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Results for "

ALDO

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (3) Aldose Reductase (12) DNA Alkylator/Crosslinker (1) Endogenous Metabolite (2) Neurokinin Receptor (1) Reference Standards (1)
By Research Areas:	Cancer (16) Inflammation/Immunology (1) Neurological Disease (1)

Inhibitors & Agonists

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Natural
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Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-109154

Obafistat	Aldose Reductase	Inflammation/Immunology
Obafistat is a potent aldo-keto reductase AKR1C3 inhibitor with an IC₅₀ of 1.2 nM for human AKR1C3 (patent WO2017202817A1, example 4) .

HY-124573

(R)-Odafosfamide OBI-3424; TH-3424; (R)-AST-3424	DNA Alkylator/Crosslinker	Cancer
(R)-Odafosfamide (OBI-3424) is a proagent that is selectively converted by AKR1C3 (aldo-keto reductase 1C3) to a potent DNA-alkylating agent. (R)-Odafosfamide can be used for hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL) research .

HY-152189

S19-1035	Others	Cancer
S19-1035 is a highly potent and specific aldo-keto reductase 1C3 (AKR1C3) inhibitor. S19-1035 inhibits AKR1C3 with an IC₅₀ value of 3.04 nM. S19-1035 can be used for the research of tumor .

HY-139696

AKR1B10-IN-1	Aldose Reductase	Cancer
AKR1B10-IN-1 is a potent inhibitor of AKR1B10 (Aldo-Keto Reductase 1B10) with an IC₅₀ of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells .

HY-P3803

[D-Pro4,D-Trp7,9] Substance P (4-11)	Neurokinin Receptor	Neurological Disease
[D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration .

HY-150646

S07-2009	Aldose Reductase	Cancer
S07-2009 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ value of 0.20 μM .

HY-150648

S07-2008	Aldose Reductase	Cancer
S07-2008 is a selective aldo-keto reductase family 1 member C3 (AKR1C3) inhibitor with an IC₅₀ of 0.16 μM. S07-2008 shows anticancer activities .

HY-163323

AKR1C3-IN-12	Aldose Reductase	Cancer
AKR1C3-IN-12 (compound 2j) is an aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ of 27 nM. AKR1C3-IN-12 enhances the efficacy of Gemcitabine and Cisplatin in bladder cancer .

HY-176084

RJG-2051	Aldose Reductase	Cancer
RJG-2051 is a selective covalent aldo-keto reductase family 1 member C3 (AKR1C3) inhibitor with an IC₅₀ value of 13 nM. RJG-2051 interferes with the metabolic process of substrates such as androgens, estrogens, and prostaglandins by AKR1C3. RJG-2051 is promising for research of cancers .

HY-150650

S07-2001	Aldose Reductase	Cancer
S07-2001 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ value of 2.08 μM. S07-2001 enhances the activity of Doxorubicin against cancer cells. S07-2001 has potential as a chemotherapeutic potentiator for cancer agent resistance .

HY-138557

AKR1C3-IN-4	17β-HSD	Cancer
AKR1C3-IN-4 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ of 0.56 μM. AKR1C3-IN-4 has the potential for castrate resistant prostate cancer (CRPC) research .

HY-155035

S07-1066	17β-HSD	Cancer
S07-1066 is an aldo-keto reductase 1C3 (AKR1C3) inhibitor, synergizing doxorubicin (DOX) cytotoxicity. S07-1066 selectively blocks AKR1C3-mediated reduction of DOX, and reverses the DOX resistance in overexpressing AKR1C3 cells .

HY-150649

S07-2005 (racemic)	17β-HSD	Cancer
S07-2005 racemic is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ value of 0.13 μM and 0.75 μM for AKR1C3 and AKR1C4, respectively. S07-2005 racemic has potential as a chemotherapeutic potentiator for cancer agent resistance .

