Cxcl11

By Targets:	Adrenergic Receptor (2) Arrestin (1) BCL6 (1) CXCR (8) Fungal (1) JAK (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (6) Endocrinology (2) Infection (1) Inflammation/Immunology (8)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15319

AMG 487 Maximum Cited Publications 28 Publications Verification	CXCR	Inflammation/Immunology Endocrinology Cancer
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC₅₀s of 8.0 and 8.2 nM, respectively .

HY-139643A

CXCR7 antagonist-1 hydrochloride 1 Publications Verification	CXCR Adrenergic Receptor	Inflammation/Immunology Cancer
CXCR7 antagonist-1 hydrochloride is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 hydrochloride is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases .

HY-139643

CXCR7 antagonist-1 1 Publications Verification	CXCR Adrenergic Receptor	Inflammation/Immunology Cancer
CXCR7 antagonist-1 is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases .

HY-15320

NBI-74330 5+ Cited Publications	CXCR	Inflammation/Immunology Endocrinology
NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of ( ¹²⁵I)CXCL10 and ( ¹²⁵I)CXCL11 specific binding with K_i of 1.5 and 3.2 nM, respectively.

HY-149055

ACT-777991	CXCR	Inflammation/Immunology
ACT-777991 is an orally active and selective CXCR3 antagonist. ACT-777991 has microsomes and hepatocytes stability across animal models. ACT-777991 inhibits the migration of activated T cells toward CXCL11 .

HY-RS16707

Cxcl11 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cxcl11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cxcl11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cxcl11 Mouse Pre-designed siRNA Set A Cxcl11 Mouse Pre-designed siRNA Set A

HY-RS23142

Cxcl11 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cxcl11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cxcl11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cxcl11 Rat Pre-designed siRNA Set A Cxcl11 Rat Pre-designed siRNA Set A

HY-RS03385

CXCL11 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CXCL11 Human Pre-designed siRNA Set A contains three designed siRNAs for CXCL11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CXCL11 Human Pre-designed siRNA Set A CXCL11 Human Pre-designed siRNA Set A

HY-167884

PF-1367550	JAK	Inflammation/Immunology
PF-1367550 is a pan-JAK inhibitor. PF-1367550 can decrease the levels of release of CXCL9, CXCL10 and CXCL11 from primary airway epithelial cells .

HY-15319A

(±)-AMG 487	CXCR	Cancer
(±)-AMG 487 is a racemate of AMG 487. AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC₅₀s of 8.0 and 8.2 nM, respectively .

HY-113730

VUF5834	CXCR	Others
VUF5834 is a non-peptide chemokine receptor CXCR3 antagonist with non-competitive antagonistic and inverse agonistic activities. VUF5834 blocks the effects of CXCL10 and CXCL11 on human CXCR3, exhibits non-competitive antagonistic and inverse agonistic properties to CXCR3, and, except for TAK-779, has a slightly lower affinity for rodent CXCR3 than for primate CXCR3.

HY-165428

SCH-900875	CXCR Arrestin	Inflammation/Immunology
SCH-900875 is an orally active, brain-penetrant and selective CXCR3 receptor inhibitor, which also shows high selectivity over CXCR1 and CXCR2 receptors. SCH-900875 binds to CXCR3, blocking the binding of ligands CXCL9, CXCL10, and CXCL11, inhibiting downstream G protein and β-arrestin signaling pathways to suppress inflammatory cell migration. SCH-900875 is promising for research of autoimmune diseases (rheumatoid arthritis, multiple sclerosis) and inflammatory disorders (psoriasis, inflammatory bowel disease) .

HY-173364

EB-TCIP BAK-04-212	BCL6	Cancer
EB-TCIP (BAK-04-212) is a bivalent molecule comprised of AP1867 (HY-114434) and BI-3812 (HY-111381). EB-TCIP can form a reversible ternary complex between FKBP ^F36V and BCL6 ^BTB. EB-TCIP recruits FKBP12 ^F36V-tagged EWS/FLI1 to DNA sites bound by the transcriptional regulator BCL6, leading to rapid expression of BCL6 target genes (eg: SOCS2 and CXCL11). EWS/FLI1 is a fusion transcription factors in Ewing sarcoma. EB-TCIP can be used for research of deregulated transcription in cancer .

HY-W505771

Seselin	Fungal	Infection Inflammation/Immunology Cancer
Seselin is an anticancer, antinociceptive, anti-inflammatory and antifungal agent. Seselin is orally active .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W505771

Seselin	Structural Classification Flavonoids Source classification Ficus erecta Thunb. var. beecheyana (Hook.et Arn.) King Plants Moraceae Other Flavonoids	Fungal
Seselin is an anticancer, antinociceptive, anti-inflammatory and antifungal agent. Seselin is orally active .

HY-167884

PF-1367550	Structural Classification Alkaloids Aristolochia debilis Sieb. et Zucc. Source classification Plants Aristolochiaceae	JAK
PF-1367550 is a pan-JAK inhibitor. PF-1367550 can decrease the levels of release of CXCL9, CXCL10 and CXCL11 from primary airway epithelial cells .

