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Human casein

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By Targets:	Casein Kinase (8) 11β-HSD (3) Apoptosis (2) Autophagy (3) DNA-PK (2) Endogenous Metabolite (1) Isotope-Labeled Compounds (1) Kallikrein (1) PI3K (2) Protease Activated Receptor (PAR) (1) Reference Standards (2) SARS-CoV (3) Ser/Thr Protease (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Inflammation/Immunology (1) Metabolic Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Casein Kinase Human leukocyte immunoglobulin (Ig)-like receptors (LILR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111378

Casein Kinase II Inhibitor IV	Casein Kinase	Metabolic Disease
Casein Kinase II Inhibitor IV is a potent, ATP-competitive of casein kinase II inhibitor with an IC₅₀ of 9 nM. Casein Kinase II Inhibitor IV ia also a human keratinocytes (NHEK) differentiation inducer .

HY-14393

Emodin 30+ Cited Publications Frangula emodin	SARS-CoV Casein Kinase Autophagy 11β-HSD	Cancer
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-14393R

Emodin (Standard) 30+ Cited Publications Frangula emodin (Standard)	Reference Standards SARS-CoV Casein Kinase Autophagy 11β-HSD	Cancer
Emodin (Standard) is the analytical standard of Emodin. This product is intended for research and analytical applications. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-10108A

LY294002 hydrochloride Maximum Cited Publications 976 Publications Verification	PI3K Casein Kinase DNA-PK Apoptosis	Cancer
LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC₅₀ values of 0.5, 0.57, and 0.97 μM for P110α, P110δ and P110β, respectively. LY294002 hydrochloride also inhibits CK2 with an IC₅₀ of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research .

HY-125865A

**Human casein**	Casein Kinase Endogenous Metabolite	Cancer
Human casein is an orally active phosphoprotein that can be separated into various electrophoretic components, such as α2-Casein, κ-Casein, β-casein, and γ-casein. Human casein has also been blended and grafted with other polymers, cross-linkers, or monomers to improve its functional properties. Human casein enhances calcium absorption and reduces the extent of fissure as well as smooth-surface caries. Human casein promotes proliferation of prostate cancer. Human casein has various applications in the paper, leather, textile, and food industries, serving as coatings, adhesives, and packaging materials .

HY-171278

Casein kinase 1δ-IN-28	Casein Kinase	Metabolic Disease Cancer
Casein kinase 1δ-IN-28 (Compound 4) is the inhibitor for CK1ε with an IC₅₀ of 0.0146 μM. Casein kinase 1δ-IN-28 exhibits a metabolite rate in human liver microsomes of 52% .

HY-129047E

Trypsin, porcine pancreas (Cell culture grade)	Ser/Thr Protease Kallikrein Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
Trypsin, porcine pancreas (Cell culture grade) is a serine protease enzyme that hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin, porcine pancreas (Cell culture grade) has an excellent protein digestibility for α-lactalbumin and β-casein. Trypsin, porcine pancreas (Cell culture grade) activates kallikrein and regulates the blood pressure. Trypsin, Human Pancreas is an activator for PAR, thereby regulating cellular inflammatory and immune responses .

HY-14393S

Emodin-d4 Frangula emodin-d₄	Isotope-Labeled Compounds SARS-CoV Casein Kinase Autophagy 11β-HSD	Cancer
Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-10108AR

LY294002 hydrochloride (Standard)	Reference Standards PI3K Casein Kinase DNA-PK Apoptosis	Cancer
LY294002 (hydrochloride) (Standard) is the analytical standard of LY294002 (hydrochloride). This product is intended for research and analytical applications. LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC50 values of 0.5, 0.57, and 0.97 μM for P110α, P110δ and P110β, respectively. LY294002 hydrochloride also inhibits CK2 with an IC50 of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research .

Cat. No.	Product Name	Type

HY-125865A

**Human casein**	Native Proteins
Human casein is an orally active phosphoprotein that can be separated into various electrophoretic components, such as α2-Casein, κ-Casein, β-casein, and γ-casein. Human casein has also been blended and grafted with other polymers, cross-linkers, or monomers to improve its functional properties. Human casein enhances calcium absorption and reduces the extent of fissure as well as smooth-surface caries. Human casein promotes proliferation of prostate cancer. Human casein has various applications in the paper, leather, textile, and food industries, serving as coatings, adhesives, and packaging materials .

Human casein

Native Proteins

Human casein is an orally active phosphoprotein that can be separated into various electrophoretic components, such as α2-Casein, κ-Casein, β-casein, and γ-casein. Human casein has also been blended and grafted with other polymers, cross-linkers, or monomers to improve its functional properties. Human casein enhances calcium absorption and reduces the extent of fissure as well as smooth-surface caries. Human casein promotes proliferation of prostate cancer. Human casein has various applications in the paper, leather, textile, and food industries, serving as coatings, adhesives, and packaging materials .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14393

Emodin 30+ Cited Publications Frangula emodin	Classification of Application Fields Polygonaceae Source classification Plants Endogenous metabolite Quinones Human Gut Microbiota Metabolites Microorganisms Rheum palmatum L. Anthraquinones Phenols Polyphenols Disease Research Fields Cancer	SARS-CoV Casein Kinase Autophagy 11β-HSD
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-14393R

Emodin (Standard) 30+ Cited Publications Frangula emodin (Standard)	Quinones Rheum palmatum L. Classification of Application Fields Polygonaceae Source classification Phenols Plants Disease Research Fields Cancer	Reference Standards SARS-CoV Casein Kinase Autophagy 11β-HSD
Emodin (Standard) is the analytical standard of Emodin. This product is intended for research and analytical applications. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

Species:	Human (22)
Tag:	His (13) Strep (1) Tag Free (2) Myc (1) GST (10)
Source:	HEK293 (4) Sf9 insect cells (14) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P70978

	*Kappa-Casein* Protein, Human (HEK293, His)** Kappa-casein; CSN3; CASK; CSN10; CSNK	Human	HEK293
	Kappa-casein (CSN3) is a member of Caseins family, and is an extracellular mammalian milk protein involved in several important physiological processes. CSN3 prevents casein precipitation in milk and increase the efficiency of digestion, prevention of neonate hypersensitivity to ingested proteins, and inhibition of gastric pathogens. Kappa-Casein Protein, Human (HEK293, His) is the recombinant human-derived Kappa-Casein protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72152

	CSNK1E Protein, Human (His) casein kinase 1 epsilon; casein kinase I; casein kinase I epsilon; casein kinase I isoform epsilon; CKI epsilon; CKI-epsilon; CKIe; CKIepsilon; CSNK 1E; CSNK1E; DBT; Doubletime, Drosophila, homolog of; EC 2.7.11.1; epsilon isoform; HCK IE; KC1E; KC1E_Human; kinase CK1 epsilon; MGC 10398	Human	E. coli
	CSNK1E protein is a casein kinase that preferentially phosphorylates acidic proteins such as casein. CSNK1E Protein, Human (His) is the recombinant human-derived CSNK1E protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702666

	CSNK1E Protein, Human (sf9, GST) CSNK1E; casein kinase 1, epsilon; casein kinase I isoform epsilon; HCKIE	Human	Sf9 insect cells
	CSNK1E protein is a casein kinase that preferentially phosphorylates acidic proteins such as casein. CSNK1E Protein, Human (sf9, GST) is the recombinant human-derived CSNK1E, expressed by Sf9 insect cells, with GST labeled tag. The total length of CSNK1E Protein, Human (sf9, GST) is 415 a.a..

HY-P72872

	*CSNK1A1/Casein* Kinase I alpha Protein, Human (sf9, GST)** casein kinase I isoform alpha; CKI-alpha; CK1; CSNK1A1	Human	Sf9 insect cells
	Casein kinase I α is a member of casein kinases that exhibits a preference for phosphorylation of acidic proteins such as casein. It phosphorylates many substrates, including CTNNB1 at "Ser-45" involved in Wnt signaling. CSNK1A1/Casein Kinase I alpha Protein, Human (sf9, GST) is the recombinant human-derived Casein Kinase I alpha protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P702670

	CSNK1A1L Protein, Human (sf9, His, GST) CSNK1A1L; casein kinase 1, alpha 1-like; casein kinase I isoform alpha-like; MGC33182; CKI-alpha-like; casein kinase I alpha S-like; CK1	Human	Sf9 insect cells
	CSNK1A1L Protein, Human (sf9, His, GST) is the recombinant human-derived CSNK1A1L, expressed by Sf9 insect cells , with His, GST labeled tag.

HY-P7741

	Casein Kinase I gamma-2 Protein, Human (His) rHucasein kinase I isoform gamma-2, His; casein kinase I isoform gamma-2; CK1G2; CSNK1G2	Human	E. coli
	Casein kinase I gamma-2 Protein, Human (His) is an approximately 55.0 kDa human casein kinase I isoform gamma-2 protein with a His-flag expressed in E. coli. Human Casein kinase I isoform gamma-2 may exhibit overexpression during tumorigenesis and belongs to the CKI family.

