Search Result
Results for "
Glycyrrhiza
" in MedChemExpress (MCE) Product Catalog:
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N7372
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Others
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Others
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Licoisoflavanone is the isoflavonoid compound isolated from Sinkiang licorice root (Glycyrrhiza) .
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- HY-N9919
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Others
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Others
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Glyasperin C is a potent and reversible noncompetitive inhibitor of neuraminidase with an IC50 of 20% at 200 μM. Glyasperin C is a polyphenol isolated from the roots of Glycyrrhiza uralensis .
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- HY-N8656
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Others
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Others
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Glycyrrhiza-flavonol A (compound 4) is a natural product of Glycyrrhiza, Fabaceae .
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- HY-N11026
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Others
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Others
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22-Beta-Acetoxyglycyrrhizin is a triterpene glucuronide that can be isolated from the roots of Glycyrrhiza .
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- HY-N8610
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Phosphatase
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Inflammation/Immunology
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Uralsaponin D is a saponin that can be isolated from Glycyrrhiza inflata. Uralsaponin D inhibits phospholipase A2 (PLA2) with an IC50 value of 32.2 μM .
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- HY-N8609
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Others
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Others
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Uralsaponin C is an analogue of oleanane-type triterpenoid saponin. Uralsaponin C can be isolated from the roots of Glycyrrhiza uralensis Fisch .
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- HY-N13021
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Endogenous Metabolite
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Others
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2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid is a metabolite, which can be isolated from endophytic fungus Phoma macrostoma inhabiting the inner tissue of medicinal plant Glycyrrhiza glabra Linn .
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- HY-108421
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Bacterial
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Infection
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Xinjiachalcone A is an active principle of Glycyrrhiza inflata Batalin. Xinjiachalcone A shows both a low MIC and a strong bactericidal activity against H. pylori, with MIC values ranged from 12.5 to 50 µM for seventeen H. pylori strains .
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- HY-N1230
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Allolicoisoflavone B
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Phosphatase
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Inflammation/Immunology
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Sophoraisoflavone A (Allolicoisoflavone B) is a nature product that could be isolated from Glycyrrhiza inflate. Sophoraisoflavone A is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 value of 0.80 μM. Sophoraisoflavone A can be used in research of inflammation .
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- HY-N3920
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Bacterial
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Infection
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Gancaonin G is a 6-prenylated isoflavanone that can be isolated from Glycyrrhiza uralensis. Gancaonin G has antibacterial activity against Streptococcus mutants and MRSA strains .
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- HY-154795
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Caspase
NOD-like Receptor (NLR)
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Inflammation/Immunology
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Magnesium isoglycyrrhizinate hydrate is the active component found in licorice plant (Glycyrrhiza glabra). Magnesium isoglycyrrhizinate hydrate exhibits anti-inflammatory activity through NLRP3 inflammasome pathway, and attenuates the chronic obstructive pulmonary disease in rats .
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- HY-N0376
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Reactive Oxygen Species (ROS)
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Neurological Disease
Inflammation/Immunology
Cancer
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Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .
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- HY-N0376R
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Reactive Oxygen Species (ROS)
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Neurological Disease
Inflammation/Immunology
Cancer
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Liquiritin (Standard) is the analytical standard of Liquiritin. This product is intended for research and analytical applications. Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .
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- HY-N6987
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- HY-N10144
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Others
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Others
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Shinpterocarpin is a flavonoid that can be found in Glycyrrhiza glabra L. .
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- HY-N1093
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(3R)-Vestitol
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Others
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Others
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(-)-Vestitol is a compound isolated from Glycyrrhiza pallidiflora (Leguminosae) .
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- HY-N2122
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Neoisoliquiritigenin
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Others
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Cancer
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Neoisoliquiritin is a bioactive component isolated from Glycyrrhiza uralensis .
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- HY-N2123
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- HY-142096
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Others
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Others
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Glycyuralin E is a natural product that can be isolated from Glycyrrhiza uralensis .
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- HY-N6983
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Others
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Cancer
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Licoricesaponin G2 is a pentacyclic triterpenoid isolated from Glycyrrhiza aspera .
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- HY-N8813
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Others
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Others
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Glucoliquiritin is a Flavonoids product that can be isolated from the roots of Glycyrrhiza glabra L. .
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- HY-N6981
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- HY-N6984
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- HY-N11771
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Reactive Oxygen Species (ROS)
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Others
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Glyurallin B is a flavonoid, that can be isolated from licorice (Glycyrrhiza inflata and Glycyrrhiza uralensis). Glyurallin B shows ABTS + radical scavenging activity and the inhibitory activity on lipid peroxidation, with EC50 values of 11.9 ± 0.58 μM and 15.3 ± 1.26 μM, respectivley .
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- HY-N7231
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Others
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Others
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Licoricesaponin E2 (compound 5) is a triterpene saponinthat can be found in Glycyrrhiza inflata .
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- HY-114693
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Others
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Others
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Licoagrochalcone B is a prenylated retrochalcone that can be found in Glycyrrhiza glabra hairy root cultures .
