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Results for "

ASM

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (1) Bacterial (3) Calcium Channel (4) Caspase (1) CCR (1) Estrogen Receptor/ERR (1) Fungal (2) GHSR (2) Glutathione S-transferase (4) HIV (1) NF-κB (4) NO Synthase (2) Phosphatase (3) Phospholipase (5) Reference Standards (3) Small Interfering RNA (siRNA) (3) Wnt (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (3) Endocrinology (1) Infection (4) Inflammation/Immunology (8) Neurological Disease (4)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116541

Acibenzolar-S-methyl ASM	Bacterial Fungal	Infection
Acibenzolar-S-methyl (ASM) is a plant resistance inducer that mimics pathogen-host interactions and leads to systemic acquired resistance in plants. Acibenzolar-S-methyl helps reduce the use of pesticides and can be used in research to prevent plant diseases .

HY-149120

ASM-IN-1	Phospholipase	Cardiovascular Disease Inflammation/Immunology
ASM-IN-1 is a potent and orally active acid sphingomyelinase (ASM) inhibitor with an IC₅₀ value of 1.5 µM. ASM-IN-1 reduces lipid plaques in the aortic arch and aorta and reduces plasma ceramide concentration and Ox-LDL levels. ASM-IN-1 shows antiatherosclerotic and anti-inflammatory activity .

HY-13723

Pimecrolimus 4 Publications Verification SDZ-ASM 981	Phosphatase	Inflammation/Immunology
Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active calcineurin inhibitor with a K_i of 117 nM. Pimecrolimus shows anti-inflammatory activity .

HY-N6681

15-Acetoxyscirpenol	Caspase Bacterial Apoptosis Antibiotic	Infection
15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other caspases independent of caspase-3 .

HY-171033

ASM-IN-3	Phospholipase	Neurological Disease
ASM-IN-3 (Compound 21b) is a selective and BBB-penetrating acid sphingomyelinase (ASM) inhibitor (IC₅₀: 3.37 μM for pure human ASM). ASM-IN-3 improves depression-like behaviors by inhibiting ASM activity and increasing neurogenesis in hippocampus in Reserpine (HY-N0480)-induced depressed rats .

HY-162613

ASM-IN-2	Phospholipase	Neurological Disease
ASM-IN-2 (Compound 46) is a potent ASM inhibitor with an IC₅₀ value of 0.87 μM, displaying good drug-like properties. ASM-IN-2 involves in multiple antidepressant mechanisms of actionin, which are associated with a decline of ceramide. It demostrates remarkable antidepressant effects in the CUMS-induced mouse, which is promising for research in the field of antidepressant drugs .

HY-116541R

Acibenzolar-S-methyl (Standard) ASM (Standard)	Bacterial Fungal Reference Standards	Infection
Acibenzolar-S-methyl (Standard) is the analytical standard of Acibenzolar-S-methyl. This product is intended for research and analytical applications. Acibenzolar-S-methyl (ASM) is a plant resistance inducer that mimics pathogen-host interactions and leads to systemic acquired resistance in plants. Acibenzolar-S-methyl helps reduce the use of pesticides and can be used in research to prevent plant diseases .

HY-13723A

Pimecrolimus hydrate SDZ-ASM 981 hydrate	Phosphatase	Inflammation/Immunology
Pimecrolimus hydrate (SDZ-ASM 981 hydrate) is a potent, nonsteroid and orally active calcineurin inhibitor. Pimecrolimus hydrate shows anti-inflammatory activity. Pimecrolimus hydrate has the potential for the research of atopic dermatitis and oral erosive lichen planus .

HY-13723R

Pimecrolimus (Standard) SDZ-ASM 981 (Standard)	Reference Standards Phosphatase	Inflammation/Immunology
Pimecrolimus (Standard) is the analytical standard of Pimecrolimus. This product is intended for research and analytical applications. Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active calcineurin inhibitor with a Ki of 117 nM. Pimecrolimus shows anti-inflammatory activity .

HY-103446

FERb 033	Estrogen Receptor/ERR	Endocrinology
FERb 033 is a selective and potent ERβ agonist (K_i=7.1 nM, EC₅₀=4.8 nM). FERb 033 shows 62-fold selectivity over ERα .

