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Results for "

Bc1

" in MedChemExpress (MCE) Product Catalog:

40

Inhibitors & Agonists

7

Natural
Products

1

Recombinant Proteins

4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-162066
    DNDI-6174

    		Parasite Infection
    DNDI-6174 is a cytochrome bc1 complex inhibitor with potent in vitro activity against a variety of Leishmania species. DNDI-6174 can reduce parasite burden in animal models of infection [1].
    DNDI-6174
  • HY-13832
    Atovaquone
    4 Publications Verification

    Atavaquone

    		 Parasite Cytochrome P450 Antibiotic Bacterial Infection Cancer
    Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and  P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia [1] .
    Atovaquone
  • HY-169987
    bc1 Complex-IN-1

    		Fungal Infection
    bc1 Complex-IN-1 (compound 12g) is a potent bc1 complex inhibitor. bc1 Complex-IN-1 shows fungicidal properties against Cucumber downy mildew (CDM) [1].
    bc1 Complex-IN-1
  • HY-117424
    Inz-4

    		Fungal Infection
    Inz-4 is a fungal-selective inhibitor of mitochondrial cytochrome bc1, with the IC50 of 0.026 μM [1].
    Inz-4
  • HY-W715444
    Mucidin

    		Antibiotic Fungal Mitochondrial Metabolism Infection
    Mucidin is an antifungal antibiotic that inhibits electron-transfer reactions in the cytochrome bc1 complex of the mitochondrial respiratory chain [1].
    Mucidin
  • HY-168656
    Ac-Atovaquone

    		Parasite Infection
    Ac-Atovaquone is a potent cytochrome bc1 inhibitor and also is an ester-linked acetyl derivative of atovaquone (HY-13832). Ac-Atovaquone has the potential for the research of malaria [1] [1] .
    Ac-Atovaquone
  • HY-W714076
    Ametoctradin

    		Fungal Infection Inflammation/Immunology
    Ametoctradin is a potent Qo site inhibitor of bc1 complex in mitochondrial respiration. Ametoctradin is a highly selective and effective Oomycete-specific fungicide that can be used against late blight and downy mildews [1].
    Ametoctradin
  • HY-W714076R
    Ametoctradin (Standard)

    		Reference Standards Fungal Infection Inflammation/Immunology
    Ametoctradin (Standard) is the analytical standard of Ametoctradin. This product is intended for research and analytical applications. Ametoctradin is a potent Qo site inhibitor of bc1 complex in mitochondrial respiration. Ametoctradin is a highly selective and effective Oomycete-specific fungicide that can be used against late blight and downy mildews [1].
    Ametoctradin (Standard)
  • HY-156137
    UHDBT

    		Biochemical Assay Reagents Others
    UHDBT is a cytochrome bc1 complex Qo site inhibitor. UHDBT can be used for electron transfer research [1].
    UHDBT
  • HY-13834
    GW844520

    		Parasite Cytochrome P450 Infection
    GW844520 is an orally active inhibitor of cytochrome bc1 complex. GW844520 can be used in malaria and anti-plasmodium related research [1].
    GW844520
  • HY-13832S2
    Atovaquone-d5

    Atavaquone-d5

    		 Isotope-Labeled Compounds Parasite Cytochrome P450 Antibiotic Infection
    Atovaquone-d5 is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome?bc1?complex. Atovaquone is against human and ?P. falciparum?cytochrome?bc1?activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia [1] .
    Atovaquone-d5
  • HY-121214
    Amisulbrom

    		Fungal Mitochondrial Metabolism Infection
    Amisulbrom is a sulfonamide fungicide used to control oomycete diseases. Amisulbrom inhibits the cytochrome-bc1 complex of the mitochondrial electron transport system.
    Amisulbrom
  • HY-13832S3
    cis-Atovaquone-d4

    cis-Atavaquone-d4

    		 Isotope-Labeled Compounds Parasite Cytochrome P450 Antibiotic Infection
    cis-Atovaquone-d4 is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and  P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].
    cis-Atovaquone-d4
  • HY-121721
    Inz-5

    		Fungal Infection
    Inz-5 is a fungal-selective mitochondrial cytochrome bc1 inhibitor. Inz-5 impairs fungal virulence and prevents the evolution of agent resistance [1].
    Inz-5
  • HY-13832R
    Atovaquone (Standard)

    Atavaquone (Standard)

