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APN

" in MedChemExpress (MCE) Product Catalog:

31

Inhibitors & Agonists

2

Peptides

2

Inhibitory Antibodies

7

Natural
Products

3

Recombinant Proteins

2

Isotope-Labeled Compounds

1

Antibodies

7

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-139859

    ADC Linker Cancer
    APN-PEG36-tetrazine is an analogue of APN-PEG4-tetrazine. APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG36-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    APN-PEG36-tetrazine
  • HY-P9933

    APN-311

    Apoptosis PERK mTOR Cancer
    Dinutuximab (APN-311) is a chimeric human-mouse anti-GD2 monoclonal antibody. Dinutuximab can bind to GD2 on the cell surface, triggering antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity, and promoting tumor regression. Dinutuximab can inhibit the growth, invasion, and migration and induce apoptosis of tumor cells. Dinutuximab can be used in the research of tumors such as neuroblastoma and breast cancer .
    Dinutuximab
  • HY-145244

    Akt Cancer
    APN/AKT-IN-1 is a potent and dual inhibitor of APN and AKT with IC50s of 0.21 and 0.27 μM, respectively. APN/AKT-IN-1 can effectively inhibit the phosphorylation of GSK3β, the intracellular substrate of AKT .
    APN/AKT-IN-1
  • HY-W190925

    Biochemical Assay Reagents Others
    APN-C3-biotin is a heterobifunctional linker containing an APN moiety with exquisite chemoselectivity for cysteine and Biotin. The superior stability of APN-cysteine conjugates in aqueous media, human plasma, and living cells makes this new thiol-click reaction a promising methodology for applications in bioconjugation.
    APN-C3-biotin
  • HY-140348

    PROTAC Linkers Cancer
    APN- NH2 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . APN- NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    APN-​NH2
  • HY-136030

    PROTAC Linkers Cancer
    APN-PEG4-PFP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . APN-PEG4-PFP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    APN-PEG4-PFP
  • HY-136044

    ADC Linker Cancer
    APN-PEG4-BCN is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG4-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    APN-PEG4-BCN
  • HY-136049

    ADC Linker Cancer
    APN-PEG4-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    APN-PEG4-DBCO
  • HY-130939

    ADC Linker Cancer
    APN-PEG4-Amine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG4-Amine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    APN-PEG4-Amine hydrochloride
  • HY-136045

    ADC Linker Cancer
    APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG4-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    APN-PEG4-tetrazine
  • HY-W123012

    3-(4-Azidophenyl)propiolonitrile

    Fluorescent Dye
    APN-Azide (3-(4-Azidophenyl)propiolonitrile) is a codon-active compound that can achieve specific labeling of target molecules in biological systems through its unique chemical structure. APN-Azide can be used for bioimaging and the development of molecular probes to study biological processes within cells.
    APN-Azide
  • HY-137557

    APN1607; PM-PBB3

    Biochemical Assay Reagents Neurological Disease
    Florzolotau (APN1607) is a positron emission tomography (PET) ligand that can be used to detect Alzheimer's disease (AD) and other tau proteinopathies. Its binding sites are located in the β-helix of the paired helical filaments (PHFs) and straight filaments (SFs) of the tau protein, as well as in the C-shaped cavity of the SFs. In addition, APN-1607 can bind to the intraneuronal inclusions in Alzheimer's disease (AD), primary age-related tauopathy (PART), and posterior cortical atrophy (PCA). Florzolotau is expected to be used in PET imaging research of neurological diseases, especially tau proteinopathies .
    Florzolotau
  • HY-116025

    PROTAC Linkers Cancer
    APN-C3-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . APN-C3-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    APN-C3-PEG4-alkyne
  • HY-E70199

    APN/CD13

    Others Others
    A Aminopeptidase N (rat) (APN/CD13) is a Zn 2+ dependent membrane-bound ectopeptidase that degrades preferentially proteins and peptides with a N-terminal neutral amino acid .
    Aminopeptidase N (rat)
  • HY-163549

    Drug-Linker Conjugates for ADC Cancer
    APN-PEG5-VC-PAB-MMAE is a drug-linker conjugate part of INA03 (a transferrin-competitive antibody-drug conjugate against CD71) .
    APN-PEG5-VC-PAB-MMAE
  • HY-140841

    PROTAC Linkers Cancer
    APN-C3-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . APN-C3-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    APN-C3-PEG4-azide
  • HY-140347

    tert-Butyl 3-(4-(2-cyanoethynyl)phenylcarbamoyl)propylcarbamate

    PROTAC Linkers Cancer
    APN-C3-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . APN-C3-NH-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    APN-C3-NH-Boc
  • HY-116306

