Search Result
Results for "
Gly-Pro
" in MedChemExpress (MCE) Product Catalog:
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-117483
-
|
|
iGluR
|
Neurological Disease
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|
Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection .
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- HY-119244
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Dipeptidyl Peptidase
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Metabolic Disease
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Gly-Pro-pNA hydrochloride is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). Gly-Pro-pNA can be used to screen for DPP IV inhibitors. Gly-Pro-pNA hydrochloride can be studied as an experimental antidiabetic agents .
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- HY-137834
-
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Fluorescent Dye
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Others
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Gly-Pro-AMC hydrobromide is a fluorescent dye, it can be used as a specific fluorescent substrate for detecting Dipeptidyl peptidase IV (DPP-IV) activity .
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-
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- HY-P0074A
-
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Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate
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Integrin
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Cardiovascular Disease
|
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GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .
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-
- HY-P0074
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GPRP
3 Publications Verification
Gly-Pro-Arg-Pro; Pefa 6003
|
Integrin
|
Cardiovascular Disease
|
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GPRP (Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .
|
-
-
- HY-137834A
-
-
-
- HY-178853
-
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Others
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Inflammation/Immunology
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3,4-Dihydroxybenzeneethanimidamide can selectively react with Gly-Pro, the substrate for prolidase, and the prolidase activity is measured by monitoring the decrease in FL intensities. 3,4-Dihydroxybenzeneethanimidamide can be used for the study of inflammation .
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- HY-170865
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Drug-Linker Conjugates for ADC
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Cancer
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OncoFAP-GlyPro-MMAF is a Drug-Linker Conjugate for ADC with potent antitumor activity. OncoFAP-GlyPro-MMAF consists of Monomethylauristatin F (HY-15579) and a linker. OncoFAP-GlyPro-MMAF can be used for synthesis of ADCs .
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-
- HY-P2718
-
-
-
- HY-175350
-
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FAP
Microtubule/Tubulin
|
Cancer
|
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OncoFAP-GlyPro-MMAE is a FAP small molecule-drug conjugate (SMDC) with an IC50 of 0.49 nM. OncoFAP-GlyPro-MMAE consists of a FAP Ligand OncoFAP (HY-145938), a Tubulin inhibitor (MMAE) (HY-15162) and a linker. OncoFAP-GlyPro-MMAE can be used for cancers like renal cancer research .
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-
- HY-145983
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FAP
Prolyl Endopeptidase (PREP)
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Cancer
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Suc-Gly-Pro-AMC is a fluorescent substrate. Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP) specific substrate. Suc-Gly-Pro-AMC reacts with recombinant porcine prolyl oligopeptidase. Suc-Gly-Pro-AMC can be used to study the activity of FAP, prolyl endopeptidase (PREP). Suc-Gly-Pro-AMC is used in glioma research .
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-
- HY-175353
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FAP
|
Cancer
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TriOncoFAP-GlyPro-MMAE is a small molecule drug conjugate (SMDC) targeting fibroblast activation protein (FAP) with an IC50 of 13 pmol/L. TriOncoFAP-GlyPro-MMAE combines a FAP-targeting ligand (TriOnco), a cleavable glycine-proline linker, and a cytotoxic payload (MMAE) .
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- HY-P4846
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CXCR
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Inflammation/Immunology
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Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis .
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- HY-P4217
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Cathepsin
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Others
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Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity .
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- HY-P4486
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Drug Derivative
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Others
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H-Pro-Gly-Pro-OH is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. H-Pro-Gly-Pro-OH is perfectly positioned to focus neutrophils on the site required and direct a localized repair response. H-Pro-Gly-Pro-OH activates the transcription of neurotrophins and their receptor genes after cerebral ischemia .
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-
- HY-P4294
-
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Amino Acid Derivatives
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Others
|
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H-Gly-Pro-Gly-OH is a tripeptide containing glycine and proline. H-Gly-Pro-Gly-OH can be used for the synthesis of other polypeptides, such as (Pro Gly Gly)n .
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- HY-A0299A
-
|
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Dipeptidyl Peptidase
|
Metabolic Disease
|
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H-Gly-Pro-Hyp-OH acetate is a dipeptidyl peptidase 4 (DPP-4) inhibitor with an IC50 value of 2.51 mM. H-Gly-Pro-Hyp-OH acetate is promising for research of diabetes .
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-
- HY-P4344
-
|
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MetAP
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Others
|
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Met-Gly-Pro-AMC is a fluorescent peptide substrate of MetAP2 .
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- HY-D1670
-
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Fluorescent Dye
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Others
|
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Z-Gly-Pro-AMC is a fluorogenic substrate. Z-Gly-Pro-AMC is hydrolyzed by prolyl endopeptidase to generate highly fluorescent 7-Amino-4-methylcoumarin (HY-D0027). (λex=380 nm, λem=465 nm) .
