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Pathways Recommended: Cell Cycle/DNA Damage
Results for "

DNA polymerase-IN-1

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128917
    DNA31

    		DNA/RNA Synthesis Infection
    DNA31 is a potent RNA polymerase inhibitor .
    DNA31
  • HY-134103A
    ddGTP trisodium

    2′,3′-DideoxyguanosINe 5′-triphosphate trisodium

    		 DNA/RNA Synthesis Others
    ddGTP (2′,3′-Dideoxyguanosine 5′-triphosphate) trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddGTP trisodium acts as an inhibitor or a substrate for DNA polymerase α .
    ddGTP trisodium
  • HY-131606B
    Cidofovir diphosphate tri(triethylamine)

    		Drug Metabolite Infection
    Cidofovir diphosphate tri triethylamine is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate tri triethylamine is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .
    Cidofovir diphosphate tri(triethylamine)
  • HY-W560689
    DNA polymerase-IN-1

    		DNA/RNA Synthesis Cancer
    DNA polymerase-IN-1 (compound 2d) is a DNA polymerase inhibitor (IC50=20.7 μM) with antiproliferative activity against tumor cells .
    DNA polymerase-IN-1
  • HY-163015
    RNA polymerase-IN-1

    		DNA/RNA Synthesis Infection
    RNA polymerase-IN-1 (compound 4) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-1 inhibits CYP isozymes .
    RNA polymerase-IN-1
  • HY-128788
    ddhCTP

    		DNA/RNA Synthesis SARS-CoV Infection
    ddhCTP is a nucleoside analog and inhibits the synthesis of DNA by specifically inhibiting the activity of DNA polymerase with the Ki values of 1.32 and 0.034 μM for DNA polymerase beta and DNA polymerase gamma .
    ddhCTP
  • HY-131606
    Cidofovir diphosphate

    		HSV CMV Infection
    Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .
    Cidofovir diphosphate
  • HY-171578
    3′-Amino-2′,3′-dideoxy-CTP

    		Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Others
    3′-Amino-2′,3′-dideoxy-CTP is an analogue of nucleoside triphosphate. 3′-Amino-2′,3′-dideoxy-CTP can selectively inhibit DNA polymerase β .
    3′-Amino-2′,3′-dideoxy-CTP
  • HY-155868
    5-Azacytidine 5′-triphosphate

    5-aza-CTP

    		 DNA/RNA Synthesis Others
    5-Azacytidine 5′-triphosphate (5-aza-CTP) is a cytidine analog that inhibitss the incorporation of [ 3H]CTP, but not [ 3H]UTP, into RNA in the DNA-dependent RNA polymerase reaction .
    5-Azacytidine 5′-triphosphate
  • HY-155868A
    5-Azacytidine 5′-triphosphate sodium

    5-aza-CTP sodium

    		 DNA/RNA Synthesis Others
    5-Azacytidine 5’-triphosphate sodium is a cytidine analog. 5-Azacytidine 5’-triphosphate sodium inhibits the incorporation of [ 3H]CTP, but not [ 3H]UTP, into RNA in the DNA-dependent RNA polymerase reaction .
    5-Azacytidine 5′-triphosphate sodium
  • HY-159078
    PolQi1

    		DNA/RNA Synthesis Cancer
    PolQi1 is a selective inhibitor targeting the Polθ domain of DNA polymerase. PolQi1 inhibits the Polθ-mediated microhomology end joining (TMEJ/alt-EJ) pathway, reducing insertion/deletion (Indels) and imprecise editing events during DNA repair. PolQi1 can enhance the efficiency and accuracy of homology-directed repair (HDR) or Prime editing, and reduce off-target effects; and in combination with DNA-PK inhibitor AZD-7648 (HY-111783), exert efficient genome editing capabilities with dual pathway regulation. PolQi1 can be mainly used in gene editing research (such as CRISPR-Cas9 or Prime editing system optimization) to improve the precision editing efficiency of difficult-to-edit cells (such as primary hepatocytes and mouse embryos) .
    PolQi1
  • HY-105099R
    Rifalazil (Standard)

    KRM-1648 (Standard); ABI-1648 (Standard)

    		 Antibiotic Reference Standards DNA/RNA Synthesis Bacterial Infection Inflammation/Immunology
    Rifalazil (Standard) is the analytical standard of Rifalazil. This product is intended for research and analytical applications. Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase[1]. Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml[3]. Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB)[2].
    Rifalazil (Standard)
  • HY-146365
    HIV-1 inhibitor-30

    		HIV Infection Inflammation/Immunology
    HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC50 value of 40 nM and an IC50 value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC50s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS .
    HIV-1 inhibitor-30

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