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Results for "

DLL3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) Antibody-Drug Conjugates (ADCs) (2) CD3 (4) CD47 (1) Drug-Linker Conjugates for ADC (1) Notch (6) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (11) Inflammation/Immunology (7)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990104

*Anti-DLL3* Antibody (anti-DLL3 arm derived from AMG-757)**	Notch	Inflammation/Immunology Cancer
Anti-DLL3 Antibody (anti-DLL3 arm derived from AMG-757) is the anti-DLL3 arm of the bispecific T-cell engager (BiTE) antibody-Tarlatamab (AMG-757) (HY-P99575). Tarlatamab targets both DLL3 and CD3.

HY-P99575

Tarlatamab 1 Publications Verification AMG-757	Notch	Inflammation/Immunology Cancer
Tarlatamab (AMG-757) is a bispecific T-cell engager (BiTE) antibody targeting delta-like ligand 3 (DLL3). DLL3 is a target that is selectively expressed in small-cell lung cancer (SCLC) tumors, but with minimal normal tissue expression. Tarlatamab has the K_Ds of 0.64 nM and 0.50 nM for human and nonhuman primate (NHP) DLL3, respectively. Tarlatamab has the K_Ds of 14.9 nM and 12 nM for human and NHP CD3, respectively. Tarlatamab is a first-in-class HLE BiTE immuno-oncology therapy targeting DLL3 and has the potential for SCLC research .

HY-132257

Rovalpituzumab tesirine SC-002	Antibody-Drug Conjugates (ADCs) Notch	Cancer
Rovalpituzumab tesirine (SC-002) is an antibody-drug conjugate (ADC) with anticancer effects. Rovalpituzumab tesirine contains a DLL3-targeting antibody Rovalpituzumab (HY-P99043) tethered to a cytotoxic agent pyrrolobenzodiazepine by means of a protease-cleavable linker. Rovalpituzumab tesirine can be used for the stduy of small cell lung cancer (SCLC) .

HY-P990896

FZ-A038	ADC Antibody	Cancer
FZ-A038 is a delta-like ligand 3 (DLL3) targeted, humanized monoclonal antibody. FZ-A038 can be used for synthesis of DLL3 targeting ADC FZ-AD005 (HY-164729) .

HY-P99043

Rovalpituzumab 1 Publications Verification	Notch	Cancer
Rovalpituzumab is a humanized monoclonal antibody against delta-like protein 3 (DLL3). Rovalpituzumab can be used in the synthesis of antibody-drug conjugate (ADC), Rovalpituzumab Tesirine. Rovalpituzumab has activity against small cell lung cancer (SCLC) .

HY-164729

FZ-AD005	Antibody-Drug Conjugates (ADCs)	Cancer
FZ-AD005 is a DLL3 target ADC compound containing a novel anti-DLL3 antibody, FZ-A038, and a valine–alanine (Val–Ala) dipeptide linker. FZ-AD005 can used in the research of small cell lung cancer .

HY-RS03809

DLL3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DLL3 Human Pre-designed siRNA Set A contains three designed siRNAs for DLL3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DLL3 Human Pre-designed siRNA Set A DLL3 Human Pre-designed siRNA Set A

HY-RS16720

Dll3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dll3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dll3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dll3 Mouse Pre-designed siRNA Set A Dll3 Mouse Pre-designed siRNA Set A

HY-RS23156

Dll3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dll3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dll3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dll3 Rat Pre-designed siRNA Set A Dll3 Rat Pre-designed siRNA Set A

HY-P991731

Alveltamig ZG006	CD3	Cancer
Alveltamig (ZG006) is a trispecific anti-T cell engager (Tri-TE) targeting Delta-like ligand 3 (DLL3) and *CD3. Alveltamig has two distinct DLL3* epitopes, and bridges tumor cells and T cells by strongly binding to DLL3 on tumor cells and CD3 on T cells, thereby mediating T cell-specific killing of DLL3-expressing tumor cells. Alveltamig can be used for the study of small cell lung cancer (SCLC) or neuroendocrine carcinoma (NEC) .

HY-P990981

Clesitamig	CD3	Inflammation/Immunology Cancer
Clesitamig is a DLL3/CD3/CD137 trispecific T cell engager, consisting of two CD3/CD137 dual-specific antigen-binding fragments (Fabs) and one additional DLL3 antigen-binding fragment (Fab). Clesitamig exhibits potent antitumor activity and can be used in research on tumors such as small cell lung cancer .

