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Anti-kinetoplastid

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-175305
    DMU759

    		Parasite Infection
    DMU759 is a Lysyl-tRNA synthetase 1 (KRS1) inhibitor. DMU759 has potent anti-kinetoplastid activity against Trypanosoma cruzi , Trypanosoma brucei and Leishmania donovani. DMU759 significantly reduces parasitemia in acute Chagas disease mice model. DMU759 can be used for parasitic infection like Chagas disease research .
    DMU759
  • HY-168619
    DNA crosslinker 6

    		Parasite Infection Cancer
    DNA crosslinker 6 (compound 1) is an anti-kinetoplastid compound. DNA crosslinker 6 has a strong ability to bind AT-DNA and can inhibit the binding of AT-hook 1 to DNA (IC50=0.03 µM). In addition, DNA crosslinker 6 also has antiprotozoal activity, with an EC50 value of 0.83 µM for the inhibition of T. brucei .
    DNA crosslinker 6

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