Search Result
        
        
            
                Results for "
COX-2-IN-2
" in MedChemExpress (MCE) Product Catalog:
            
         
        
        
            
                
            
            
            
                
            
            
            
            
            
            
                
            
            
            
                
                    7
Isotope-Labeled Compounds
 
                    
                 
            
            
            
            
         
        
            
            
                
                    
                    
                        
                            | Cat. No. | 
                            Product Name | 
                            Target | 
                            Research Areas | 
                            Chemical Structure | 
                        
                    
                    
                        
                            
                            - 
                                
                                    - HY-101655
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    COX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC50 of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.
                                                 | 
                                            
                                        
                                     
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                            - 
                                
                                    - HY-B0736A
 
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                                                | 
                                                    
                                                     FI7056 
                                                 | 
                                                
                                                    
                                                        Fungal
                                                    
                                                        Autophagy
                                                    
                                                        Apoptosis
                                                    
                                                        p38 MAPK
                                                    
                                                        Microtubule/Tubulin
                                                    
                                                 | 
                                                
                                                    
                                                        Infection
                                                    
                                                        Cancer
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells    .
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                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-B1130
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis . Isoxicam is a nonselective inhibitor of COX-1 and COX-2 .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-150755
 
                                    - 
                                        
                                    
 
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-163188
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                        Lipoxygenase
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    COX-2/LOX-IN-2 (compound 6) is a dual inhibitor of COX-2/LOX with IC50s of 7.0 μM and 27.5 μM, respectively. COX-2/LOX-IN-2 has antioxidant activity and has the potential to be used in the development of nonsteroidal anti-inflammatory drugs (tNSAIDs) .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-N11880
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                 | 
                                                
                                                    
                                                        Cancer
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    2-O-Sinapoyl makisterone A (compound 2), a sinapinic acid-ecdysterone hybrid, is a selective inhibitor of COX-2. 2-O-Sinapoyl makisterone A significantly inhibits the expression of COX-2 protein .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-162228
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                        Phospholipase
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    VI-60 is a dual, orally active inhibitor of cPLA2 and COX-2, which reveals an anti-inflammtory efficacy through the inhibition of p38 MAPK/cPLA2/COX-2/PGE2 pathway .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-B0736
 
                                    - 
                                        
                                    
 
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-B0736AR
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                     FI7056 (Standard) 
                                                 | 
                                                
                                                    
                                                        Reference Standards
                                                    
                                                        Fungal
                                                    
                                                        Autophagy
                                                    
                                                        Apoptosis
                                                    
                                                        p38 MAPK
                                                    
                                                        Microtubule/Tubulin
                                                    
                                                 | 
                                                
                                                    
                                                        Infection
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Sertaconazole (nitrate) (Standard) is the analytical standard of Sertaconazole (nitrate). This product is intended for research and analytical applications. Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells    .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-145988
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    COX-2-IN-11 (compound 7b2) is a potent and selective inhibitor of COX-2. COX-2-IN-11 has the potential for the research of inflammation diseases .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-B0360S
 
                                    - 
                                        
                                    
 
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                            - 
                                
                                    - HY-109158
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Rebamipide mofetil is an orally active proagent of Rebamipide (OPC12759). Rebamipide is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-B1130R
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        Reference Standards
                                                    
                                                        COX
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Isoxicam (Standard) is the analytical standard of Isoxicam. This product is intended for research and analytical applications. Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis . Isoxicam is a nonselective inhibitor of COX-1 and COX-2 .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-B0580S1
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        Isotope-Labeled Compounds
                                                    
                                                        COX
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Ketorolac-d4 (RS37619 D4) is the deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2  .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-163187
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                        Lipoxygenase
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    COX-2/LOX-IN-1 (compound 5) is a dual cyclooxygenase-2/lipoxygenase (COX-2/LOX) inhibitor with IC50s of 30 μM and 0.55 μM, for LOX and COX-2, respectively.  .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-19384
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                     E 6087 
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2).?Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-100516
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                     UR-8880 
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Cimicoxib (CX) is an orally active potent and selective COX-2 (cyclo-oxygenase-2) inhibitor. Cimicoxib exhibits promising anti-inflammatory and analgesic activity. The PK parameters of Cimicoxib in dogs given precise (2 mg/kg) and approximate doses (1.95-2.5 mg/kg) are similar .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-N0523S
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                     3,4,5-Trihydroxybenzoic acid-d2 
                                                 | 
                                                
