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ATP Citrate Lyase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ATP Citrate Lyase (17) AMPK (4) Autophagy (1) Fatty Acid Synthase (FASN) (1) Free Fatty Acid Receptor (1) HIF/HIF Prolyl-Hydroxylase (1) Reference Standards (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Inflammation/Immunology (2) Metabolic Disease (15)

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Natural
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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: ATP Citrate Lyase ATP Synthase ATP-binding cassette (ABC) transporters P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1437

Hydroxycitric acid 1 Publications Verification	ATP Citrate Lyase HIF/HIF Prolyl-Hydroxylase	Metabolic Disease Inflammation/Immunology Cancer
Hydroxycitric acid is the major active ingredient of Garcinia cambogia. Hydroxycitric acid competitively inhibits **ATP citrate lyase with weight loss benefits. Hydroxycitric acid effective inhibits stones formation and also inhibits HIF**, and has antioxidation, anti-inflammation and anti-tumor effects .

HY-16450

SB 204990 Maximum Cited Publications 21 Publications Verification	ATP Citrate Lyase	Metabolic Disease
SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.

HY-16107

BMS-303141 10+ Cited Publications	ATP Citrate Lyase	Metabolic Disease
BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC₅₀ of 0.13 μM.

HY-12357

Bempedoic acid 15+ Cited Publications ETC-1002; ESP-55016	ATP Citrate Lyase AMPK	Metabolic Disease
Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates AMPK .

HY-127111

NDI-091143 2 Publications Verification	ATP Citrate Lyase	Cancer
NDI-091143 is a potent and high-affinity *human ATP-citrate* lyase (ACLY) inhibitor with an IC₅₀ of 2.1 nM (ADP-Glo assay), a K_i of 7.0 nM and a K_d of 2.2 nM. NDI-091143 inhibits ACLY** catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate .

HY-12357S2

Bempedoic acid-d4 ETC-1002-d₄; ESP-55016-d₄	ATP Citrate Lyase AMPK	Others
Bempedoic acid-d₄ is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK .

HY-N12336

Gnetuhainin I	Others	Metabolic Disease
Gnetuhainin I (Compound 5) is a lignin derived from Pouzolzia zeylanica. Gnetuhainin I shows good inhibitory effect on ATP citrate lyase (ACLY) (IC₅₀=2.63 μM) .

HY-N11781

Forrestiacids J	ATP Citrate Lyase	Metabolic Disease
Forrestiacids J is an ATP-citrate lyase (ACL) inhibitor with an IC₅₀ of 2.6 μM .

HY-N11782

Forrestiacids K	ATP Citrate Lyase	Others
Forrestiacids K, a terpenoid isolated from Pseudotsuga forrestii, acts as an ATP-citrate lyase (ACL) inhibitor .

HY-12357S

Bempedoic acid-d5 ETC-1002-d₅; ESP-55016-d₅	ATP Citrate Lyase AMPK	Metabolic Disease
Bempedoic acid-d₅ is the deuterium labeled Bempedoic acid . Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates AMPK .

HY-N7347

(-)-Hydroxycitric acid lactone Garcinia lactone	ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of **ATP-citrate lyase*. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate* to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-17640

Nicodicosapent	Fatty Acid Synthase (FASN) Autophagy	Metabolic Disease
Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.

HY-12357R

Bempedoic acid (Standard) ETC-1002 (Standard); ESP-55016 (Standard)	ATP Citrate Lyase AMPK	Metabolic Disease
Bempedoic acid (Standard) is the analytical standard of Bempedoic acid. This product is intended for research and analytical applications. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates AMPK .

HY-P1123

MEDICA16	ATP Citrate Lyase Free Fatty Acid Receptor	Metabolic Disease
MEDICA16, an **ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle, and this reduction is accompanied by an increase in insulin sensitivity. MEDICA16 is a selective agonist for GPR40 as well as selective partial agonists for GPR120** .

HY-177136

ACLY-IN-2	ATP Citrate Lyase	Metabolic Disease Inflammation/Immunology Cancer
ACLY-IN-2 (Compound 7) has inhibitory effect against *human ATP* citrate lyase (hACLY), with an IC₅₀** of less than 1 nM. ACLY-IN-2 can be studied in research on liver-related diseases, type-2 diabetes, autoimmunity, and cancer .

HY-N7347R

(-)-Hydroxycitric acid lactone (Standard) Garcinia lactone (Standard)	Reference Standards ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-172914

ACLY-IN-1	ATP Citrate Lyase	Cardiovascular Disease Metabolic Disease
ACLY-IN-1 (compound 55) is a potent ACLY inhibitor with an IC₅₀ of 8.3 nM. ACLY-IN-1 can be used in the study of hyperlipidemia .

HY-N14035

Garcinia cambogia extract	ATP Citrate Lyase	Cardiovascular Disease Metabolic Disease
Garcinia cambogia extract contains several active compounds, including hydroxycitric acid (HCA) (an ECC inhibitor), xanthones, benzophenones, hydroxycitric acid (an **ATP-citrate lyase** inhibitor). Garcinia cambogia extract lowers the body weight gain, visceral fat accumulation, blood and hepatic lipid concentrations, and plasma insulin and leptin levels in a high-fat diet (HFD)-induced obesity mouse model. Garcinia cambogia extract is promising for research of fatty liver, dyslipidemia, hyperinsulinemia and hyperleptinemia rendered by HFD .

