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FKBP12 ligands

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114872
    SLF

    		Ligands for Target Protein for PROTAC FKBP Cancer
    SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC .
    SLF
  • HY-114872A
    SLF TFA

    		Ligands for Target Protein for PROTAC FKBP Cancer
    SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC .
    SLF TFA
  • HY-172266
    FKBP12 Ligand-Linker Conjugate 2

    		Target Protein Ligand-Linker Conjugates Others
    FKBP12 Ligand-Linker Conjugate 2 is a conjugate of the FKBP12 target protein ligand and a linker, and it can be used for the synthesis of FKBP12 PROTAC FM4 (HY-172265) .
    FKBP12 Ligand-Linker Conjugate 2
  • HY-176477
    BRD4/FKBP12 degrader-2

    		Epigenetic Reader Domain FKBP Cancer
    BRD4/FKBP12 degrader-2 (a1dj) is a BRD4/FKBP12 degrader and shows anticancer activity (BRD4 ligand: HY-78695, FKBP12 ligand: HY-176502, linker: HY-140212) .
    BRD4/FKBP12 degrader-2
  • HY-170987
    FKBP12 Ligand-Linker Conjugate 1

    		Target Protein Ligand-Linker Conjugates FKBP Cancer
    FKBP12 Ligand-Linker Conjugate 1 is the conjugate composed of a target protein ligand for FKBP12 and a linker. FKBP12 Ligand-Linker Conjugate 1 can be used for synthesis of PROTAC degrader MC-25B (HY-170983) .
    FKBP12 Ligand-Linker Conjugate 1
  • HY-176501
    FKBP12 ligand-2

    		FKBP Cancer
    FKBP12 ligand-2 (compound d) is a high affinity ligand targeting FKBP12. FKBP12 ligand-2 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-2 can be used for selective cancer research based on differences in intracellular presenter protein levels .
    FKBP12 ligand-2
  • HY-176502
    FKBP12 ligand-3

    		FKBP Cancer
    FKBP12 ligand-3 (compound dj) is a high-affinity ligand targeting FKBP12. FKBP12 ligand-3 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-3 can be used for selective cancer research based on differences in intracellular presenter protein levels .
    FKBP12 ligand-3
  • HY-176476
    BRD4/FKBP12 degrader-1

    		Epigenetic Reader Domain FKBP Cancer
    BRD4/FKBP12 degrader-1(a1d) is a BRD4/FKBP12 degrader with anti-cancer activity (BRD4 ligand: HY-78695, FKBP12 ligand: HY-176501, linker: HY-140212) .
    BRD4/FKBP12 degrader-1
  • HY-170988
    FKBP12 ligand-1

    		FKBP Ligands for Target Protein for PROTAC Cancer
    FKBP12 ligand-1 is a targeting protein ligand of MC-25B (HY-170983), which is a specific FKBP12 PROTAC .
    FKBP12 ligand-1
  • HY-170983
    MC-25B

    		FKBP Cancer
    MC-25B is a specific FKBP12 PROTAC degrader. MC-25B degrades FKBP12 with a DC50 of 0.35 μM and a Dmax of 89%. MC-25B facilitates the degradation of nuclear-localized FKBP12 through a DCAF16-dependent mechanism. (Pink: FKBP12 ligand (HY-170988); Blue: E3 ligase ligand HY-170986); Black: linker (HY-128844); FKBP12 ligand+ linker (HY-170987)) .
    MC-25B
  • HY-103634
    dFKBP-1
    1 Publications Verification

    		 PROTACs FKBP Cancer
    dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF (HY-114872) of FKBP12, the Thalidomide based Cereblon ligand and a linker .
    dFKBP-1
  • HY-130835
    FKBP12 PROTAC RC32

    RC32

    		 PROTACs FKBP Cancer
    FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an Cereblon E3 ubiquitin ligase (Pomalidomide; HY-10984) .
    FKBP12 PROTAC RC32
  • HY-173082
    10-SLF

