2. Search Result
Search Result
Results for "

FEN1

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

2

Recombinant Proteins

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-122695
    FEN1-IN-2
    1 Publications Verification

    		 FLAP Cancer
    FEN1-IN-2 (compound 20) is a flap endonuclease 1 (FEN1) inhibitor, with IC50 values of 3 nM and 226 nM for FEN1 and XPG, respectively [1].
    FEN1-IN-2
  • HY-123834
    FEN1-IN-1
    Maximum Cited Publications
    6 Publications Verification

    		 FLAP ATM/ATR Cancer
    FEN1-IN-1 (compound 1) is a small molecule flap endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg 2+ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers [1].
    FEN1-IN-1
  • HY-145758
    FEN1-IN-SC13
    1 Publications Verification

    		 Endonuclease Cancer
    FEN1-IN-SC13 is a potent DNA fragmentation endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-SC13 interferes with DNA replication and repair in vitro and in cells [1].
    FEN1-IN-SC13
  • HY-153790
    FEN1-IN-5

    		FLAP Cancer
    FEN1-IN-5 (compound 12A) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC50=12 nM), involving in DNA repair [1].
    FEN1-IN-5
  • HY-136484
    FEN1-IN-3

    		FLAP Cancer
    FEN1-IN-3 (Compound 4) is a human flap endonuclease-1 (hFEN1) inhibitor. FEN1-IN-3 stabilizes hFEN1 with an EC50 of 6.8 μM [1].
    FEN1-IN-3
  • HY-RS16635
    Fen1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Fen1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fen1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Fen1 Mouse Pre-designed siRNA Set A
    Fen1 Mouse Pre-designed siRNA Set A
  • HY-RS04861
    FEN1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    FEN1 Human Pre-designed siRNA Set A contains three designed siRNAs for FEN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FEN1 Human Pre-designed siRNA Set A
    FEN1 Human Pre-designed siRNA Set A
  • HY-RS23070
    Fen1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Fen1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fen1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Fen1 Rat Pre-designed siRNA Set A
    Fen1 Rat Pre-designed siRNA Set A
  • HY-153792
    FEN1-IN-7

    		FLAP Cancer
    FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents [1].
    FEN1-IN-7
  • HY-153791
    FEN1-IN-6

    		FLAP Cancer
    FEN1-IN-6 (compound 9) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC50=10 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-6 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 23 nM [1].
    FEN1-IN-6
  • HY-136485
    FEN1-IN-4
    1 Publications Verification

    		 FLAP Cancer
    FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor [1].
    FEN1-IN-4
  • HY-170845
    MU1409

    		Endonuclease Cancer
    MU1409 is an inhibitor of MRE11 nuclease with an IC50 of 12.1 μM. Additionally, MU1409 also inhibits FEN1 and EXO1, with IC50 values of 24.2 and 176.4 μM, respectively. MU1409 affects DNA repair in cells, preventing the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for research on BRCA2 mutation-induced cancers [1].
    MU1409

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: