IKB

By Targets:	Apoptosis (3) Btk (3) Caspase (1) EGFR (1) FLT3 (1) GABA Receptor (1) IAP (1) IKK (4) IRAK (1) PARP (1) Phosphatase (1) PI3K (1) PPAR (1) PROTACs (3) Reference Standards (1) Small Interfering RNA (siRNA) (1) TNF Receptor (1)
By Research Areas:	Cancer (8) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19362

AZD3264 2 Publications Verification	IKK	Inflammation/Immunology
AZD3264 is a selective IkB-kinase IKK2 inhibitor.

HY-19383

Ertiprotafib 2 Publications Verification PTP 112	Phosphatase IKK PPAR	Metabolic Disease
Ertiprotafib is an inhibitor of *PTP1B, IkB* kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC₅₀ of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC₅₀** of ~1 μM for PPARα/PPARβ.

HY-12461

WS6	PI3K EGFR GABA Receptor FLT3 IKK	Neurological Disease Metabolic Disease Inflammation/Immunology
WS6 is an *IkB* kinase and EBP1 inhibitor, with IC₅₀ values of 0.24 nM, 0.21 nM, and 40.48 nM in MV4-11, MOLM13, and K562 cells, respectively. WS6 promotes the proliferation of alpha and beta cells in the pancreas, has antioxidant and anti-inflammatory activities, and can alleviate depression like behavior in rats ^[1][2][4].

HY-151966

TD1092	PROTACs IAP Caspase	Cancer
TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research .

HY-112557

PROTAC TBK1 degrader-2	PROTACs IKK	Cancer
PROTAC TBK1 degrader-2 is a Ligands for Target Protein for PROTAC. PROTAC TBK1 degrader-2 is a potent degrader based on the serine/threonine kinase TANK-binding kinase 1 (TBK1) (DC₅₀=15 nM; K_d=4.6 nM) with a maximum efficiency of 96%. PROTAC TBK1 degrader-2 also targets to IkB kinase IKKε (IC₅₀=8.7 nM), with low selectivity over TBK1 (IC₅₀=1.3 nM) .

HY-153188

JNJ-1013	PROTACs Apoptosis IRAK	Cancer
JNJ-1013 is a potent and selective IRAK1 PROTAC degrader with an IC₅₀s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKBα, pSTAT3(Tyr705) (Pink: ligand for target protein (HY-138834); black: linker (HY-Y1760); Blue: E3 ligase ligand (HY-112078)) .

HY-N12836

Peniditerpenoid A	Others	Metabolic Disease
Peniditerpenoid A is a di-seco-indole diterpenoid. Peniditerpenoid A decreases the expression of p-IkBαby RANKL induced. Peniditerpenoid A inhibits RANKL induced osteoclast differentiation. Peniditerpenoid A has the potential for the research of osteoporosis .

HY-173210

TNF-α-IN-22	Apoptosis TNF Receptor	Cancer
TNF-α-IN-22 (Compound 30) is a TNFα inhibitor. It can induce Apoptosis by inhibiting the downregulation of IkBα induced by TNFα and blocking the cell cycle. TNF-α-IN-22 can be used in the research of triple-negative breast cancer .

HY-147906

Anticancer agent 71	Apoptosis PARP	Cancer
Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity .

HY-RS20185

Nfkbib Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nfkbib Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nfkbib gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nfkbib Mouse Pre-designed siRNA Set A Nfkbib Mouse Pre-designed siRNA Set A

HY-17600S

Acalabrutinib-d4 ACP-196-d₄	Btk	Cancer
Acalabrutinib-d₄ is a deuterium labeled Acalabrutinib. Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor . Acalabrutinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17600R

Acalabrutinib (Standard) ACP-196 (Standard)	Reference Standards Btk	Cancer
Acalabrutinib (Standard) is the analytical standard of Acalabrutinib. This product is intended for research and analytical applications. Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL) . Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17600

Acalabrutinib Maximum Cited Publications 29 Publications Verification ACP-196	Btk	Cancer
Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL) . Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N12836

Peniditerpenoid A	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Others
Peniditerpenoid A is a di-seco-indole diterpenoid. Peniditerpenoid A decreases the expression of p-IkBαby RANKL induced. Peniditerpenoid A inhibits RANKL induced osteoclast differentiation. Peniditerpenoid A has the potential for the research of osteoporosis .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P76986

	IKB beta/NFKBIB Protein, Human (His) NF-kappa-B inhibitor beta; NF-kappa-BIB; TRIP-9; IKBB	Human	E. coli
	IKB beta/NFKBIB protein effectively inhibits NF-kappa-B and prevents NF-kappa-B activation by forming a cytoplasmic complex. After cell stimulation, the non-phosphorylated form is resynthesized, binds to NF-kappa-B, aids nuclear transport, and protects NF-kappa-B from NFKBIA-dependent inactivation. IKB beta/NFKBIB Protein, Human (His) is the recombinant human-derived IKB beta/NFKBIB protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701230

