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Results for "

Fe2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (2) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (1) Cholinesterase (ChE) (2) Ferroportin (1) Ferroptosis (9) Fluorescent Dye (4) Glutathione Peroxidase (2) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (1) IKZF Family (1) Interleukin Related (1) Isotope-Labeled Compounds (1) LDLR (2) MEK (1) MMP (4) PROTACs (2) Reactive Oxygen Species (ROS) (3) Reference Standards (1) Tau Protein (2) Transferrin Receptor (1) VDAC (1) Zinc Finger Protein (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (4) Infection (1) Inflammation/Immunology (6) Neurological Disease (3)

By Targets:

Antibiotic (1)

Apoptosis (2)

Autophagy (1)

Bacterial (1)

Biochemical Assay Reagents (1)

Cholinesterase (ChE) (2)

Ferroportin (1)

Ferroptosis (9)

Fluorescent Dye (4)

Glutathione Peroxidase (2)

HDAC (1)

HIF/HIF Prolyl-Hydroxylase (1)

Histamine Receptor (1)

IKZF Family (1)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

LDLR (2)

MEK (1)

MMP (4)

PROTACs (2)

Reactive Oxygen Species (ROS) (3)

Reference Standards (1)

Tau Protein (2)

Transferrin Receptor (1)

VDAC (1)

Zinc Finger Protein (1)

By Research Areas:

Cancer (6)

Cardiovascular Disease (4)

Infection (1)

Inflammation/Immunology (6)

Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

MCE Kits

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1913

FerroOrange 5+ Cited Publications	Fluorescent Dye	Others
FerroOrange is a Fe ²⁺ selective probe with an excitation wavelength of 543 nm and an emission wavelength of 580 nm. FerroOrange emits fluorescence after binding to intracellular Fe ²⁺, thereby achieving specific labeling of Fe ²⁺. FerroOrange is used to detect the content and distribution of Fe ²⁺ in cells .

HY-D1533

RhoNox-1 Maximum Cited Publications 16 Publications Verification	Fluorescent Dye	Others
RhoNox-1 is a fluorescent probe for the specific detection of divalent iron ions, and when RhoNox-1 reacts with Fe ²⁺. RhoNox-1 can generate an irreversible orange (red) fluorescent product (Ex/Em：540/575 nm) . FeRhoNox-1 can enter the cell well, suitable for the detection of Fe ²⁺ in living cells, and tends to be localized in the Golgi apparatus .

HY-126823

Phen Green SK diacetate (5/6-mixture) 5+ Cited Publications PGSK diacetate (5/6-mixture)	Fluorescent Dye	Others
Phen green SK (PGSK) diacetate (PGSK diacetate (5/6-mixture)) is a metal ion-sensitive fluorescent probe that can penetrate cell membranes. Phen green SK (PGSK) diacetate can react with a variety of metal ions, including Fe ²⁺, Cd ²⁺, Co ²⁺, Ni ²⁺, Zn ²⁺, etc. Phen green SK (PGSK) diacetate chelates Fe ²⁺, resulting in fluorescence quenching, which can be restored when a membrane-permeable chelator is added, thereby reflecting the changes in the intracellular chelatable iron pool. The excitation/emission maxima of Phen green SK diacetate are 507/532 nm, respectively ^[2] .

HY-155539

Cisd2 agonist 2 1 Publications Verification	IKZF Family Zinc Finger Protein	Inflammation/Immunology
Cisd2 agonist 2 (compound 6) is a *Cisd2* activator (EC₅₀=191 nM), and Cisd2 levels are associated with non-alcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant in vivo toxicity in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout). Cisd2 (CDGSH iron sulfur domain 2) is a zinc finger protein that is mainly localized in the endoplasmic reticulum or mitochondrial membrane. Cisd2 participates in mitochondrial function by forming homodimers containing two redox-active 2Fe-2S clusters ^[2].

