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Results for "

HCN

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HCN Channel (17) 5-HT Receptor (1) Antibiotic (1) Drug Metabolite (4) Endogenous Metabolite (1) Isotope-Labeled Compounds (1) PKA (1) Potassium Channel (2) Reference Standards (1) Serotonin Transporter (1) Small Interfering RNA (siRNA) (13)
By Research Areas:	Cancer (4) Cardiovascular Disease (10) Endocrinology (3) Infection (1) Inflammation/Immunology (2) Neurological Disease (10)
Oligonucleotides:	Rat Pre-designed siRNA Sets (4) Mouse Pre-designed siRNA Sets (4) Human Pre-designed siRNA Sets (5) siRNAs (13)

Inhibitors & Agonists

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: HCN Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS06048

HCN3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HCN3 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN3 Human Pre-designed siRNA Set A HCN3 Human Pre-designed siRNA Set A

HY-RS25631

Hcn3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hcn3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hcn3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn3 Rat Pre-designed siRNA Set A Hcn3 Rat Pre-designed siRNA Set A

HY-RS25103

Hcn2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hcn2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hcn2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn2 Rat Pre-designed siRNA Set A Hcn2 Rat Pre-designed siRNA Set A

HY-RS06047

HCN2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HCN2 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN2 Human Pre-designed siRNA Set A HCN2 Human Pre-designed siRNA Set A

HY-RS18617

Hcn2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hcn2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hcn2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn2 Mouse Pre-designed siRNA Set A Hcn2 Mouse Pre-designed siRNA Set A

HY-RS20286

Hcn4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hcn4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hcn4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn4 Mouse Pre-designed siRNA Set A Hcn4 Mouse Pre-designed siRNA Set A

HY-RS06046

HCN1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HCN1 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN1 Human Pre-designed siRNA Set A HCN1 Human Pre-designed siRNA Set A

HY-RS26794

Hcn4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hcn4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hcn4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn4 Rat Pre-designed siRNA Set A Hcn4 Rat Pre-designed siRNA Set A

HY-RS06049

HCN4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HCN4 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN4 Human Pre-designed siRNA Set A HCN4 Human Pre-designed siRNA Set A

HY-RS22198

Hcn1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hcn1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hcn1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn1 Mouse Pre-designed siRNA Set A Hcn1 Mouse Pre-designed siRNA Set A

HY-RS19140

Hcn3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hcn3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hcn3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn3 Mouse Pre-designed siRNA Set A Hcn3 Mouse Pre-designed siRNA Set A

HY-RS28720

Hcn1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hcn1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hcn1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn1 Rat Pre-designed siRNA Set A Hcn1 Rat Pre-designed siRNA Set A

HY-163455

*pan-HCN-IN-1*	HCN Channel	Neurological Disease
pan-HCN-IN-1 (Compound J&J12e) is an inhibitor for hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with IC₅₀ of 58 nM. pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rats brain slices .

HY-160209

KIO-301	HCN Channel	Cardiovascular Disease
KIO-301 is a photoswitchable HCN channel blocker, and can be used as the vitreous “light switch” molecule that reactivates retinitis pigmentosa .

HY-172550

MS7710	HCN Channel	Neurological Disease
MS7710 is a brain-penetrant inhibitor targeting the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. MS7710 reduces the I_h current and decreases the activity of ventral tegmental area (VTA) dopamine neurons by inhibiting HCN channels. MS7710 can effectively improve social interaction deficits and reward-related cognitive flexibility in the chronic social defeat stress (CSDS) mouse model. MS7710 is promising for research of depression .

HY-161092

KIO-301 chloride	HCN Channel Potassium Channel	Neurological Disease
KIO-301 chloride is an azobenzene photoswitch compound that can block voltage-gated ion channels, including hyperpolarisation-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium channels during exposure to visible light .

HY-N6789

KT5720 3 Publications Verification	PKA	Neurological Disease Cancer
KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor (IC₅₀=3.3 μM). KT5720 is effective in reversing MDR1-mediated multidrug resistance. KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2 ⁺ concentrations. KT5720 can be used in the study of haematological malignancies as well as HCN and DRG neuron-related diseases .

HY-161092A

KIO-301 chloride hydrochloride	HCN Channel Potassium Channel	Neurological Disease
KIO-301 chloride hydrochloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including hyperpolarization-activated cyclic nucleotide gating (HCN, during exposure to visible light) ) and voltage-gated potassium channels (voltage-gated potassium channels) .

HY-W052508

Norquetiapine N-Desalkylquetiapine	Drug Metabolite 5-HT Receptor HCN Channel Serotonin Transporter	Neurological Disease
Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), 5-HT_2C(K_i = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation .

HY-160505

RO-275	HCN Channel	Neurological Disease
RO-275 (compound 29) is a potent, selective and orally active *HCN1* inhibitor with IC₅₀ values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder .

HY-13422

Zatebradine hydrochloride 2 Publications Verification UL-FS-49; UL-FS-49CL	HCN Channel	Cardiovascular Disease
Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of *hyperpolarization-activated cyclic nucleotide-gated (HCN) channels* with an IC₅₀ values 1.96 µM. Zatebradine blocks the slow inward current through human *HCN1, HCN2, HCN3* and HCN4 channels, with IC₅₀ values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively .