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- HY-N8925
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Others
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Others
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Glyasperin F is a Flavonoids product that can be isolated from the roots of Glycyrrhiza aspera Pall. .
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- HY-N8613
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Others
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Others
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Gancaonin N is a Flavonoids product that can be isolated from the roots of Glycyrrhiza aspera Pall. .
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- HY-N3922
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Others
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Others
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Gancaonin M is a Flavonoids product that can be isolated from the roots of Glycyrrhiza uralensis Fisch .
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- HY-N12289
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Others
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Others
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Kanzonol D is a flavonoid compound that can be found in the hairy root cultures of Glycyrrhiza glabra .
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- HY-N11115
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Others
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Others
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Macedonoside A (compound 3) is a kind of saponin. Macedonoside A can be isolated from the stolons of Glycyrrhiza lepidota .
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- HY-N11111
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Others
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Others
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Glycyrrhizin-6'-methylester is a natural product that can be isolated from licorice (Glycyrrhiza glabra) .
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- HY-N6975
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Bacterial
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Infection
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Glyasperin D is a flavonoid isolated from Glycyrrhiza uralensis, and possesses weaker anti-Helicobacter pylori activity .
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- HY-N3385
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7-O-Methyllicorisoflavan B
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Others
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Others
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Licorisoflavan A (7-O-Methyllicorisoflavan B) is a isoflavan-quinone, that can be isolated from Glycyrrhiza uralensis .
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- HY-N7804
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Others
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Others
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4'-O-Methylcoumestrol is a Coumarins product that can be isolated from the herbs of Glycyrrhiza pallidiflora Maxim. .
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- HY-N0180
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- HY-N4186
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- HY-N3947
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Bacterial
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Infection
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Glepidotin B is a dihydroflavonol compound isolated from the extracts of American licorice, Glycyrrhiza lepidota (Leguminosae). Glepidotin B is an antimicrobial agent .
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- HY-N6583
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Bacterial
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Infection
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Licoflavonol, a minor flavone from the roots of Glycyrrhiza uralensis, is an inhibitor of the Salmonella type III secretion system (T3SS) .
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- HY-N6911
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(18β,20α)-Glycyrrhizic acid
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Others
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Metabolic Disease
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Licorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) is a saponin from Glycyrrhiza uralensis Fischer .
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- HY-N2123R
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Others
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Inflammation/Immunology
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Neoliquiritin (Standard) is the analytical standard of Neoliquiritin. This product is intended for research and analytical applications. Neoliquiritin is isolated from Glycyrrhiza uralensis with an anti-inflammatory activity .
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- HY-W049311
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Others
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Others
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4-Methyl-5,6,7,8-tetrahydroquinoline, a tetrahydroquinoline alkaloid, is isolated from the roots of Glycyrrhiza uralensis Fisch .
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- HY-N4194
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PPAR
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Metabolic Disease
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Glabrone is an isoflavone isolated from Glycyrrhiza glabra roots. Glabrone exhibits anti-influenza activity and significant PPAR-γ ligand-binding activity .
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- HY-N0377
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- HY-N4182
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Akt
p38 MAPK
Autophagy
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Inflammation/Immunology
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Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation .
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- HY-N6989
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Cytochrome P450
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Metabolic Disease
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Isoglycycoumarin is a flavonoid isolated from the roots of Glycyrrhiza uralensis. Isoglycycoumarin is a highly selective probe for human cytochrome P450 2A6 (CYP2A6) .
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- HY-N4185
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Phosphatase
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Neurological Disease
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Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B), with an IC50 of 54.5 μM .
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- HY-N0102
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- HY-N3961
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Others
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Cardiovascular Disease
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Neoglycyrol is isolated from the root of Glycyrrhiza uralensis Fisch . Neoglycyrol is a potential myocardial protection active compound screened from traditional patent medicine Tongmai Yangxin pill (TMYXP) .
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- HY-N4184
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Parasite
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Infection
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Licoflavone B is a flavonoid isolated from Glycyrrhiza inflata, inhibits S. mansoni ATPase (IC50, 23.78 µM) and ADPase (IC50, 31.50 µM) activity. Anti-schistosomiasis activity .
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- HY-121054
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Bacterial
Parasite
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Inflammation/Immunology
Cancer
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Chalcone is isolated from Glycyrrhiza uralensis and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities .
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- HY-N8947
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Endogenous Metabolite
Glycosidase
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Metabolic Disease
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Glyurallin A (Compound 79) is isolated from the
naturalGlycyrrhiza uralensis. Glyurallin A inhibitsα-Glucosidase(HY-P2802)(IC50=0.3 μM). Glyurallin A
can be used in the study of anti-diabetes .
