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Results for "

FMK

" in MedChemExpress (MCE) Product Catalog:

46

Inhibitors & Agonists

3

Fluorescent Dye

2

Biochemical Assay Reagents

18

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-52101A
    FMK
    4 Publications Verification

    		 Ribosomal S6 Kinase (RSK) Cancer
    FMK is a an irreversible RSK2 kinase inhibitor, that covalently modifies the C-terminal kinase domain of RSK.
    FMK
  • HY-52101C
    FMK-MEA

    		Ribosomal S6 Kinase (RSK) Cancer
    FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor.
    FMK-MEA
  • HY-100522
    FMK 9a
    2 Publications Verification

    		 Atg4 Autophagy Cancer
    FMK 9a is an autophagin-1 inhibitor with IC50 values of 80 and 73 μM in FRET and LRA assay.
    FMK 9a
  • HY-101297
    Z-IETD-FMK
    60+ Cited Publications

    Z-IE(OMe)TD(OMe)-FMK

    		 Caspase Cancer
    Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor . Z-IETD-FMK is also a granzyme B inhibitor .
    Z-IETD-FMK
  • HY-16658
    Z-VAD(OMe)-FMK
    185+ Cited Publications

    Z-Val-Ala-Asp(OMe)-FMK

    		 Caspase Cancer
    Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor . Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1 .
    Z-VAD(OMe)-FMK
  • HY-141867
    Z-FF-FMK

    Z-Phe-Phe-FMK

    		 Cathepsin Neurological Disease
    Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation .
    Z-FF-FMK
  • HY-153614
    Ac-VLPE-FMK

    Ac-Val-Leu-Pro-Glu(OMe)-CH2F

    		 Cathepsin Cancer
    Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), is a Cat-B and Cat-L inhibitor. Ac-VLPE-FMK can be used for the research of cancer aggressiveness .
    Ac-VLPE-FMK
  • HY-P1009
    Z-YVAD-FMK
    15+ Cited Publications

    		 Caspase Cancer
    Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities .
    Z-YVAD-FMK
  • HY-P10244
    Ac-YVAD-FMK

    		Caspase Others
    Ac-YVAD-FMK is an inhibitor for caspase 1-like protease .
    Ac-YVAD-FMK
  • HY-P5975
    Z-Leu-Leu-Leu-fluoromethyl ketone

    Z-LLL-FMK

    		 Cathepsin SARS-CoV Infection
    Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge .
    Z-Leu-Leu-Leu-fluoromethyl ketone
  • HY-P0109A
    Z-FA-FMK
    5+ Cited Publications

    (1S)-Z-FA-FMK

    		 SARS-CoV Cathepsin Apoptosis Caspase Infection Cancer
    Z-FA-FMK ((1S)-Z-FA-FMK) is a potent Cathepsin B and L inhibitor. Z-FA-FMK blocks the induction of DEVDase activity, DNA fragmentation, and externalization of phosphatidylserine by selective synthetic retinoid-related molecules (RRMs). Z-FA-FMK inhibits apoptosis. Z-FA-FMK inhibits caspase activity and selectively inhibits recombinant effector caspases 2, -3, -6, and -7. Z-FA-FMK is a viral inhibitor. Z-FA-FMK inhibits reovirus replication in a susceptible host .
    Z-FA-FMK
  • HY-P1007
    Z-VEID-FMK

    Z-VE(OMe)ID(OMe)-FMK

    		 Caspase Apoptosis Cancer
    Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a selective and irreversible caspase-6 peptide inhibitor. Z-VEID-FMK alleviates the drug-induced augmentation of caspase-6 activity, DNA fragmentation, and cell apoptosis .
    Z-VEID-FMK
  • HY-13229R
    BOC-D-FMK (Standard)

    		Caspase Apoptosis Cancer
    BOC-D-FMK (Standard) is the analytical standard of BOC-D-FMK. This product is intended for research and analytical applications. Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC50 of 39 μM.
    BOC-D-FMK (Standard)
  • HY-P1008
    Z-VDVAD-FMK
    4 Publications Verification

    Z-VD(OMe)VAD(OMe)-FMK

    		 Caspase Cancer
    Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis .
    Z-VDVAD-FMK
  • HY-P0110
    (Iso)-Z-VAD(OMe)-FMK

    (Iso)-Z-Val-Ala-Asp(OMe)-FMK

    		 Caspase Cancer
    (Iso)-Z-VAD(OMe)-FMK ((Iso)-Z-Val-Ala-Asp(OMe)-FMK) is an isomer of the caspase and UCHL1 inhibitor Z-VAD(OMe)-FMK (HY-16658) .
    (Iso)-Z-VAD(OMe)-FMK
  • HY-P1008A
    Z-VDVA-(DL-Asp)-FMK

