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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

Glioma stem cells

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Peptides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-117651
    2-Fluoropalmitic acid

    		Acyltransferase Cancer
    2-Fluoropalmitic acid, an acyl-CoA synthetase inhibitor, acts as a candidate anti-glioma agent. 2-Fluoropalmitic acid suppresses the viability and stem-like phenotype of glioma stem cells (GSCs). 2-Fluoropalmitic acid also inhibits proliferation and invasion of glioma cell lines .
    2-Fluoropalmitic acid
  • HY-150082
    CP681301

    		CDK DNA/RNA Synthesis Cancer
    CP681301 is a potent CDK5 inhibitor. CP681301 shows antiproliferative activity. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs (Glioma stem cells). CP681301 reduces self-renewal in mouse glioma xenografts. CP681301 shows anti-tumor activity in Drosophila .
    CP681301
  • HY-161303
    ZNF207-IN-1

    		Others Cancer
    ZNF207-IN-1 (compound C16) is a potent inhibitor of Zinc Finger Protein 207 (ZNF207)， with IC50 values ranging from 0.5–2.5 μM for inhibiting sphere formation and 0.5–15 μM for cytotoxicity. ZNF207-IN-1 exhibites efficient permeability across the blood–brain barrier .
    ZNF207-IN-1
  • HY-174212
    MXC-017

    		Apoptosis
    MXC-017 is a BBB-penetrable and ureabased compound, directly targeting glioma stem cells (GSCs). MXC-017 prevents radiation-induced GSC formation but increases G0/G1 arrest and apoptosis. MXC-017 has minimal off-target effects with no significant cell toxicity up to 10 µM. MXC-017 significantly extends median survival in patient-derived orthotopic xenograft (PDOX) glioblastoma (GBM) mice models with combination of radiation .
    MXC-017
  • HY-P10782
    Pt(IV)-M13

    		Peptide-Drug Conjugates (PDCs) Cancer
    Pt(IV)-M13 is a BBB-penetrable Platinum (IV) prodrug-perfluoroaryl macrocyclic peptide conjugate. Pt(IV)-M13 is cytotoxic to glioma stem cells and increases uptake of platinum in the brain. Pt(IV)-M13 can be used in the study of glioblastoma .
    Pt(IV)-M13
  • HY-117651R
    2-Fluoropalmitic acid (Standard)

    		Reference Standards Acyltransferase Cancer
    Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM .
    2-Fluoropalmitic acid (Standard)

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