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Results for "

Cryptococcus

" in MedChemExpress (MCE) Product Catalog:

49

Inhibitors & Agonists

3

Peptides

18

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153410
    Antifungal agent 49

    		Fungal Infection
    Antifungal agent 49 (Example 112) is an antifungal agent. Antifungal agent 49 is active against Cryptococcus neoformans with a MIC value of 49 μM .
    Antifungal agent 49
  • HY-153409
    Antifungal agent 48

    		Fungal Infection
    Antifungal agent 48 (Example 308) is an antifungal agent. Antifungal agent 48 is active against Cryptococcus neoformans with a MIC value of 11 μM .
    Antifungal agent 48
  • HY-114220
    T-2307

    		Fungal Infection
    T-2307, an arylamidine, has antifungal activities in vitro and in vivo. T-2307 exhibits broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans (MIC range, 0.0039 to 0.0625 μg/ml), and Aspergillus species (MIC range, 0.0156 to 4 μg/mL) .
    T-2307
  • HY-150972
    P163-0892

    		Fungal Infection
    P163-0892 is a potent and selective antifungal agent against Cryptococcus species. P163-0892 is predicted to show medium BBB penetration .
    P163-0892
  • HY-176417
    Antifungal agent 132

    		Fungal Infection
    Antifungal agent 132 (compound 25) is a selective and potent antifungal agent. Antifungal agent 132 inhibits Cryptococcus neoformans May1 with a Ki of 180 pM .
    Antifungal agent 132
  • HY-19584
    Variotin

    		Fungal Infection
    Variotin is an Anti-Fungal Agent. Variotin has a strong antibiotic activity on dermatophytes such as Trichophyton, Microsporum, and Epidermophyton, and also pathogenic fungi in internal mycosis such as Blastomyces and Cryptococcus .
    Variotin
  • HY-N1817
    Demethoxypiplartine

    		Fungal Infection
    Demethoxypiplartine is an amide alkaloids which can be isolated from Piper flaviflorum and Piper sarmentosum. Demethoxypiplartine has antifungal activity against Cryptococcus neoformans with the IC50 of 18.1 μg/mL .
    Demethoxypiplartine
  • HY-146060
    Antibacterial agent 100

    		Bacterial Fungal Infection
    Antibacterial agent 100 (Compound 7c) is an antibacterial and antifungal agent. Antibacterial agent 100 shows promising activity with MIC values of 4, 4 and 8 μg/mL against Staphylococcus aureus, Candida albicans and Cryptococcus neoformans, respectively .
    Antibacterial agent 100
  • HY-169119
    Antifungal agent 114

    		Cytochrome P450 Fungal Infection
    Antifungal agent 114 (Compound 19g) is an inhibitor for Cytochrome P450, that inhibits CYP1A2, CYP2C9, CYP2C19 CYP2D6 and CYP3A4 at 10 μM. Antifungal agent 114 exhibits antifungal activity against Cryptococcus neoformans, Candida and Aspergillus, with MIC <0.0625 μg/mL. Antifungal agent 114 exhibits good metabolic stability in human liver microsomes with a half-time of 107 minutes .
    Antifungal agent 114
  • HY-146024
    Antifungal agent 28

    		Fungal Infection
    Antifungal agent 28 (compound 18) is a potent and selective antifungal agent. Antifungal agent 28 inhibits pathogenic strains of C. albicans and non-albicans species including fluconazole-resistant strains. Antifungal agent 28 inhibits Cryptococcus and Aspergillus strains. Antifungal agent 28 disrupts mature Candida biofilm .
    Antifungal agent 28
  • HY-N7626
    Eleutherol

    		Fungal Glycosidase Infection
    Eleutherol is a naphthalene isolated from E. americana with antifungal activities . Eleutherol is against yeasts Candida albicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with MIC values between 7.8 µg/mL and 250 µg/mL . Eleutherol inhibits α-glucosidase function with an IC50>1.00 mM .
    Eleutherol
  • HY-169919
    HDM-IN-1

    		Histone Demethylase Fungal Infection
    HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase (HDM), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC50s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC80 of 0.5-2 μg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model .
    HDM-IN-1
  • HY-146427
    Antifungal agent 29

    		Fungal Infection
    Antifungal agent 29 (compound 9d) is a potent, selective and non-toxic antifungal agent. Antifungal agent 29 shows antifungal activity towards Cryptococcus neoformans (MIC ≤ 0.23 μM) .
    Antifungal agent 29
  • HY-19404
    Embeconazole

