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Aldehyde dehydrogenases

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By Targets:	Aldehyde Dehydrogenase (ALDH) (31) Apoptosis (2) Cuproptosis (2) Drug Intermediate (1) Endogenous Metabolite (2) Fluorescent Dye (1) Interleukin Related (2) NF-κB (2) p38 MAPK (2) Parasite (2) Pyroptosis (2) Reference Standards (3)
By Research Areas:	Cancer (18) Cardiovascular Disease (3) Infection (3) Inflammation/Immunology (3) Metabolic Disease (11) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126003

ALDH1A1-IN-2	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH1A1-IN-2 is a potent inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1). Aldehyde dehydrogenases (ALDH) constitute a family of enzymes that play a critical role in oxidizing various cytotoxic xenogenic and biogenic aldehydes. ALDH1A1-IN-2 has the potential for the research of cancer, inflammation, or obesity (extracted from patent WO2019089626A1, compound 295) .

HY-76006

3-Hydroxybenzaldehyde M-HydroxybenzAldehyde	Aldehyde Dehydrogenase (ALDH) NF-κB p38 MAPK	Cardiovascular Disease Inflammation/Immunology
3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA) (HY-N0295). 3-Hydroxybenzaldehyde, produced by 3-hydroxybenzyl-alcohol dehydrogenase, is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans. 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo. 3-Hydroxybenzaldehyde is proming for research of atherosclerosis .

HY-135841

CM010	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease Cancer
CM010 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC₅₀s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM010 does not inhibit any of the other ALDH family members. CM010 can regulate metabolism and has anti-cancer activity .

HY-P2947

ALDH Aldehyde dehydrogenase (NAD(P))	Aldehyde Dehydrogenase (ALDH)	Others Cancer
ALDH (Aldehyde dehydrogenase (NAD(P))) catalyzes the oxidation of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H, is often used in biochemical studies. The ALDHs are one of many enzyme systems the body utilizes to alleviate aldehyde stress .

HY-121817

Sulfiram	Parasite Aldehyde Dehydrogenase (ALDH)	Infection
Sulfiram, an ectoparasiticide, is a weak aldehyde dehydrogenase (ALDH) inhibitor. Sulfiram can be used for the study of scabies .

HY-168985

Mirivadelgat	Aldehyde Dehydrogenase (ALDH)	Cancer
Mirivadelgat is an activator of aldehyde dehydrogenase 2 activator. Mirivadelgat is promising for research of interstitial lung disease-pulmonary hypertension and cancers .

HY-139005

BODIPY aminoacetaldehyde diethyl acetal BAAA-DA	Fluorescent Dye	Others
BODIPY aminoacetaldehyde diethyl acetal is a stable precursor to BODIPY-aminoacetaldehyde and can be converted into BODIPY-aminoacetaldehyde under acidic conditions. BODIPY-aminoacetaldehyde is a fluorescent substrate for aldehyde dehydrogenase (ALDH) .

HY-134917

Aldi-2	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease Cancer
Aldi-2 is a potent and specific covalent inhibitor of aldehyde dehydrogenases (ALDHs) with IC₅₀s of 2.5, 6.4 and 1.9 μM against ALDH1A1, ALDH2 and ALDH3A1, respectively. Aldi-2 can be utilized in cancer research .

HY-76006R

3-Hydroxybenzaldehyde (Standard) M-HydroxybenzAldehyde (Standard)	Reference Standards Aldehyde Dehydrogenase (ALDH) NF-κB p38 MAPK	Cardiovascular Disease Inflammation/Immunology
3-Hydroxybenzaldehyde (Standard) is the analytical standard of 3-Hydroxybenzaldehyde. This product is intended for research and analytical applications. 3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA) (HY-N0295). 3-Hydroxybenzaldehyde, produced by 3-hydroxybenzyl-alcohol dehydrogenase, is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans. 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo. 3-Hydroxybenzaldehyde is proming for research of atherosclerosis[1][2][3][4].

HY-113734

CM026	Aldehyde Dehydrogenase (ALDH)	Others
CM026 is a selective aldehyde dehydrogenase 1A1 inhibitor with submicromolar inhibitory activity against aldehyde dehydrogenase 1A1. Its inhibitory mechanism is related to binding to the aldehyde binding pocket and utilizing a unique glycine residue. It can be used as a chemical tool to study the role of this enzyme in disease.

HY-148617

ALDH2 modulator 1	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
ALDH2 modulator 1 is a potent and orally active aldehyde dehydrogenase-2 (ALDH2) modulator. ALDH2 modulator 1 reduces blood alcohol levels in mice .