HY-Y1841R

o-Phenanthroline monohydrate (Standard)	MMP	Others
o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a MMP inhibitor ^[2].

HY-W004544S

o-Phenanthroline-d8 1,10-Phenanthroline-d₈	Isotope-Labeled Compounds MMP	Others
o-Phenanthroline-d₈ is the deuterium labeled o-Phenanthroline. o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor ^[2].

HY-157926

Nitroso-PSAP	Biochemical Assay Reagents	Others
Nitroso-PSAP is a sensitive and specific chromogenic reagent for iron (Fe ²⁺), which is used for the colorimetric determination of iron in blood after mineralization with periodic acid. TNitroso-PSAP chelates with iron (Fe ²⁺) to produce a green complex (λmax=756 nm, Epsilon = 4.5 x 10 < sup > 4 < / sup > dm < sup > 3 < / sup > mol < sup > 1 < / sup > cm < sup > 1 < / sup >) ^[2].

HY-160414

TRX-COBI (R,R)-TRX-COBI; TRX-cobimetinib	MEK	Cancer
TRX-COBI ((R,R)-TRX-COBI; Trx-cobimetinib) is a MEK inhibitor targeting TRX fragments based on Fe ²⁺. TRX-COBI has antitumor activity .

HY-B1159S

Nitroxoline-d4 8-Hydroxy-5-nitroquinoline-d₄; 5-Nitro-8-quinolinol-d₄	Bacterial Autophagy Antibiotic	Infection Cancer
Nitroxoline-d₄ is the deuterium labeled Nitroxoline. Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe ²⁺ and Zn ²⁺ ions from the biofilm matrix ^[2].

HY-N15282

Broussoflavonol G	Interleukin Related	Cardiovascular Disease
Broussoflavonol G is an active ingredient of Moraceae plants, which can be isolated from Broussonetia papyrifera. Broussoflavonol G can effectively inhibit Fe ²⁺-induced lipid oxidation in rat brain homogenate and significantly inhibit the proliferation of rat vascular smooth muscle cells .

HY-Y1841

o-Phenanthroline monohydrate 4 Publications Verification 1,10-Phenanthroline monohydrate	MMP	Others
o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe ²⁺ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a MMP inhibitor ^[2].

HY-W004544

o-Phenanthroline 4 Publications Verification 1,10-Phenanthroline	MMP	Others
o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe ²⁺ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor ^[2].

HY-136300

PHD-1-IN-1	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease Inflammation/Immunology
PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC₅₀ of 0.034 μM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe ²⁺ ion and induces the formation of an "Arg367-out" pocket .

HY-155158

Anticancer agent 147	Ferroptosis	Cancer
Anticancer agent 147 (compound 6j) is a derivative of sophoridine (HY-N1373) and is a ferroptosis inducer. Anticancer agent 147 can promote the accumulation of intracellular Fe ²⁺, reactive oxygen species (ROS) and MDA, increase ER stress, and upregulate the expression of the activating transcription factor ATF3. Anticancer agent 147 has good anti-liver cancer effects in vitro and in vivo .

HY-P3267A

Apo-Bovine Transferrin	Ferroportin Transferrin Receptor	Neurological Disease
Apo-Bovine Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrin receptor ligand and mediates iron release from endothelial cells. Apo-Transferrin can directly bind to hephaestin, which can convert Fe ²⁺ to Fe ³⁺. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1. Apo-Bovine Transferrin can be used in neuroretinal research ^[2].

HY-158779

Sulfane sulfur probe 4 SSP4	Fluorescent Dye	Others
Sulfane sulfur probe 4 (SSP4) is a fluorescent probe used to detect sulfane sulfur species (E_x/E_m=494/515 nm). Sulfane sulfur probe 4 exhibits high sensitivity in detecting sulfane sulfur, even in the presence of other substances such as homocysteine, methionine, cysteine, glutathione, N-acetyl-L-cysteine, glycine, tyrosine, tryptophan, arginine, and metal ions (Fe ²⁺, Fe ³⁺, Mg ²⁺, Ca ²⁺, and Zn ²⁺) .