HY-P991016

Peluntamig PT-217	CD47	Inflammation/Immunology
HY-P991016 is an *CD47/DLL3*-targeting H-γ1_L-κ type bispecific antibody .

HY-W1126504

ETN029	Notch	Cancer
ETN029 is a *DLL3* ligand. ETN029 labeled with 225Ac has dose-dependent cytotoxicity in SCLC, NEPC and metastatic melanoma cells and increases the phosphorylation of H2AX expression. ETN029 labeled with 177Lu shows rapid uptake persistent tumor retention and favorable tumor-to-kidney ratio. ETN029 can be used for cancers like SCLC and NEPC imaging and research .

HY-P990920

Gocatamig MK-6070; HPN328	CD3	Inflammation/Immunology
HY-P990920 is an *CD3E/ALB/DLL3*-targeting (scFv-heavy-lamdba)-VH-VH' type chimeric humanized antibody .

HY-P991173

AMG-119	Notch	Cancer
AMG-119 is a humanized IgG1 monoclonal antibody that targets delta-like ligand 3 (DLL3). AMG-119 can be used for the study of relapsed/refractory (R/R) small cell lung cancer (SCLC). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990932

Obrixtamig BI 764532; OBT 620	CD3	Inflammation/Immunology
HY-P990932 is an *CD3E/DLL3*-targeting L-κ-G1-h-CH2-CH3_L-λ-G1-h-CH2-CH3 type human antibodychimeric antibody .

HY-159072

Mal-Val-Ala-PAB-N(SO2Me)-Exatecan	Drug-Linker Conjugates for ADC	Cancer
Mal-Val-Ala-PAB-N(SO2Me)-Exatecan (Compound LE14) is a conjugate of an ADC toxin Exatecan (HY-13631) and a linker Mal-Val-Ala-PAB-N(SO2Me). Mal-Val-Ala-PAB-N(SO2Me)-Exatecan can be used for synthesis of ADC FZ-AD005. FZ-AD005 is a delta-like ligand 3 (DLL3, *K_D*=58.3 pM) targeting ADC, that exhibits antitumor efficacy against SCLC cancer .

Cat. No.	Product Name	Target	Research Area

HY-P990401

*Anti-DLL3* Antibody**	Inhibitory Antibodies	Inflammation/Immunology
The Anti-DLL3 Antibody is a humanized antibody expressed in CHO, targeting *DLL3. The predicted molecular weight (MW) of the Anti-DLL3* Antibody is 146.36 kDa. The isotype control for the Anti-DLL3 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990104

*Anti-DLL3* Antibody (anti-DLL3 arm derived from AMG-757)**	Notch	Inflammation/Immunology Cancer
Anti-DLL3 Antibody (anti-DLL3 arm derived from AMG-757) is the anti-DLL3 arm of the bispecific T-cell engager (BiTE) antibody-Tarlatamab (AMG-757) (HY-P99575). Tarlatamab targets both DLL3 and CD3.

HY-P99575

Tarlatamab 1 Publications Verification AMG-757	Notch	Inflammation/Immunology Cancer
Tarlatamab (AMG-757) is a bispecific T-cell engager (BiTE) antibody targeting delta-like ligand 3 (DLL3). DLL3 is a target that is selectively expressed in small-cell lung cancer (SCLC) tumors, but with minimal normal tissue expression. Tarlatamab has the K_Ds of 0.64 nM and 0.50 nM for human and nonhuman primate (NHP) DLL3, respectively. Tarlatamab has the K_Ds of 14.9 nM and 12 nM for human and NHP CD3, respectively. Tarlatamab is a first-in-class HLE BiTE immuno-oncology therapy targeting DLL3 and has the potential for SCLC research .

HY-P990896

FZ-A038	ADC Antibody	Cancer
FZ-A038 is a delta-like ligand 3 (DLL3) targeted, humanized monoclonal antibody. FZ-A038 can be used for synthesis of DLL3 targeting ADC FZ-AD005 (HY-164729) .

