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SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1(SMS1) inhibitor with an IC50 value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis [1].
α-Glucosidase-IN-61 (Compd 1j), a competitive α-glucosidase inhibitor, demonstrates excellent inhibition with an IC50 of 0.73 μM. α-Glucosidase-IN-61 (Compd 1j) is used for the research of type 2 diabetes mellitus [1].
Dolichos Biflorus Agglutinin (DBA) Fluorescein is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Dolichos Biflorus Agglutinin (DBA) Fluorescein is a biological material or organic compound that can be used in life science research [1] .
Dolichos Biflorus Agglutinin (DBA，Biotinylated) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Dolichos Biflorus Agglutinin (DBA，Biotinylated) is a biological material or organic compound that can be used in life science research [1] .
Dolichos Biflorus Agglutinin (DBA) Rhodamine is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Dolichos Biflorus Agglutinin (DBA) Rhodamine is a biological material or organic compound that can be used in life science research [1] .
BPR1J-340 is a potent FLT3 inhibitor with an IC50 of ~25 nM. BPR1J-340 inhibits the phosphorylation of FLT3 and STAT5 and triggered apoptosis in FLT3-ITD + acute myeloid leukemia (AML) cells. BPR1J-340 exhibits significant anti-tumor activities [1].
FF2039 (compound 1j) is a specific HDAC1, HDAC6, and HDAC isoforms of class I, IIa and IIb PROTAC degrader. FF2039 demonstrates s significant antiproliferative activity against both hematological and solid cancer cell lines, driven by cell cycle arrest and Apoptosis induction. FF2039 inhibits HDAC isoform of HDAC1, HDAC2, HDAC4 and HDAC6 with IC50s of 1.03, 2.15, 12.4 and 0.053 μM, respectively. FF2039 shows antiproliferative activity against different tumor entities of MM.1S, MDA-MB-231 and U-87MG with EC50s of 2.8, 28 and 30 μM, respectively. (Pink: PRMT5 ligand (HY-168864); Blue: E3 ligase ligand HY-W957284); Black: linker (HY-W881439); E3+linker (HY-172185 )) [1].
Ppm1j Rat Pre-designed siRNA Set A contains three designed siRNAs for Ppm1j gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Ppm1j Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ppm1j gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
PPM1J Human Pre-designed siRNA Set A contains three designed siRNAs for PPM1J gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms [1] .
Dibenz[a,h]anthracene (Standard) is the analytical standard of Dibenz[a,h]anthracene. This product is intended for research and analytical applications. Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms [1] .
(S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of GluR2. (S)-4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice [1].
JNJ-1930942 is a selective and blood-brain barrier (BBB) penetrant α(7) nAChR positive allosteric modulator.JNJ-1930942 enhances the Choline (HY-B0282)-evoked rise in intracellular Ca 2+ levels and neurotransmission at hippocampal dentate gyrus synapses. JNJ-1930942 reverses the naturally occurring sensory gating deficit in DBA/2 mice [1].
Dibenzylideneacetone (DBA) is a fruit antifungal agent with inhibitory activity against Botrytis cinerea Chitinase with an IC50 of 13.10 μg/mL. Dibenzylideneacetone has an MIC of 32 μg/mL against B. cinerea and EC50 values of 16.29 and 14.64 μg/mL in inhibiting mycelial growth and spore germination, respectively. Dibenzylideneacetone can overcomes Botrytis cinerea infection in cherry tomatoes by inhibiting chitinase activity [1].
GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.
GSK-J2 sodium is the sodium form of GSK-J2 (HY-15648A). GSK-J2 is an isomer of GSK-J1, and does not have any specific activity. GSK-J1 (HY-15648) is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A [1].
(±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist with a Ki of 1.8 nM for cloned human ORL1. J-113397 inhibited nociceptin/orphanin FQ-stimulated GTPγS binding to CHO cells expressing ORL1 with an IC50 value of 5.3 nM. J-113397 can be used for researching the physiological roles of nociceptin/orphanin FQ [1].
GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1[1] .
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable proagent of GSK-J1[1] . GSK-J4 induces endoplasmic reticulum stress-related apoptosis .
Dolichos Biflorus Agglutinin (DBA) Fluorescein is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Dolichos Biflorus Agglutinin (DBA) Fluorescein is a biological material or organic compound that can be used in life science research [1] .
Dolichos Biflorus Agglutinin (DBA，Biotinylated) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Dolichos Biflorus Agglutinin (DBA，Biotinylated) is a biological material or organic compound that can be used in life science research [1] .
Dolichos Biflorus Agglutinin (DBA) Rhodamine is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Dolichos Biflorus Agglutinin (DBA) Rhodamine is a biological material or organic compound that can be used in life science research [1] .
The H2BC11 protein functions as a core component of nucleosomes, the fundamental units in chromatin structure that wrap and compact DNA, regulating its accessibility to cellular processes that require DNA as a template. Histones, including H2BC11, play central roles in transcriptional regulation, DNA repair, DNA replication, and chromosome stability. H2BC11 Protein, Human is the recombinant human-derived H2BC11 protein, expressed by E. coli , with tag free.
HOXA13 Antibody (YA2561) is a non-conjugated IgG antibody, targeting HOXA13, with a predicted molecular weight of 40 kDa (observed band size: 40 kDa). HOXA13 Antibody (YA2561) can be used for WB experiment in human, mouse, rat background.
RPS19 Antibody (YA1752) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1752), targeting RPS19, with a predicted molecular weight of 16 kDa (observed band size: 16 kDa). RPS19 Antibody (YA1752) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.
Ppm1j Rat Pre-designed siRNA Set A contains three designed siRNAs for Ppm1j gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Ppm1j Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ppm1j gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
PPM1J Human Pre-designed siRNA Set A contains three designed siRNAs for PPM1J gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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