    		PROTACs FKBP Cancer
    10-SLF is a PROTAC FKBP12 degrader. 10-SLF induces a ternary complex between FKBP12 and FBXW7-R465C, and promotes FBXW7-R465C-dependent proteasomal degradation of FKBP12. 10-SLF selectively reduces FKBP12 levels in cells expressing FBXW7-R465C. Pink: FKBP12 ligand (HY-170988); Black: linker (HY-W004640); Blue: E3 ligase ligand .
    10-SLF
  • HY-134184
    AUTAC2

    		AUTACs Autophagy Inflammation/Immunology Cancer
    AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12 .
    AUTAC2
  • HY-123941
    FKBP12 PROTAC dTAG-7
    2 Publications Verification

    dTAG-7

    		 PROTACs FKBP Epigenetic Reader Domain Others
    FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional PROTAC degrader. FKBP12 PROTAC dTAG-7 targets FKBP12 F36V and BET BRD4. FKBP12 PROTAC dTAG-7 enables rapid and selective degradation of target proteins, and is suitable for cellular and in vivo studies to analyze protein functions and validate targets . (Pink: target protein ligand (HY-114420); Black: linker (HY-128844); Blue: CRBN Ligand (HY-103597); CRBN Ligand+linker: (HY-W722323))
    FKBP12 PROTAC dTAG-7
  • HY-107452
    SLF-amido-C2-COOH

    PROTAC FKBP12-binding moiety 1

    		 Ligands for Target Protein for PROTAC FKBP Cancer
    SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) is a synthetic ligand for FKBP (SLF). SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) can be used in the synthesis of PROTACs .
    SLF-amido-C2-COOH
  • HY-153806
    RapaBlock

    ZZY05-092

    		 FKBP Cancer
    RapaBlock is a potent, non-immunosuppressive and brain-impermeable FKBP12 ligand .
    RapaBlock
  • HY-114434
    AP1867
    4 Publications Verification

    		 FKBP Cancer
    AP1867 is a synthetic FKBP12 F36V-directed ligand .
    AP1867
  • HY-172265
    FKBP12 PROTAC FM4

    		PROTACs Cancer
    FKBP12 PROTAC FM4 is a PROTAC degrader of MTH1, with a DC50 values of 0.09–0.22 nM. FKBP12 PROTAC FM4 is composed of PROTAC target protein ligand AP1867-3-(aminoethoxy) (HY-129363) (red part), E3 ligase ligand MTH1 ligand 1 (HY-134724) (blue part) and PROTAC Linker t-Boc-N-amido-PEG5-acetic acid (HY-W190962) (black part), among which the conjugate of PROTAC target protein ligand + Linker is FKBP12 Ligand-Linker Conjugate 2 (HY-172266) .
    FKBP12 PROTAC FM4
  • HY-170986
    E3 ligase Ligand 57

    		Ligands for E3 Ligase Cancer
    E3 ligase Ligand 57 is an E3 ligase ligand of MC-25B (HY-170983) which is a specific FKBP12 PROTAC .
    E3 ligase Ligand 57
  • HY-145514C
    dTAGV-1 hydrochloride
    2 Publications Verification

    		 FKBP PROTACs Cancer
    dTAGV-1 hydrochloride is a potent and selective degrader of FKBP12 F36V-tagged proteins PROTAC degrader. dTAGV-1 hydrochloride can induce degradation of FKBP12 F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420); Black: Linker (HY-W012001); Blue: VHL Ligand (HY-112078); VHL Ligan+Linker (HY-173628A)) .
    dTAGV-1 hydrochloride
  • HY-150410
    TSPO ligand-3

    		AUTACs Cancer
    TSPO ligand-3 is a ligand of AUTAC2. AUTAC2 contains an p-fluorobenzylguanine (FBnG) and an synthetic ligand of FKBP (SLF) moiety, which can cause significant silencing of FKBP12 in HeLa cells .
    TSPO ligand-3
  • HY-145514
    dTAGV-1 TFA
    2 Publications Verification