HY-P99043

Rovalpituzumab 1 Publications Verification	Notch	Cancer
Rovalpituzumab is a humanized monoclonal antibody against delta-like protein 3 (DLL3). Rovalpituzumab can be used in the synthesis of antibody-drug conjugate (ADC), Rovalpituzumab Tesirine. Rovalpituzumab has activity against small cell lung cancer (SCLC) .

HY-P990920

Gocatamig MK-6070; HPN328	CD3	Inflammation/Immunology
HY-P990920 is an *CD3E/ALB/DLL3*-targeting (scFv-heavy-lamdba)-VH-VH' type chimeric humanized antibody .

HY-P991731

Alveltamig ZG006	CD3	Cancer
Alveltamig (ZG006) is a trispecific anti-T cell engager (Tri-TE) targeting Delta-like ligand 3 (DLL3) and *CD3. Alveltamig has two distinct DLL3* epitopes, and bridges tumor cells and T cells by strongly binding to DLL3 on tumor cells and CD3 on T cells, thereby mediating T cell-specific killing of DLL3-expressing tumor cells. Alveltamig can be used for the study of small cell lung cancer (SCLC) or neuroendocrine carcinoma (NEC) .

HY-P990981

Clesitamig	CD3	Inflammation/Immunology Cancer
Clesitamig is a DLL3/CD3/CD137 trispecific T cell engager, consisting of two CD3/CD137 dual-specific antigen-binding fragments (Fabs) and one additional DLL3 antigen-binding fragment (Fab). Clesitamig exhibits potent antitumor activity and can be used in research on tumors such as small cell lung cancer .

HY-P991016

Peluntamig PT-217	CD47	Inflammation/Immunology
HY-P991016 is an *CD47/DLL3*-targeting H-γ1_L-κ type bispecific antibody .

HY-P991173

AMG-119	Notch	Cancer
AMG-119 is a humanized IgG1 monoclonal antibody that targets delta-like ligand 3 (DLL3). AMG-119 can be used for the study of relapsed/refractory (R/R) small cell lung cancer (SCLC). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990932

Obrixtamig BI 764532; OBT 620	CD3	Inflammation/Immunology
HY-P990932 is an *CD3E/DLL3*-targeting L-κ-G1-h-CH2-CH3_L-λ-G1-h-CH2-CH3 type human antibodychimeric antibody .

Recombinant Proteins Recommended:

Delta-like 3 (DLL3)

Species:	Human (14) Rhesus Macaque (1) Mouse (1) Cynomolgus (2)
Tag:	His (17) Avi (6) Flag (1) Fc (1)
Source:	HEK293 (17) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P77641

	*Delta-like protein 3/DLL3* Protein, Cynomolgus (HEK293, His)** Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Cynomolgus	HEK293
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Delta-like protein 3/DLL3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77916

	*Delta-like protein 3/DLL3* Protein, Mouse (HEK293, His)** Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Mouse	HEK293
	Delta-like protein 3 (DLL3) inhibits primary neurogenesis and directs neurons towards specific differentiation pathways. It also contributes to the formation of somite boundaries in the paraxial mesoderm segmentation. DLL3's importance in developmental processes is highlighted by its ability to bind and activate Notch-1 or other Notch receptors. Delta-like protein 3/DLL3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Delta-like protein 3/DLL3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P78115

	*Delta-like protein 3/DLL3* Protein, Human (Biotinylated, HEK293, His)** Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Human	HEK293
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Delta-like protein 3/DLL3 protein, expressed by HEK293 , with N-His labeled tag.

HY-P77642

	*Delta-like protein 3/DLL3* Protein, Rhesus Macaque (HEK293, His)** Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Rhesus Macaque	HEK293
	Delta-like protein 3 (DLL3), also known as Delta-like protein 3, is a protein that lacks conserved residues required for propagation of feature annotations. Missing residues in DLL3 prevent the propagation of specific functional features associated with this protein. Delta-like protein 3/DLL3 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Delta-like protein 3/DLL3 protein, expressed by HEK293 , with N-His labeled tag.

HY-P700982

	*Delta-like protein 3/DLL3* Protein, Human (HEK293, His-Flag)** Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Human	HEK293
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (HEK293, His-Flag) is the recombinant human-derived Delta-like protein 3/DLL3 protein, expressed by HEK293 , with N-His, N-Flag labeled tag.

