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Results for "

HATU

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (4) Biochemical Assay Reagents (41) Caspase (1) E3 Ligase Ligand-Linker Conjugates (1) Fluorescent Dye (6) Ligands for E3 Ligase (1) Liposome (3) PROTAC Linkers (13)
By Research Areas:	Cancer (19) Infection (1)
Click Chemistry:	DBCO (3) Tetrazine (1)
Oligonucleotides:	Pegylated Lipids (1) Phospholipids (1) Cationic Lipids (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1703

*HATU*	Biochemical Assay Reagents	Others
HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate) is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid. HATU can be used along with Hünig's base (N,N-diisopropylethylamine, DIPEA) to form amide bonds .

HY-W800655

Thalidomide-O-PEG4-acid	PROTAC Linkers	Cancer
Thalidomide-O-PEG4-Acid is a PROTAC linker that can react with Amine containing moiety in the presence of Activator EDC or HATU.

HY-W614135

7-Methyl-8-oxononanoic acid	Biochemical Assay Reagents	Others
7-Methyl-8-oxononanoic acid is an intermediate for synthesis of conjugated molecules. The acid group can derivatize amine-containing molecules in the presence of activators such as EDC or HATU.

HY-W800686

Acid-PEG4-NHS ester	Biochemical Assay Reagents	Others
Acid-PEG4-NHS ester is a PEG linker with a carboxylic acid and an NHS ester. Both functional group can react with primary amine, but the carboxylic acid will need activators such as EDC or HATU.

HY-W441005

Amino-Gly-Gly-DSPE hydrochloride	Liposome	Cancer
Amino-Gly-Gly-DSPE (hydrochloride) is a specially modified phospholipid that has been used to synthesize liposomes. The terminal amine is reactive with an NHS ester compound or carboxylic acid molecule in the presence of activator, such as HATU or EDC.

HY-P10162

Ac-DMQD-AMC	Caspase	Cancer
Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) .

HY-W800682

Bis-sulfone-PEG4-acid	Biochemical Assay Reagents	Others
Bis-Sulfone-PEG4-acid is a reagent with a sulfone and an acid. The sulfone group can be conjugated with thiol groups of proteins. The terminal acid reacts with primary amines with the help of activators (EDC or HATU) to from stable amide bonds.

HY-W671472

10-Oxononadecanedioic acid	Biochemical Assay Reagents	Others
10-Oxononadecanedioic acid is a long alkane linker with two terminal carboxylic acid groups. The terminal carboxylic acid groups can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.

HY-W800681

Benzyloxy carbonyl-PEG4-acid	Biochemical Assay Reagents	Others
Benzyloxy carbonyl-PEG4-acid is a linker with a benzyl protecting group and a carboxylic acid. The carboxylic acid can undergo reactions with primary amines with the help of activators (EDC or HATU). The benzyl protecting group can be removed via hydrogenolysis.

HY-140531A

N-(Biotin-PEG4)-N-bis(PEG4-acid) hydrochloride	Biochemical Assay Reagents	Others
N-(Biotin-PEG4)-N-bis(PEG4-acid) hydrochloride is a branched biotinylation reagent for labeling. The carboxylic acid groups can react with primary amines in the presence of EDC and HATU to form stable amide bonds.

HY-W585390

BDP 581/591 hydrazide hydrochloride	Fluorescent Dye	Others
BDP 581/591 hydrazide hydrochloride is a BDP linker containing a hydrazide. The BDP 581/591 is very photostable. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W105737

18-Methoxy-18-oxooctadecanoic acid	Biochemical Assay Reagents	Others
18-Methoxy-18-oxooctadecanoic acid is a long alkane linker with a terminal carboxylic acid group. The terminal carboxylic acid group can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.

HY-W591352

Thalidomide-5-(C6-amine)	Ligands for E3 Ligase	Cancer
Thalidomide-5-(C6-amine) is a PROTAC building block that contains an E3 ligase ligand substituted with a terminal amine group. The amine group can react with NHS ester group or carboxylic acid in the presence of EDC or HATU.

HY-W585383

BDP TR hydrazide hydrochloride	Fluorescent Dye	Others
BDP TR hydrazide is a BDP TR linker with a hydrazide group. The BDP dye is popular for the microscopy and fluorescence polarization assays. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W800825

Octadecanedioic acid mono-L-carnitine ester	Liposome	Cancer
Octadecanedioic Acid Mono-L-carnitine ester is a cationic lipid which may be used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Its terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.

HY-W800715

(Acid-PEG10)-Tri-(Azide-PEG10-ethoxymethyl)-methane	Biochemical Assay Reagents	Others
(Acid-PEG10)-Tri-(Azide-PEG10-ethoxymethyl)-methane can undergo Click Chemistry with Propargyl, BCN or DBCO reagents. Carboxylic acid (CO2H) group is reactive with primary amino groups in the presence of EDCor HATU.