    Aminopeptidase Others
    Probestin is a potent aminopeptidase N (APN) inhibitor produced by Streptomyces cyanogens MH663-2F6 .
    Probestin
  • HY-170962

    Neprilysin Aminopeptidase Neurological Disease
    SDUY817 is a dual APN/NEP inhibitor, with IC50 values of 0.29 μM for APN and 7.4 μM for NEP. SDUY817 exerts analgesic effects in a concentration- and time-dependent manner, and can be used for research in the field of neuropathic pain disorders .
    SDUY817
  • HY-B0134B

    Ubenimex trifluoroacetate

    Aminopeptidase Bacterial Antibiotic Infection Cancer
    Bestatin trifluoroacetate is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.
    Bestatin trifluoroacetate
  • HY-B0134A
    Bestatin hydrochloride
    Maximum Cited Publications
    7 Publications Verification

    Ubenimex hydrochloride

    Aminopeptidase Bacterial Antibiotic Infection Cancer
    Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.
    Bestatin hydrochloride
  • HY-172879

    Aminopeptidase Cancer
    Aminopeptidase N inhibitor 2 (Compound 2k) is an APN inhibitor (IC50: 4.3 μM) and has antitumor activity.
    Aminopeptidase N inhibitor 2
  • HY-170961

    Aminopeptidase Neprilysin Neurological Disease
    SDUY816 is an oral active dual APN/NEP inhibitor, with IC50 values of 0.68 μM for APN and 6.9 μM for NEP. SDUY816 exhibits analgesic effects and demonstrates good safety and pharmacokinetic profiles, with an oral bioavailability of 27% and a half-life of 4.02 hours in rats (oral administration, 10 mg/kg). SDUY816 has potential applications in the research of neuropathic pain disorders .
    SDUY816
  • HY-B0134
    Bestatin
    Maximum Cited Publications
    7 Publications Verification

    Ubenimex

    Aminopeptidase Bacterial Antibiotic Infection Cancer
    Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .
    Bestatin
  • HY-B0134AS

    Ubenimex-d7 hydrochloride

    Isotope-Labeled Compounds Aminopeptidase Bacterial Antibiotic Infection Cancer
    Bestatin-d7 (hydrochloride) is deuterium labeled Bestatin (hydrochloride). Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.
    Bestatin-d7 hydrochloride
  • HY-B0134AR

    Ubenimex hydrochloride (Standard)

    Aminopeptidase Bacterial Antibiotic Infection Cancer
    Bestatin (hydrochloride) (Standard) is the analytical standard of Bestatin (hydrochloride). This product is intended for research and analytical applications. Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.
    Bestatin hydrochloride (Standard)
  • HY-P1043A
    NGR peptide Trifluoroacetate
    1 Publications Verification

    Aminopeptidase Cancer
    NGR peptide Trifluoroacetatecontaining the Asn-Gly-Arg (NGR) motif. NGR peptide Trifluoroacetate binds to APN/CD13. NGR peptide Trifluoroacetate is directly conjugated to imaging agents that can be used for tumor imaging .
    NGR peptide Trifluoroacetate
  • HY-P1043

    Aminopeptidase Cancer
    NGR peptide containing the Asn-Gly-Arg (NGR) motif. NGR peptide binds to APN/CD13. NGR peptide is directly conjugated to imaging agents that can be used for tumor imaging .
    NGR peptide
  • HY-B0134R

    Aminopeptidase Bacterial Antibiotic Infection Cancer
    Bestatin (Standard) is the analytical standard of Bestatin. This product is intended for research and analytical applications. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .
    Bestatin (Standard)
  • HY-B0134S1

    Ubenimex-d10

    Isotope-Labeled Compounds Bacterial Antibiotic Aminopeptidase Infection Cancer
    Bestatin-d10 (Ubenimex-d10) is deuterium labeled Bestatin. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .
    Bestatin-d10
  • HY-N2150

    HDAC DNA Methyltransferase DNA/RNA Synthesis Bacterial Aminopeptidase Farnesyl Transferase PPAR Apoptosis Infection Inflammation/Immunology Cancer
    Psammaplin A is a marine metabolite. Psammaplin A is a selective HDAC1 (IC50: 45 nM), DNA methyltransferases (IC50: 18.6 nM) and aminopeptidase N (APN) (IC50: 18 μM) inhibitor. Psammaplin A also inhibits DNA topoisomerase and farnesyl protein transferase. Psammaplin A is a PPARγ activator and induces apoptosis. Psammaplin A has antitumor and anti-inflammatory activities. Psammaplin A has antibacterial activity against Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Psammaplin A inhibits angiogenesis .
    Psammaplin A

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