                                                    
                                                        Apoptosis
                                                    
                                                        COX
                                                    
                                                        Ferroptosis
                                                    
                                                        Endogenous Metabolite
                                                    
                                                        Reactive Oxygen Species (ROS)
                                                    
                                                 | 
                                                
                                                    
                                                        Cancer
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Gallic acid-d2 is the deuterium labeled Gallic acid . Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-147748
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    COX-2-IN-17 (compound 10) is a potent and BBB-penetrated COX-2 (cyclooxygenase-2) inhibitor, with an IC50 of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-D0053
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                     6-Carboxy-X-rhodamINe 
                                                 | 
                                                
                                                    
                                                        Fluorescent Dye
                                                    
                                                 | 
                                                
                                                    
                                                        Others
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    6-ROX is a selective fluorescent probe and potential inhibitor of COX-2. 6-ROX binds to the active site of COX-2 and inhibits its conversion of arachidonic acid into prostaglandins. 6-ROX is often used in the field of optical imaging related to tumors and inflammation, and helps detect diseased tissues with high expression of COX-2  .
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                            - 
                                
                                    - HY-161266
 
                                    - 
                                        
                                    
 
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                            - 
                                
                                    - HY-100516R
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                     UR-8880 (Standard) 
                                                 | 
                                                
                                                    
                                                        Reference Standards
                                                    
                                                        COX
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Cimicoxib (Standard) is the analytical standard of Cimicoxib. This product is intended for research and analytical applications. Cimicoxib (CX) is an orally active potent and selective COX-2 (cyclo-oxygenase-2) inhibitor. Cimicoxib exhibits promising anti-inflammatory and analgesic activity. The PK parameters of Cimicoxib in dogs given precise (2 mg/kg) and approximate doses (1.95-2.5 mg/kg) are similar .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-15038
 
                                    - 
                                        
                                            
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                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                        Apoptosis
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                        Cancer
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
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                            - 
                                
                                    - HY-15036
 
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                                                            Diclofenac
                                                            
                                                        
                                                        
                                                            
                                                                
                                                                    Maximum Cited Publications 
                                                                    18 Publications Verification 
                                                                
                                                                
                                                                
                                                             
                                                        
                                                     
                                                    
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                                                        COX
                                                    
                                                        Apoptosis
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                        Cancer
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
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                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-147692
 
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                                                        COX
                                                    
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                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice .
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                            - 
                                
                                    - HY-15037
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                     GP 45840 
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                        Apoptosis
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                        Cancer
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
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                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-15036A
 
                                    - 
                                        
                                            
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                                                        COX
                                                    
                                                        Apoptosis
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                        Cancer
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
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                            - 
                                
                                    - HY-N0920
 
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                                                | 
                                                    
                                                     7,8-DihydrokawaIN;  7,8-DihydrokavaIN;  MarINdININ 
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                        Cytochrome P450
                                                    
                                                 | 
                                                
                                                    
                                                        Neurological Disease
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Dihydrokavain (7,8-Dihydrokawain) is a natural kavalactone compound. Dihydrokavain inhibits COX-1, COX-2, CYP2C9 (IC50 = 130.95 μM), CYP2C19 (IC50 = 10.05 μM) and CYP3A4 (IC50 = 78.59 μM). Dihydrokavain  reduces TNFα secretion. Dihydrokavain shows analgesic and anxiolytic effects     .
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                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-W007539
 
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                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        Endogenous Metabolite
                                                    
                                                        Drug Intermediate
                                                    
                                                        NO Synthase
                                                    
                                                        Reactive Oxygen Species (ROS)
                                                    
                                                        COX
                                                    
                                                 | 
                                                
                                                    
                                                        Metabolic Disease
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    2,4-Dihydroxybenzaldehyde is an endogenous metabolite. 2,4-Dihydroxybenzaldehyde is a pharmaceutical intermediate that can be used to synthesize various Schiff base compounds. 2,4-Dihydroxybenzaldehyde exhibits significant anti angiogenic, anti-inflammatory, and analgesic activities. 2,4-Dihydroxybenzaldehyde reduces the production of NO and ROS by inhibiting the expression of iNOS and COX-2. 2,4-Dihydroxybenzaldehyde is commonly used in the study of inflammatory conditions  .
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                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-115866
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                 | 
                                                