HY-W800676

DBCO-N-bis(PEG4-acid)	Biochemical Assay Reagents	Others
DBCO-N-bis(PEG4-acid) is a branched click chemistry reagent. The DBCO group enables copper-free Click Chemistry reactions. carboxylic acid groups allows for reactions with primary amine groups using activators such as EDC or HATU to form a stable amide bond.

HY-W190752

m-PEG13-acid	Biochemical Assay Reagents	Others
m-PEG13-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

HY-W585384

BDP 558/568 carboxylic acid	Fluorescent Dye	Others
BDP 558/568 carboxylic acid is a BDP linker containing a carboxylic acid. The BDP 558/568 has similar excitation and emission wavelengths to Cy3. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-D1366A

Sulfo-Cyanine5.5 carboxylic acid potassium	Fluorescent Dye	Others
Sulfo-Cyanine5.5 carboxylic acid potassium is a fluorescent dye with excitation/emission wavelengths at 673/707 nm. The introduction of the sulfite group enhances the hydrophilic properties of the compound. The terminal carboxylic acid can react with primary amine groups in the presence of activators such as EDC and HATU, to form stable amide bonds.

HY-W591353

Thalidomide-5-(PEG2-amine)	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-5-(PEG2-amine) is a PROTAC building block that contains an E3 ligase ligand substituted with a terminal amine group. The amine group can react with NHS ester group or carboxylic acid in the presence of EDC or HATU. The PEG spacer improves water solubility.

HY-W190910

AZD-PEG2-acid	Biochemical Assay Reagents	Others
AZD-PEG2-acid is a PEG linker containing an AZD group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W800713

SPDP-Gly-Pro-acid	Biochemical Assay Reagents	Others
SPDP-Gly-Pro-acid is a linker with SPDP and carboxylic acid moieties. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W190951

3-((2-(2,2,2-Trifluoroacetamido)ethyl)disulfanyl)propanoic acid	Biochemical Assay Reagents	Others
3-((2-(2,2,2-Trifluoroacetamido)ethyl)disulfanyl)propanoic acid is a cleavable linker containing a carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The disulfide bond can be cleaved via reduction reactions.

HY-W190947

Iodoacetamido-PEG8-acid	Biochemical Assay Reagents	Others
Iodoacetamido-PEG8-acid is a PEG reagent containing an Iodoacetamide group and a carboxlic acid moiety. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The iodoacetamide group is an alkylating agent that can be used to bind covalently with the thiol group.

HY-W143822

6-(Tritylthio)hexanoic acid	Biochemical Assay Reagents	Others
6-(Tritylthio)hexanoic acid is a linker with a Tst group and a terminal carboxylic acid. The Tst group can be deprotected under acidic conditions to obtain the free thiol which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W130607

Biotinyl-8-amino-3, 6-dioxaoctanoic acid	Biochemical Assay Reagents	Others
Biotinyl-8-amino-3,6-dioxaoctanoic acid is a biotinylating reagent linked with a PEG chain for improved water solubility. Biotin is an affinity ligand and it is used in biochemical applications such as pull-down assays or for ligating with streptavidin proteins. The carboxylic group can react with amine-containing molecules in the presence of activators such as HATU.

HY-W510032

9-Ethoxy-9-oxononanoic acid	Biochemical Assay Reagents	Infection
9-Ethoxy-9-oxononanoic acid is a C-11 fatty acid that has an ethyl ester group at the end of the saturated tail. The carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Azelaic Acid Monoethyl Ester has antifungal activity against Cladosporium herbarum.

HY-W440953

Stearic acid-PEG-CH2CO2H (MW 1000)	Biochemical Assay Reagents	Others
Stearic acid-PEG-CH2CO2H, MW 1000 is an amphiphatic PEG polymer which forms micelles in an aqueous solution for drug-loaded nanoparticles. The terminal carboxyl can react with amine via condensation reaction in the presence of HATU/EDC activator. Reagent grade, for research use only.

HY-D1656

BDP 581/591 carboxylic acid	Fluorescent Dye	Others
BDP 581/591 carboxylic acid is a fluorescent dye (Ex=585 nm, Em=594 nm). BDP 581/591 carboxylic acid has a free carboxylic acid group, which can be catalyzed by a catalyst (such as EDC or HATU) to react with primary amines to form stable amide bonds. BDP 581/591 carboxylic acid is highly photostable and can be used for ROS detection.

HY-W190934

Fmoc-Ala-Pro-OH	Biochemical Assay Reagents	Others
Fmoc-Ala-Pro-OH is a linker with an Fmoc-protected amine and a terminal carboxylic acid. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W190955

N-(t-Butyl ester-PEG3)-N-bis(PEG3-amine)	Biochemical Assay Reagents	Others
N-(t-butyl ester-PEG3)-N-bis(PEG3-amine) is a PEG reagent that can easily react with activated NHS esters or carboxylic acid in the presence of EDC or HATU. The t-butyl group can be deprotected under acidic conditions. The hydrophilic PEG spacers increase the compounds water solubility in aqueous media.