HY-152188

AKR1C3-IN-9	Aldose Reductase	Cancer
AKR1C3-IN-9 is a selective inhibitor of Aldo-keto Reductase 1C3 (AKR1C3) with an IC₅₀ value of 8.92 nM. AKR1C3-IN-9 significantly reverses the Doxorubicin (HY-15142A) (DOX) resistance in a resistant breast cancer cell line .

HY-W008270

2(5H)-Furanone γ-Crotonolactone	Endogenous Metabolite	Others
2(5H)-Furanone (γ-Crotonolactone) is an endogenous metabolite. 2(5H)-Furanone is present in a wide variety of biologically active natural products. 2(5H)-Furanone can undergo oraganocatalytic asymmetric direct vinylogous aldo reactions to provide diastereomerically and enantiomerically enriched 5-substituted 2(5H) furanones .

HY-157810

AKR1C3-IN-11	Aldose Reductase	Cancer
AKR1C3-IN-11 (Compound 6e) is a Aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ of 2.0 μM. AKR1C3-IN-11 inhibit cell proliferation in combination with abiraterone (HY-70013). AKR1C3-IN-11 can be used for the research of prostate cancer .

HY-W008270R

2(5H)-Furanone (Standard) γ-Crotonolactone (Standard)	Reference Standards Endogenous Metabolite	Others
2(5H)-Furanone (Standard) is the analytical standard of 2(5H)-Furanone. This product is intended for research and analytical applications. 2(5H)-Furanone (γ-Crotonolactone) is an endogenous metabolite. 2(5H)-Furanone is present in a wide variety of biologically active natural products. 2(5H)-Furanone can undergo oraganocatalytic asymmetric direct vinylogous aldo reactions to provide diastereomerically and enantiomerically enriched 5-substituted 2(5H) furanones .

HY-116170

SN34037	Aldose Reductase	Cancer
SN34037 is a specific inhibitor of Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188) with the ability to inhibit the cytotoxic activity of PR-104A. SN34037-sensitive coumberone reduction provides a rapid and specific assay for AKR1C3 activity. SN34037 inhibits the aerobic cytotoxicity of PR-104A in TF1 erythroleukemia cells with high AKR1C3 expression, but not in Nalm6 pre-B acute lymphoblastic leukemia cells with low AKR1C3 expression .

HY-150644

S07-2010 1 Publications Verification	Aldose Reductase	Cancer
S07-2010 is a potent pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC₅₀ values of 0.19, 0.36, 0.47, and 0.73 μM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively. S07-2010 induces apoptosis in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells .

HY-173132

AKR1Cs-IN-1	Aldose Reductase	Cancer
AKR1Cs-IN-1 (Compound 29) is a potent and broad-spectrum inhibitor targeting members of the Aldo-Keto Reductase 1C family (AKR1C1-1C4). By simultaneously occupying the SP2 and SP3 pockets, it effectively inhibits multiple isoforms and disrupts metabolic pathways associated with drug resistance. In enzymatic activity assays, AKR1Cs-IN-1 exhibited significant inhibitory potency, with IC₅₀ values of 0.09, 0.28, 0.05, and 0.51 µM against AKR1C1, AKR1C2, AKR1C3, and AKR1C4, respectively. In the doxorubicin (DOX)-resistant breast cancer cell line MCF-7/ADR, AKR1Cs-IN-1 showed remarkable resensitization effects and significantly enhanced the cytotoxicity of DOX. AKR1Cs-IN-1 holds promise for research on overcoming drug resistance in breast cancer .

Cat. No.	Product Name	Target	Research Area

HY-P3803

[D-Pro4,D-Trp7,9] Substance P (4-11)	Neurokinin Receptor	Neurological Disease
[D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration .

2(5H)-Furanone γ-Crotonolactone	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2(5H)-Furanone (γ-Crotonolactone) is an endogenous metabolite. 2(5H)-Furanone is present in a wide variety of biologically active natural products. 2(5H)-Furanone can undergo oraganocatalytic asymmetric direct vinylogous aldo reactions to provide diastereomerically and enantiomerically enriched 5-substituted 2(5H) furanones .

