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Results for "

FOXP3 expression

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

3

Peptides

1

Inhibitory Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1453A
    CMD178 TFA

    		STAT Cancer
    CMD178 TFA is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development .
    CMD178 TFA
  • HY-W107024
    BMS-986260

    		TGF-β Receptor Inflammation/Immunology Cancer
    BMS-986260, an immuno-oncology agent, is a potent, selective, and orally active TGFβR1 inhibitor (IC50=1.6 nM). BMS-986260 displays exquisite selectivity for TGFβR1 over its isozyme TGFβR2, as well as in a panel of more than 200 kinases examined. BMS-986260 inhibits TGFβ mediated nuclear translocation of pSMAD2/3 in MINK and NHLF cells lines with an IC50 of 350 nM and 190 nM, respectively .
    BMS-986260
  • HY-162943
    P60-L3-VHL

    		PROTACs Cancer
    P60-L3-VHL is a PROTAC-class Foxp3 degrader. P60-L3-VHL reduced cell differentiation and Foxp3 expression in activated Treg cells in vitro and had anti-tumor activity (Blue: E3 ligase ligand (HY-162945); Pink: target protein ligand (HY-162946); Black: linker (HY-162947)) .
    P60-L3-VHL
  • HY-P991392
    TGTB227

    		Transmembrane Glycoprotein Cancer
    TGTB227 is a human monoclonal antibody (mAb) targeting TIGIT. TGTB227 inhibits the immunosuppressive function of Tregs by reducing the expression of Foxp3 in Tregs. TGTB227 can be used in tumor immunity research .
    TGTB227
  • HY-P1453
    CMD178

    		STAT Cancer
    CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development .
    CMD178
  • HY-160040A
    Cobitolimod sodium

    		Toll-like Receptor (TLR) Inflammation/Immunology
    Cobitolimod sodium is a DNA oligonucleotide agonist of TLR-9 with anti-inflammatory activity. Cobitolimod sodium inhibits Th17 cells and induces anti-inflammatory FoxP3 and IL-10 expression, inhibiting the IL-17 signaling pathway .
    Cobitolimod sodium
  • HY-160040
    Cobitolimod

    		Toll-like Receptor (TLR) Inflammation/Immunology
    Cobitolimod is a DNA oligonucleotide agonist of TLR-9 with anti-inflammatory activity. Cobitolimod suppresses Th17 cells and induces anti-inflammatory FoxP3 and IL-10 expression, inhibiting the IL-17 signaling pathway .
    Cobitolimod
  • HY-162600
    CDK8-IN-15

    		CDK Inflammation/Immunology
    CDK8-IN-15 (Compound 46) is a potent CDK8 inhibitors with an IC50 value of 57 nM. It can enhance the thermal stability of CDK8 along with inhibition against NF-κB and have favourable selectivity across the CDK family and tyrosine kinase. Additionally, it also demostrates a positive effect in vitro psoriasis model induced by TNF-α and alleviats the inflammatory response enhancing the expression of Foxp3 and IL-10, which is promising for research of psoriasis diseases .
    CDK8-IN-15

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