HY-W572763

Tos-PEG6-acid	Biochemical Assay Reagents	Others
Tos-PEG6-acid is a PEG linker containing a tosyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.

HY-W160298

N-Cbz-7-Aminoheptanoic acid	Biochemical Assay Reagents	Others
N-Cbz-7-Aminoheptanoic acid is a six carbon linker containing an carboxylic acid (CO2H) group and a benzyl (Cbz) protecting group. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.

HY-W190958

Boc-NH-Tri-(carbonylethoxymethyl)-methane	Biochemical Assay Reagents	Others
Boc-NH-Tri-(carbonylethoxymethyl)-methane is a branched PEG linker with a Boc-protected amino and three terminal carboxilic acid groups. The Boc group can be deprotected under mild acidic conditions to form the free amine. The terminal carboxylic acid groups can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W591402

3,4-Dibromo-Mal-PEG4-Acid	ADC Linker	Cancer
3,4-Dibromo-Mal-PEG4-acid is a site specific ADC linker with a dibromomaleimide group and an acid group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. The carboxylic acid can react with primary amines in the presence of EDC and HATU to form a stable amide bond. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

HY-W800706

Azidobutanamide-tri-(carboxyethoxymethyl)-methane	Biochemical Assay Reagents	Others
Azidobutanamide-tri-(carboxyethoxymethyl)-methane is a aqueous soluble PEG linker with an azide group with three terminal carboxylic acids. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W800653

N-(Azido-PEG3)-NH-PEG3-t-butyl ester	Biochemical Assay Reagents	Others
N-(Azido-PEG3)-NH-PEG3-t-butyl ester is a click chemistry reagent with a terminal azide group and secondary amine NH group. NH group is reactive with NHS ester, The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The azide group can participate in Click Chemistry.

HY-W800722

N-(PEG1-acid)-L-Lysine-amido-Mal	Biochemical Assay Reagents	Others
N-(PEG1-acid)-L-Lysine-amido-Mal is a PEG based linker with terminal malimide and carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-131699

t-Butyl ester-PEG4-CH2COOH	Biochemical Assay Reagents	Others
t-Butyl ester-PEG4-CH2COOH is a PEG linker containing a t-butyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl group can be deprotected under acidic conditions.

HY-W440954

Stearic acid-PEG-CH2CO2H, MW 2000	Liposome	Others
Stearic acid-PEG-CH2CO2H, MW 2000 is a heterobifunctional polyPEG with 18-carbon aliphatic chain and carboxyl. The polymer has stearic acid as the hydrophobic tail and PEG as the hydrophilic chain, therefore it forms micelles in water. Carboxyl can react with amine in the presence of activator, such as HATU/EDC to generate a stable amide bond. Reagent grade, for research use only.

HY-W097128

Fmoc-12-aminododecanoic acid	PROTAC Linkers	Cancer
Fmoc-12-aminododecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W800813

Carboxy-Amido-PEG5-N-Boc	Biochemical Assay Reagents	Others
Carboxy-Amido-PEG5-N-Boc is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W005828

9-(Boc-amino)nonanoic acid	PROTAC Linkers	Cancer
9-(Boc-amino)nonanoic Acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. 9-(Boc-amino)nonanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W591982

t-Boc-N-amido-PEG12-acid	Biochemical Assay Reagents	Others
t-Boc-N-amido-PEG12-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W591967

N-Boc-15-aminopentadecanoic acid	PROTAC Linkers	Cancer
N-Boc-15-aminopentadecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. N-Boc-15-aminopentadecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-400361

BocNH-PEG2-CH2COONHS	Biochemical Assay Reagents	Others
BocNH-PEG2-CH2COONHS ester is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W111228

Fmoc-9-Aminononanoic acid	PROTAC Linkers	Cancer
Fmoc-9-aminononanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and and other conjugation applications. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W089232

Boc-10-Aminodecanoic acid	PROTAC Linkers	Cancer
Boc-10-Aminodecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Boc-10-Aminodecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W101723

Boc-12-Ado-OH	PROTAC Linkers	Cancer
Boc-12-Ado-OH can be used as a PROTAC linker in the synthesis of PROTACs. Boc-12-Ado-OH is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Cat. No.	Product Name	Type

HY-D1656

BDP 581/591 carboxylic acid	Fluorescent Dyes/Probes
BDP 581/591 carboxylic acid is a fluorescent dye (Ex=585 nm, Em=594 nm). BDP 581/591 carboxylic acid has a free carboxylic acid group, which can be catalyzed by a catalyst (such as EDC or HATU) to react with primary amines to form stable amide bonds. BDP 581/591 carboxylic acid is highly photostable and can be used for ROS detection.

