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Results for "

Human TNF mRNA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	mRNA (11) TNF Receptor (1) Apoptosis (1) IFNAR (1) Interleukin Related (1) MMP (1) NF-κB (1) p38 MAPK (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Inflammation/Immunology (7)
Oligonucleotides:	mRNA (11)

Inhibitors & Agonists

Inhibitory Antibodies

Oligonucleotides

Targets Recommended: mRNA TNF Receptor Human leukocyte immunoglobulin (Ig)-like receptors (LILR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-174518

**Human TNF mRNA**	mRNA	Cancer
Human TNF mRNA encodes the human tumor necrosis factor (TNF) protein, a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. TNF is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.

HY-174516

**Human TNFRSF1A mRNA**	mRNA	Cancer
Human TNFRSF1A mRNA encodes the human TNF receptor superfamily member 1A (TNFRSF1A) protein, a member of the TNF receptor superfamily.

HY-174515

**Human TNFRSF1B mRNA**	mRNA	Cancer
Human TNFRSF1B mRNA encodes the human TNF receptor superfamily member 1B (TNFRSF1B) protein, a member of the TNF receptor superfamily.

HY-174514

**Human TNFRSF4 mRNA**	mRNA	Cancer
Human TNFRSF4 mRNA encodes the human TNF receptor superfamily member 4 (TNFRSF4) protein, a member of the TNF receptor superfamily. TNFRSF4 has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5.

HY-174587

**Human LTB mRNA**	mRNA	Inflammation/Immunology
Human LTB mRNA encodes the human lymphotoxin beta (LTB) protein, a type II membrane protein of the TNF family. LTB is an inducer of the inflammatory response system and also involved in normal development of lymphoid tissue.

HY-174513

**Human TNFRSF8 mRNA**	mRNA	Inflammation/Immunology
Human TNFRSF8 mRNA encodes the human TNF receptor superfamily member 8 (TNFRSF8) protein, a member of the TNF receptor superfamily. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

HY-174512

**Human TNFSF8 mRNA**	mRNA	Cancer
Human TNFSF8 mRNA encodes the human TNF superfamily member 8 (TNFSF8) protein, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF8 was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines.

HY-174517

**Human TNFRSF14 mRNA**	mRNA	Inflammation/Immunology
Human TNFRSF14 mRNA encodes the human TNF receptor superfamily member 14 (TNFRSF14) protein, a member of the TNF receptor superfamily. TNFRSF14 functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells.

HY-174714

**Human FAS mRNA**	mRNA	Inflammation/Immunology
Human FAS mRNA encodes the human Fas cell surface death receptor (FAS) protein, a member of the TNF-receptor superfamily. FAS has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system.

HY-174738

**Human CD40 mRNA**	mRNA	Inflammation/Immunology
Human CD40 mRNA encodes the human CD40 molecule (CD40) protein, a member of the TNF-receptor superfamily. CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.

HY-174736

**Human CD70 mRNA**	mRNA	Inflammation/Immunology
Human CD70 mRNA encodes the human CD70 molecule (CD70) protein, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. CD70 induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. It is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

HY-N3063

Pimaric acid	Apoptosis MMP NF-κB p38 MAPK	Cardiovascular Disease Cancer
Pimaric acid is a resin acid that has been found in A. cordata and various pines. Pimaric acid exerts anticancer effects via endoplasmic reticulum stress, caspase-dependent apoptosis, cell cycle arrest, and inhibition of cell migration in human ovarian cancer cells. Pimaric acid reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) .

HY-P991408

DLX-105	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology
DLX-105 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa. DLX-105 reduces skin epidermal thickness and the expression of K16 and Ki67. DLX-105 down-regulates the mRNA levels of IL-17, TNF-α, IL-23p19, IL-12p40, and IFN-γ. DLX-105 can be used in psoriasis research .

Cat. No.	Product Name	Target	Research Area

HY-P991408

DLX-105	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology
DLX-105 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa. DLX-105 reduces skin epidermal thickness and the expression of K16 and Ki67. DLX-105 down-regulates the mRNA levels of IL-17, TNF-α, IL-23p19, IL-12p40, and IFN-γ. DLX-105 can be used in psoriasis research .

Cat. No.	Product Name		Classification

HY-174518

**Human TNF mRNA**		mRNA
Human TNF mRNA encodes the human tumor necrosis factor (TNF) protein, a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. TNF is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.

HY-174516

**Human TNFRSF1A mRNA**		mRNA
Human TNFRSF1A mRNA encodes the human TNF receptor superfamily member 1A (TNFRSF1A) protein, a member of the TNF receptor superfamily.

HY-174515

**Human TNFRSF1B mRNA**		mRNA
Human TNFRSF1B mRNA encodes the human TNF receptor superfamily member 1B (TNFRSF1B) protein, a member of the TNF receptor superfamily.

HY-174514

**Human TNFRSF4 mRNA**		mRNA
Human TNFRSF4 mRNA encodes the human TNF receptor superfamily member 4 (TNFRSF4) protein, a member of the TNF receptor superfamily. TNFRSF4 has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5.

HY-174587

**Human LTB mRNA**		mRNA
Human LTB mRNA encodes the human lymphotoxin beta (LTB) protein, a type II membrane protein of the TNF family. LTB is an inducer of the inflammatory response system and also involved in normal development of lymphoid tissue.

HY-174513

**Human TNFRSF8 mRNA**		mRNA
Human TNFRSF8 mRNA encodes the human TNF receptor superfamily member 8 (TNFRSF8) protein, a member of the TNF receptor superfamily. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

HY-174512

**Human TNFSF8 mRNA**		mRNA
Human TNFSF8 mRNA encodes the human TNF superfamily member 8 (TNFSF8) protein, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF8 was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines.

HY-174517

**Human TNFRSF14 mRNA**		mRNA
Human TNFRSF14 mRNA encodes the human TNF receptor superfamily member 14 (TNFRSF14) protein, a member of the TNF receptor superfamily. TNFRSF14 functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells.

HY-174714

**Human FAS mRNA**		mRNA
Human FAS mRNA encodes the human Fas cell surface death receptor (FAS) protein, a member of the TNF-receptor superfamily. FAS has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system.

HY-174738

**Human CD40 mRNA**		mRNA
Human CD40 mRNA encodes the human CD40 molecule (CD40) protein, a member of the TNF-receptor superfamily. CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.

HY-174736

**Human CD70 mRNA**		mRNA
Human CD70 mRNA encodes the human CD70 molecule (CD70) protein, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. CD70 induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. It is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

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