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- HY-P2708
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|
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Integrin
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Cardiovascular Disease
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H-Gly-Pro-Arg-Pro-NH2 is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein. H-Gly-Pro-Arg-Pro-NH2 prevents fibrin polymerization .
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- HY-W018717
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- HY-137220
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- HY-P4448
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Fluorescent Dye
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Others
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Ac-Gly-Pro-AFC is a fluorogenic substrate for the determination of fibroblast activation protein (FAP) endopeptidase activity .
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- HY-P4366
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- HY-P4292
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HIV
Amino Acid Derivatives
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Infection
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H-Gly-Pro-Gly-NH2 is a tripeptide that inhibits HIV-1 replication. H-Gly-Pro-Gly-NH2 inhibits the activity of HIV-1 IIIB and HIV-2 ROD with EC50 values of 35 µM and 30 µM, respectively. H-Gly Pro Gly NH2 inhibits HIV-1 replication in vitro by interfering with capsid formation. H-Gly Pro Gly NH2 has antiviral activity and can be used for virus research .
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- HY-W016887R
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H-Gly-Pro-OH (Standard)
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
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H-Gly-Pro-OH (Standard) is the analytical standard of H-Gly-Pro-OH. This product is intended for research and analytical applications. H-Gly-Pro-OH is an end product of collagen metabolism that is further cleaved by prolidase.
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- HY-W095029
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Biochemical Assay Reagents
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Others
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Cbz-Gly-Pro-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-P4474
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Bacterial
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Infection
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Pz-Pro-Leu-Gly-Pro-d-Arg is a synthetic substrate of bacterial collagenase. Pz-Pro-Leu-Gly-Pro-d-Arg can be used to test bacterial collagenase activity .
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- HY-P2661
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-
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- HY-P4496
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Phosphatase
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Others
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Tos-Gly-Pro-Lys-pNA is a substrate for the serine protease ALP and can be used to measure the activity of this enzyme .
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- HY-163382
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Beta-lactamase
Cholinesterase (ChE)
Amyloid-β
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Neurological Disease
|
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Cbz-Gly-Pro-Ala-O-cinnamyl (compound 25) is a small peptide targeting BACE-1 and AChE with the IC50 values of 0.02 μM and 1 μM, respectively. Cbz-Gly-Pro-Ala-O-cinnamyl shows neuroprotective effect and can be used for study of Alzheimer’s disease .
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- HY-P3792
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Biochemical Assay Reagents
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Others
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Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) is a FRET substrate of Thimet oligopeptidase. Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) can be used for the determination of Thimet oligopeptidase activity .
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-
-
- HY-P0020
-
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tos-GPR-ANBA-IPA
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Biochemical Assay Reagents
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Others
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Tos-Gly-Pro-Arg-ANBA-IPA is a chromogenic peptide substrate. Tos-Gly-Pro-Arg-ANBA-IPA can be used for luminescence measurement .
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- HY-P2661A
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MMP
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Others
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FA-Leu-Gly-Pro-Ala-OH TFA is a substrate of microbial collagenase .
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- HY-W016887
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-
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- HY-P0020A
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tos-GPR-ANBA-IPA acetate
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Biochemical Assay Reagents
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Others
|
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Tos-Gly-Pro-Arg-ANBA-IPA (tos-GPR-ANBA-IPA) acetate is a chromogenic peptide substrate. Tos-Gly-Pro-Arg-ANBA-IPA acetate can be used for luminescence measurement .
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- HY-W800711
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Biochemical Assay Reagents
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Others
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SPDP-Gly-Pro-NHS ester is a linker with SPDP and NHS ester moieties. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions. The NHS ester is amine reactive and forms stable amide bonds.
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- HY-W800713
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Biochemical Assay Reagents
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Others
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SPDP-Gly-Pro-acid is a linker with SPDP and carboxylic acid moieties. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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- HY-P4593
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Thrombin
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Others
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Z-Gly-Pro-Arg-4MβNA is the cleavage of the substrate of thrombin to release free 4-methoxy-2-naphthylamine (4MβNA). Free 4MβNA can be captured by 5-nitrosalicylaldehyde to produce an insoluble yellow fluorescent and marks the site of thrombin activity .
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- HY-168772
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H-Gly-Pro-OH TFA
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Amino Acid Derivatives
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Others
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Glycyl-L-Proline TFA (H-Gly-Pro-OH TFA) is a dipeptide, which is composed of a glycine and a L-proline. Glycyl-L-Proline TFA can be used in research about the co-relationship between transmembrane potential/proton gradient and intestinal transport .
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- HY-P10007
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Z-GPFL-CHO
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Proteasome
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Cancer
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Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity) .
