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Results for "

GPER

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adhesion G Protein-coupled Receptors (AGPCRs) (2) Bcl-2 Family (1) Drug Metabolite (1) Endogenous Metabolite (3) Estrogen Receptor/ERR (10) PI3K (1) Reactive Oxygen Species (ROS) (2) Reference Standards (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (7) Endocrinology (3) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W013935

Bisphenol B	Endogenous Metabolite Estrogen Receptor/ERR Reactive Oxygen Species (ROS)	Endocrinology
Bisphenol B is a close structural analog of Bisphenol A (BPA) (HY-18260). Bisphenol B is a potent, orally active endocrine disruptor (ED). Bisphenol B binds to G protein-coupled estrogen receptor (GPER) (IC₅₀ = 3.3 μM) with higher affinity and agonistic activity than BPA. Bisphenol B promotes GPER mediated cell migration. Bisphenol B exerts estrogenic effects via GPER pathway at nanomolar concentration. Bisphenol B is used in the manufacture of polycarbonate resin with ED properties .

HY-RS25000

Gper1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gper1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gper1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gper1 Rat Pre-designed siRNA Set A Gper1 Rat Pre-designed siRNA Set A

HY-RS18518

Gper1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gper1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gper1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gper1 Mouse Pre-designed siRNA Set A Gper1 Mouse Pre-designed siRNA Set A

HY-RS05636

GPER1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GPER1 Human Pre-designed siRNA Set A contains three designed siRNAs for GPER1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GPER1 Human Pre-designed siRNA Set A GPER1 Human Pre-designed siRNA Set A

HY-174338

GPER/Bcl-2-IN-1	Estrogen Receptor/ERR Bcl-2 Family	Neurological Disease Cancer
GPER/Bcl-2 Inhibitor is a *GPER/Bcl-2* inhibitor. GPER/Bcl-2 Inhibitor can inhibit the proliferation and neurospheres formation of glioblastoma cells. GPER/Bcl-2 Inhibitor can be used for the study of glioblastoma multiforme (GBM) .

HY-163755

GPER activator 1	Estrogen Receptor/ERR	Inflammation/Immunology
GPER activator 1 (compound 6-26) is a GPER-selective compound without cytotoxicity. GPER activator 1 exhibits dual inhibition of TNFα- and IL-6-induced inflammation .

HY-149500

CITFA	Estrogen Receptor/ERR	Metabolic Disease
CITFA is a *GPER* agonist. CITFA can promote neurite growth of hippocampal neurons in rat embryo (E18) .

HY-107216A

(3aS,4R,9bR)-G-1	Adhesion G Protein-coupled Receptors (AGPCRs) PI3K	Neurological Disease Cancer
(3aS,4R,9bR)-G-1 is a highly selective G protein-coupled receptor GPR30 (GPER) agonist with a K_i value of approximately 7 nM. (3aS,4R,9bR)-G-1 activates rapid signaling pathways such as intracellular calcium mobilization and PI3K signaling through GPR30, promoting uterine epithelial cell proliferation and exerting antidepressant effects. (3aS,4R,9bR)-G-1 is promising for research of breast cancer and depression .

HY-W013935R

Bisphenol B (Standard)	Reference Standards Endogenous Metabolite Estrogen Receptor/ERR Reactive Oxygen Species (ROS)	Endocrinology
Bisphenol B (Standard) is the analytical standard of Bisphenol B. This product is intended for research and analytical applications. Bisphenol B is a close structural analog of Bisphenol A (BPA) (HY-18260). Bisphenol B is a potent, orally active endocrine disruptor (ED). Bisphenol B binds to G protein-coupled estrogen receptor (GPER) (IC₅₀ = 3.3 μM) with higher affinity and agonistic activity than BPA. Bisphenol B promotes GPER mediated cell migration. Bisphenol B exerts estrogenic effects via GPER pathway at nanomolar concentration. Bisphenol B is used in the manufacture of polycarbonate resin with ED properties .

HY-173178

LNS8801	Estrogen Receptor/ERR	Cancer
LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). By activating *GPER, LNS8801 mediates downstream signaling pathways, such as promoting the production of cyclic adenosine monophosphate (cAMP) and activating the cAMP response element-binding protein (CREB) signaling, thereby exerting anti-tumor activities including inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. LNS8801 can be used in the research of various cancers (e.g., melanoma, pancreatic cancer, colorectal cancer, lung cancer, etc.) and relevant studies exploring the roles of GPER* in normal physiological and pathological processes .

HY-103449

G15 25+ Cited Publications	Estrogen Receptor/ERR	Cancer
G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a K_i of 20 nM .

