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Adiponectin Receptor

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By Targets:	Adiponectin Receptor (5) Adrenergic Receptor (1) AMPK (1) Autophagy (3) GLUT (2) Insulin Receptor (2) NF-κB (2) P2X Receptor (1) p38 MAPK (2) PGC-1α (1) PPAR (3) Reference Standards (2) Reverse Transcriptase (2) Sirtuin (1)
By Research Areas:	Cancer (4) Endocrinology (4) Infection (2) Inflammation/Immunology (1) Metabolic Disease (9)

10

Inhibitors & Agonists

5

Natural
Products

1

Recombinant Proteins

2

Antibodies

Targets Recommended: Adiponectin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

AdipoRon Maximum Cited Publications 35 Publications Verification	Adiponectin Receptor	Metabolic Disease
AdipoRon is an orally active adiponectin receptor (AdipoR) agonist, binding to AdipoR1 and AdipoR2 with K_ds of 1.8 and 3.1 μM, respectively.

Gramine 3 Publications Verification Donaxine	Adiponectin Receptor Reverse Transcriptase	Infection Metabolic Disease Endocrinology Cancer
Gramine (Donaxine) is an alkaloid, acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse *β2-Adrenergic receptor* (β2-AR)** agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

Zeaxanthin dipalmitate Physalien	Adiponectin Receptor P2X Receptor Autophagy	Inflammation/Immunology
Zeaxanthin dipalmitate (Physalien) is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact with p2X7 receptor (K_d=81.2 nM) and adiponectin receptor 1 (AdipoR1; K_d=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrial autophagy functions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP) .

Rhoifolin	Insulin Receptor GLUT NF-κB p38 MAPK Autophagy	Metabolic Disease Endocrinology Cancer
Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .

AdipoRon (Standard)	Adiponectin Receptor	Metabolic Disease
AdipoRon (Standard) is the analytical standard of AdipoRon. This product is intended for research and analytical applications. AdipoRon is an orally active adiponectin receptor (AdipoR) agonist, binding to AdipoR1 and AdipoR2 with Kds of 1.8 and 3.1 μM, respectively.

AdipoR agonist 1	Adiponectin Receptor PPAR PGC-1α Sirtuin AMPK	Metabolic Disease
AdipoR agonist 1 (Compound 112254) is an agonist for adiponectin receptor (AdipoR), which activates the transcriptional regulators like peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). AdipoR agonist 1 is utilized in preventive doping research .

PPARγ/δ modulator 1	PPAR	Metabolic Disease
PPARγ/δ modulator 1 (compound 3e) is a potent PPAR modulator. PPARγ/δ modulator 1 is a PPARδ antagonist and a PPARγ partial agonist , with K_i values of 14.4 nM and 5.31 μM, respectively. PPARγ/δ modulator 1 has the EC₅₀ of 7.3 and 12.6 μM for PPARδ corepression and adiponectin production, respectively .

Gramine (Standard) Donaxine (Standard)	Reference Standards Adrenergic Receptor Reverse Transcriptase	Infection Metabolic Disease Endocrinology Cancer
Gramine (Standard) is the analytical standard of Gramine. This product is intended for research and analytical applications. Gramine (Donaxine) is an alkaloid, acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse *β2-Adrenergic receptor* (β2-AR)** agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

E-3030 free acid	PPAR	Metabolic Disease
E-3030 free acid is a potent dual activator of peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma, exhibiting significant antidiabetic and lipid-modulating effects. E-3030 decreases blood glucose, triglyceride, non-esterified fatty acids, and insulin levels, while increasing blood adiponectin levels. E-3030 improves glucose tolerance and shows remarkable triglyceride- and non-high-density lipoprotein cholesterol-lowering effects in animal models.

Rhoifolin (Standard)	Reference Standards Insulin Receptor GLUT NF-κB p38 MAPK Autophagy	Metabolic Disease Endocrinology Cancer
Rhoifolin (Standard) is the analytical standard of Rhoifolin. This product is intended for research and analytical applications. Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .

Cat. No.	Compare	Product Name	Species	Source

	ADIPOR1 Protein, Human (Cell-Free) Adiponectin Receptor protein 1; Progestin and adipoQ Receptor family member 1; Progestin and adipoQ Receptor family member I	Human	E. coli Cell-free
	ADIPOR1 Protein, a receptor for adiponectin (ADIPOQ), crucially regulates glucose and lipid metabolism, maintaining homeostasis and healthy body weight. Upon ADIPOQ binding, ADIPOR1 activates AMPK, promoting fatty acid oxidation and glucose uptake while inhibiting gluconeogenesis. ADIPOR1 interacts with APPL2, negatively regulating signaling, and with APPL1, enhancing ADIPOQ-induced recruitment and positive regulation of adiponectin signaling. ADIPOR1 Protein, Human (Cell-Free) is the recombinant human-derived ADIPOR1 protein, expressed by E. coli Cell-free , with tag free.

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	Adiponectin receptor protein 1 Antibody (YA2700) Adiponectin Receptor protein 1; Progestin and adipoQ Receptor family member I; CGI-45; PAQR1; ADIPOR1	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Adiponectin receptor protein 1 Antibody (YA2700) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Adiponectin receptor protein 1.

	Adiponectin receptor protein 1 Antibody (YA638) ACDCR1; ADIPO R1; Adiponectin Receptor protein 1; ADIPOR 1; ADIPOR1; CGI-45; CGI-45 protein; FLJ25385; PAQR1; Progestin and adipoQ Receptor family member I; TESBP1A; ADR1_HUMAN.	ICC/IF, IHC-P, FC	Human, Mouse
	Adiponectin receptor protein 1 Antibody (YA638) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Adiponectin receptor protein 1.

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