HY-171962A

KARI 201 hydrochloride	Phospholipase GHSR	Neurological Disease
KARI 201 hydrochloride is a selective, brain penetrant pand competitive acid sphingomyelinase (ASM) inhibitor with an IC₅₀ of 338.3?nM. KARI 201 hydrochloride is a ghrelin receptor agonist. KARI 201 hydrochloride improves neuropathological features of Alzheimer's disease .

HY-171962

KARI 201	Phospholipase GHSR	Neurological Disease
KARI 201 is a selective, brain penetrant pand competitive acid sphingomyelinase (ASM) inhibitor with an IC₅₀ of 338.3?nM. KARI 201 is a ghrelin receptor agonist. KARI 201 improves neuropathological features of Alzheimer's disease .

HY-RS13447

SMPD1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMPD1 Human Pre-designed siRNA Set A contains three designed siRNAs for SMPD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMPD1 Human Pre-designed siRNA Set A SMPD1 Human Pre-designed siRNA Set A

HY-RS17994

Smpd1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Smpd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smpd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smpd1 Mouse Pre-designed siRNA Set A Smpd1 Mouse Pre-designed siRNA Set A

HY-B1640

Ethacrynic acid Maximum Cited Publications 7 Publications Verification Etacrynic acid	Wnt Glutathione S-transferase NF-κB Calcium Channel NO Synthase	Cardiovascular Disease Inflammation/Immunology Cancer
Ethacrynic acid has anti-inflammatory and anticancer activity. Ethacrynic acid is an orally active diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferase (GSTs) and Wnt signaling pathways. Ethacrynic acid is a radiosensitizer. Ethacrynic acid can inhibit airway smooth muscle (ASM) contraction in mice. Ethacrynic acid can increase the outflow of aqueous humor from the eye for the study of glaucoma .

HY-B1640A

Ethacrynic acid sodium Etacrynic acid sodium; Sodium etacrynate	NF-κB Glutathione S-transferase Calcium Channel NO Synthase	Cardiovascular Disease Inflammation/Immunology Cancer
Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice .

HY-108538

Ethacrynic acid D5	Glutathione S-transferase NF-κB Calcium Channel	Inflammation/Immunology
Ethacrynic acid D5 is a deuterium labeled Ethacrynic acid. Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice .

HY-B1640R

Ethacrynic acid (Standard) Maximum Cited Publications 7 Publications Verification Etacrynic acid (Standard)	Reference Standards Glutathione S-transferase NF-κB Calcium Channel	Inflammation/Immunology Cancer
Ethacrynic acid (Standard) is the analytical standard of Ethacrynic acid. This product is intended for research and analytical applications. Ethacrynic acid (Etacrynic acid) is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice .

HY-107401

Ancriviroc SCH-351125	HIV CCR	Infection
Ancriviroc (SCH-351125) is an orally active CCR5 antagonist. Ancriviroc has a broad-spectrum antiviral activity against HIV-1 isolates using CCR5 as their entry coreceptor (such as ASM 80, 92US715 and YU-2) with IC₅₀s of 0.4-9 nM. Ancriviroc strongly inhibits the replication of R5-using HIV-1 isolates in SCID-hu Thy/Liv mice model of HIV-1 infection. Ancriviroc can be used for HIV infection research .

HY-RS16353

H19 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
H19 Human Pre-designed siRNA Set A contains three designed siRNAs for H19 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

H19 Human Pre-designed siRNA Set A H19 Human Pre-designed siRNA Set A

15-Acetoxyscirpenol	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Caspase Bacterial Apoptosis Antibiotic
15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other caspases independent of caspase-3 .

Species:	Human (2) Mouse (3)
Tag:	His (5)
Source:	HEK293 (2) Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P76134

	SMPD1 Protein, Mouse (sf9, His) Sphingomyelin phosphodiesterase; Acid sphingomyelinase; ASMase; Smpd1; ASM	Mouse	Sf9 insect cells
	The SMPD1 protein converts sphingomyelin to ceramide through two enzymatic forms, one targeted to endolysosomes and the other released extracellularly.Lysosomal exocytosis becomes a significant source of the secretory form during stress responses.SMPD1 also exports cholesterol from intraendolysosomal membranes and exhibits phospholipase C activities.Its role in stress-induced apoptosis modulation is mediated through ceramide production.SMPD1 Protein, Mouse (sf9, His) is the recombinant mouse-derived SMPD1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P76710