    Z-VD(OMe)VAD(OMe)-(DL-Asp)-FMK

    		 Caspase Cancer
    Z-VDVA-(DL-Asp)-FMK is a Z-VDVAD-FMK derivative. Z-VDVAD-FMK (HY-P1008) is a special inhibitor of caspase-2 .
    Z-VDVA-(DL-Asp)-FMK
  • HY-P10326
    Z-ATAD-FMK

    		Caspase Apoptosis Cancer
    Z-ATAD-FMK is an inhibitor of caspase-12. Z-ATAD-FMK is an inhibitor of caspase-12. Z-ATAD-FMK prevents endoplasmic reticulum stress-mediated apoptosis by inhibiting the activity of caspase-12 and reducing the activity of caspase-9 .
    Z-ATAD-FMK
  • HY-P0111
    Z-WEHD-FMK
    3 Publications Verification

    Z-WE(OMe)HD(OMe)-FMK

    		 Caspase Cathepsin Cancer
    Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis .
    Z-WEHD-FMK
  • HY-128707
    Z-LEVD-FMK
    4 Publications Verification

    		 Caspase Apoptosis Cancer
    Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells .
    Z-LEVD-FMK
  • HY-16658B
    Z-VAD-FMK
    Maximum Cited Publications
    610 Publications Verification

    Z-VAD(OH)-FMK

    		 Caspase Apoptosis Cancer
    Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM .
    Z-VAD-FMK
  • HY-13229
    BOC-D-FMK
    5+ Cited Publications

    		 Caspase Apoptosis Cancer
    Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC50 of 39 μM.
    BOC-D-FMK
  • HY-16658C
    Z-VA-DL-D-FMK

    Z-VA-DL-D(OH)-FMK

    		 Caspase Infection
    Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) is an inhibitor for caspase . Z-VA-DL-D-FMK binds irreversibly to caspases, increases the sensitivity of TNF-α, and activates HIV replication in infected T cell ACH-2 .
    Z-VA-DL-D-FMK
  • HY-123185
    (Rac)-Z-FA-FMK

    		Cathepsin Caspase SARS-CoV Interleukin Related NF-κB Infection
    (Rac)-Z-FA-FMK is the racemate of Z-FA-FMK. (Rac)-Z-FA-FMK is an inhibitor of cathepsin B with a Ki of 1.5 μM. (Rac)-Z-FA-FMK inhibits caspase-2, -3, -6, -7, and -9 with IC50s of 6.147, 15.41, 32.45, 9.077, and 110.7 μM. (Rac)-Z-FA-FMK inhibits the main protease of SARS-CoV-2 replication with an IC50 of 11.39 μM. (Rac)-Z-FA-FMK inhibits the increased IL-1β level induced by LPS and NF-κB transactivation in macrophages .
    (Rac)-Z-FA-FMK
  • HY-P5122
    Z-LEED-FMK

    		Caspase Inflammation/Immunology
    Z-LEED-FMK is a caspase-13 and caspase-4 inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages .
    Z-LEED-FMK
  • HY-16658BG
    Z-VAD-FMK

    		Caspase Apoptosis Cancer
    Z-VAD-FMK (GMP) is Z-VAD-FMK (HY-16658B) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM .
    Z-VAD-FMK
  • HY-125305
    Z-AEVD-FMK

    		Caspase Apoptosis Cancer
    Z-AEVD-FMK is a caspase-10 inhibitor. Z-AEVD-FMK can inhibit the activation of Bid and the release of apoptosis-inducing factor (AIF) in mitochondria in cells, resulting in a significant decrease in the number of apoptotic cells .
    Z-AEVD-FMK
  • HY-P1010
    Z-LEHD-FMK
    10+ Cited Publications

    		 Caspase Apoptosis Neurological Disease Cancer
    Z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma .
    Z-LEHD-FMK
  • HY-136750
    Z-LLY-FMK

    Calpain Inhibitor IV

    		 Apoptosis Proteasome Parasite Cancer
    Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation. Z-LLY-FMK reduces parasite burden in mice challenged with Taenia crassiceps cysts. Z-LLY-FMK can be used for the study of cysticercosis .
    Z-LLY-FMK
  • HY-120231
    Z-VRPR-FMK

    		MALT1 Cancer
    Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression .
    Z-VRPR-FMK
  • HY-P1010A
    Z-LEHD-FMK TFA

    		Caspase Apoptosis Neurological Disease Cancer
    Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal cord trauma .
    Z-LEHD-FMK TFA
  • HY-138203
    Z-LE(OMe)TD(OMe)-FMK

    		Caspase Apoptosis Cancer
    Z-LE(OMe)TD(OMe)-FMK is a selective caspase-8 inhibitor. Z-LE(OMe)TD(OMe)-FMK can inhibit cell apoptosis .
    Z-LE(OMe)TD(OMe)-FMK
  • HY-12466
    Z-DEVD-FMK
    105+ Cited Publications

