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Bactericidal effect

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (13) Bacterial (22) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Fungal (3) Interleukin Related (1) Isotope-Labeled Compounds (1) OAT (1) Oct3/4 (1) Reference Standards (7) ROS Kinase (1) Succinate Dehydrogenase (1) TGF-β Receptor (1) TNF Receptor (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (26) Inflammation/Immunology (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7066

Difloxacin hydrochloride	Bacterial Antibiotic	Infection
Difloxacin hydrochloride is a broad-spectrum antibacterial agent. Difloxacin hydrochloride inhibits bacterial DNA gyrase and exhibits a concentration-dependant bactericidal effect by interference with the activity of DNA gyrase and topoisomerase IV .

HY-133825

Cyazofamid IKF-916	Oct3/4 OAT	Infection
Cyazofamid exerts its bactericidal effect by impairing ATP production. Cyazofamid inhibits organic cation transporter 3 (OCT3) and OAT1, with IC₅₀ values of 1.54 and 17.3 μM, respectively .

HY-W753375

Fluindapyr	Fungal Succinate Dehydrogenase	Infection
Fluindapyr is a broad-spectrum pyrazolamide chiral fungicide of succinate dehydrogenase inhibitor (SDHIs) with broad bactericidal spectrum and good efficacy. Fluopimomide is effective against M. incognita in vitro and application of fuopimomide shows some growth promotion effect in cucumber .

HY-106575

Nifurzide	Bacterial	Infection
Nifurzide, a nitrofuran derivative, is used as an intestinal antiinfectious agent. Nifurzide shows strong bactericidal effect .

HY-18999

4-epi-Chlortetracycline hydrochloride	Antibiotic	Infection
4-epi-Chlortetracycline hydrochloride is an epimetabolite of Chlortetracycline hydrochloride. Chlortetracycline hydrochloride is an orally active, potent and selective inhibitor of methanogenic bacteria with bactericidal effect .

HY-123175

Chinfloxacin	Bacterial	Others
Chinfloxacin is a compound with antibacterial activity. It is active against a variety of clinical isolates in vitro. Its antibacterial activity is similar to that of moxifloxacin, and it has a bactericidal effect in a concentration-dependent manner.

HY-152495

MenA-IN-1	Bacterial	Infection
MenA IN-1 is an effective inhibitor of 1,4-dihydroxy-2-naphthoate isoprenyltransferase (MenA) from Mycobacterium tuberculosis (MTB) with an IC₅₀ value of 13 µM and an GIC₅₀ value of 8 µM. MenA IN-1 can be used to curb the continuous spread of tuberculosis .

HY-170488

CM-728	ROS Kinase Bacterial	Infection Cancer
CM-728 is a oxazepine-naphthoquinone that has cytotoxic and bactericidal effect. CM-728 is a human peroxiredoxin-1 inhibitor. CM-728 is an oxidative stressor that affects mitochondrial function .

HY-106668

Isepamicin Sch 21420	Antibiotic Bacterial	Infection
Isepamicin (Sch 21420) is an aminoglycoside antibacterial. Isepamicin has better activity against strains producing type I 6'-acetyltransferase. Isepamicin’s antibacterial spectrum includes Enterobacteriaceae and staphylococci. Anaerobes, Neisseriaceae and streptococci are resistant. Isepamicin exhibits a strong concentration-dependent bactericidal effect, a long post-antibiotic effect (several hours) and induces adaptive resistance .

HY-124408

Mepronil	Fungal	Infection
Mepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection .

HY-N7066R

Difloxacin hydrochloride (Standard)	Reference Standards Bacterial Antibiotic	Infection
Difloxacin (hydrochloride) (Standard) is the analytical standard of Difloxacin (hydrochloride). This product is intended for research and analytical applications. Difloxacin hydrochloride is a broad-spectrum antibacterial agent. Difloxacin hydrochloride inhibits bacterial DNA gyrase and exhibits a concentration-dependant bactericidal effect by interference with the activity of DNA gyrase and topoisomerase IV .

HY-12903R

Macozinone (Standard) PBTZ169 (Standard)	Reference Standards Bacterial Antibiotic	Infection
Macozinone (Standard) is the analytical standard of Macozinone. This product is intended for research and analytical applications. Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect[1][2].

HY-N0666BR

Aspartic acid calcium (Standard) Calcium L-aspartate (Standard)	Reference Standards Endogenous Metabolite	Cardiovascular Disease
4-epi-Chlortetracycline (hydrochloride) (Standard) is the analytical standard of 4-epi-Chlortetracycline (hydrochloride). This product is intended for research and analytical applications. 4-epi-Chlortetracycline hydrochloride is an epimetabolite of Chlortetracycline hydrochloride. Chlortetracycline hydrochloride is an orally active, potent and selective inhibitor of methanogenic bacteria with bactericidal effect .