    		 Reference Standards Parasite Cytochrome P450 Antibiotic Bacterial Infection Cancer
    Atovaquone (Standard) is the analytical standard of Atovaquone. This product is intended for research and analytical applications. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and  P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia [1] .
    Atovaquone (Standard)
  • HY-13836
    ELQ-300

    		Parasite Infection
    ELQ-300 is a potent and orally bioavailable antimalarial agent, acts as an inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (cyt bc1). ELQ-300 inhibits growth of P. falciparum Dd2, Tm90-C2B, and D1 with IC50 values of 6.6, 4.6 and 160 nM, respectively. ELQ-300 can be used for the research of antimalarial [1] .
    ELQ-300
  • HY-112177
    Myxothiazol

    		Fungal Mitochondrial Metabolism Antibiotic Infection
    Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml [1] .
    Myxothiazol
  • HY-172349
    JNJ-2901

    		Bacterial Infection
    JNJ-2901 is an inhibitor of M. tuberculosis cytochrome bc1:aa3. JNJ-2901 reduces bacterial load in the acute/chronic mouse infection models of M. tuberculosis H37Rv-ΔcydAB. JNJ-2901 can be used in tuberculosis (TB) research [1].
    JNJ-2901
  • HY-121214R
    Amisulbrom (Standard)

    		Reference Standards Mitochondrial Metabolism Fungal Infection
    Amisulbrom (Standard) is the analytical standard of Amisulbrom (HY-121214). This product is intended for research and analytical applications. Amisulbrom is a sulfonamide fungicide used to control oomycete diseases. Amisulbrom inhibits the cytochrome-bc1 complex of the mitochondrial electron transport system.
    Amisulbrom (Standard)
  • HY-125776
    Kresoxim-methyl

    BAS 490 F

    		 Fungal Mitochondrial Metabolism Infection
    Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme [1] .
    Kresoxim-methyl
  • HY-N14038
    Crocacin A

    		Fungal Infection
    Crocacin A has anti-yeast and filamentous fungal activity. Crocacin A can inhibit mouse fibroblasts L929. In the microsomes of the calf's heart, Crocacin A can interrupt the bc1 segment of electronic transmission, causes redshift of 569 nm peak in cytochrome B reduction spectrum [1].
    Crocacin A
  • HY-121248
    Hydramethylnon

    AC217300

    		 Mitochondrial Metabolism Infection
    Hydramethylnon (AC217300) is an amidinohydrazone insecticide. Hydramethylnon's mechanism of action is through inhibition of mitochondrial respiration by inhibiting the electron transport chain at the cytochrome b-c1 complex. Hydramethylnon can be used to eliminate red imported fire ants, cockroaches, and other insects [1].
    Hydramethylnon
  • HY-174342
    ELQ-453

    		Cytochrome P450 Parasite Infection
    ELQ-453 is an inhibitor targeting the Qo site of the Plasmodium falciparum cytochrome bc1 complex (CytB) with an IC50 value of 0.57 nM. ELQ-453 blocks the mitochondrial function of the parasite, and suppresses Plasmodium infection in mosquitoes. ELQ-453 is promising for research of malaria [1].
    ELQ-453
  • HY-N14043
    Crocacin C

    		Fungal Infection
    Crocacin C has anti-yeast and filamentous fungal activity. Crocacin C can inhibit mouse fibroblasts L929. In the microsomes of the calf's heart, Crocacin C can interrupt the bc1 segment of electronic transmission, causes redshift of 569 nm peak in cytochrome B reduction spectrum [1].
    Crocacin C
  • HY-N14044
    Crocacin D

    		Fungal Infection
    Crocacin D has anti-yeast and filamentous fungal activity. Crocacin D can inhibit mouse fibroblasts L929. In the microsomes of the calf's heart, Crocacin D can interrupt the bc1 segment of electronic transmission, causes redshift of 569 nm peak in cytochrome B reduction spectrum [1].
    Crocacin D
  • HY-B0849
    Azoxystrobin
    1 Publications Verification

    		 Fungal Reactive Oxygen Species (ROS) Apoptosis Bacterial Phosphatase Infection
    Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis [1] .
    Azoxystrobin
  • HY-N14040
    Crocacin B