    CS-758; R-120758

    		 Fungal Infection
    Embeconazole (CS-758; R-120758) is an antifungal agent against Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus and Aspergillus flavus, with MICs of 8, 16, 63 and 250 μM, respectively .
    Embeconazole
  • HY-N8540
    Ilicicolin H

    		Phosphoglycerate Kinase (PGK) Fungal Apoptosis Infection Cancer
    Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC50 = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC50 = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with KD of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection .
    Ilicicolin H
  • HY-P10410
    AEC5

    		Fungal Infection
    AEC5 is a Lipopeptoid with antifungal activity against Cryptococcus neoformans. AEC5 has no observable cytotoxicity against human lung, liver, or red blood cells at the MIC value (6.3 μg/mL) for Cryptococcus neoformans .
    AEC5
  • HY-133157
    FAICAR

    5-Formamidoimidazole-4-carboxamide ribotide

    		 DNA/RNA Synthesis Infection
    FAICAR (5-Formamidoimidazole-4-carboxamide ribotide) is a purine nucleotide and substrate for the IMP cyclohydrolase of ATIC from Cryptococcus neoformans. FAICAR is a key intermediate in the de novo purine biosynthesis pathway. FAICAR can be used in the research of diseases associated with Cryptococcus neoformans infection .
    FAICAR
  • HY-173428
    Antifungal agent 130

    		Fungal Infection
    Antifungal agent 130 (Compound A7) is an orally active antifungal agent. Antifungal agent 130 has good antifungal activity against Candida albicans (MIC = 0.12 ng/mL) and Cryptococcus neoformans (MIC = 0.12 ng/mL) and has excellent antivirulence effect. Antifungal agent 130 exerts its antifungal effect by disrupting the iron homeostasis of fungal cells and inducing oxidative stress damage. Antifungal agent 130 can inhibit the formation of fungal virulence factors (such as biofilm, capsule, urease and melanin). Antifungal agent 130 has good antifungal effect and can be used in the study of drug-resistant fungal infections .
    Antifungal agent 130
  • HY-156195
    BHBM

    		Fungal Infection
    BHBM (compound 1) is an aromatic acylhydrazone antifungal agent with high bactericidal activity against Cryptococcus neoformans .
    BHBM
  • HY-N14011
    Cedarmycin A

    		Antibiotic Bacterial Infection
    Cedarmycin A has activities against Candida, Cryptococcus neoforme and Aspergillus fumigatus, with the MIC values of 12.5-50 μg/mL .
    Cedarmycin A
  • HY-N14547
    Crotocin

    		Fungal Infection
    Crotocin has the fungal activity of anti-cryptococcus neoforme, candida albicans, Tinea trichoderma of brewer's yeast, and can be inactivated by blood .
    Crotocin
  • HY-N14012
    Cedarmycin B

    		Antibiotic Bacterial Infection
    Cedarmycin B has activities against Candida, Cryptococcus neoforme and Aspergillus fumigatus, with the MIC values of 12.5-50 μg/mL .
    Cedarmycin B
  • HY-P5569
    SP-B peptide

    		Fungal Infection
    SP-B peptide is an antimicrobial peptide. SP-B peptide has antifungal activity against strains of Cryptococcus neoformans, Candida albicans and Aspergillus fumigatus
    SP-B peptide
  • HY-111357
    Antifungal agent 2

    		Fungal Infection
    Antifungal agent 2 is a broad-spectrum fungal inhibitor which inhibits growth of pertinent species of Candida, Cryptococcus, and Aspergillus at a concentration as low as 0.5 μg/mL.
    Antifungal agent 2
  • HY-161049
    Antifungal agent 89

    		Fungal Infection
    Antifungal agent 89 (compound 28) is a antifungal agent against Cryptococcus neoformans with minimum inhibitory concentration value ranging from 0.8 to 52.17 μM .
    Antifungal agent 89
  • HY-109040
    Quilseconazole

    VT-1129

    		 Fungal Cytochrome P450 Infection Inflammation/Immunology
    Quilseconazole (VT-1129) is an orally active, highly selective fungal cytochrome P450 enzyme Cyp51 inhibitor that can cross the blood-brain barrier. Quilseconazole prevents the synthesis of ergosterol, an important component of the fungal cell membrane, by inhibiting Cyp51. Quilseconazole has minimal effects on human CYP enzymes. Quilseconazole has antifungal activity and can be used in the study of cryptococcal meningitis and other diseases .
    Quilseconazole
  • HY-118847
    Antifungal agent 86