HY-N15398

Chaetoglobosin E	Ferroptosis	Cancer
Chaetoglobosin E is a Ferroptosis inducer that exhibits significant cytotoxicity against human tumor cell lines MDA-MB231 and A549, with IC₅₀ values of 9.14 and 7.47 μM, respectively. By downregulating the expression of GPX4 in A549 cells, Chaetoglobosin E markedly increases intracellular levels of Fe ²⁺ and the lipid peroxidation product malondialdehyde (MDA), leading to mitochondrial shrinkage, reduction or disappearance of cristae, and subsequent induction of ferroptosis. Chaetoglobosin E can be used for research in the field of cancer .

HY-176212

Ferroptosis-IN-20	Ferroptosis VDAC Reactive Oxygen Species (ROS)	Inflammation/Immunology
Ferroptosis-IN-20 (Compound 34a) is a Ferroptosis inhibitor (EC₅₀: 24.2 nM) targeting voltage-dependent anion channel (VDAC). Ferroptosis-IN-20 inhibits VDAC oligomerization and lipid peroxidation. Ferroptosis-IN-20 reduces content of ROS, attenuates TFR1-mediated iron uptake, inhibits Fe ²⁺ level and restores glutathione (GSH) level. Ferroptosis-IN-20 alleviates Folic acid (HY-16637)-induced acute kidney injury (AKI) .

HY-149418

BChE/HDAC6-IN-2	HDAC Cholinesterase (ChE) Tau Protein	Neurological Disease
BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC₅₀s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe ²⁺ and Cu ²⁺). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.

HY-172092

BG11	Apoptosis Ferroptosis	Cancer
BG11 induces the accumulation of Fe ²⁺ and intracellular lipid peroxides, induces ferroptosis. BG11 regulates the expression of Bax and Bcl-2 proteins, and induces apoptosis in MDA-MB-231 cell. BG11 arrests the cell cycle at G0/G1 and S phase, inhibits the proliferation of TNBC cancer cell (IC₅₀ for MDA-MB-231 and BT549 is 0.49 μM and 0.52 μM), and inhibits the cell migration and invasion. BG11 exhibits antitumor efficacy in mouse models .

HY-163897

PROTAC NCOA4 degrader-1	PROTACs Ferroptosis	Inflammation/Immunology
PROTAC NCOA4 degrader-1 (Compound V3) is a PROTAC NCOA4 degrader (DC₅₀: 3 nM in HeLa cells). PROTAC NCOA4 degrader-1 is a ferroptosis inhibitor. PROTAC NCOA4 degrader-1 reduces NCOA4 levels and downregulates intracellular ferrous iron (Fe ²⁺) levels. PROTAC NCOA4 degrader-1 ameliorates liver damage in a CCl₄-induced acute liver injury model. (Red: NCOA4 ligand (HY-149457). Black: linker (HY-163903). Blue: VHL ligand (HY-138678B)) .

HY-174867

AY-4	PROTACs Ferroptosis	Cancer
AY-4 (Compound AY-4) is an efficient PROTAC degrader targeting FTH1 (K_d = 3.17 nM). AY-4 effectively upregulates the levels of ferrous (Fe ²⁺) and ferric (Fe ³⁺) ions in cells. AY-4 is a potential anticancer candidate compound that regulates iron homeostasis through ferritin degradation and enhances the efficacy of existing drugs. AY-4 can effectively reduce the level of FTH1 in breast cancer cells (Pink: FTH1 ligand AY-2 (HY-174871); Blue: E3 ligand Pomalidomide (HY-10984); Black: Linker, Pomalidomide-PEG3-acid (HY-174872)) .

HY-W015600

2-Acetamidophenol Orthocetamol	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS) LDLR	Cardiovascular Disease Inflammation/Immunology
2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC₅₀s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe ²⁺), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation ^[2].