Species:	Human (3) Mouse (2) Pig (1)
Tag:	His (3) Tag Free (3)
Source:	HEK293 (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P71886

	*I-TAC/CXCL11* Protein, Mouse** Cxcl11; Scyb11C-X-C motif chemokine 11; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11	Mouse	E. coli
	The CXCL11 protein selectively attracts interleukin-activated T cells and induces calcium release in these cells. Its binding to CXCR3 suggests a complex role in T cell chemotaxis and may be important in CNS diseases involving T cell recruitment. I-TAC/CXCL11 Protein, Mouse is the recombinant mouse-derived CXCL11 protein, expressed by E. coli , with tag free.

HY-P700169AF

	*Animal-Free I-TAC/CXCL11* Protein, Mouse (His)** 1 Publications Verification Cxcl11; Scyb11C-X-C motif chemokine 11; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11	Mouse	E. coli
	The CXCL11 protein selectively attracts interleukin-activated T cells and induces calcium release in these cells. Its binding to CXCR3 suggests a complex role in T cell chemotaxis and may be important in CNS diseases involving T cell recruitment. Animal-Free I-TAC/CXCL11 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeI-TAC/CXCL11 protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

HY-P7229

	*I-TAC/CXCL11* Protein, Human** 1 Publications Verification rHuI-TAC/Cxcl11; C-X-C motif chemokine 11; Beta-R1; H174; IP-9; SCYB11	Human	E. coli
	CXCL11, also known as IFN-inducible T-cell α-chemoattractant (I-TAC), belongs to the ELR-negative CXC chemokine family. CXCL11 is produced by a variety of cells including leukocytes, fibroblasts, and endothelial cells upon stimulation with interferons (IFNs). CXCL11 signals through CXCR3. CXCL11 is associated with pleiotropic functions including chemotactic migration, regulation of cell proliferation and self-renewal, increasing cell adhesion, and modulation of angiostatic effects. I-TAC/CXCL11 Protein, Human consists of 73 amino acids (F22-F94) and is expressed in E. coli.

HY-P7228

	*I-TAC/CXCL11* Protein, Human (HEK293)** rHuI-TAC/Cxcl11; C-X-C motif chemokine 11; Beta-R1; H174; IP-9; SCYB11	Human	HEK293
	CXCL11, also known as IFN-inducible T-cell α-chemoattractant (I-TAC), belongs to the ELR-negative CXC chemokine family. CXCL11 is produced by a variety of cells including leukocytes, fibroblasts, and endothelial cells upon stimulation with interferons (IFNs). CXCL11 signals through CXCR3. CXCL11 is associated with pleiotropic functions including chemotactic migration, regulation of cell proliferation and self-renewal, increasing cell adhesion, and modulation of angiostatic effects. I-TAC/CXCL11 Protein, Human (HEK293) consists of 73 amino acids (F22-F94) and is expressed in HEK293 cells.

HY-P700042AF

	*Animal-Free I-TAC/CXCL11* Protein, Human (His)** I-TAC/Cxcl11; C-X-C motif chemokine 11; Beta-R1; H174; IP-9; SCYB11	Human	E. coli
	I-TAC/CXCL11 protein selectively attracts interleukin-activated T-cells, inducing calcium release and binding to CXCR3 receptors. It does not attract unstimulated T-cells, neutrophils, or monocytes. This protein may play a role in T-cell recruitment in central nervous system diseases and skin immune responses. It also interacts with TNFAIP6, potentially modulating inflammatory processes. Animal-Free I-TAC/CXCL11 Protein, Human (His) is the recombinant human-derived animal-FreeI-TAC/CXCL11 protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

HY-P700233AF

	*Animal-Free I-TAC/CXCL11* Protein, Pig (His)** C-X-C motif chemokine 11; Beta-R1; H174; IP-9; SCYB11	Pig	E. coli
	I-TAC/CXCL11 Protein exhibits broad expression, notably in the lung (RPKM 3.0), mixtures (RPKM 2.0), and seven other tissues. This widespread distribution suggests its integral role in diverse physiological processes across different organ systems, underscoring the protein's significance in various biological contexts. Animal-Free I-TAC/CXCL11 Protein, Pig (His) is the recombinant pig-derived animal-FreeI-TAC/CXCL11 protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

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HY-P82024

	CXCL11 Antibody (YA1769) betaR; CXC11; Cxcl11; H174; I TAC; IP9; ITAC; SCYB11; SCYB9B	WB, ICC/IF	Human
	CXCL11 Antibody (YA1769) is a non-conjugated IgG antibody, targeting CXCL11, with a predicted molecular weight of 10 kDa. CXCL11 Antibody (YA1769) can be used for WB, ICC/IF experiment in human background.

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Cat. No.	Product Name		Classification

HY-RS16707

Cxcl11 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cxcl11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cxcl11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23142

Cxcl11 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Cxcl11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cxcl11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03385

CXCL11 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CXCL11 Human Pre-designed siRNA Set A contains three designed siRNAs for CXCL11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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