological Disease
L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases. L-Glutamic acid monosodium salt acts at ionotropic and metabotropic glutamate receptors .

HY-172609

SL-176	Phosphatase Apoptosis	Cancer
SL-176, a WIP1 inhibitor, induces cell cycle arrest and apoptosis when combined with GSK-J4 (HY-15648B), thereby suppressing tumor growth both in vitro and in vivo .

HY-107736

AI-3	Quinone Reductase Others	Inflammation/Immunology Cancer
AI-3 is a potent ARE (antioxidant response element) activator. AI-3 increases the NQO1 at the transcript levels and protein expression levels. AI-3 has the potential for the research of oxidative stress related diseases .

HY-103472

FPR-A14	Formyl Peptide Receptor (FPR)	Neurological Disease
FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca ²⁺ mobilization and chemotaxis with EC₅₀s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation .

HY-N0293R

Paeoniflorin (Standard) Peoniflorin (Standard)	Reference Standards HSP	Infection Neurological Disease Cancer
Paeoniflorin (Standard) is the analytical standard of Paeoniflorin. This product is intended for research and analytical applications. Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .

HY-N0293

Paeoniflorin Maximum Cited Publications 28 Publications Verification Peoniflorin	HSP	Infection Neurological Disease Cancer
Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .

Cat. No.	Product Name	Target	Research Area

HY-P3275

β-Amyloid (17-40) Aβ(17-40)	Amyloid-β	Neurological Disease
β-Amyloid (17-40) (Aβ(17-40)) is a fragment of Amyloid-β peptide that has shown neurotoxic activities in SH-SY5Y and IMR-32 cells. β-Amyloid (17-40) can be used for the research of neurological disease .

L-Glutamic acid (Standard)	Structural Classification Microorganisms Source classification Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Cancer	Reference Standards Endogenous Metabolite iGluR Ferroptosis Apoptosis
L-Glutamic acid (Standard) is the analytical standard of L-Glutamic acid. This product is intended for research and analytical applications. L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases . IC₅₀ & Target:DA . In Vitro: L-Glutamic acid (120, 500, 750, 1000 mg/dL) can reduce the harmful effect of lithium on the embryonic development of Xenopus Xenopus . L-Glutamic acid (2, 5, 10, 20 mM, 24-48 h) can induce neuroexcitotoxicity in neuroblastoma . In Vivo: L-Glutamic acid (3 g/kg, subcutaneous injection) can promote excitotoxic degeneration of retinal ganglion cells in mice . L-Glutamic acid (750 mg/kg, intraperitoneal injection) can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats .

L-Glutamic acid 10+ Cited Publications	Structural Classification Microorganisms Source classification Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Cancer	Endogenous Metabolite iGluR Ferroptosis Apoptosis
L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors .

L-Glutamic acid monosodium salt 10+ Cited Publications	Structural Classification Microorganisms other families Animals Source classification Amino acids Plants	iGluR Apoptosis Ferroptosis Endogenous Metabolite
L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases. L-Glutamic acid monosodium salt acts at ionotropic and metabotropic glutamate receptors .

Paeoniflorin (Standard) Peoniflorin (Standard)	Structural Classification Other Monoterpenes Paeonia lactiflora Pall. Terpenoids Source classification Plants Paeoniaceae	Reference Standards HSP
Paeoniflorin (Standard) is the analytical standard of Paeoniflorin. This product is intended for research and analytical applications. Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .

Paeoniflorin Maximum Cited Publications 28 Publications Verification Peoniflorin	Structural Classification Other Monoterpenes Paeonia lactiflora Pall. Terpenoids Source classification Plants Paeoniaceae	HSP
Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .

Antiviral agent 64	Structural Classification Monophenols Source classification Phenols Alpinia officinarum Hance Plants Zingiberaceae	Enterovirus Influenza Virus RSV HSV
Antiviral agent 64 (Compound 12) is a diarylheptanoid that can be isolated from Alpinia officinarum. Antiviral agent 64 exhibits cytotoxicity in human neuroblastoma cell IMR-32 with an IC₅₀ of 0.23 μM. Antiviral agent 64 exhibits antiviral efficacy, that inhibits RSV, poliovirus, measles virus, HSV-1, and influenza virus H1N1, with EC₅₀ of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively .

Alpinoid D	Structural Classification Source classification Phenols Alpinia officinarum Hance Plants Zingiberaceae	Others
Alpinoid D, a diarylheptanoid, can be isolated from the MeOH extract from the rhizomes of Alpinia officinarum Hance. Alpinoid D shows cytotoxic effect against IMR-32 human neuroblastoma cell line .

L-Glutamic acid monosodium salt (Standard)	Structural Classification Microorganisms other families Animals Source classification Amino acids Plants	Reference Standards iGluR Apoptosis Ferroptosis Endogenous Metabolite
L-Glutamic acid (monosodium salt) (Standard) is the analytical standard of L-Glutamic acid (monosodium salt). This product is intended for research and analytical applications. L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases .

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