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Results for "

Caspase-2 Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (11) Apoptosis (2) Autophagy (1) Bcl-2 Family (1) Cathepsin (2) Necroptosis (1) SARS-CoV (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (3) Infection (2)
Oligonucleotides:	siRNA drugs (2) siRNAs (2)

Inhibitors & Agonists

Peptides

Oligonucleotides

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1008

Z-VDVAD-FMK 3 Publications Verification Z-VD(OMe)VAD(OMe)-FMK	Caspase	Cancer
Z-VDVAD-FMK is a special inhibitor of *caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis* .

HY-164388

Z-VAD 4 Publications Verification	Caspase Apoptosis Autophagy Necroptosis	Cardiovascular Disease Cancer
Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2). Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation .

HY-134567A

Ac-VDVAD-CHO TFA	Caspase	Others
Ac-VDVAD-CHO (TFA) is a *caspase-2/3* inhibitor (IC₅₀: 46 and 15 nM) .

HY-120838

Heptelidic acid 1 Publications Verification Koningic acid	Caspase	Infection Cancer
Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic . Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of *caspases* . Koningic acid (KA) is a specific GAPDH inhibitor with an IC₅₀of 90 μM .

HY-158820

Cosdosiran QPI-1007	Small Interfering RNA (siRNA) Caspase	Cardiovascular Disease
Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the *caspase 2* protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

HY-P10147

Ac-LDESD-AMC	Caspase	Cancer
Ac-LDESD-AMC is a *caspase-2* inhibitor. Ac-LDESD-AMC has a peptide sequence of Leu-Asp-Glu-Ser-Asp .

HY-P1008A

Z-VDVA-(DL-Asp)-FMK Z-VD(OMe)VAD(OMe)-(DL-Asp)-FMK	Caspase	Cancer
Z-VDVA-(DL-Asp)-FMK is a Z-VDVAD-FMK derivative. Z-VDVAD-FMK (HY-P1008) is a special inhibitor of caspase-2 .

HY-P2012

TRP-601	Caspase Bcl-2 Family	Others
TRP-601 is a *caspase* inhibitor. TRP-601 reversed the increased expression of active *caspase-2*, the activation of endogenous apoptotic pathway and the up-regulation of key protein triggered by hyperoxia .

HY-P0109

(S,S)-Z-FA-FMK	Cathepsin	Others
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .

HY-134567

Ac-VDVAD-CHO	Caspase	Others
Ac-VDVAD-CHO is a *caspase-2/3* inhibitor (IC₅₀: 46 and 15 nM) .

HY-158820A

Cosdosiran sodium QPI-1007 sodium	Small Interfering RNA (siRNA) Caspase	Cardiovascular Disease
Cosdosiran sodium is a chemically modified siRNA designed to temporarily inhibit expression of the *caspase 2* protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

HY-P0109A

Z-FA-FMK 5 Publications Verification (1S)-Z-FA-FMK	SARS-CoV Cathepsin Apoptosis Caspase	Infection Cancer
Z-FA-FMK ((1S)-Z-FA-FMK) is a potent Cathepsin B and L inhibitor. Z-FA-FMK blocks the induction of DEVDase activity, DNA fragmentation, and externalization of phosphatidylserine by selective synthetic retinoid-related molecules (RRMs). Z-FA-FMK inhibits apoptosis. Z-FA-FMK inhibits caspase activity and selectively inhibits recombinant effector caspases 2, -3, -6, and -7. Z-FA-FMK is a viral inhibitor. Z-FA-FMK inhibits reovirus replication in a susceptible host .

Cat. No.	Product Name	Target	Research Area

HY-P1008

Z-VDVAD-FMK 3 Publications Verification Z-VD(OMe)VAD(OMe)-FMK	Caspase	Cancer
Z-VDVAD-FMK is a special inhibitor of *caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis* .

HY-164388

Z-VAD 4 Publications Verification	Caspase Apoptosis Autophagy Necroptosis	Cardiovascular Disease Cancer
Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2). Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation .

HY-134567A

Ac-VDVAD-CHO TFA	Caspase	Others
Ac-VDVAD-CHO (TFA) is a *caspase-2/3* inhibitor (IC₅₀: 46 and 15 nM) .

HY-P10147

Ac-LDESD-AMC	Caspase	Cancer
Ac-LDESD-AMC is a *caspase-2* inhibitor. Ac-LDESD-AMC has a peptide sequence of Leu-Asp-Glu-Ser-Asp .

HY-P2012

TRP-601	Caspase Bcl-2 Family	Others
TRP-601 is a *caspase* inhibitor. TRP-601 reversed the increased expression of active *caspase-2*, the activation of endogenous apoptotic pathway and the up-regulation of key protein triggered by hyperoxia .

HY-P0109

(S,S)-Z-FA-FMK	Cathepsin	Others
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .

HY-134567

Ac-VDVAD-CHO	Caspase	Others
Ac-VDVAD-CHO is a *caspase-2/3* inhibitor (IC₅₀: 46 and 15 nM) .

Cat. No.	Product Name		Classification

HY-158820

Cosdosiran QPI-1007		siRNAs siRNA drugs
Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the *caspase 2* protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

HY-158820A

Cosdosiran sodium QPI-1007 sodium		siRNAs siRNA drugs
Cosdosiran sodium is a chemically modified siRNA designed to temporarily inhibit expression of the *caspase 2* protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

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