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IL-12p70

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (1) Apoptosis (1) Bradykinin Receptor (2) CD28 (1) Phosphatase (1) STING (1) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (5) Metabolic Disease (2)

5

Inhibitors & Agonists

2

Peptides

1

MCE Kits

1

Inhibitory Antibodies

2

Recombinant Proteins

Targets Recommended: Interleukin Related IRAK Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

ATUX-1215	Phosphatase Apoptosis	Inflammation/Immunology Cancer
ATUX-1215 is an activator of protein phosphatase 2A (PP2A). ATUX-1215 reduced the phosphorylation of ERK, p38, JNK, and Akt and the secretion of IL-12p70, GM-CSF, and IL1α in BLM-treated animals. ATUX-1215 can slow the progression of lung fibrosis .

Lys-[Des-Arg9]Bradykinin TFA	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a K_i of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin TFA has low inhibitory activity on B2 receptors .

TLR7 agonist 18	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
TLR7 agonist 18 (Compound 21a) is a selective Toll-like receptor 7 (TLR7) agonist with an EC₅₀ of 7.8 μM. TLR7 agonist 18 is not cytotoxic to hTLR7 cotransfected HEK293 cell lines and can induce the secretion of several cytokines, including IL-1β, IL-12p70, IL-8, and TNF-α. TLR7 agonist 18 can be used in vaccine, asthma, allergy and anti-cancer research .

M04	STING TNF Receptor Interleukin Related CD28	Inflammation/Immunology
M04 is an agonist of STING. It induces the expression of the IFN reporter gene in HEK293T cells expressing wild-type human STING, but does not induce this expression in HEK293T cells expressing the R71H-G230A-R293Q (HAQ) STING variant or in mouse RAW 264.7 cells, indicating that its activity is dependent on allelic and species variations. M04 induces the production of TNF-α, IL-10, IL-1β, and *IL-12p70* in human peripheral blood mononuclear cells (PBMCs). At a concentration of 50 µM, M04 stimulates dendritic cells isolated from PBMCs to express the MHC class II cell surface receptor HLA-DR and co-stimulatory molecules CD40, CD80, and CD86, and also enhances their ability to activate T cells in an ex vivo assay. M04 can be used in research on inflammatory immune diseases .

Lys-[Des-Arg9]Bradykinin	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
Lys-[Des-Arg9]Bradykinin, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a K_i of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin has low inhibitory activity on B2 receptors .

Cat. No.	Product Name	Target	Research Area

Lys-[Des-Arg9]Bradykinin TFA	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a K_i of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin TFA has low inhibitory activity on B2 receptors .

Lys-[Des-Arg9]Bradykinin	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
Lys-[Des-Arg9]Bradykinin, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a K_i of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin has low inhibitory activity on B2 receptors .

Cat. No.	Product Name

*HOLO Human Interleukin-12p70 (IL-12p70) Detection Kit*
MCE HOLO Human Interleukin-12p70 (IL-12p70) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of human IL-12p70 concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Cat. No.	Product Name	Target	Research Area

*Anti-IL-12 p70* Antibody (20C2)**	Inhibitory Antibodies	Others
Anti-IL-12 p70 Antibody (20C2) is a kind of rat IgG1, κ chimeric antibody, targeting to human *IL-12 p70. The recommend isotype control of Anti-IL-12 p70* Antibody (20C2): Rat IgG1 kappa, Isotype Control (HY-P99979).

Species:	Human (1) Cynomolgus (1)
Tag:	His (2) Avi (1)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

	IL-12 Protein, Cynomolgus (HEK293, His) CLMF; CLMF2; IL-12A; IL-12B; IL12; IL12 p70; IMD28; IMD29; NFSK; NKSF1; NKSF2; P35; IL-12 subunit p35; IL12A; interleukin 12	Cynomolgus	HEK293
	IL-12 Protein, forming a heterodimer with IL23A, generates the cytokine IL-23, pivotal in innate and adaptive immunity. Collaborating with IL-17, IL-23 prompts an acute response to infection in peripheral tissues. Binding to the receptor complex IL12RB1 and IL23R, IL-23 activates Jak-Stat signaling, preferentially stimulates memory T-cells, and induces pro-inflammatory cytokine production. Implicated in autoimmune inflammation and tumorigenesis, IL-23 acts as a growth factor for activated T and NK cells, enhances NK cell lytic activity, and stimulates IFN-gamma production by resting PBMC. IL-12 Protein, Cynomolgus (HEK293, His) is a recombinant protein dimer complex containing cynomolgus-derived IL-12 protein, expressed by HEK293, with C-His labeled tag. IL-12 Protein, Cynomolgus (HEK293, His), has molecular weight of 45-48 kDa (IL-12B) & 38-44 kDa (IL-12A), respectively.

	IL-12 Protein, Human (Biotinylated, HEK293, His-Avi) CLMF; CLMF2; IL-12A; IL-12B; IL12; IL12 p70; IMD28; IMD29; NFSK; NKSF1; NKSF2; P35; IL-12 subunit p35; IL12A; interleukin 12	Human	HEK293
	IL-35 protein plays a key role in immune regulation, forming IL-12 cytokine with IL12B or IL-35 cytokine with EBI3/IL27B. IL-12 modulates T cell and natural killer cell responses and induces interferon gamma production. IL-12 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived IL-12 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. IL-12 Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of ~40-45 kDa.

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