	SMPD1 Protein, Human (sf9, His) Sphingomyelin phosphodiesterase; Acid sphingomyelinase; ASMase; Smpd1; ASM	Human	Sf9 insect cells
	SMPD1 protein converts sphingomyelin to ceramide in lysosomes and has phospholipase C activity. SMPD1 Protein, Human (sf9, His) is the recombinant human-derived SMPD1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P77209

	SMPDL3A Protein, Mouse (HEK293, His) Acid sphingomyelinase-like phosphodiesterase 3a; ASM-like phosphodiesterase 3a; SMPDL3A; ASML3A	Mouse	HEK293
	SMPDL3A protein hydrolyzes nucleotide triphosphates, particularly ATP, and p-nitrophenyl-TMP. It has limited activity with nucleoside diphosphates and none with nucleoside monophosphates. SMPDL3A also catalyzes the conversion of CDP-choline to CMP and phosphocholine, and CDP-ethanolamine. However, it lacks sphingomyelin phosphodiesterase activity. SMPDL3A Protein, Mouse (HEK293, His) is the recombinant mouse-derived SMPDL3A protein, expressed by HEK293 , with C-His labeled tag.

HY-P76134A

	SMPD1 Protein, Mouse (sf9, C-His) Sphingomyelin phosphodiesterase; Acid sphingomyelinase; ASMase; Smpd1; ASM	Mouse	Sf9 insect cells
	The SMPD1 protein converts sphingomyelin to ceramide through two enzymatic forms, one targeted to endolysosomes and the other released extracellularly.Lysosomal exocytosis becomes a significant source of the secretory form during stress responses.SMPD1 also exports cholesterol from intraendolysosomal membranes and exhibits phospholipase C activities.Its role in stress-induced apoptosis modulation is mediated through ceramide production.SMPD1 Protein, Mouse (sf9, C-His) is the recombinant mouse-derived SMPD1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P71325

	SMPDL3A Protein, Human (HEK293, His) Acid sphingomyelinase-like phosphodiesterase 3a; ASM-like phosphodiesterase 3a; SMPDL3A; ASML3A	Human	HEK293
	SMPDL3A exhibits in vitro nucleotide phosphodiesterase activity, specifically toward ATP and p-nitrophenyl-TMP, less activity toward nucleoside diphosphates, and no activity toward nucleoside monophosphates. Notably, it showed in vitro activity with CDP-choline and CDP-ethanolamine, producing specific products. SMPDL3A Protein, Human (HEK293, His) is the recombinant human-derived SMPDL3A protein, expressed by HEK293 , with C-6*His labeled tag.

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HY-P80484

	alpha smooth muscle Actin Antibody (YA627) 1 Publications Verification alpha sarcomeric Actin; alpha smooth muscle Actin; Actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; ACTSA; ACTVS; Alpha 2 actin; Alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; Actin, aortic smooth muscle; Alpha 2 actin; Alpha actin 2; Alpha cardiac actin; Alpha-actin 2; Alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5 α-Smooth Muscle Actin; α Smooth Muscle Actin;	WB, IHC-P, FC, IP	Human, Mouse
	alpha smooth muscle Actin Antibody is a non-conjugated and Rabbit origined IgG monoclonal antibody, targeting to alpha smooth muscle Actin. It can be used as a loading control antibody.

HY-P83739

	alpha smooth muscle Actin Antibody(YA3468) alpha sarcomeric Actin; alpha smooth muscle Actin; Actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; ACTSA; ACTVS; Alpha 2 actin; Alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; Actin, aortic smooth muscle; Alpha 2 actin; Alpha actin 2; Alpha cardiac actin; Alpha-actin 2; Alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5 α-Smooth Muscle Actin; α Smooth Muscle Actin;	WB, IHC-P, ICC/IF, FC, IF-Tissue, mIHC	Human, Mouse, Rat
	alpha smooth muscle Actin Antibody(YA3468) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to alpha smooth muscle Actin.

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SMPD1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SMPD1 Human Pre-designed siRNA Set A contains three designed siRNAs for SMPD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smpd1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Smpd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smpd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

H19 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
H19 Human Pre-designed siRNA Set A contains three designed siRNAs for H19 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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