    		Fungal Infection
    Antifungal agent 86 (Compound 41F5) is an antifungal agent. Antifungal agent 86 is highly active against Histoplasma yeast and Cryptococcus neoformans (MIC50: 0.4-0.8 μM) .
    Antifungal agent 86
  • HY-N15300
    Acremorin E

    		Fungal Infection
    Acremorin E (Compound 7) is a terpenoid compound with antifungal activity. Acremorin E exerts its anti-C. gattiii effect by upregulating genes related to biosynthesis and RNA binding of ribosomes, as well as inhibiting RNA and nucleic acid metabolism and ATPase activity (MIC: 8 μg/mL) .
    Acremorin E
  • HY-152896
    Ys-II

    		Fungal Infection
    Ys-II (Compound 1) is a spirostanol glycoside that can be isolated from the stem of Yucca elephantipe. Ys-II has antifungal activity against the growth of Candida albicans and Cryptococcus neoformans (IC50: 5 and 6 μg/mL respectively) .
    Ys-II
  • HY-170616
    JH-FK-08

    		Fungal Interleukin Related Infection Inflammation/Immunology
    JH-FK-08 is an inhibitor for the serine/threonine-specific phosphatase calcineurin. JH-FK-08 exhibits antifungal activity that inhibits C. neoformans with MIC80 of 0.8 µg/mL. JH-FK-08 exhibits immunosuppressive activity and inhibits the IL-2 expression with an IC50 of 42.6 nM. JH-FK-08 exhibits anti-infectious activity in mouse models .
    JH-FK-08
  • HY-N14685
    Heptaibin

    		Antibiotic Fungal Infection
    Heptaibin is a peptaibol antifungal antibiotic. Heptaibin has the activity against Gram-positive bacteria (MIC is 8 μg/mL) such as Staphylococcus aureus and fungi (MIC is 13-32 μg/mL) such as Aspergillus, Candida albicans and cryptococcus neofordii, and it has moderate anti-Rhabditella pseudoelongata activity (MIC is 50 μg/mL) .
    Heptaibin
  • HY-P2450
    Leucinostatin A

    Antibiotic P168

    		 Fungal Antibiotic Infection Cancer
    Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies .
    Leucinostatin A
  • HY-N8537
    Enfumafungin

    		Fungal Infection
    Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis .
    Enfumafungin
  • HY-155710
    Antifungal agent 68

    		Fungal Infection
    Antifungal agent 68 (compound 10) is an antifungal agent against Candida and Cryptococcus gattii. Antifungal agent 68 inhibits fungal ergosterol biosynthesis, possibly by targeting lanosterol 14α-demethylase (CYP51). There is an interaction between the imidazole ring of antifungal agent 68 and the heme group of CYP51 .
    Antifungal agent 68
  • HY-125693
    L685818

    		Fungal Infection Neurological Disease
    L685818 is a specific immunophilin ligand. L685818 was neuroregenerative and non-neuroprotective in primary brain cultures. L685818 protects dopaminergic neurons from toxic inhibition of MPP+ and 6-OHDA, reduces tyrosine hydroxylase (TH) loss, and promotes neuronal process regeneration. L685818 is also an antifungal reagent for Cryptococcus neoformans .
    L685818
  • HY-113637
    Galbonolide A

    Rustmicin

    		 Fungal Infection
    Galbonolide A (Rustmicin) is a potent antifungal agent.Galbonolide A inhibits inositol phosphoceramide synthase. Galbonolide A shows antifungal activity .
    Galbonolide A
  • HY-N16051
    Bromoflavone

    CJ-19784

    		 Bacterial Fungal Infection
    Bromoflavone (CJ-19784) is a flavone that can be isolated from Aspergillus candidus. Bromoflavone shows anti-Mtb activity with an MIC90 value of 1.2 μM. Bromoflavone is also an antifungal agent. Bromoflavone inhibits the growth of pathogenic fungi, Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus with IC50 values of 0.11, 20 and 0.54 μg/mL, respectively. .
    Bromoflavone
  • HY-136153
    Amphotericin X1

    		Fungal Infection
    Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively .
    Amphotericin X1
  • HY-109125A
    Amcipatricin L-aspartate