HY-13422A

Zatebradine 2 Publications Verification UL-FS-49 free base; UL-FS-49CL free base	HCN Channel	Cardiovascular Disease
Zatebradine (UL-FS-49 (free base); UL-FS-49CL (free base)) is a potent inhibitor of *hyperpolarization-activated cyclic nucleotide-gated (HCN) channels* with an IC₅₀ value of 1.96 µM. Zatebradine blocks the slow inward current through human *HCN1, HCN2, HCN3* and HCN4 channels, with IC₅₀ values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively .

HY-13422R

Zatebradine hydrochloride (Standard)	HCN Channel	Cardiovascular Disease
Zatebradine (hydrochloride) (Standard) is the analytical standard of Zatebradine (hydrochloride). This product is intended for research and analytical applications. Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 μM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 μM, 2.21 μM, 1.90 μM and 1.88 μM, respectively .

HY-18940

Cilobradine Cilo	Endogenous Metabolite	Cardiovascular Disease
Cilobradine (Cilo) is a HCN channel blocker with heart rate reducing activity. Cilobradine blocks the slow inward current of human HCN1, HCN2, HCN3, and HCN4 channels. Cilobradine has a slightly higher efficiency in blocking endogenous If in mouse sinoatrial node cells (IC50 value is 0.62μM). Cilobradine can dose-dependently reduce the heart rate from 600 to 200 bpm with an ED50 value of 1.2 mg/kg. Cilobradine induces arrhythmias at doses greater than 5 mg/kg, which are characterized by periodic fluctuations between T waves and P waves .

HY-119102

BPU-11	HCN Channel	Inflammation/Immunology
BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease .

HY-101346

ZD7288 Maximum Cited Publications 9 Publications Verification ICI D7288	HCN Channel	Neurological Disease
ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker .

HY-18940A

Cilobradine hydrochloride DK-AH 269	HCN Channel	Cardiovascular Disease Neurological Disease
Cilobradine hydrochloride is a *HCN* channel blocker. Cilobradine hydrochloride induces cardiac pacemaker currents and produces antidepressant effects .

HY-131281

Ivabradine impurity 1	Drug Metabolite	Others
Ivabradine impurity 1 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker .

HY-131282

Ivabradine impurity 2	Drug Metabolite	Others
Ivabradine impurity 2 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker .

HY-131283

8-Demethyl Ivabradine	Drug Metabolite	Endocrinology
8-Demethyl Ivabradine is a metabolite of Ivabradine. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker .

HY-RS16342

MALAT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MALAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for MALAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MALAT1 Human Pre-designed siRNA Set A MALAT1 Human Pre-designed siRNA Set A

HY-B0162

Ivabradine	HCN Channel	Cardiovascular Disease Cancer
Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-B0162A

Ivabradine hydrochloride 2 Publications Verification	HCN Channel	Cardiovascular Disease Endocrinology Cancer
Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-B0162S

Ivabradine-d6	HCN Channel	Cardiovascular Disease
Ivabradine-d₆ is the deuterium labeled Ivabradine . Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-B0162AR

Ivabradine hydrochloride (Standard)	Reference Standards HCN Channel	Cardiovascular Disease Endocrinology Cancer
Ivabradine (hydrochloride) (Standard) is the analytical standard of Ivabradine (hydrochloride). This product is intended for research and analytical applications. Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-114735

Mandelonitrile benzoate	Antibiotic	Infection
Mandelonitrile benzoate is a defensive secretion of millipedes that releases other chemicals during the cyanidation process in addition to hydrocyanic acid (HCN) and benzaldehyde. Several families of millipedes, including Polydesmidae, Paradoxosomatidae, and Euryuridae, have been shown to secrete phenols and guaiaeol, with one Paradoxosomatid also producing ethylbenzoic acid and benzoic acid. In addition, members of the Xystodesmidae family commonly produce three compounds: benzoic acid, mandelonitrile benzoate, and benzoyl cyanide. Benzoyl cyanide has not been previously discovered as a natural product. These additional natural products are discussed as defensive antipredator and antibiotic agents. Benzoyl cyanide appears to have anesthetic properties for some predators. The study provides a preliminary chemotaxonomic basis for distinguishing various taxonomic groups of millipedes.

HY-W052508S

Norquetiapine-d8 N-Desalkylquetiapine-d₈	Isotope-Labeled Compounds	Others Neurological Disease Inflammation/Immunology
Norquetiapine-d8 (N-Desalkylquetiapine-d8) is the deuterium labeled Norquetiapine.Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), 5-HT_2C(K_i = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation .

Cat. No.	Product Name	Chemical Structure

HY-W052508S

Norquetiapine-d8
Norquetiapine-d8 (N-Desalkylquetiapine-d8) is the deuterium labeled Norquetiapine.Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), 5-HT_2C(K_i = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation .

Norquetiapine-d8

Norquetiapine-d8 (N-Desalkylquetiapine-d8) is the deuterium labeled Norquetiapine.Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), 5-HT_2C(K_i = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation .

HY-B0162S

Ivabradine-d6
Ivabradine-d₆ is the deuterium labeled Ivabradine . Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HCN3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
HCN3 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Hcn3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hcn3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Hcn2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hcn2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
HCN2 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Hcn2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hcn2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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