HY-P72873

	Casein Kinase I gamma-2 Protein, Human (sf9, His) casein kinase I isoform gamma-2; CKI-gamma 2; CSNK1G2; CK1G2	Human	Sf9 insect cells
	Casein kinase I gamma-2 is a serine/threonine protein kinase that targets acidic proteins and phosphorylates a variety of substrates, such as COL4A3BP/CERT, MTA1 and SMAD3, especially destabilizing SMAD3 and inhibiting TGF- beta reaction. Hyperphosphorylation of COL4A3BP/CERT disrupts ER-to-Golgi transport and affects the synthesis of ceramide and sphingomyelin. Casein Kinase I gamma-2 Protein, Human (sf9, His) is the recombinant human-derived Casein Kinase I gamma-2 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P702668

	*CSNK1A1/Casein* Kinase I alpha Protein, Human (sf9, His, Strep)** CSNK1A1; casein kinase 1, alpha 1; casein kinase I isoform alpha; CK1; CK1a; CK1alpha; CKIa; CKIalpha; clock regulator kinase; CKI-alpha; down-regulated in lung cancer; HLCDGP1; PRO2975	Human	Sf9 insect cells
	Casein kinase I α is a member of casein kinases that exhibits a preference for phosphorylation of acidic proteins such as casein. It phosphorylates many substrates, including CTNNB1 at "Ser-45" involved in Wnt signaling. CSNK1A1/Casein Kinase I alpha Protein, Human (sf9, His, Strep) is the recombinant human-derived CSNK1A1, expressed by Sf9 insect cells, with Strep, His labeled tag.

HY-P71184

	PACSIN2 Protein, Human (HEK293, His) Protein Kinase C and casein Kinase Substrate in Neurons Protein 2; PACSIN2	Human	HEK293
	The PACSIN2 protein coordinates caveolar morphogenesis and endocytosis to dynamically regulate cell membrane structure. As a lipid-binding protein, PACSIN2 regulates phosphatidic acid-containing membranes. PACSIN2 Protein, Human (HEK293, His) is the recombinant human-derived PACSIN2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P702669

	CSNK1G1 Protein, Human (sf9, GST) casein kinase I isoform gamma-1; CKI-gamma 1	Human	Sf9 insect cells
	The CSNK1G1 protein is a member of the casein kinase family that preferentially phosphorylates acidic proteins, including casein, exhibiting broad substrate specificity. Functionally, it actively participates in the Wnt signaling pathway and regulates cellular responses. CSNK1G1 Protein, Human (sf9, GST) is the recombinant human-derived CSNK1G1, expressed by Sf9 insect cells, with GST labeled tag. The total length of CSNK1G1 Protein, Human (sf9, GST) is 421 a.a..

HY-P76850

	CSNK1G1 Protein, Human (sf9, His-GST) casein kinase I isoform gamma-1; CKI-gamma 1	Human	Sf9 insect cells
	The CSNK1G1 protein is a member of the casein kinase family that preferentially phosphorylates acidic proteins, including casein, exhibiting broad substrate specificity. Functionally, it actively participates in the Wnt signaling pathway and regulates cellular responses. CSNK1G1 Protein, Human (sf9, His-GST) is the recombinant human-derived CSNK1G1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P71183

	PACSIN1 Protein, Human (HEK293, His) Protein Kinase C and casein Kinase Substrate in Neurons Protein 1; PACSIN1; KIAA1379	Human	HEK293
	The PACSIN1 protein has multiple functions in cell dynamics, reorganizing microtubules and the actin cytoskeleton. PACSIN1 interacts with MAPT, reduces microtubule stability and inhibits MAPT-induced polymerization. PACSIN1 Protein, Human (HEK293, His) is the recombinant human-derived PACSIN1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P705484

	CK1d Protein, Human (His) CSNK1D; casein kinase I isoform delta; CKI-delta; CKId; Tau-protein kinase CSNK1D	Human	E. coli

HY-P76263

	CSNK2A1 Protein, Human (sf9, GST) 1 Publications Verification casein kinase II subunit alpha; CK II alpha; CSNK2A1; CK2A1	Human	Sf9 insect cells
	CK2α/CSNK2A1 protein can phosphorylate serine or threonine. It is involved in the regulation of cell cycle, apoptosis, transcription and viral infection, and has protective effects on the spindle assembly checkpoint and p53/TP53-mediated apoptosis. CK2α/CSNK2A1 can also participate in signal transduction by phosphorylating various factors, affecting circadian clock function and virus life cycle. CSNK2A1 Protein, Human (sf9, GST) is the recombinant human-derived CK2 alpha/CSNK2A1 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P701659

	CK1γ3 Protein, Human (sf9) CSNK1G3; casein kinase I isoform gamma-3; CKI-gamma 3	Human	Sf9 insect cells
	The CK1γ3 protein is a serine/threonine protein kinase in the casein kinase family that prefers acidic proteins, including casein. It has broad substrate specificity and can phosphorylate a variety of proteins, affecting diverse cellular processes. CK1γ3 Protein, Human (sf9) is the recombinant human-derived CK1γ3 protein, expressed by sf9 insect cells , with tag free.