HY-103450

G36	Estrogen Receptor/ERR	Endocrinology Cancer
G-36 is a cell-permeable nonsteroidal antagonist of the G protein-coupled estrogen receptor (GPER/GPR30), which selectively inhibits estrogen-mediated PI3K activation through GPER, rather than Erα. G-36 also inhibits estrogen-mediated calcium mobilization (IC₅₀=112 nM). G-36 is promising for research in the field of cancer .

HY-16950A

(E/Z)-4-Hydroxytamoxifen 1 Publications Verification Afimoxifene; 4-OHT	Estrogen Receptor/ERR Adhesion G Protein-coupled Receptors (AGPCRs) Drug Metabolite	Metabolic Disease Cancer
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity .

HY-16950AR

(E/Z)-4-Hydroxytamoxifen (Standard) Afimoxifene (Standard); 4-OHT (Standard)	Reference Standards Estrogen Receptor/ERR Endogenous Metabolite	Cancer
(E/Z)-4-Hydroxytamoxifen (Standard) is the analytical standard of (E/Z)-4-Hydroxytamoxifen. This product is intended for research and analytical applications. (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity .

Bisphenol B	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite Estrogen Receptor/ERR Reactive Oxygen Species (ROS)
Bisphenol B is a close structural analog of Bisphenol A (BPA) (HY-18260). Bisphenol B is a potent, orally active endocrine disruptor (ED). Bisphenol B binds to G protein-coupled estrogen receptor (GPER) (IC₅₀ = 3.3 μM) with higher affinity and agonistic activity than BPA. Bisphenol B promotes GPER mediated cell migration. Bisphenol B exerts estrogenic effects via GPER pathway at nanomolar concentration. Bisphenol B is used in the manufacture of polycarbonate resin with ED properties .

(E/Z)-4-Hydroxytamoxifen 1 Publications Verification Afimoxifene; 4-OHT	Structural Classification Alkaloids Monophenols Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Estrogen Receptor/ERR Adhesion G Protein-coupled Receptors (AGPCRs) Drug Metabolite
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity .

Bisphenol B (Standard)	Structural Classification Source classification Phenols Polyphenols Endogenous metabolite	Reference Standards Endogenous Metabolite Estrogen Receptor/ERR Reactive Oxygen Species (ROS)
Bisphenol B (Standard) is the analytical standard of Bisphenol B. This product is intended for research and analytical applications. Bisphenol B is a close structural analog of Bisphenol A (BPA) (HY-18260). Bisphenol B is a potent, orally active endocrine disruptor (ED). Bisphenol B binds to G protein-coupled estrogen receptor (GPER) (IC₅₀ = 3.3 μM) with higher affinity and agonistic activity than BPA. Bisphenol B promotes GPER mediated cell migration. Bisphenol B exerts estrogenic effects via GPER pathway at nanomolar concentration. Bisphenol B is used in the manufacture of polycarbonate resin with ED properties .

(E/Z)-4-Hydroxytamoxifen (Standard) Afimoxifene (Standard); 4-OHT (Standard)	Structural Classification Alkaloids Monophenols Other Alkaloids Source classification Phenols Endogenous metabolite	Reference Standards Estrogen Receptor/ERR Endogenous Metabolite
(E/Z)-4-Hydroxytamoxifen (Standard) is the analytical standard of (E/Z)-4-Hydroxytamoxifen. This product is intended for research and analytical applications. (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P86196

	GPER1 Antibody (YA5888)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	GPER1 Antibody (YA5888) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPER1. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

HY-P81150

	GPR30 Antibody G Protein Coupled Receptor 30; G-protein coupled receptor 30; G-protein coupled estrogen receptor 1; Membrane estrogen receptor; mER; Chemokine receptor-like 2; IL8-related receptor DRY12; Flow-induced endothelial G-protein coupled receptor 1; FEG-1; Lymphocyte-derived G-protein coupled receptor; LYGPR; GPCR-BR; CEPR; CMKRL2; DRY12; GPER.	WB, IHC-P, IHC-F, ICC/IF, FC, ELISA	Human, Mouse, Rat
	GPR30 Antibody is an unconjugated, approximately 42 kDa, rabbit-derived, anti-GPR30 polyclonal antibody. GPR30 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, and predicted: chicken, cow, horse, rabbit background without labeling.

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Gper1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Gper1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gper1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gper1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Gper1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gper1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

GPER1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GPER1 Human Pre-designed siRNA Set A contains three designed siRNAs for GPER1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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