HY-W653739

(+)-Abscisic aldehyde Abscisic Aldehyde	Others	Others
(+)-Abscisic Aldehyde (ABAld) is an intermediate in the biosynthesis of the plant hormone abscisic acid (ABA). (+)-Abscisic Aldehyde is produced by the dehydrogenation of xanthoxin by xanthoxin dehydrogenases, followed by selective oxidation by abscisic aldehyde oxygenase. (+)-Abscisic Aldehyde has an oxidizing PsAOγ activity and it correlates with ABA accumulation in the old leaves of pea plants with long exposure of salinity, ammonium or nitrogen deficiency. (+)-Abscisic Aldehyde can be used for plant growth and development research .

HY-107030

Nitrefazole EMD-15700	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
Nitrefazole is a 4-nitroimidazole derivative with strong and long lasting inhibition of aldehyde dehydrogenase (ALDH), an enzyme involved in the metabolism of alcohol.

HY-112278

NCT-506	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC₅₀ of 7 nM .

HY-N2597

Prunetin 1 Publications Verification	Aldehyde Dehydrogenase (ALDH)	Inflammation/Immunology
Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor .

HY-129314

CM-39	Aldehyde Dehydrogenase (ALDH)	Cancer
CM-39 is a non-covalent and reversible inhibitor for aldehyde dehydrogenase 1A (ALDH1A) with an IC₅₀ of 0.9 μM .

HY-122577

EN40	Aldehyde Dehydrogenase (ALDH)	Cancer
EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC₅₀ value of 2 uM

HY-107030R

Nitrefazole (Standard)	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
Nitrefazole (Standard) is the analytical standard of Nitrefazole. This product is intended for research and analytical applications. Nitrefazole is a 4-nitroimidazole derivative with strong and long lasting inhibition of aldehyde dehydrogenase (ALDH), an enzyme involved in the metabolism of alcohol.

HY-W016645

4-Diethylaminobenzaldehyde 3 Publications Verification	Aldehyde Dehydrogenase (ALDH)	Cancer
4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenases (ALDHs) inhibitor, with a K_i of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC₅₀= 1.71μM) .

HY-18768

NCT-501 4 Publications Verification	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-501 is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC₅₀ of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC₅₀ >57 μM).

HY-121817R

Sulfiram (Standard)	Reference Standards Parasite Aldehyde Dehydrogenase (ALDH)	Infection
Sulfiram (Standard) is the analytical standard of Sulfiram (HY-121817). This product is intended for research and analytical applications. Sulfiram, an ectoparasiticide, is a weak aldehyde dehydrogenase (ALDH) inhibitor. Sulfiram can be used for the study of scabies .

HY-151229

S-Methyl-N,N-diethylthiolcarbamate DETC-Me; DDTC-Me; Diethyldithiocarbamic acid methyl ester	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me) is the active metabolite of the aldehyde dehydrogenase inhibitor disulfiram (HY-B0240). It is produced by the methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes. S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me) inhibits rat liver low Km aldehyde dehydrogenase (ALDH) (ID50=15.5 mg/kg). When administered at a dose of 20.6 mg/kg, it decreases mean arterial pressure (MAP) and increases heart rate in rats during ethanol stimulation.

HY-18768A

NCT-501 hydrochloride	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-501 hydrochloride is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC₅₀ of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC₅₀ >57 μM) .

HY-19801

CVT-10216 1 Publications Verification	Aldehyde Dehydrogenase (ALDH)	Neurological Disease
CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC₅₀ of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC₅₀ of 1.3 μM. CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects .

HY-Z12431

Silodosin carboxylic acid impurity KMD-3293	Endogenous Metabolite	Metabolic Disease
Silodosin carboxylic acid impurity (KMD-3293) is an inactive silodosin metabolite. Silodosin carboxylic acid impurity is the major metabolite that can be generated via oxidation by alcohol and aldehyde dehydrogenase. Silodosin carboxylic acid impurity can be studied in research for benign prostatic hyperplasia .

HY-W587751

Arteannuic alcohol Amorpha-4,11-diene-12-ol	Drug Intermediate	Infection
Arteannuic alcohol (Amorpha-4,11-diene-12-ol) is a precursor substance in the biosynthetic pathway of Artemisinin (HY-B0094). Alcohol dehydrogenase catalyzes the dehydrogenation reaction of chlorogenic alcohol to produce artemisinic aldehyde .

HY-157872

ALDH1A1-IN-4	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH1A1-IN-4 (compound A1) is a potent inhibitor of aldehyde dehydrogenase (ALDH) A1, with IC₅₀ value of 0.32 μM. ALDH1A1-IN-4 plays an important role in cancer research .