HY-175606

EVT0185	ATP Citrate Lyase	Cancer
EVT0185 is an orally active **ATP citrate lyase (ACLY) inhibitor. EVT0185 is converted to a CoA thioester in the liver by SLC27A2 and interacts with the CoA-binding site of ACLY. EVT0185-CoA inhibits ACLY activity with an IC₅₀** of 2.5 μM. EVT0185 can phenocopy the immune and antitumour effects of genetic ACLY deletion. EVT0185 can increases tumour-infiltrating B cells and chemokine CXCL13 levels. EVT0185 can be used for the research of cancer, such as hepatocellular carcinoma (HCC) .

Hydroxycitric acid 1 Publications Verification	Structural Classification Ketones, Aldehydes, Acids Guttiferae Source classification Plants Garcinia gummi-gutta (L.) Roxb.	ATP Citrate Lyase HIF/HIF Prolyl-Hydroxylase
Hydroxycitric acid is the major active ingredient of Garcinia cambogia. Hydroxycitric acid competitively inhibits **ATP citrate lyase with weight loss benefits. Hydroxycitric acid effective inhibits stones formation and also inhibits HIF**, and has antioxidation, anti-inflammation and anti-tumor effects .

(-)-Hydroxycitric acid lactone Garcinia lactone	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Disease Research Fields	ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of **ATP-citrate lyase*. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate* to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

Garcinia cambogia extract	Structural Classification Natural Products Guttiferae Source classification Garcinia cambogia Desr. Plants	ATP Citrate Lyase
Garcinia cambogia extract contains several active compounds, including hydroxycitric acid (HCA) (an ECC inhibitor), xanthones, benzophenones, hydroxycitric acid (an **ATP-citrate lyase** inhibitor). Garcinia cambogia extract lowers the body weight gain, visceral fat accumulation, blood and hepatic lipid concentrations, and plasma insulin and leptin levels in a high-fat diet (HFD)-induced obesity mouse model. Garcinia cambogia extract is promising for research of fatty liver, dyslipidemia, hyperinsulinemia and hyperleptinemia rendered by HFD .

Gnetuhainin I	Structural Classification Urticaceae Pouzolzia zeylanica (L.) Benn. Source classification Phenols Polyphenols Plants	Others
Gnetuhainin I (Compound 5) is a lignin derived from Pouzolzia zeylanica. Gnetuhainin I shows good inhibitory effect on ATP citrate lyase (ACLY) (IC₅₀=2.63 μM) .

Forrestiacids J	Triterpenes Structural Classification Classification of Application Fields Pinaceae Terpenoids Source classification Metabolic Disease Plants Pseudotsuga forrestii Craib Disease Research Fields	ATP Citrate Lyase
Forrestiacids J is an ATP-citrate lyase (ACL) inhibitor with an IC₅₀ of 2.6 μM .

Forrestiacids K	Structural Classification Pinaceae Terpenoids Source classification Diterpenoids Plants Pseudotsuga forrestii Craib	ATP Citrate Lyase
Forrestiacids K, a terpenoid isolated from Pseudotsuga forrestii, acts as an ATP-citrate lyase (ACL) inhibitor .

(-)-Hydroxycitric acid lactone (Standard) Garcinia lactone (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Source classification Plants	Reference Standards ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

Cat. No.	Compare	Product Name	Species	Source

HY-P72070

	ACLY Protein, Human (His-SUMO) ACL; Acly; ACLY_HUMAN; ATP Citrate pro-S; Lyase; ATP Citrate Lyase; ATP Citrate synthase; ATP-Citrate pro-S-; -Lyase; ATP-Citrate synthase; ATPCitrate synthase; ATPCL; Citrate cleavage enzyme; CLATP; OTTHUMP00000164773	Human	E. coli
	ACLY Protein, Human (His-SUMO) is an important enzyme in the cholesterol biosynthetic pathway. ACLY produces acetyl-CoA (AcCoA) from mitochondrial citrate for cholesterol and fatty acid biosynthesis.

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Cat. No.	Product Name	Chemical Structure

HY-12357S2

Bempedoic acid-d4
Bempedoic acid-d₄ is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK .

HY-12357S

Bempedoic acid-d5
Bempedoic acid-d₅ is the deuterium labeled Bempedoic acid . Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates AMPK .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80560

	ATP Citrate Lyase Antibody (YA829) ACLY; ATP-Citrate synthase; ATP-Citrate; pro-S-)-Lyase; ACL; Citrate cleavage enzyme	WB, ICC/IF, FC	Human, Mouse, Monkey
	ATP Citrate Lyase Antibody (YA829) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ATP Citrate Lyase.

HY-P80380

	ATP Citrate Lyase Antibody (YA596)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	ATP Citrate Lyase Antibody (YA596) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATP Citrate Lyase.

HY-P84388

	ATP Citrate Lyase Antibody (YA4085) ACL; ATPCL; CLATP	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
	ATP Citrate Lyase Antibody (YA4085) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATP Citrate Lyase.

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ATP Citrate Lyase

Inhibitors & Agonists

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
Products