                                                    
                                                        Cancer
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    COX-2-IN-6 (compound 10) is an orally active, gut-restricted and selective cyclooxygenase-2 (COX-2) inhibitor for colorectal Chemoprevention of cancer. COX-2-IN-6 selectively targets COX-2 with an IC50 of 0.84 μM and a Ki of 69 nM. COX-2-IN-6 also inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM .
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                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-15036S
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        Isotope-Labeled Compounds
                                                    
                                                        COX
                                                    
                                                        Apoptosis
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Diclofenac-d4 is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-15037S
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        Isotope-Labeled Compounds
                                                    
                                                        COX
                                                    
                                                        Apoptosis
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Diclofenac- 13C6 (sodium heminonahydrate) is the  13C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-15036R
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        Reference Standards
                                                    
                                                        COX
                                                    
                                                        Apoptosis
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                        Cancer
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Diclofenac (Standard) is the analytical standard of Diclofenac. This product is intended for research and analytical applications. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-15037R
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                     GP 45840 (Standard) 
                                                 | 
                                                
                                                    
                                                        Reference Standards
                                                    
                                                        COX
                                                    
                                                        Apoptosis
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                        Cancer
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Diclofenac (Sodium) (Standard) is the analytical standard of Diclofenac (Sodium). This product is intended for research and analytical applications. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-15037S1
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                        Apoptosis
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Diclofenac-d4 (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-15038R
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        Reference Standards
                                                    
                                                        COX
                                                    
                                                        Apoptosis
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                        Cancer
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Diclofenac (potassium) (Standard) is the analytical standard of Diclofenac (potassium). This product is intended for research and analytical applications. Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-N0920R
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                     7,8-DihydrokawaIN (Standard); 7,8-DihydrokavaIN (Standard); MarINdININ (Standard) 
                                                 | 
                                                
                                                    
                                                        Reference Standards
                                                    
                                                        COX
                                                    
                                                        Cytochrome P450
                                                    
                                                 | 
                                                
                                                    
                                                        Neurological Disease
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Dihydrokavain (Standard) (7,8-Dihydrokawain (Standard)) is the analytical standard of Dihydrokavain (HY-N0920). This product is intended for research and analytical applications. Dihydrokavain is a natural kavalactone compound. Dihydrokavain inhibits COX-1, COX-2, CYP2C9 (IC50 = 130.95 μM), CYP2C19 (IC50 = 10.05 μM) and CYP3A4 (IC50 = 78.59 μM). Dihydrokavain reduces TNFα secretion. Dihydrokavain shows analgesic and anxiolytic effects.
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-15036AR
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        Reference Standards
                                                    
                                                        COX
                                                    
                                                        Apoptosis
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                        Cancer
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Diclofenac (diethylamine) (Standard) is the analytical standard of Diclofenac (diethylamine). This product is intended for research and analytical applications. Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-W007539R
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        Reference Standards
                                                    
                                                        Endogenous Metabolite
                                                    
                                                        Drug Intermediate
                                                    
                                                        NO Synthase
                                                    
                                                        Reactive Oxygen Species (ROS)
                                                    
                                                        COX
                                                    
                                                 | 
                                                
                                                    
                                                        Metabolic Disease
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    2,4-Dihydroxybenzaldehyde (Standard) is the analytical standard of 2,4-Dihydroxybenzaldehyde. This product is intended for research and analytical applications. 2,4-Dihydroxybenzaldehyde is an endogenous metabolite. 2,4-Dihydroxybenzaldehyde is a pharmaceutical intermediate that can be used to synthesize various Schiff base compounds. 2,4-Dihydroxybenzaldehyde exhibits significant anti angiogenic, anti-inflammatory, and analgesic activities. 2,4-Dihydroxybenzaldehyde reduces the production of NO and ROS by inhibiting the expression of iNOS and COX-2. 2,4-Dihydroxybenzaldehyde is commonly used in the study of inflammatory conditions  .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-175637
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                        MyD88
                                                    