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- HY-171489
-
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Drug-Linker Conjugates for ADC
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Cancer
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Mal-VC-PAB-EDA-N-Ac-Calicheamicin is a Drug-Linker Conjugate for ADC with potent antitumor activity. OncoFAP-GlyPro-MMAF consists of ADC toxin Calicheamicin (HY-19609) and a linker. OncoFAP-GlyPro-MMAF can be used for synthesis of ADC, PF-06647263 (HY-111965) .
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- HY-156960
-
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Aminopeptidase
Leukotriene Receptor
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Inflammation/Immunology
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JNJ-40929837 is a selective and orally active LTA4H (leukotriene A4 hydrolase) inhibitor. JNJ-40929837 effectively inhibits aminopeptidase activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 can be used in asthma research .
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- HY-156960A
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Aminopeptidase
Leukotriene Receptor
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Inflammation/Immunology
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JNJ-40929837 succinate is a selective and orally active LTA4H (leukotriene A4 hydrolase) inhibitor. JNJ-40929837 succinate effectively inhibits aminopeptidase activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 succinate can be used in asthma research .
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- HY-E70528
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Biochemical Assay Reagents
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Others
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PreScission Protease is a recombinant protease that combines human rhinovirus (HRV) type 14 3C protease and a GST-tag. PreScission Protease can specifically recognize the short peptide Leu-Glu-Val-Leu-Phe-Gln-Gly-Pro at 4°C and cleave between Gln and Gly amino acids .
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- HY-151871
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Dipeptidyl Peptidase
HIV
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Infection
|
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ICeD-2 is a inducer of cell death, can induce HIV-1 infected cell kill. ICeD-2-mediated HIV-1 infected cell kill is dependent on HIV-1 protease activity. ICeD-2 potently blocks hydrolysis of Gly-Pro-AMC by dipeptidyl peptidase DPP8 and DPP9. ICeD-2 shows strong stabilization of DPP9 in PBMCs .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-137834
-
|
|
Fluorescent Dyes/Probes
|
|
Gly-Pro-AMC hydrobromide is a fluorescent dye, it can be used as a specific fluorescent substrate for detecting Dipeptidyl peptidase IV (DPP-IV) activity .
|
-
- HY-D1670
-
|
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Chromogenic Substrates
|
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Z-Gly-Pro-AMC is a fluorogenic substrate. Z-Gly-Pro-AMC is hydrolyzed by prolyl endopeptidase to generate highly fluorescent 7-Amino-4-methylcoumarin (HY-D0027). (λex=380 nm, λem=465 nm) .
|
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- HY-137834A
-
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Fluorescent Dyes/Probes
|
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Gly-Pro-AMC is a biological active peptide. (This is a fluorescent dipeptidylaminopeptidase IV substrate, Abs/Em=353/442 nm.)
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-117483
-
|
|
iGluR
|
Neurological Disease
|
|
Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection .
|
-
- HY-P0074A
-
|
Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate
|
Integrin
|
Cardiovascular Disease
|
|
GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .
|
-
- HY-P0074
-
GPRP
3 Publications Verification
Gly-Pro-Arg-Pro; Pefa 6003
|
Integrin
|
Cardiovascular Disease
|
|
GPRP (Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .
|
-
- HY-P4846
-
|
|
CXCR
|
Inflammation/Immunology
|
|
Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis .
|
-
- HY-P4217
-
|
|
Cathepsin
|
Others
|
|
Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity .
|
-
- HY-P4486
-
|
|
Drug Derivative
|
Others
|
|
H-Pro-Gly-Pro-OH is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. H-Pro-Gly-Pro-OH is perfectly positioned to focus neutrophils on the site required and direct a localized repair response. H-Pro-Gly-Pro-OH activates the transcription of neurotrophins and their receptor genes after cerebral ischemia .
|
-
- HY-P4344
-
|
|
MetAP
|
Others
|
|
Met-Gly-Pro-AMC is a fluorescent peptide substrate of MetAP2 .
|
-
- HY-137834A
-
-
- HY-P2718
-
-
- HY-P4294
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-Gly-Pro-Gly-OH is a tripeptide containing glycine and proline. H-Gly-Pro-Gly-OH can be used for the synthesis of other polypeptides, such as (Pro Gly Gly)n .
|
-
- HY-P2708
-
|
|
Integrin
|
Cardiovascular Disease
|
|
H-Gly-Pro-Arg-Pro-NH2 is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein. H-Gly-Pro-Arg-Pro-NH2 prevents fibrin polymerization .
|
-
- HY-W018717
-
-
- HY-P4448
-
|
|
Fluorescent Dye
|
Others
|
|
Ac-Gly-Pro-AFC is a fluorogenic substrate for the determination of fibroblast activation protein (FAP) endopeptidase activity .