HY-W015600R

2-Acetamidophenol (Standard) Orthocetamol (Standard)	Reference Standards Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS) LDLR	Cardiovascular Disease Inflammation/Immunology
2-Acetamidophenol (Standard) is the analytical standard of 2-Acetamidophenol. This product is intended for research and analytical applications. 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC₅₀s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe ²⁺), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation ^[2].

HY-162812

H3R antagonist 4	Apoptosis Cholinesterase (ChE) Tau Protein Ferroptosis Histamine Receptor	Neurological Disease
H3R antagonist 4 (compound 11L) was a dual inhibitor of cholinesterase and histamine receptor (H3R), with corresponding IC₅₀ of 7.04 μM (eeAChE), 9.73 μM (hAChE)(reversible) and 1.09 nM (H3R) , respectively. H3R antagonist 4 inhibited the aggregation of Aβ_1-42 induced by itself and Cu ²⁺ (95.48% and 88.63%) , and degraded the Aβ_1-42 fibrils induced by itself and Cu ²⁺ (80.16% and 89.30%) . H3R antagonist 4 chelate biometals such as Cu ²⁺, Zn ²⁺, Al ³⁺, and Fe ²⁺. H3R antagonist 4 significantly reduced tau protein hyperphosphorylation induced by Aβ_1-42 and inhibited RSL-3-induced apoptosis and ferroptosis in PC12 cells. H3R antagonist 4 had the best blood-brain barrier permeability and intestinal absorption in hCMEC/D3 and hPepT1-MDCK cells.H3R antagonist 4 ameliorates learning and memory impairment in a mouse model of Alzheimer's disease induced by scopolamine (HY-N0296) .

Cat. No.	Product Name	Type

HY-D1913

FerroOrange 5+ Cited Publications	Fluorescent Dyes/Probes
FerroOrange is a Fe ²⁺ selective probe with an excitation wavelength of 543 nm and an emission wavelength of 580 nm. FerroOrange emits fluorescence after binding to intracellular Fe ²⁺, thereby achieving specific labeling of Fe ²⁺. FerroOrange is used to detect the content and distribution of Fe ²⁺ in cells .

HY-D1533

RhoNox-1 15+ Cited Publications	Fluorescent Dyes/Probes
RhoNox-1 is a fluorescent probe for the specific detection of divalent iron ions, and when RhoNox-1 reacts with Fe ²⁺. RhoNox-1 can generate an irreversible orange (red) fluorescent product (Ex/Em：540/575 nm) . FeRhoNox-1 can enter the cell well, suitable for the detection of Fe ²⁺ in living cells, and tends to be localized in the Golgi apparatus .

HY-158779

Sulfane sulfur probe 4 SSP4	Fluorescent Dyes/Probes
Sulfane sulfur probe 4 (SSP4) is a fluorescent probe used to detect sulfane sulfur species (E_x/E_m=494/515 nm). Sulfane sulfur probe 4 exhibits high sensitivity in detecting sulfane sulfur, even in the presence of other substances such as homocysteine, methionine, cysteine, glutathione, N-acetyl-L-cysteine, glycine, tyrosine, tryptophan, arginine, and metal ions (Fe ²⁺, Fe ³⁺, Mg ²⁺, Ca ²⁺, and Zn ²⁺) .

Sulfane sulfur probe 4

SSP4

Fluorescent Dyes/Probes

Sulfane sulfur probe 4 (SSP4) is a fluorescent probe used to detect sulfane sulfur species (E_x/E_m=494/515 nm). Sulfane sulfur probe 4 exhibits high sensitivity in detecting sulfane sulfur, even in the presence of other substances such as homocysteine, methionine, cysteine, glutathione, N-acetyl-L-cysteine, glycine, tyrosine, tryptophan, arginine, and metal ions (Fe ²⁺, Fe ³⁺, Mg ²⁺, Ca ²⁺, and Zn ²⁺) .

Cat. No.	Product Name	Type