    		 PROTACs FKBP Cancer
    dTAGV-1 TFA is a potent and selective degrader of FKBP12 F36V-tagged proteins PROTAC degrader. dTAGV-1 TFA can induce degradation of FKBP12 F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420); Black: Linker (HY-W012001); Blue: VHL Ligand (HY-112078); VHL Ligan+Linker (HY-173628A))
    dTAGV-1 TFA
  • HY-169148
    YT117R

    		PROTACs FKBP Epigenetic Reader Domain Cancer
    YT117R is a PROTAC degrader of FKBP12 and Pink: Target protein ligand: (HY-158301); Black: linker (HY-42776); Blue: E3 ligase ligand (HY-78695)) .
    YT117R
  • HY-114420
    AP1867-2-(carboxymethoxy)
    1 Publications Verification

    PROTAC FKBP12-binding moiety 2

    		 FKBP Ligands for Target Protein for PROTAC Cancer
    AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12 F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules .
    AP1867-2-(carboxymethoxy)
  • HY-129610
    KB02-SLF

    		PROTACs FKBP Cancer
    KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF .
    KB02-SLF
  • HY-129363
    AP1867-3-(aminoethoxy)

    		Ligands for Target Protein for PROTAC FKBP Cancer
    AP1867-3-(aminoethoxy), the AP1867 based moiety, is a synthetic ligand for FKBP. AP1867-3-(aminoethoxy) can be used in the synthesis of PROTAC FKBP12 F36V degrader .
    AP1867-3-(aminoethoxy)
  • HY-135250B
    Thalidomide-4-O-C6-NH2 hydrochloride

    		E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis Cancer
    Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12 F36V and BET .
    Thalidomide-4-O-C6-NH2 hydrochloride
  • HY-135250A
    Thalidomide-4-O-C6-NH2 TFA

    		E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis Cancer
    Thalidomide-4-O-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13 (HY-114421), a degrader of FKBP12 F36V and BET .
    Thalidomide-4-O-C6-NH2 TFA
  • HY-112210
    Shield-1
    Maximum Cited Publications
    6 Publications Verification

    Shld1

    		 FKBP Others
    Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD) .
    Shield-1
  • HY-147196
    KB03-SLF

    		PROTACs FKBP Cancer
    KB03-SLF (compound 6) is an electrophilic PROTAC degrader that binds to DCAF16 to degrade the nuclear protein FKBP12. KB03-SLF can be used in cancer research . (Pink: Ligand for target protein SLF (HY-114872); Black: Linker (HY-W040168); Blue: Ligand for E3 ligase (HY-169968)).
    KB03-SLF
  • HY-169147
    MY-11B

    		Ligands for E3 Ligase Cancer
    MY-11B is a DCAF1 ligand. MY-11B shows reactivity with DCAF1_C1113. MY-11B blockes YT41R and YT47R-mediated degradation of HA-FKBP12. MY-11B can be used in the synthesis of PROTACs .
    MY-11B
  • HY-172152
    MP-010

    		FKBP Calcium Channel Neurological Disease
    MP-010 is a FKBP12 ligand that regulates cytosolic calcium by stabilizing RyR channel activity. MP-010 promotes functional improvement in SOD1 G93A amyotrophic lateral sclerosis (ALS) mice, as evidenced by improved motor coordination, increased integrity of neuromuscular junctions, and significantly enhanced survival of spinal motor neurons. MP-010 can be used for research in the field of neurological diseases .
    MP-010
  • HY-163807
    22-SLF

    		PROTACs FKBP Cancer
    22-SLF is a PROTAC degrader, that degrades FK506-binding protein 12 (FKBP12) with a DC50 of 0.5 µM in a FBXO22 dependent manner. 22-SLF degrades other endogenous proteins, such as BRD4 and EML4-ALK fusion protein.(Pink: Ligand for target protein SLF (HY-114872); Black: Linker (HY-163821); Blue: Ligand for E3 ligase (HY-163826)) .
    22-SLF
  • HY-145712
    ElteN378

    		FKBP Cancer
    ElteN378 is an inhibitors of FKBP12e. ElteN378 can be used in study Alzheimer disease, Parkinson disease, Amyotrophic Lateral Sclerosis, proliferation disorders and cancer .
    ElteN378

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