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Antifolate agent1

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-133887
    Methotrexate α-tert-butyl ester

    		Antifolate DNA/RNA Synthesis Cancer
    Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent .
    Methotrexate α-tert-butyl ester
  • HY-175428
    Antifolate agent 1

    		Antifolate Cancer
    Antifolate agent 1 (Compound 1) is an antifolate agent with one-carbon bridge. Antifolate agent 1 lacks RFC transport and has no affinity for FRα and FRβ and no GARFTase inhibitory activity. Antifolate agent 1 can be used as a negative control for the development of folate receptor-targeting antifolates .
    Antifolate agent 1

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