HY-112277

NCT-505	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-505 is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC₅₀ of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC₅₀s, >57, 22.8, 20.1, >57 μM).

HY-176716

ALDH2 activator 1	Aldehyde Dehydrogenase (ALDH)	Cardiovascular Disease
ALDH2 activator 1 (Compound Z17) is an allosteric aldehyde dehydrogenase 2 (ALDH2) agonist. ALDH2 activator 1 enhances cardiac function and reduces myocardial necrosis in a mouse model of myocardial ischemia-reperfusion. ALDH2 activator 1 is promising for research of cardiovascular diseases such as myocardial infarction (MI) .

HY-144669

ALDH1A3-IN-2	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH1A3-IN-2 (Compound 15) is a potent inhibitor of ALDH1A3 with an IC₅₀ of 1.29 μM. Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer. ALDH1A3-IN-2 has the potential for the research of cancer diseases .

HY-144671

ALDH3A1-IN-2	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH3A1-IN-2 (Compound 19) is a potent inhibitor of ALDH3A1 with an IC₅₀ of 1.29 μM. Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer. ALDH3A1-IN-2 has the potential for the research of cancer diseases .

HY-158026

ALDH1A1-IN-5	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH1A1-IN-5 (compound 25) is a potent aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with EC₅₀ value of 83, 45, 43 µM for ALDH1A1, ALDH1A2, ALDH1A3, respectively. ALDH1A1-IN-5 has the potential for the research of high-grade serous ovarian cancer (HGSOC) .

HY-146240

ALDH1A1-IN-3	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
ALDH1A1-IN-3 (compound 57) is an excellent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC₅₀ value of 0.379 μM. ALDH1A1-IN-3 can effectively improve glucose consumption in HepG2 cells. ALDH1A1-IN-3 can be used for researching glucose metabolism improvement .

HY-B0240

Disulfiram Maximum Cited Publications 101 Publications Verification Tetraethylthiuram disulfide; TETD	Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis	Metabolic Disease Cancer
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu ²⁺ increases intracellular ROS levels and induces cuproptosis .

HY-B0240R

Disulfiram (Standard) Tetraethylthiuram disulfide (Standard); TETD (Standard)	Reference Standards Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis	Metabolic Disease Cancer
Disulfiram (Standard) is the analytical standard of Disulfiram. This product is intended for research and analytical applications. Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram + Cu ²⁺ increases intracellular ROS levels triggering apoptosis of ovarian cancer stem cells ^[1-6].

HY-137555

11-dehydro-2,3-dinor Thromboxane B2 11-dehydro-2,3-dinor TXB2	Endogenous Metabolite	Metabolic Disease
11-dehydro-2,3-dinor Thromboxane B2 (11-dehydro-2,3-dinor TXB2) is a metabolite of the TXA2 inactive metabolite TXB2 (Item No. 19030). It is formed from TXB2 by cytosolic aldehyde dehydrogenase (ALDH) and β-oxidation. Levels of 11-dehydro-2,3-dinor TXB2 are increased 5.2-fold in a surgery-induced rat model of tendon overuse.

3-Hydroxybenzaldehyde M-HydroxybenzAldehyde	Cardiovascular Disease Structural Classification Monophenols Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Plants Disease Research Fields	Aldehyde Dehydrogenase (ALDH) NF-κB p38 MAPK
3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA) (HY-N0295). 3-Hydroxybenzaldehyde, produced by 3-hydroxybenzyl-alcohol dehydrogenase, is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans. 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo. 3-Hydroxybenzaldehyde is proming for research of atherosclerosis .

Prunetin 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Trifolium pratense Linn. Plants Flavonoids Leguminosae Phenols Polyphenols Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Isoflavones	Aldehyde Dehydrogenase (ALDH)
Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor .

3-Hydroxybenzaldehyde (Standard) M-HydroxybenzAldehyde (Standard)	Structural Classification Monophenols Microorganisms other families Ketones, Aldehydes, Acids Source classification Phenols Plants	Reference Standards Aldehyde Dehydrogenase (ALDH) NF-κB p38 MAPK
3-Hydroxybenzaldehyde (Standard) is the analytical standard of 3-Hydroxybenzaldehyde. This product is intended for research and analytical applications. 3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA) (HY-N0295). 3-Hydroxybenzaldehyde, produced by 3-hydroxybenzyl-alcohol dehydrogenase, is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans. 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo. 3-Hydroxybenzaldehyde is proming for research of atherosclerosis[1][2][3][4].

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Aldehyde dehydrogenases

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