|
-
- HY-P4366
-
-
- HY-P4292
-
|
|
HIV
Amino Acid Derivatives
|
Infection
|
|
H-Gly-Pro-Gly-NH2 is a tripeptide that inhibits HIV-1 replication. H-Gly-Pro-Gly-NH2 inhibits the activity of HIV-1 IIIB and HIV-2 ROD with EC50 values of 35 µM and 30 µM, respectively. H-Gly Pro Gly NH2 inhibits HIV-1 replication in vitro by interfering with capsid formation. H-Gly Pro Gly NH2 has antiviral activity and can be used for virus research .
|
-
- HY-W016887R
-
|
H-Gly-Pro-OH (Standard)
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
|
H-Gly-Pro-OH (Standard) is the analytical standard of H-Gly-Pro-OH. This product is intended for research and analytical applications. H-Gly-Pro-OH is an end product of collagen metabolism that is further cleaved by prolidase.
|
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- HY-P5037
-
|
|
Peptides
|
Others
|
|
Fmoc-Gly-Pro-Hyp-OH is a tripeptide that can be used in peptide synthesis .
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-
- HY-P4474
-
|
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Bacterial
|
Infection
|
|
Pz-Pro-Leu-Gly-Pro-d-Arg is a synthetic substrate of bacterial collagenase. Pz-Pro-Leu-Gly-Pro-d-Arg can be used to test bacterial collagenase activity .
|
-
- HY-P2661
-
-
- HY-P4496
-
|
|
Phosphatase
|
Others
|
|
Tos-Gly-Pro-Lys-pNA is a substrate for the serine protease ALP and can be used to measure the activity of this enzyme .
|
-
- HY-P5037A
-
|
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Peptides
|
Others
|
|
Fmoc-Gly-Pro-Hyp-OH TFA is a tripeptide that can be used in peptide synthesis .
|
-
- HY-P3792
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) is a FRET substrate of Thimet oligopeptidase. Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) can be used for the determination of Thimet oligopeptidase activity .
|
-
- HY-P0020
-
|
tos-GPR-ANBA-IPA
|
Biochemical Assay Reagents
|
Others
|
|
Tos-Gly-Pro-Arg-ANBA-IPA is a chromogenic peptide substrate. Tos-Gly-Pro-Arg-ANBA-IPA can be used for luminescence measurement .
|
-
- HY-P2661A
-
|
|
MMP
|
Others
|
|
FA-Leu-Gly-Pro-Ala-OH TFA is a substrate of microbial collagenase .
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-
- HY-134113
-
|
CBZ-Chromozym TH
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Peptides
|
Others
|
|
Z-Gly-Pro-Arg-pNA (z-GPR-pNA) is a photometric substrate in Prostate-Specific Antigen (PSA) activation protease assays. Z-Gly-Pro-Arg-pNA (z-GPR-pNA) can be used for the test of trypsin activity .
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- HY-W016887
-
-
- HY-P5962
-
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Peptides
|
Others
|
|
Fmoc-Gly-Pro-Hyp(OtBu)-OH (TFA) is a tripeptide that can be used in peptide synthesis .
|
-
- HY-P0020A
-
|
tos-GPR-ANBA-IPA acetate
|
Biochemical Assay Reagents
|
Others
|
|
Tos-Gly-Pro-Arg-ANBA-IPA (tos-GPR-ANBA-IPA) acetate is a chromogenic peptide substrate. Tos-Gly-Pro-Arg-ANBA-IPA acetate can be used for luminescence measurement .
|
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- HY-111922
-
|
Glycyl-Glycyl-L-Proline
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Peptides
|
Others
|
|
H-Gly-Gly-Pro-OH is a peptide with 3 amino acid.
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-
- HY-P4921
-
|
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Peptides
|
Others
|
|
Suc-Gly-Pro-pNA is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
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-
- HY-P4593
-
|
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Thrombin
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Others
|
|
Z-Gly-Pro-Arg-4MβNA is the cleavage of the substrate of thrombin to release free 4-methoxy-2-naphthylamine (4MβNA). Free 4MβNA can be captured by 5-nitrosalicylaldehyde to produce an insoluble yellow fluorescent and marks the site of thrombin activity .
|
-
- HY-P3827
-
|
|
Peptides
|
Inflammation/Immunology
|
|
Cys-Gly-Tyr-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly is a13-mer synthetic peptide containing seven amino acids homologous to SV40 T antigen. Cys-Gly-Tyr-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly is capable of inducing nuclear transport .
|
-
- HY-P10007
-
|
Z-GPFL-CHO
|
Proteasome
|
Cancer
|
|
Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity) .
|
-
- HY-A0299
-
|
Tripeptide 29
|
Peptides
|
Others
|
|
HGly-Pro-Hyp-OH (Tripeptide 29) is an orally active bioactive peptide against UVB-induced skin aging and has been reported used as a cosmetic ingredient [1]
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
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