HY-18999R

4-epi-Chlortetracycline hydrochloride (Standard)	Reference Standards Antibiotic	Infection
4-epi-Chlortetracycline (hydrochloride) (Standard) is the analytical standard of 4-epi-Chlortetracycline (hydrochloride). This product is intended for research and analytical applications. 4-epi-Chlortetracycline hydrochloride is an epimetabolite of Chlortetracycline hydrochloride. Chlortetracycline hydrochloride is an orally active, potent and selective inhibitor of methanogenic bacteria with bactericidal effect .

HY-12903

Macozinone 4 Publications Verification PBTZ169	Bacterial Antibiotic	Infection
Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect .

HY-120777

GSK729	Bacterial	Others
GSK729 is a THPP inhibitor with the activity of inhibiting EchA6 and inhibiting Mycobacterium tuberculosis. GSK729 can selectively pull down EchA6 in a stereospecific manner, inhibit its activity, inhibit fatty acid synthesis of Mycobacterium tuberculosis, and has a bactericidal effect in a mouse chronic tuberculosis infection model.

HY-124408R

Mepronil (Standard)	Reference Standards Fungal	Infection
Mepronil (Standard) is the analytical standard of Mepronil. This product is intended for research and analytical applications. Mepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection .

HY-B0276A

Ethionamide hydrochloride 2-Ethylthioisonicotinamide hydrochloride	Bacterial	Infection
Ethionamide hydrochloride (2-Ethylthioisonicotinamide hydrochloride) is an antituberculosis drug with mycobacterial activity. Ethionamide hydrochloride interferes with the bacterial cell wall synthesis process by inhibiting the synthesis of fatty acids in the bacterial cell wall. Ethionamide hydrochloride may have bacteriostatic or bactericidal effects, depending on the concentration of the drug at the site of infection and the susceptibility of the associated microorganisms. Ethionamide hydrochloride combines with NAD+ to form an adduct, thereby exerting its antibacterial effect .

HY-B0330D

(R)-Ofloxacin Dextrofloxacin	Bacterial Antibiotic	Infection
(R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .

HY-19750

TBA-7371 1 Publications Verification	Bacterial	Infection
TBA-7371 is an orally active and non-covalent inhibitor of Decaprenylphosphoryl-β-D-ribose oxidase (DprE1) of Mycobacterium tuberculosis (MIC=0.64 μg/mL). TBA-7371 can block the synthesis of arabinose in the bacterial cell wall, resulting in cell wall structural defects, thereby exerting an anti-tuberculosis effect. TBA-7371 can be used in the research of anti-tuberculosis drugs and has a synergistic bactericidal effect with Bedaquiline (HY-14881) and other drugs .

HY-125785A

2-Mercaptopyridine N-oxide sodium	Bacterial	Infection
2-Mercaptopyridine N-oxide sodium has *bactericidal* effect and is against a standard strain of Mycobacterium tuberculosis H37Rv (ATCC 27294) with MIC₉₀ of 7.20 μM. 2-Mercaptopyridine N-oxide sodium and its complex with iron, gallium, and bismuth have good anti-M. tuberculosis activity. 2-Mercaptopyridine N-oxide sodium has potential for the treatment of tuberculosis .

HY-B0330DS

(R)-Ofloxacin-d3	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
(R)-Ofloxacin-d₃ is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .

HY-155060

Antibacterial agent 144	Bacterial DNA/RNA Synthesis	Infection
Antibacterial agent 144 (compound 8e) is an antibacterial agent，with better effect against multi-resistant Staphylococcus aureus than Chloromycin and Amoxicillin (HY-B0467A). Antibacterial agent 144 destroys the cytoplasmic membrane of bacteria，and inhibits the biofilms formation. Antibacterial agent 144 binds to HSA (Kd=13.2 μM)，and exerts bactericidal efficacy. Antibacterial agent 144 also binds with DNA to for supramolecular complex to obstruct DNA replications .

HY-P1068

Lysozyme Maximum Cited Publications 8 Publications Verification Muramidase	Bacterial TNF Receptor Interleukin Related TGF-β Receptor	Infection Inflammation/Immunology
Lysozyme (Muramidase) is a conserved antimicrobial protein. Lysozyme exerts its bactericidal effect by hydrolyzing bacterial cell wall peptidoglycan (PG). Lysozyme plays an important role in limiting bacterial growth on mucosal surfaces and other sites, not only controlling potential pathogens but also limiting overgrowth of microbiota to prevent dysbiosis. Extracellular lysozyme can also degrade polymeric PG into soluble fragments, activate NOD receptors in mucosal epithelial cells, and lead to the secretion of chemokines and activating factors by neutrophils and macrophages .