    		 Caspase Cancer
    Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC50 of 18 μM .
    Z-DEVD-FMK
  • HY-D1433
    FITC-C6-LEHD-FMK

    		Fluorescent Dye Cancer
    FITC-C6-LEHD-FMK, a fluorescently labeled caspase-9 inhibitor, can be used for detection of active caspase-9 in mammalian cells undergoing apoptosis. FITC-C6-LEHD-FMK provides a convenient means for sensitive detection of activated caspase-9 in living cells. Z-LEHD-FMK is a specific caspase-9 inhibitor .
    FITC-C6-LEHD-FMK
  • HY-D1432
    FITC-C6-DEVD-FMK

    		Fluorescent Dye Cancer
    FITC-C6-DEVD-FMK, a fluorescently labeled caspase-3 inhibitor, can be used for detection of active caspase-3 in mammalian cells undergoing apoptosis. FITC-C6-DEVD-FMK provides a convenient means for sensitive detection of activated caspase-3 in living cells. Z-DEVD-FMK is a specific caspase-3 inhibitor .
    FITC-C6-DEVD-FMK
  • HY-P1407
    Z-VRPR-FMK TFA

    VRPR

    		 MALT1 Influenza Virus Infection Cancer
    Z-VRPR-FMK (TFA) (VRPR), a tetrapeptide, is a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. Z-VRPR-FMK (TFA) can protect against influenza A virus (IAV) infection .
    Z-VRPR-FMK TFA
  • HY-P0109
    (S,S)-Z-FA-FMK

    		Cathepsin Others
    (S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .
    (S,S)-Z-FA-FMK
  • HY-100894
    Biotin-VAD-FMK
    1 Publications Verification

    		 Caspase Cancer
    Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.
    Biotin-VAD-FMK
  • HY-115733
    Cathepsin L-IN-2
    1 Publications Verification

    (Rac)-Z-Phe-Phe-FMK

    		 Cathepsin Cancer
    Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC50 of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.
    Cathepsin L-IN-2
  • HY-153613
    Ac-PLVE-FMK

    Ac-Pro-Leu-Val-Glu(OMe)-CH2F

    		 Cathepsin Cancer
    Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl m-FMKs, is a Cats inhibitor. Ac-PLVE-FMK can be used for the research of cancer .
    Ac-PLVE-FMK
  • HY-P5989
    Calpain inhibitor V

    Mu-Val-HPh-FMK

    		 Antibiotic Infection
    Calpain inhibitor V (Mu-Val-HPh-FMK) is a cell-permeable and irreversible inhibitor of calpain that has anti-chlamydial activity .
    Calpain inhibitor V
  • HY-134563
    Z-Asp(OMe)-Gln-Met-Asp(OMe)-FMK

    		Caspase Apoptosis Cancer
    Z-Asp(OMe)-Gln-Met-Asp(OMe)-FMK is an inhibitor for caspase-3, and inhibits Dihydroartemisinin (HY-N0176) and Dictamnine (HY-N0849) co-induced apoptosis .
    Z-Asp(OMe)-Gln-Met-Asp(OMe)-FMK
  • HY-126226
    MK-6240 Precursor

    		Drug Intermediate Neurological Disease
    MK-6240 Precursor (Compound 6e) is a crucial intermediate in the synthesis of [ 18F]-MK-6240 (Compound 6). [ 18F]-MK-6240 is a highly specific and selective positron emission tomography (PET) imaging agent used for the quantification of neurofibrillary tangles (NFTs) .
    MK-6240 Precursor
  • HY-52101
    CMK
    5+ Cited Publications

    		 Ribosomal S6 Kinase (RSK) Cancer
    CMK is a RSK2 kinase inhibitor which exhibits similar potency but less chemical stability compared with FMK.
    CMK
  • HY-10397A
    MX1013
    1 Publications Verification

    CV1013; Z-VD-FMK

    		 Caspase Cancer
    MX1013 is a potent, irreversible dipeptide caspase inhibitor vith antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC50 of 30 nM .
    MX1013
  • HY-103348
    Boc-Asp(OMe)-fluoromethyl ketone

    Boc-Asp(OMe)-FMK

    		 Caspase Inflammation/Immunology
    Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8 .
    Boc-Asp(OMe)-fluoromethyl ketone
  • HY-163390
    RIP1 kinase inhibitor 9

    		RIP kinase Necroptosis Inflammation/Immunology Cancer
    RIP1 kinase inhibitor 9 (compound SY-1) is a selective RIP kinase inhibitor. RIP1 kinase inhibitor 9 effectively suppresses the central inflammatory response induced by epilepsy. RIP1 kinase inhibitor 9 inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis in HT-29 cells with an EC50 of 7.04 nM .
    RIP1 kinase inhibitor 9

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