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- HY-N4187
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- HY-N0180R
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Endogenous Metabolite
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Inflammation/Immunology
Cancer
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18β-Glycyrrhetinic acid (Standard) is the analytical standard of 18β-Glycyrrhetinic acid. This product is intended for research and analytical applications. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
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- HY-N6980
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HIV
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Infection
Cancer
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Licorice glycoside C2 is a oleanane-type triterpene oligoglycoside isolated from Glycyrrhiza uralensis. Various biological activities are associated with licorice extracts, such as anti-viral, anti-microbial, antioxidant, anti-inflammatory, anti-ulcer, anti-cancer and anti-HIV effects .
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- HY-N0102R
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Aldose Reductase
Influenza Virus
Autophagy
Apoptosis
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Infection
Inflammation/Immunology
Cancer
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Isoliquiritigenin (Standard) is the analytical standard of Isoliquiritigenin. This product is intended for research and analytical applications. Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.
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- HY-N6986
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Liquiritigenin-7-apiosylglucoside
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Others
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Cancer
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Liquiritigenin-7-O-β-D-glucopyranosyl-(1→2)-β-D-apiofuranoside (Liquiritigenin-7-apiosylglucoside) is a flavonoid isolated from the roots of Glycyrrhiza, has weaker cytotoxicity against several tumor cells and normal cells .
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- HY-N0393
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PPAR
Reactive Oxygen Species (ROS)
Bacterial
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Infection
Cardiovascular Disease
Inflammation/Immunology
Cancer
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Glabridin is a natural isoflavan from Glycyrrhiza glabra L., binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities .
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- HY-121054R
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Bacterial
Parasite
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Inflammation/Immunology
Cancer
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Chalcone (Standard) is the analytical standard of Chalcone. This product is intended for research and analytical applications. Chalcone is isolated from Glycyrrhiza uralensis and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities .
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- HY-N1280
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Amyloid-β
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Neurological Disease
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Semilicoisoflavone B, an isoflavone, mainly derived from Glycyrrhiza uralensis Fisch.. Semilicoisoflavone B reduces amyloid β (Aβ) secretion by inhibiting β-secretase-1 (BACE1) expression and activity. Semilicoisoflavone B decreases BACE1 expression mainly through increasing PPARγ expression and inhibiting STAT3 phosphorylation .
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- HY-N0393R
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PPAR
Reactive Oxygen Species (ROS)
Bacterial
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Infection
Inflammation/Immunology
Cancer
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Glabridin (Standard) is the analytical standard of Glabridin. This product is intended for research and analytical applications. Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities .
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- HY-N3716
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Aldose Reductase
COX
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Metabolic Disease
Inflammation/Immunology
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Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi .
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- HY-N6851
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Glycyrrhetic acid 3-O-mono-β-D-glucuronide; 3-monoglucuronyl-glycyrrhetinic acid
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Others
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Inflammation/Immunology
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Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity . Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β-glucuronidases (β-GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG .Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.
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- HY-B0398AR
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Bacterial
Antibiotic
Topoisomerase
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Infection
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Liquiritin (Standard) is the analytical standard of Liquiritin. This product is intended for research and analytical applications. Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .
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- HY-N0373
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Amyloid-β
Apoptosis
NOD-like Receptor (NLR)
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Neurological Disease
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Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction .
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- HY-N0373R
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Amyloid-β
Apoptosis
NOD-like Receptor (NLR)
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Neurological Disease
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Licochalcone B (Standard) is the analytical standard of Licochalcone B. This product is intended for research and analytical applications. Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction .
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- HY-N3387
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Apoptosis
NF-κB
Akt
MMP
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Inflammation/Immunology
Cancer
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Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC50=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer . Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect . Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo . Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations .
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- HY-N2609
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COX
CCR
NF-κB
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Inflammation/Immunology
Endocrinology
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7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
- HY-N6980
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-
- HY-N0102R
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-
- HY-N6986
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-
- HY-N0393
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Structural Classification
Classification of Application Fields
Source classification
Plants
Infection
Flavonoids
Leguminosae
Phenols
Polyphenols
Glycyrrhiza uralensis Fisch.
Inflammation/Immunology
Disease Research Fields
Isoflavones
|
PPAR
Reactive Oxygen Species (ROS)
Bacterial
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Glabridin is a natural isoflavan from Glycyrrhiza glabra L., binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities .
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- HY-121054R
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- HY-N1280
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-
- HY-N0393R
-
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Infection
Structural Classification
Flavonoids
Classification of Application Fields
Leguminosae
Source classification
Phenols
Plants
Glycyrrhiza uralensis Fisch.
Inflammation/Immunology
Disease Research Fields
|
PPAR
Reactive Oxygen Species (ROS)
Bacterial
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Glabridin (Standard) is the analytical standard of Glabridin. This product is intended for research and analytical applications. Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities .
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- HY-N3716
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- HY-N6851
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- HY-N0373
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- HY-N0373R
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- HY-N3387
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- HY-N2609
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Structural Classification
Flavonoids
Classification of Application Fields
Flavones
Leguminosae
Source classification
Phenols
Polyphenols
Plants
Glycyrrhiza uralensis Fisch.
Disease Research Fields
Endocrinology
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COX
CCR
NF-κB
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7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .
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