                                                 | 
                                                
                                                    
                                                        Neurological Disease
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    COX-2-IN-57 is an orally active COX-2 inhibitor with an IC50 value of 0.02 μM. COX-2-IN-57 reduces MyD88 expression and decreases serum levels of COX-2, PGE2, and COX-1 in Cisplatin (HY-17394)/radiation-induced neuropathy rat model. COX-2-IN-57 demonstrates superior antinociceptive efficacy in hot plate, cold allodynia, and Randall-Selitto tests, along with hepato-/renal protection. COX-2-IN-57 can be used for the study of inflammation .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-N7064
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        Pyruvate Kinase
                                                    
                                                        COX
                                                    
                                                        STAT
                                                    
                                                        TNF Receptor
                                                    
                                                        NO Synthase
                                                    
                                                        Interleukin Related
                                                    
                                                        HIF/HIF Prolyl-Hydroxylase
                                                    
                                                 | 
                                                
                                                    
                                                        Cardiovascular Disease
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases  .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-W753956
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                        Isotope-Labeled Compounds
                                                    
                                                        Interleukin Related
                                                    
                                                        Pyruvate Kinase
                                                    
                                                        COX
                                                    
                                                        STAT
                                                    
                                                        TNF Receptor
                                                    
                                                        HIF/HIF Prolyl-Hydroxylase
                                                    
                                                        NO Synthase
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Iminostilbene-d10 is the deuterium labeled Iminostilbene (HY-N7064). Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases  .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-116115
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                     17-Oxo-DPA;  17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA 
                                                 | 
                                                
                                                    
                                                        NF-κB
                                                    
                                                        PPAR
                                                    
                                                 | 
                                                
                                                    
                                                        Inflammation/Immunology
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid (17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA) is an electrophilic oxo-derivative (EFOX) of the docosahexaenoic acid (DHA) (HY-B2167). 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is generated during inflammation by COX-2-catalyzed mechanism in activated macrophages. 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid acts as an agonist for PPARγ and a modulator for NF-κB signaling pathway, inhibits the production of pro-inflammatory cytokines and nitric oxide, and exhibits anti-inflammatory efficacy .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                        
                    
                 
            
            
            
            
            
                
                    
                        
                            | Cat. No. | 
                            Product Name | 
                            Type | 
                        
                    
                    
                        
                            
                            - 
                                
                                    - HY-D0053
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                     6-Carboxy-X-rhodamINe 
                                                 | 
                                                
                                                    
                                                    
                                                        
                                                            
                                                            
                                                                Oligonucleotide Labeling
                                                            
                                                        
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    6-ROX is a selective fluorescent probe and potential inhibitor of COX-2. 6-ROX binds to the active site of COX-2 and inhibits its conversion of arachidonic acid into prostaglandins. 6-ROX is often used in the field of optical imaging related to tumors and inflammation, and helps detect diseased tissues with high expression of COX-2  .
                                                 | 
                                            
                                        
                                     
                                
                             
                        
                        
                    
                 
            
            
            
            
            
            
            
            
            
            
            
                
                    
                        
                            | Cat. No. | 
                            Product Name | 
                            Category | 
                            Target | 
                            Chemical Structure | 
                        
                    
                    
                        
                            
                            - 
                                
                                    - HY-N0920
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                     7,8-DihydrokawaIN;  7,8-DihydrokavaIN;  MarINdININ 
                                                 | 
                                                
                                                    
                                                    
                                                        
                                                            
                                                                Natural Products
                                                            
                                                            
                                                        
                                                            
                                                            
                                                                other families
                                                            
                                                        
                                                            
                                                            
                                                                Source classification
                                                            
                                                        
                                                            
                                                            
                                                                Plants
                                                            
                                                        
                                                    
                                                     
                                                        
                                                     
                                                 | 
                                                
                                                    
                                                        COX
                                                    
                                                        Cytochrome P450
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Dihydrokavain (7,8-Dihydrokawain) is a natural kavalactone compound. Dihydrokavain inhibits COX-1, COX-2, CYP2C9 (IC50 = 130.95 μM), CYP2C19 (IC50 = 10.05 μM) and CYP3A4 (IC50 = 78.59 μM). Dihydrokavain  reduces TNFα secretion. Dihydrokavain shows analgesic and anxiolytic effects     .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-W007539
 