    SPA-S-753; SPA-S-752 L-aspartate

    		 Antibiotic Fungal Infection
    Amcipatricin diaspartate (SPA-S-753) is a semi-synthetic polyene antibiotic, with potent broad-spectrum antifungal activity .
    Amcipatricin L-aspartate
  • HY-173452
    DT-23

    		Fungal Infection
    DT-23 is a potent antifungal agent with an MIC50 of 15 μg/mL. DT-23 inhibits recombinant Arg1 and Kcs1 with IC50s of 0.6 and 0.68 μM, respectively .
    DT-23
  • HY-N8537R
    Enfumafungin (Standard)

    		Reference Standards Fungal Infection
    Enfumafungin (Standard) is the analytical standard of Enfumafungin. This product is intended for research and analytical applications. Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis[1][2].
    Enfumafungin (Standard)
  • HY-144632
    Antifungal agent 22

    		Fungal Infection
    Antifungal agent 22 (compound D16) is a potential and orally active antifungal agent for CM (cryptococcal meningitis), with an IC50 of 0.5 μg/mL. Antifungal agent 22 can penetrate the blood-brain barrier and kill the C. neoformans H99 cells by destroying the integrity of fungal cell membranes. Antifungal agent 22 shows selective anti-Cryptococcus activity with good metabolic stability and low cytotoxicity .
    Antifungal agent 22
  • HY-N11287
    UDP-xylose

    		Endogenous Metabolite Others
    UDP-xylose is an endogenous sugar nucleotide and a catalytic substrate of UDP-xylose synthase (UXS). UDP-xylose is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites and oligosaccharides in plants, vertebrates and fungi, and participates in the synthesis of proteoglycans as a glycosyl donor. UDP-xylose participates in the regulation of the synthesis of extracellular matrix components and can be used to study the mechanism of proteoglycan biosynthesis in glycobiology and related diseases (such as connective tissue diseases)[1][2].
    UDP-xylose
  • HY-N11287A
    UDP-xylose disodium
    1 Publications Verification

    		 Endogenous Metabolite Others
    UDP-xylose disodium is an endogenous sugar nucleotide and a catalytic substrate of UDP-xylose disodium synthase (UXS). UDP-xylose disodium is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites and oligosaccharides in plants, vertebrates and fungi, and participates in the synthesis of proteoglycans as a glycosyl donor. UDP-xylose disodium participates in the regulation of the synthesis of extracellular matrix components and can be used to study the mechanism of proteoglycan biosynthesis in glycobiology and related diseases (such as connective tissue diseases)[1][2].
    UDP-xylose disodium
  • HY-E70120
    Phosphomannose isomerase

    		Fungal Infection
    Phosphomannose isomerase is the first enzyme involved in the biosynthesis pathway of GDP-Man. Phosphomannose isomerase catalyzes the conversion between fructose-6-phosphate (Fru6P) and mannose-6-phosphate (Man6P). Phosphomannose isomerase is important for cell wall synthesis and protein glycosylation. Phosphomannose isomerase is a potent antifungal target to curb the threats posed by A. flavus .
    Phosphomannose isomerase
  • HY-147110
    APX2039

    		Fungal Infection Inflammation/Immunology
    APX2039 is an orally active and potent inhibitor of the fungal Gwt1 enzyme. APX2039 has extremely potent anticryptococcal activity against C. neoformans and C. gattii. APX2039 blocks the localization of GPI (glycosylphosphatidyl inositol)-anchored cell wall mannoproteins. APX2039 can be used for Cryptococcal meningitis (CM) research .
    APX2039
  • HY-P2460
    SMAP-29

    		Bacterial Fungal Infection Inflammation/Immunology
    SMAP-29, a promising antiinfective agent, is a broad spectrum antibacterial and antifungal α-helical cathelicidin-derived peptide. SMAP-29 acts by permeabilizing bacterial membranes and inducing remarkable changes in the surface morphology of susceptible microorganism .
    SMAP-29
  • HY-146023
    Antifungal agent 27

    		Bacterial Fungal Infection
    Antifungal agent 27 (compound 7) is a antifungal agent. Antifungal agent 27 shows moderate antibacterial and weak antifungal activities against MRSA and C. albicans SS5314, with MIC values of 8 and 32 μg/mL, respectively .
    Antifungal agent 27
  • HY-153624
    Antifungal agent 59

    		Fungal Infection
    Antifungal agent 59 is an antifungal agent, with MIC values of 0.01-1 μg/mL. Antifungal agent 59 prevents the formation of fungi biofilms, but also has safety .
    Antifungal agent 59

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