2(5H)-Furanone (Standard) γ-Crotonolactone (Standard)	Natural Products Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
2(5H)-Furanone (Standard) is the analytical standard of 2(5H)-Furanone. This product is intended for research and analytical applications. 2(5H)-Furanone (γ-Crotonolactone) is an endogenous metabolite. 2(5H)-Furanone is present in a wide variety of biologically active natural products. 2(5H)-Furanone can undergo oraganocatalytic asymmetric direct vinylogous aldo reactions to provide diastereomerically and enantiomerically enriched 5-substituted 2(5H) furanones .

Species:	Human (8)
Tag:	His (7) SUMO (1) Tag Free (3)
Source:	E. coli (10)

Cat. No.	Compare	Product Name	Species	Source

HY-P701972

	Aldose-reductase Protein, Human AKR1B10; ALDO-keto reductase family 1 member B10; ARL-1; ALDOse reductase-like; ALDOse reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase	Human	E. coli
	The Aldose-reductase protein reduces carbonyl-containing compounds to alcohols, including retinals. It detoxifies unsaturated carbonyls like crotonaldehyde and 4-hydroxynonenal, but lacks reductase activity towards glucose. Aldose-reductase Protein, Human is the recombinant human-derived Aldose-reductase protein, expressed by E. coli , with tag free.

HY-P76137

	AKR1A1 Protein, Human (His) ALDO-keto reductase family 1 member A1; Aldehyde reductase; Glucuronate reductase; ALDR1; ALR	Human	E. coli
	The AKR1A1 protein uses NADPH to reduce various carbonyl compounds to alcohols. AKR1A1 Protein, Human (His) is the recombinant human-derived AKR1A1 protein, expressed by E. coli , with N-His labeled tag.

HY-P7470

	AKR1C4 Protein, Human (His) rHuALDO-keto Reductase 1C4, His; AKR-1C4; ALDO-keto Reductase 1C4	Human	E. coli
	AKR1C4 Protein, Human (His) is a human recombinant AKR1C4 with a N-Terminal His-tag. AKR1C4 Protein, Human (His) is derived from E. coli and corresponding to the amino acids 1-323 of human Aldo-keto Reductase 1C4/AKR1C4.

HY-P75521

	AKR1B1 Protein, Human (His) ALDO-keto reductase family 1 member B1; AKR1B1; ALDR1; ALR2	Human	E. coli
	The AKR1B1 protein uses NADPH to reduce various carbonyl compounds to alcohols. AKR1B1 Protein, Human (His) is the recombinant human-derived AKR1B1 protein, expressed by E. coli , with N-10*His labeled tag.

HY-P72163

	CYP11B2 Protein, Human (His-SUMO) ALDOS; ALDOsterone synthase; ALDOsterone-synthesizing enzyme; C11B2_HUMAN; CYP11B2; CYPXIB2; Cytochrome P-450ALDO; Cytochrome P-450C18; Cytochrome P450 11B2; Cytochrome P450 11B2; mitochondrial; mitochondrial; P-450ALDO; P-450C18; Steroid 18-hydroxylase	Human	E. coli
	CYP11B2 Protein, a cytochrome P450 monooxygenase, synthesizes aldosterone, pivotal for salt and water balance, impacting blood pressure and cardiovascular health. Mechanistically, it orchestrates three oxidative reactions, forming aldosterone, utilizing molecular oxygen and a mitochondrial transfer system. Additionally, CYP11B2 may be involved in the androgen metabolic pathway, expanding its physiological roles. CYP11B2 Protein, Human (His-SUMO) is the recombinant human-derived CYP11B2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P75520

	AKR1C2 Protein, Human (His) AKR-1C2; ALDO-keto reductase family 1 member C2; DD-2; AKR1C2	Human	E. coli
	AKR1C2 protein: Cytoplasmic aldehyde-keto reductase, which uses NADH and NADPH to reduce ketosteroids to hydroxysteroids. AKR1C2 Protein, Human (His) is the recombinant human-derived AKR1C2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7469

	AKR1C2 Protein, Human rHuALDO-keto reductase family 1 member C2; AKR-1C2; ALDO-keto reductase family 1 member C2	Human	E. coli
	AKR1C2 Protein, Human is a recombinant human AKR1C2. AKR1C2 is a member of the aldo/keto reductase superfamily and has critical roles in the tumorigenesis and progression of malignant tumours.