HY-P700983

	*Delta-like protein 3/DLL3* Protein, Human (HEK293, His-Avi)** Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Human	HEK293
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Delta-like protein 3/DLL3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P704566

	*Delta-like protein 3/DLL3* Protein, Human (HEK293, Llama Fc)** Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Human	HEK293
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (HEK293, Llama Fc) is the recombinant human-derived Delta-like protein, expressed by HEK293, with C-Llama Fc labeled tag.

HY-P703931

	*Delta-like protein 3/DLL3* Protein, Human (Biotinylated, HEK293, His, Avi)** Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Human	HEK293
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (Biotinylated, HEK293, His, Avi) is the recombinant human-derived Delta-like 3/DLL3 , Human (Biotinylated, HEK293, His, Avi) protein, expressed by HEK293, with C-His and C-Avi labeled tag.

HY-P705151

	*Delta-like protein 3/DLL3* Protein, Cynomolgus (Biotinylated, HEK293, His-Avi)** Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Cynomolgus	HEK293

HY-P704563

	*Delta-like protein 3/DLL3* Protein, Human (140a.a, HEK293, His)** Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Human	HEK293
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (140a.a, HEK293, His) is the recombinant human-derived Delta-like protein, expressed by HEK293, with C-His labeled tag.

HY-P704564

	*Delta-like protein 3/DLL3* Protein, Human (317a.a, HEK293, His)** Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Human	HEK293
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (317a.a, HEK293, His) is the recombinant human-derived Delta-like protein, expressed by HEK293, with C-His labeled tag.

HY-P704565

	*Delta-like protein 3/DLL3* Protein, Human (172a.a, HEK293, His)** Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Human	HEK293
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (172a.a, HEK293, His) is the recombinant human-derived Delta-like protein, expressed by HEK293, with C-His labeled tag.

HY-P703933

	*Delta-like protein 3/DLL3* Protein, Human (128a.a, HEK293, His, Avi)** Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Human	HEK293
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (128a.a, HEK293, His, Avi) is the recombinant human-derived Delta-like protein, expressed by HEK293, with C-His and C-Avi labeled tag.

HY-P703934

	*Delta-like protein 3/DLL3* Protein, Human (Biotinylated, 169a.a, HEK293, His, Avi)** Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Human	HEK293
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (Biotinylated, 169a.a, HEK293, His, Avi) is the recombinant human-derived Delta-like 3/DLL3 , Human (Biotinylated, 169a.a, HEK293, His, Avi) protein, expressed by HEK293, with C-Avi and C-His labeled tag.

HY-P704592

	*Delta-like protein 3/DLL3* Protein, Human (Biotinylated, 453a.a, HEK293, His-Avi)** Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Human	HEK293
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (Biotinylated, 453a.a, HEK293, His-Avi) is the recombinant human-derived Delta-like protein, expressed by HEK293, with C-Avi and C-His labeled tag.

HY-P700456

	*Delta-like protein 3/DLL3* Protein, Human (HEK293, His)** SCDO1; DLL3; delta like canonical Notch ligand 3; Drosophila Delta homolog 3 ; Delta3	Human	HEK293
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (HEK293, His) is the recombinant human-derived Delta-like protein 3/DLL3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P701306

	*FITC-Labeled Delta-like protein 3/DLL3* Protein, Human (HEK293, His)** Delta3; delta-like 3 (Drosophila); delta-like protein 3; DLL3; Pudgy; SCDO1; SCDO1delta3	Human	HEK293
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. FITC-Labeled Delta-like protein 3/DLL3 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled Delta-like protein 3/DLL3 protein, expressed by HEK293 , with His labeled tag.

HY-P71852

	*Delta-like protein 3/DLL3* Protein, Human (P.pastoris, His)** Delta Drosophila like 3; Delta like 3 Drosophila; Delta like 3 homolog Drosophila; Delta like 3 protein; Delta like protein 3 precursor; SCDO1; SCOD1	Human	P. pastoris
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (P.pastoris, His) is the recombinant human-derived Delta-like protein 3/DLL3 protein, expressed by P. pastoris , with N-6*His labeled tag.

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HY-P83770

	DLL3 Antibody(YA3566) SCDO1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat
	DLL3 Antibody(YA3566) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to DLL3.

HY-P84837

	DLL3 Antibody (YA4534) SCDO1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat
	DLL3 Antibody (YA4534) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to DLL3.

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