	*NFKBIE/IKB* epsilon Protein, Human (His)** C20orf18; HOIL-1; HOIL1; PBMEI; PGBM1; RBCK2; RNF54; UBCE7IP3; XAP3; XAP4; ZRANB4	Human	E. coli
	NFKBIE/IKB epsilon Protein crucially inhibits NF-kappa-B by forming a cytoplasmic complex, preventing its DNA-binding activity. It targets specific complexes involving p50-p65, p50-c-Rel, and interacts with subunits RELA, REL, NFKB1 (p50), and NFKB2 (p52). NFKBIE/IKB epsilon plays a pivotal role in regulating NF-kappa-B signaling, controlling nuclear translocation and transcriptional activities. NFKBIE/IKB epsilon Protein, Human (His) is the recombinant human-derived NFKBIE/IKB epsilon protein, expressed by E. coli , with N-10*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-17600S

Acalabrutinib-d4
Acalabrutinib-d₄ is a deuterium labeled Acalabrutinib. Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor . Acalabrutinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80718

	IKB alpha Antibody (YA350) NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IKB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3	WB, IHC-P, IP	Human, Mouse, Rat
	IKB alpha Antibody (YA350) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKB alpha.

HY-P80466

	*Phospho-IKB* alpha (Ser32) Antibody (YA183)**	WB, ICC/IF, IP	Human, Mouse
	Phospho-IKB alpha (Ser32) Antibody (YA183) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-IKB alpha (Ser32).

HY-P80826

	*Phospho-IKB* alpha (Ser32) Antibody (YA185)** NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IKB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3	WB, IP	Human, Mouse
	Phospho-IKB alpha (Ser32) Antibody (YA185) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-IKB alpha (Ser32).

HY-P80827

	*Phospho-IKB* alpha (Ser36) Antibody (YA184)** NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IKB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3	WB	Human, Mouse
	Phospho-IKB alpha (Ser36) Antibody (YA184) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-IKB alpha (Ser36).

HY-P86197

	IκB-α Antibody (YA5889) 1 Publications Verification NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IKB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3;	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	IκB-α Antibody (YA5889) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IκB-α.

HY-P83267

	IKB epsilon Antibody (YA3012) NFKBIE; IKBE; NF-kappa-B inhibitor epsilon; NF-kappa-BIE; I-kappa-B-epsilon; IKB-E; IKB-epsilon; IkappaBepsilon	WB, IP	Human
	IKB epsilon Antibody (YA3012) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKB epsilon.

HY-P86252

	IKB epsilon Antibody (YA5944) NFKBIE; IKBE; NF-kappa-B inhibitor epsilon ; NF-kappa-BIE; I-kappa-B-epsilon; IKB-E; IKB-epsilon; IkappaBepsilon;	WB, IHC-P, ICC/IF, IP	Human
	IKB epsilon Antibody (YA5944) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKB epsilon.

HY-P84592

	IKB beta Antibody (YA4289) IKBB; TRIP9; NFKBIB	WB, ELISA	Human
	IKB beta Antibody (YA4289) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IKB beta.

HY-P85710

	IKB beta Antibody (YA5402) NF-kappa-B inhibitor beta; NF-kappa-BIB; I-kappa-B-beta; IKB-B; IKB-beta; IkappaBbeta; Thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP-9;	IHC-P, WB	Human, Mouse, Rat
	IKB beta Antibody (YA5402) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKB beta.

HY-P83343

	IKB beta Antibody (YA3088) NFKBIB; IKBB; TRIP9; NF-kappa-B inhibitor beta; NF-kappa-BIB; I-kappa-B-beta; IKB-B; IKB-beta; IkappaBbeta; Thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP-9	WB, IHC-P, IP	Human, Mouse
	IKB beta Antibody (YA3088) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKB beta.

HY-P87026

	*Phospho-IKB* alpha (S36) Antibody (YA6719)** I kappa B alpha antibody; I-kappa-B-alpha antibody; IkappaBalpha antibody; IKB-alpha antibody; IKBA antibody; IKBA_HUMAN antibody; IKBalpha antibody; MAD 3 antibody; MAD3 antibody; Major histocompatibility complex enhancer-binding protein MAD3 antibody; I kappa B alpha antibody; I-kappa-B-alpha antibody; IkappaBalpha antibody; IKB-alpha antibody; IKBA antibody; IKBA_HUMAN antibody; IKBalpha antibody; MAD 3 antibody; MAD3 antibody; Major histocompatibility complex enhancer-binding protein MAD3 antibody; NF kappa B inhibitor alpha antibody; NF-kappa-B inhibitor alpha antibody; NFKBI antibody; NFKBIA antibody; Nuclear factor of kappa light chain gene enhancer in B cells antibody; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha antibody;	WB	Human, Mouse, Rat
	Phospho-IKB alpha (S36) Antibody (YA6719) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-IKB alpha (S36).

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HY-RS20185

Nfkbib Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Nfkbib Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nfkbib gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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IKB

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