                                    - 
                                        
                                    
 
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-N11880
 
                                    - 
                                        
                                    
 
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-N0920R
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                     7,8-DihydrokawaIN (Standard); 7,8-DihydrokavaIN (Standard); MarINdININ (Standard) 
                                                 | 
                                                
                                                    
                                                    
                                                        
                                                            
                                                                Natural Products
                                                            
                                                            
                                                        
                                                            
                                                            
                                                                other families
                                                            
                                                        
                                                            
                                                            
                                                                Source classification
                                                            
                                                        
                                                            
                                                            
                                                                Plants
                                                            
                                                        
                                                    
                                                     
                                                        
                                                     
                                                 | 
                                                
                                                    
                                                        Reference Standards
                                                    
                                                        COX
                                                    
                                                        Cytochrome P450
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Dihydrokavain (Standard) (7,8-Dihydrokawain (Standard)) is the analytical standard of Dihydrokavain (HY-N0920). This product is intended for research and analytical applications. Dihydrokavain is a natural kavalactone compound. Dihydrokavain inhibits COX-1, COX-2, CYP2C9 (IC50 = 130.95 μM), CYP2C19 (IC50 = 10.05 μM) and CYP3A4 (IC50 = 78.59 μM). Dihydrokavain reduces TNFα secretion. Dihydrokavain shows analgesic and anxiolytic effects.
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-W007539R
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                    
                                                 | 
                                                
                                                    
                                                    
                                                        
                                                            
                                                            
                                                                Monophenols
                                                            
                                                        
                                                            
                                                            
                                                                Ketones, Aldehydes, Acids
                                                            
                                                        
                                                            
                                                            
                                                                Source classification
                                                            
                                                        
                                                            
                                                            
                                                                Phenols
                                                            
                                                        
                                                            
                                                            
                                                                Polyphenols
                                                            
                                                        
                                                            
                                                            
                                                                Endogenous metabolite
                                                            
                                                        
                                                    
                                                     
                                                        
                                                     
                                                 | 
                                                
                                                    
                                                        Reference Standards
                                                    
                                                        Endogenous Metabolite
                                                    
                                                        Drug Intermediate
                                                    
                                                        NO Synthase
                                                    
                                                        Reactive Oxygen Species (ROS)
                                                    
                                                        COX
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    2,4-Dihydroxybenzaldehyde (Standard) is the analytical standard of 2,4-Dihydroxybenzaldehyde. This product is intended for research and analytical applications. 2,4-Dihydroxybenzaldehyde is an endogenous metabolite. 2,4-Dihydroxybenzaldehyde is a pharmaceutical intermediate that can be used to synthesize various Schiff base compounds. 2,4-Dihydroxybenzaldehyde exhibits significant anti angiogenic, anti-inflammatory, and analgesic activities. 2,4-Dihydroxybenzaldehyde reduces the production of NO and ROS by inhibiting the expression of iNOS and COX-2. 2,4-Dihydroxybenzaldehyde is commonly used in the study of inflammatory conditions  .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                        
                    
                 
            
            
            
            
            
                
                    
                        
                            | Cat. No. | 
                            Product Name | 
                            Chemical Structure | 
                        
                    
                    
                        
                            
                            - 
                                
                                    - HY-B0360S
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Rebamipide-d4 is deuterium labeled Rebamipide. Rebamipide is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-N0523S
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Gallic acid-d2 is the deuterium labeled Gallic acid . Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-15036S
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Diclofenac-d4 is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-15037S1
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Diclofenac-d4 (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-B0580S1
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Ketorolac-d4 (RS37619 D4) is the deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2  .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-15037S
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Diclofenac- 13C6 (sodium heminonahydrate) is the  13C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                            
                            - 
                                
                                    - HY-W753956
 
                                    - 
                                        
                                            
                                                | 
                                                    
                                                 | 
                                            
                                            
                                                | 
                                                    Iminostilbene-d10 is the deuterium labeled Iminostilbene (HY-N7064). Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases  .
                                                 | 
                                            
                                        
                                     
                                    - 
                                        
                                        
                                            
                                        
                                     
                                
                             
                        
                        
                    
                 
            
            
            
            
            
                
                
         
        
        
        
        
        
        
            
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