Glutathione diethyl ester

By Targets:	Biochemical Assay Reagents (1) Endogenous Metabolite (2)
By Research Areas:	Metabolic Disease (2)

Targets Recommended: Glutathione Peroxidase Glutathione Reductase (GR) Glutathione S-transferase CETP Carboxylesterase (CES)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P5069A

Glutathione diethyl ester TFA	Endogenous Metabolite	Metabolic Disease
Glutathione diethyl ester (TFA) is a delivery agent for glutathione monoester, and thus for glutathione, in human cells and therefore could serve to decrease oxidative stress and toxicity .

HY-Y1147

Diethyl maleate 1 Publications Verification Maleic acid diethyl ester	Biochemical Assay Reagents	Others
Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter X_{O ^-}. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].

HY-P5069

Glutathione diethyl ester	Endogenous Metabolite	Metabolic Disease
Glutathione diethyl ester is a delivery agent for glutathione monoester, and thus for glutathione, in human cells and therefore could serve to decrease oxidative stress and toxicity .

Cat. No.	Product Name	Type

HY-Y1147

Diethyl maleate 1 Publications Verification Maleic acid diethyl ester	Biochemical Assay Reagents
Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter X_{O ^-}. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].

Diethyl maleate

1 Publications Verification

Maleic acid diethyl ester

Biochemical Assay Reagents

Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter X_{O ^-}. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].

Cat. No.	Product Name	Target	Research Area

HY-P5069A

Glutathione diethyl ester TFA	Endogenous Metabolite	Metabolic Disease
Glutathione diethyl ester (TFA) is a delivery agent for glutathione monoester, and thus for glutathione, in human cells and therefore could serve to decrease oxidative stress and toxicity .

HY-P5069

Glutathione diethyl ester	Endogenous Metabolite	Metabolic Disease
Glutathione diethyl ester is a delivery agent for glutathione monoester, and thus for glutathione, in human cells and therefore could serve to decrease oxidative stress and toxicity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P5069A

Glutathione diethyl ester TFA	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glutathione diethyl ester (TFA) is a delivery agent for glutathione monoester, and thus for glutathione, in human cells and therefore could serve to decrease oxidative stress and toxicity .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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Glutathione diethyl ester

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Natural
Products