    		Fungal Infection
    Crocacin B has anti-yeast and filamentous fungal activity. Crocacin B can inhibit mouse fibroblasts L929. In the microsomes of the calf's heart, Crocacin B can interrupt the bc1 segment of electronic transmission, causes redshift of 569 nm peak in cytochrome B reduction spectrum [1].
    Crocacin B
  • HY-N8540
    Ilicicolin H

    		Phosphoglycerate Kinase (PGK) Fungal Apoptosis Infection Cancer
    Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC50 = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC50 = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with KD of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection [1] .
    Ilicicolin H
  • HY-B0849S
    Azoxystrobin-d4

    		Isotope-Labeled Compounds Fungal Reactive Oxygen Species (ROS) Apoptosis Infection
    Azoxystrobin-d4 is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.
    Azoxystrobin-d4
  • HY-B0849S1
    Azoxystrobin-d3

    		Isotope-Labeled Compounds Fungal Reactive Oxygen Species (ROS) Apoptosis Infection
    Azoxystrobin-d3 is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis [1].
    Azoxystrobin-d3
  • HY-B0849A
    (Z)-Azoxystrobin

    		Fungal Reactive Oxygen Species (ROS) Apoptosis Bacterial Phosphatase Infection
    (Z)-Azoxystrobin is an enantiomer of Azoxystrobin. Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis [1] .
    (Z)-Azoxystrobin
  • HY-B0849R
    Azoxystrobin (Standard)

    		Reference Standards Fungal Reactive Oxygen Species (ROS) Apoptosis Infection
    Azoxystrobin (Standard) is the analytical standard of Azoxystrobin. This product is intended for research and analytical applications. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.
    Azoxystrobin (Standard)
  • HY-126640
    Phomoxanthone A

    		Parasite Infection Cancer
    Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC50 is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC50 is 0.99, 0.51 and 1.4 µg/mL, respectively [1].
    Phomoxanthone A
  • HY-116686
    Inz-1

    		Cytochrome P450 Fungal Infection
    Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans [1].
    Inz-1
  • HY-125776R
    Kresoxim-methyl (Standard)

    BAS 490 F (Standard)

    		 Reference Standards Fungal Mitochondrial Metabolism Infection
    Kresoxim-methyl (Standard) is the analytical standard of Kresoxim-methyl. This product is intended for research and analytical applications. Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme [1] .
    Kresoxim-methyl (Standard)
  • HY-19877
    GSK932121

    		Parasite Infection
    GSK932121 is an antimalarial drug with activity that inhibits the electron transport chain of P. falciparum. GSK932121 acts selectively on this pathogen at the level of cytochrome bc1 (complex III). The synthesis method of GSK932121 is highly efficient, and the final structure can be obtained in only 5 steps. The synthesis of GSK932121 can be prepared atKilog scale to support clinical studies [1].
    GSK932121
  • HY-B1036
    Decoquinate

    		Parasite Infection
    Decoquinate is an orally active, selective inhibitor of the mitochondrial bc1 complex, targeting Eimeria spp. sporozoites and first generation schizonts, and Plasmodium spp. Decoquinate inhibits electron transfer by competitively binding to the mitochondrial cytochrome b system, blocking the parasite's energy metabolism, thereby inhibiting its development and reproduction. Decoquinate has significant anticoccidial activity, preventing intestinal damage and improving host growth performance, and also has inhibitory effects on the liver and blood stages of Plasmodium. Decoquinate is mainly used in veterinary research to prevent and treat coccidiosis in ruminants and poultry [1] .
    Decoquinate
  • HY-156136
    5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole

    		Biochemical Assay Reagents Others
    5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole is a competitive Qo site inhibitor of the cytochrome bc 1 complex (cytochrome c oxidoreductase) from Saccharomyces cerevisiae [1].
    5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole
  • HY-151556
    Antifungal agent 45

    		Fungal Infection
    Antifungal agent 45 is with fungicidal activities. Antifungal agent 45 shows excellent characteristics superior to Kresoxim-methyl (HY-125776), in which the activity enhancement against Phytophthora capsici was the most remarkable, with an EC50 value of about 5 μM [1].
    Antifungal agent 45
  • HY-163483
    ELQ-598

    		Parasite Others
    ELQ-598, as a prodrug, is converted into the active drug ELQ-596 upon oral administration. ELQ-598 demonstrates potent parasitic growth inhibition capabilities (IC50= 37 nM). ELQ-598 also shows low toxicity towards human cells (IC50= 19 μM). ELQ-598 can be used for research into babesiosis [1].
    ELQ-598

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