HY-P701973

	Aldose-reductase Protein, Human (His) AKR1B10; ALDO-keto reductase family 1 member B10; ARL-1; ALDOse reductase-like; ALDOse reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase	Human	E. coli
	The Aldose-reductase protein reduces carbonyl-containing compounds to alcohols, including retinals. It detoxifies unsaturated carbonyls like crotonaldehyde and 4-hydroxynonenal, but lacks reductase activity towards glucose. Aldose-reductase Protein, Human (His) is the recombinant human-derived Aldose-reductase protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701871

	GRE3 Protein, Saccharomyces cerevisiae GRE3; NADPH-dependent ALDOse reductase GRE3; AR; Genes de respuesta a estres protein 3; NADPH-dependent ALDO-keto reductase GRE3; Xylose reductase	Others	E. coli
	The GRE3 protein is an aldose reductase that reduces the cytotoxic compound methylglyoxal (MG) to acetol and (R)-lactaldehyde, especially under stress conditions. MG is synthesized from dihydroxyacetone phosphate and is involved in cell cycle regulation and stress adaptation. GRE3 Protein, Saccharomyces cerevisiae is the recombinant GRE3 protein, expressed by E. coli , with tag free.

HY-P701872

	GRE3 Protein, Saccharomyces cerevisiae (His) GRE3; NADPH-dependent ALDOse reductase GRE3; AR; Genes de respuesta a estres protein 3; NADPH-dependent ALDO-keto reductase GRE3; Xylose reductase	Others	E. coli
	The GRE3 protein is an aldose reductase that reduces the cytotoxic compound methylglyoxal (MG) to acetol and (R)-lactaldehyde, especially under stress conditions. MG is synthesized from dihydroxyacetone phosphate and is involved in cell cycle regulation and stress adaptation. GRE3 Protein, Saccharomyces cerevisiae (His) is the recombinant GRE3 protein, expressed by E. coli , with N-6*His labeled tag.

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HY-P81368

	AKR1B10 Antibody (YA1113) AKR1B10; AKR1B11; ALDO-keto reductase family 1 member B10; ARL-1; ALDOse reductase-like; ALDOse reductase-related protein (ARP; hARP); Small intestine reductase (SI reductase)	IHC-P	Human
	AKR1B10 Antibody (YA1113) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AKR1B10.

HY-P85558

	Aldose Reductase Antibody (YA5250) ADR; AKR1B 1; Akr1b1; Aldehyde reductase 1; Aldehyde reductase; ALDO keto reductase family 1, member B1; ALDO-keto reductase family 1 member B1; ALDO-keto reductase family 1, member B1; ALDOse reductase; ALDOse reductase; aldr 1; ALDR_HUMAN; ALDR1; ALR2; AR; Lii5 2 CTCL tumor antigen; Low Km ALDOse reductase; MGC1804.	WB	Human, Mouse, Rat
	Aldose Reductase Antibody (YA5250) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Aldose Reductase.

HY-P85418

	Aldose Reductase Antibody (YA5110) AKR1B1; ALDR1; ALDOse reductase; AR; Aldehyde reductase; ALDO-keto reductase family 1 member B1	WB	Human, Mouse, Dog, Rabbit
	Aldose Reductase Antibody (YA5110) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Aldose Reductase.

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ALDO

Inhibitors & Agonists

Peptides

NaturalProducts

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