HY-B0330DR

(R)-Ofloxacin (Standard) Dextrofloxacin (Standard)	Reference Standards Bacterial Antibiotic	Infection
(R)-Ofloxacin (Standard) is the analytical standard of (R)-Ofloxacin (HY-B0330D). (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .

HY-B1831

Oritavancin LY 333328; Orbactiv	Antibiotic Bacterial	Infection Inflammation/Immunology
Oritavancin (LY 333328), a semisynthetic derivative of Vancomycin (HY-B0671), is an orally active glycopeptide antibiotic with *bactericidal* activity against gram-positive organisms. Oritavancin shows antibacterial effect against B. anthracis, such as Ames strain with a MIC value of 0.015 g/mL. Oritavancin inhibits cell wall synthesis and disrupts the membrane potential. Oritavancin inhibits ArlS kinase activity thereby interfering the signal transduction. Oritavancin enters cells by adsorptive endocytosis, which drives it to lysosomes, where it exerts antibiotic activity .

HY-B1831A

Oritavancin diphosphate 2 Publications Verification LY333328 diphosphate	Bacterial Antibiotic	Infection Inflammation/Immunology
Oritavancin diphosphate (LY333328 diphosphate), a semisynthetic derivative of Vancomycin (HY-B0671), is an orally active glycopeptide antibiotic with *bactericidal* activity against gram-positive organisms. Oritavancin diphosphate shows antibacterial effect against B. anthracis, such as Ames strain with a MIC value of 0.015 g/mL. Oritavancin diphosphate inhibits cell wall synthesis and disrupts the membrane potential. Oritavancin diphosphate inhibits ArlS kinase activity thereby interfering the signal transduction. Oritavancin diphosphate enters cells by adsorptive endocytosis, which drives it to lysosomes, where it exerts antibiotic activity .

HY-B1831AR

Oritavancin diphosphate (Standard) LY333328 diphosphate (Standard)	Reference Standards Bacterial Antibiotic	Infection Inflammation/Immunology
Oritavancin (diphosphate) (Standard) is the analytical standard of Oritavancin (diphosphate). Oritavancin diphosphate (Standard), a semisynthetic derivative of Vancomycin (HY-B0671), is an orally active glycopeptide antibiotic with *bactericidal* activity against gram-positive organisms. Oritavancin diphosphate (Standard) shows antibacterial effect against B. anthracis, such as Ames strain with a MIC value of 0.015 g/mL. Oritavancin diphosphate (Standard) inhibits cell wall synthesis and disrupts the membrane potential. Oritavancin diphosphate (Standard) inhibits ArlS kinase activity thereby interfering the signal transduction. Oritavancin diphosphate (Standard) enters cells by adsorptive endocytosis, which drives it to lysosomes, where it exerts antibiotic activity .

HY-173054

FtsZ-IN-12	Bacterial	Infection
FtsZ-IN-12 (Compound 16e) is the inhibitor for filamentous temperature-sensitive mutant Z (FtsZ) that promotes the polymerization of FtsZ protein, inhibits its GTPase activity, thereby interfering with bacterial cell division process. FtsZ-IN-12 exhibits boardspectrum antibacterial activity that inhibits B. subtilis ATCC9372, B. pumilus CMCC63202, S. aureus ATCC25923, E. coli BW25113 and A. baumannii ATCC19606 with MIC of 0.062-1 μg/mL. FtsZ-IN-12 inhibits the formation of bacterial biofilms and exhibits a clearing effect on mature biofilms. FtsZ-IN-12 exhibits bactericidal activity without hemolytic toxicity to mammalian red blood cells (15 mg/kg) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0666BR

Aspartic acid calcium (Standard) Calcium L-aspartate (Standard)	Structural Classification Microorganisms other families Animals Source classification Amino acids Plants	Reference Standards Endogenous Metabolite
4-epi-Chlortetracycline (hydrochloride) (Standard) is the analytical standard of 4-epi-Chlortetracycline (hydrochloride). This product is intended for research and analytical applications. 4-epi-Chlortetracycline hydrochloride is an epimetabolite of Chlortetracycline hydrochloride. Chlortetracycline hydrochloride is an orally active, potent and selective inhibitor of methanogenic bacteria with bactericidal effect .

Cat. No.	Product Name	Chemical Structure

HY-B0330DS

(R)-Ofloxacin-d3
(R)-Ofloxacin-d₃ is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .

(R)-Ofloxacin-d3

(R)-Ofloxacin-d₃ is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .

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