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Results for "

CYP1A Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aryl Hydrocarbon Receptor (3) Cytochrome P450 (11) DNA/RNA Synthesis (1) Drug Metabolite (1) Fungal (2) HBV (1) Isotope-Labeled Compounds (2) Reference Standards (3) ROCK (1)
By Research Areas:	Cancer (6) Infection (2) Metabolic Disease (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0125

Diosmetin 10+ Cited Publications	Cytochrome P450	Cancer
Diosmetin is a natural flavonoid which inhibits human *CYP1A* enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-B0973

Dibenzothiophene DBT; Diphenylene sulfide	Cytochrome P450 Aryl Hydrocarbon Receptor	Metabolic Disease
Dibenzothiophene is an orally active and a noncompetitive *CYP1A* inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with a K_m of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms .

HY-B0973S

Dibenzothiophene-d8	Isotope-Labeled Compounds Cytochrome P450 Aryl Hydrocarbon Receptor	Metabolic Disease
Dibenzothiophene-d₈ is the deuterium labeled Dibenzothiophene (HY-B0973). Dibenzothiophene is an orally active and a noncompetitive *CYP1A* inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with K_m of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms .

HY-118216

Bitertanol Biloxazol	Fungal Cytochrome P450	Infection
Bitertanol (Biloxazol) is a potent antifungal agent. Bitertanol also is an CYP1A1, CYP2B, and CYP3A inducer in vivo and an *CYP1A* inhibitor in vitro .

HY-121213

Erysolin	Cytochrome P450	Cancer
Erysolin is a *CYP1A* inhibitor with antigenic toxicity. Erysolin reduces benzo(a)pyrene-induced genotoxicity .

HY-N0125S

Diosmetin-d3	Isotope-Labeled Compounds Cytochrome P450	Cancer
Diosmetin-d₃ is the deuterium labeled Diosmetin. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.

HY-B0973R

Dibenzothiophene (Standard) DBT (Standard); Diphenylene sulfide (Standard)	Reference Standards Cytochrome P450 Aryl Hydrocarbon Receptor	Metabolic Disease
Dibenzothiophene (Standard) is the analytical standard of Dibenzothiophene (HY-B0973). This product is intended for research and analytical applications. Dibenzothiophene is an orally active and a noncompetitive *CYP1A* inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with K_m of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms .

HY-N0125R

Diosmetin (Standard)	Reference Standards Cytochrome P450	Cancer
Diosmetin (Standard) is the analytical standard of Diosmetin. This product is intended for research and analytical applications. Diosmetin is a natural flavonoid which inhibits human *CYP1A* enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-W401407

Diosmetin-3-O-glucuronide	Drug Metabolite Cytochrome P450	Metabolic Disease
Diosmetin-3-O-glucuronide is a major circulating metabolite of Diosmetin (HY-N0125) in plasma and in urine. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity .

HY-118216R

Bitertanol (Standard) Biloxazol (Standard)	Reference Standards Fungal Cytochrome P450	Infection
Bitertanol (Standard) is the analytical standard of Bitertanol. This product is intended for research and analytical applications. Bitertanol (Biloxazol) is a potent antifungal agent. Bitertanol also is an CYP1A1, CYP2B, and CYP3A inducer in vivo and an CYP1A inhibitor in vitro .

HY-W110138

Chloroxoquinoline	DNA/RNA Synthesis Cytochrome P450 ROCK	Cancer
Chloroxoquinoline is an anticancer agent. Chloroxoquinoline damages the DNA templates of cancer cells, inducing DNA breaks and cell death, and inhibits cell invasion via down-regulating Rho/Rho kinase signaling pathway. Chloroxoquinoline enhances the radiation sensitivity of Lewis lung cancer cells and xenograft tumors in tumor-bearing mouse models but decreases efficacy after long term exposure in rat models by auto-induction effects on *CYP1A* and CYP3A. Chloroxoquinoline has a broad-spectrum anticancer activity, such as non-small-cell lung carcinoma (NSCLC), breast cancer and gastric cancer .

HY-120377

CYP1A1 inhibitor 8a	HBV	Cancer
CYP1A1 inhibitor 8a is a compound that potently and selectively inhibits the CYP1A1 enzyme and has the potential to prevent cancer. CYP1A1 inhibitor 8a exhibits more than 10-fold selectivity for CYP1A1 and more than 100-fold selectivity over other enzymes in the CYP1 subfamily. CYP1A1 inhibitor 8a can effectively antagonize B[a]P-mediated activation of the aryl hydrocarbon receptor (AhR) in yeast cells and protect human cells from CYP1A1-mediated B[a]P toxicity. CYP1A1 inhibitor 8a has the potential to be developed as a cancer chemopreventive agent .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0125

Diosmetin 10+ Cited Publications	Human Gut Microbiota Metabolites Flavonoids Classification of Application Fields Flavones Citrus limon (L.) Burm. F. Source classification Rutaceae Plants Endogenous metabolite Disease Research Fields Cancer	Cytochrome P450
Diosmetin is a natural flavonoid which inhibits human *CYP1A* enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-N0125R

Diosmetin (Standard)	Human Gut Microbiota Metabolites Flavonoids Classification of Application Fields Citrus limon (L.) Burm. F. Source classification Rutaceae Plants Endogenous metabolite Disease Research Fields Cancer	Reference Standards Cytochrome P450
Diosmetin (Standard) is the analytical standard of Diosmetin. This product is intended for research and analytical applications. Diosmetin is a natural flavonoid which inhibits human *CYP1A* enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

Cat. No.	Product Name	Chemical Structure

HY-B0973S

Dibenzothiophene-d8
Dibenzothiophene-d₈ is the deuterium labeled Dibenzothiophene (HY-B0973). Dibenzothiophene is an orally active and a noncompetitive *CYP1A* inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with K_m of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms .

Dibenzothiophene-d8

Dibenzothiophene-d₈ is the deuterium labeled Dibenzothiophene (HY-B0973). Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with K_m of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms .

HY-N0125S

Diosmetin-d3
Diosmetin-d₃ is the deuterium labeled Diosmetin. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.

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