HY-P701658

	CK1d Protein, Human (sf9, GST) CSNK1D; casein kinase I isoform delta; CKI-delta; CKId; Tau-protein kinase CSNK1D	Human	Sf9 insect cells
	The CK1d protein is an important serine/threonine protein kinase that complexly controls cellular processes such as Wnt signaling, DNA repair, and circadian rhythms. Its versatility is evident in phosphorylating a variety of proteins, including connexin-43/GJA1, MAP1A, p53/TP53, and YAP1. CK1d Protein, Human (sf9, GST) is the recombinant human-derived CK1d protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P701660

	CK1γ3 Protein, Human (sf9, GST) CSNK1G3; casein kinase I isoform gamma-3; CKI-gamma 3	Human	Sf9 insect cells
	The CK1γ3 protein is a serine/threonine protein kinase in the casein kinase family that prefers acidic proteins, including casein. It has broad substrate specificity and can phosphorylate a variety of proteins, affecting diverse cellular processes. CK1γ3 Protein, Human (sf9, GST) is the recombinant human-derived CK1γ3 protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P702667

	CSNK1G2 Protein, Human (sf9, GST) CSNK1G2; casein kinase 1 gamma 2; CK1g2	Human	Sf9 insect cells
	Casein kinase I gamma-2 is a serine/threonine protein kinase that targets acidic proteins and phosphorylates a variety of substrates, such as COL4A3BP/CERT, MTA1 and SMAD3, especially destabilizing SMAD3 and inhibiting TGF- beta reaction. Hyperphosphorylation of COL4A3BP/CERT disrupts ER-to-Golgi transport and affects the synthesis of ceramide and sphingomyelin. CSNK1G2 Protein, Human (sf9, GST) is the recombinant human-derived CSNK1G2, expressed by Sf9 insect cells, with GST labeled tag. The total length of CSNK1G2 Protein, Human (sf9, GST) is 414 a.a..

HY-P76296

	CK2 alpha/CSNK2A2 Protein, Human (sf9) casein kinase II subunit alpha'; CK II alpha'; CSNK2A2; CK2A2	Human	Sf9 insect cells
	The CK2 α/CSNK2A2 protein is the catalytic subunit of the constitutively active serine/threonine protein kinase complex and can phosphorylate a variety of substrates, affecting cell cycle progression, apoptosis, transcription, and viral infection. CK2 alpha/CSNK2A2 Protein, Human (sf9) is the recombinant human-derived CK2 alpha/CSNK2A2 protein, expressed by Sf9 insect cells, with tag free.

HY-P702741

	CSNK2A1 Protein, Human (His) CSNK2A1; casein kinase 2 alpha 1; CKII; Cka1; Cka2; CK2A1; OCNDS	Human	E. coli
	The CSNK2A2 protein is a constitutively active kinase that phosphorylates substrates and controls the cell cycle, apoptosis, and transcription. CSNK2A1 Protein, Human (His) is the recombinant human-derived CSNK2A1, expressed by E. coli , with His labeled tag.

HY-P76297

	CK2 alpha/CSNK2A2 Protein, Human (sf9, His-GST) casein kinase II subunit alpha'; CK II alpha'; CSNK2A2; CK2A2	Human	Sf9 insect cells
	CSNK2A2 is the catalytic subunit of the serine/threonine protein kinase complex. It regulates important processes such as cell cycle, apoptosis, and transcription, and affects viral infection. During mitosis, CSNK2A2 maintains CDK1 activity and induces cell cycle arrest. In addition, CSNK2A2 phosphorylates p53/TP53 and negatively regulates apoptosis. It widely affects cell signaling, phosphorylated caspases, the apoptotic factor NOL3, and RNA polymerase, among others. CSNK2A2 also regulates Wnt signaling and acts as a kinase for extracellular proteins. CK2 alpha/CSNK2A2 Protein, Human (sf9, His-GST) is the recombinant human-derived CK2 alpha/CSNK2A2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P71677

	FAM20C Protein, Human (HEK293, Myc, His) C76981; Dentin matrix protein 4; Family with sequence similarity 20 member C; GEF CK; Golgi enriched fraction casein kinase; Protein FAM20C; RNS	Human	HEK293
	The FAM20C protein is a Golgi kinase that phosphorylates secretory pathway proteins and contributes to the biomineralization of bones and teeth. FAM20C phosphorylates caseins and proteins involved in biomineralization and also affects lipid homeostasis, wound healing, and cell migration and adhesion. FAM20C Protein, Human (HEK293, Myc, His) is the recombinant human-derived FAM20C protein, expressed by HEK293 , with N-His, C-Myc labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-14393S

Emodin-d4
Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

Emodin-d4

Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

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