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Results for "

CYR61

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Small Interfering RNA (siRNA) (3) Survivin (1) TAM Receptor (1) YAP (9)
By Research Areas:	Cancer (9) Inflammation/Immunology (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155310

AF-2112	YAP	Cancer
AF-2112 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2.

HY-155309

LM-41	YAP	Cancer
LM-41 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2. LM-41 inhibits migration of human MDA-MB-231 breast cancer cells .

HY-168704

YAP/TAZ-TEAD-IN-2	YAP TAM Receptor Survivin	Cancer
YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that inhibits the interaction between YAP/TAZ and TEAD. YAP/TAZ-TEAD-IN-2 suppresses the transcriptional activity of TEAD, with an IC₅₀ of 1.2 nM. YAP/TAZ-TEAD-IN-2 inhibits YAP/TAZ-TEAD target genes expression (Cyr61, CTGF, AXL and Survivin) and breast cancer cell proliferation .

HY-162012

HC-258	YAP	Cancer
HC-258 (compound 26) binds with the cysteine in TEAD’s PA pocket. HC-258 reduces the CTGF, CYR61, AXL, and NF2 transcript levels and inhibits the migration of MDA-MB-231 breast cancer cells .

HY-168085

CV-4-26	YAP Apoptosis	Cancer
CV-4-26 (Compound 22) is a covalent inhibitor of TEAD. CV-4-26 inhibits YAP/TEAD-based transcription, leading to the reduction of CTGF and CYR61 expression. CV-4-26 inhibits Huh7 and HepG2 cell colony formation, induces cell cycle arrest, and apoptosis. CV-4-26 shows antitumor activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB) .

HY-159912

pan-TEAD-IN-1	YAP	Cancer
pan-TEAD-IN-1 (Compound 3) is an orally active pan-TEAD inhibitor targeting the palmitoylation site of TEAD, disrupting its interaction with the coactivators YAP/TAZ, thereby suppressing the transcriptional upregulation of oncogenes (e.g., Ctgf and *Cyr61) in the Hippo* signaling pathway. pan-TEAD-IN-1 exhibits excellent activity with a luciferase IC₅₀ of 0.36 nM and an H226 cell IC₅₀ of 1.52 nM. It also shows favorable pharmacokinetics (AUC_0–∞ = 228.7 μg/mL·min, T_1/2 = 183.9 min). In TEAD-dependent xenograft mouse models, pan-TEAD-IN-1 significantly inhibited tumor growth, showing promise for research in TEAD-dependent cancers .

HY-RS24420

Ccn1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccn1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccn1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccn1 Rat Pre-designed siRNA Set A Ccn1 Rat Pre-designed siRNA Set A

HY-RS17949

Ccn1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccn1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccn1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccn1 Mouse Pre-designed siRNA Set A Ccn1 Mouse Pre-designed siRNA Set A

HY-RS02110

CCN1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCN1 Human Pre-designed siRNA Set A contains three designed siRNAs for CCN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCN1 Human Pre-designed siRNA Set A CCN1 Human Pre-designed siRNA Set A

HY-P1727A

Super-TDU TFA	YAP	Cancer
Super-TDU TFA is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU TFA suppresses tumor growth in gastric cancer mouse model .

HY-P1727

Super-TDU 5 Publications Verification	YAP	Cancer
Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model .

HY-147208

MSC-4106	YAP	Cancer
MSC-4106 is an orally active and potent inhibitor of YAP/TAZ-TEAD. MSC-4106 inhibits TEAD1 or TEAD3 auto-palmitoylation and shows inhibitory effect on NCI-H226 tumor xenograft model .

Cat. No.	Product Name	Target	Research Area

HY-P1727

Super-TDU 5 Publications Verification	YAP	Cancer
Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model .

HY-P1727A

Super-TDU TFA	YAP	Cancer
Super-TDU TFA is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU TFA suppresses tumor growth in gastric cancer mouse model .

Cat. No.	Product Name	Target	Research Area

HY-P990396

*Anti-CYR61/CCN1 Antibody*	Inhibitory Antibodies	Inflammation/Immunology
Anti-CYR61/CCN1 Antibody is a CHO-expressed human antibody that targets *CYR61/CCN1. The Anti-CYR61/CCN1 Antibody contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CYR61*/CCN1 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Species:	Human (1) Mouse (1)
Tag:	His (1) Fc (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P7842

	*CCN1/Cyr61* Protein, Human (HEK293, Fc)** 1 Publications Verification rHuCCN family member 1/CYR61, Fc; Protein CYR61; CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10 ; GIG1; CYR61; CCN1; IGFBP10;	Human	HEK293
	CCN1/Cyr61 proteins play critical roles in cellular processes, promoting cell proliferation, chemotaxis, angiogenesis, and adhesion. It coordinates wound healing by upregulating key genes related to angiogenesis, inflammation and matrix remodeling in skin fibroblasts and is heparin binding dependent. CCN1/Cyr61 Protein, Human (HEK293, Fc) is the recombinant human-derived CCN1/Cyr61 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P704010

	*CCN1/Cyr61* Protein, Mouse (His)** Ccn1; CYR61; Igfbp10; CCN family member 1; 3CH61; Cellular communication network factor 1; Cysteine-rich angiogenic IGFBP-10; Protein CYR61; inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10;	Mouse	E. coli
	CCN1/Cyr61 Protein, Mouse (His) is the recombinant mouse-derived CCN1/Cyr61 protein, expressed by E. coli, with N-10*His tag.

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HY-P86830

	CYR61/CCN1 Antibody (YA6523) 3CH61 antibody; CCN 1 antibody; CCN family member 1 antibody; CCN1 antibody; CYR 61 antibody; CYR61 antibody; CYR61 protein antibody; CYR61_HUMAN antibody; Cysteine rich angiogenic inducer 61 antibody; Cysteine rich heparin binding protein 61 antibody; 3CH61 antibody; CCN 1 antibody; CCN family member 1 antibody; CCN1 antibody; CYR 61 antibody; CYR61 antibody; CYR61 protein antibody; CYR61_HUMAN antibody; Cysteine rich angiogenic inducer 61 antibody; Cysteine rich heparin binding protein 61 antibody; Cysteine-rich angiogenic inducer 61 antibody; GIG 1 antibody; GIG1 antibody; IBP-10 antibody; IGF-binding protein 10 antibody; Igfbp 10 antibody; IGFBP-10 antibody; Igfbp10 antibody; Insulin like growth factor binding protein 10 antibody; Insulin-like growth factor-binding protein 10 antibody; Protein CYR61 antibody; Protein GIG1 antibody	WB, ICC/IF, IHC-P, IF-Tissue	Human

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Cat. No.	Product Name		Classification

HY-RS24420

Ccn1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ccn1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccn1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17949

Ccn1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ccn1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccn1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS02110

CCN1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CCN1 Human Pre-designed siRNA Set A contains three designed siRNAs for CCN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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