HY-W585390

BDP 581/591 hydrazide hydrochloride	Fluorescent Dyes/Probes
BDP 581/591 hydrazide hydrochloride is a BDP linker containing a hydrazide. The BDP 581/591 is very photostable. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W585383

BDP TR hydrazide hydrochloride	Fluorescent Dyes/Probes
BDP TR hydrazide is a BDP TR linker with a hydrazide group. The BDP dye is popular for the microscopy and fluorescence polarization assays. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W585384

BDP 558/568 carboxylic acid	Fluorescent Dyes/Probes
BDP 558/568 carboxylic acid is a BDP linker containing a carboxylic acid. The BDP 558/568 has similar excitation and emission wavelengths to Cy3. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-D1366A

Sulfo-Cyanine5.5 carboxylic acid potassium	Fluorescent Dyes/Probes
Sulfo-Cyanine5.5 carboxylic acid potassium is a fluorescent dye with excitation/emission wavelengths at 673/707 nm. The introduction of the sulfite group enhances the hydrophilic properties of the compound. The terminal carboxylic acid can react with primary amine groups in the presence of activators such as EDC and HATU, to form stable amide bonds.

HY-D2747

BP Fluor 405 acid

Fluorescent Dyes/Probes

BP Fluor 405 acid is a water-soluble, blue-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 conjugates are pH-insensitive from pH 4 to pH 10. The carboxylic acid of BP Fluor 405 is a reagent of choice for the preparation of custom activated esters that often are not commercially available. Examples of such activated esters include sulfo-NHS, TFP (2,3,5,6-Tetrafluorophenol), and STP (4-Sulfo-2,3,5,6-Tetrafluorophenol, Sodium Salt). Another common application for the non-activated carboxylic acid is peptide modification during solid phase synthesis, which usually requires in-situ activation with peptide coupling regents, e.g. HATU. BP Fluor 405 acid is also often used for control experiments, and for calibration.

Cat. No.	Product Name	Type

HY-W440953

Stearic acid-PEG-CH2CO2H (MW 1000)	Drug Delivery
Stearic acid-PEG-CH2CO2H, MW 1000 is an amphiphatic PEG polymer which forms micelles in an aqueous solution for drug-loaded nanoparticles. The terminal carboxyl can react with amine via condensation reaction in the presence of HATU/EDC activator. Reagent grade, for research use only.

HY-W440955

Stearic acid-PEG-CH2CO2H (MW 3400)

Drug Delivery

Stearic acid-PEG-CH2CO2H, MW 3400 is a lipophilic thiol-reactive PEG polymer. The stearic acid can be used to encapsulate hydrophobic therapeutic agents while the PEG chain increases overall water solubility and biocompatibilty. Reaction between carboxylic acid (-COOH) and amine (-NH2) vai condensation in the presence of activator, such as HATU or EDC, generates a stable amide linkage. Reagent grade, for research use only.

Cat. No.	Product Name	Target	Research Area

HY-P10162

Ac-DMQD-AMC	Caspase	Cancer
Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) .

Cat. No.	Product Name		Classification

HY-151820

DBCO-PEG24-acid		DBCO
DBCO-PEG24-acid is a click chemistry reagent. DBCO-PEG24-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-151821

Sulfo DBCO-PEG3-acid		DBCO
Sulfo DBCO-PEG3-acid is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-148840

Sulfo DBCO-PEG3-NHS ester		DBCO
Sulfo DBCO-PEG3-NHS ester is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-NHS ester is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-151833

Methyltetrazine-amido-N-bis(PEG4-acid)		Tetrazine
Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only . Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Cat. No.	Product Name		Classification

HY-W441005

Amino-Gly-Gly-DSPE hydrochloride		Phospholipids
Amino-Gly-Gly-DSPE (hydrochloride) is a specially modified phospholipid that has been used to synthesize liposomes. The terminal amine is reactive with an NHS ester compound or carboxylic acid molecule in the presence of activator, such as HATU or EDC.

HY-W800825

Octadecanedioic acid mono-L-carnitine ester		Cationic Lipids
Octadecanedioic Acid Mono-L-carnitine ester is a cationic lipid which may be used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Its terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.

HY-W440954

Stearic acid-PEG-CH2CO2H, MW 2000		Pegylated Lipids
Stearic acid-PEG-CH2CO2H, MW 2000 is a heterobifunctional polyPEG with 18-carbon aliphatic chain and carboxyl. The polymer has stearic acid as the hydrophobic tail and PEG as the hydrophilic chain, therefore it forms micelles in water. Carboxyl can react with amine in the presence of activator, such as HATU/EDC to generate a stable amide bond. Reagent grade, for research use only.

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MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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