2. Search Result
Search Result
Results for "

FTH1

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Recombinant Proteins

3

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-148409
    MMRi62

    		Ferroptosis Apoptosis Autophagy MDM-2/p53 Cancer
    MMRi62, a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12 [1] .
    MMRi62
  • HY-RS05133
    FTH1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    FTH1 Human Pre-designed siRNA Set A contains three designed siRNAs for FTH1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FTH1 Human Pre-designed siRNA Set A
    FTH1 Human Pre-designed siRNA Set A
  • HY-RS16862
    Fth1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Fth1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fth1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Fth1 Mouse Pre-designed siRNA Set A
    Fth1 Mouse Pre-designed siRNA Set A
  • HY-RS23303
    Fth1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Fth1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fth1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Fth1 Rat Pre-designed siRNA Set A
    Fth1 Rat Pre-designed siRNA Set A
  • HY-174867
    AY-4

    		PROTACs Ferroptosis Cancer
    AY-4 (Compound AY-4) is an efficient PROTAC degrader targeting FTH1 (Kd = 3.17 nM). AY-4 effectively upregulates the levels of ferrous (Fe 2+) and ferric (Fe 3+) ions in cells. AY-4 is a potential anticancer candidate compound that regulates iron homeostasis through ferritin degradation and enhances the efficacy of existing drugs. AY-4 can effectively reduce the level of FTH1 in breast cancer cells (Pink: FTH1 ligand AY-2 (HY-174871); Blue: E3 ligand Pomalidomide (HY-10984); Black: Linker, Pomalidomide-PEG3-acid (HY-174872)) [1].
    AY-4
  • HY-174871
    AY-2

    		Ligands for Target Protein for PROTAC Cancer
    AY-2 is a binding ligand for FTH1 and can be used to synthesize PROTACs such as AY-4 (HY-174867) [1].
    AY-2
  • HY-168894
    CT-1

    		Ferroptosis Cancer
    CT-1 is a derivative of Cryptotanshinone (HY-N0174). CT-1 is a ferroptosis inducer. CT-1 promotes the interaction between NCOA4 and ferritin by targeting FTH1, triggering ferritinophagy-mediated ferroptosis. CT-1 has anticancer activity against triple-negative breast cancer (TNBC). CT-1 induces ferroptosis in both N2-type tumor-associated neutrophils (TANs) and TNBC cancer cells [1].
    CT-1
  • HY-176271
    MAO-B-IN-45

    		Ferroptosis Monoamine Oxidase Glutathione Peroxidase Reactive Oxygen Species (ROS) Tau Protein Amyloid-β Neurological Disease
    MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. MAO-B-IN-45 shows selectivity towards MAO-B with an IC50 of 87.47 nM and selectivity exceeding 229-fold for MAO-B over MAO-A. MAO-B-IN-45 has excellent antiferroptosis activity through modulation of the iron metabolic pathway and GSH-GPX4 axis in vitro. MAO-B-IN-45 improves cognitive and behavioral impairments in 3×Tg (APP/Tau/Ps1) AD mouse and significantly reduced the levels of ferritin heavy chain 1 (FTH1), APP, and Tau phosphorylation (p-Tau) proteins in the brain.
    MAO-B-IN-45

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: