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Results for "

ACE inhibition

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Peptides

2

Inhibitory Antibodies

1

Natural
Products

1

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-137188
    Perindopril acyl-β-D-glucuronide

    		Drug Metabolite Cardiovascular Disease
    Perindopril acyl-β-D-glucuronide is a metabolite of Perindopril (HY-B0130). Perindopril is an ACE inhibitor .
    Perindopril acyl-β-D-glucuronide
  • HY-P99818
    Ramatercept

    ACE-031

    		 TGF-β Receptor Metabolic Disease
    Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy .
    Ramatercept
  • HY-130199
    Psoromic acid

    Parellic acid

    		 Others Metabolic Disease
    Psoromic acid is a potent and selective RabGGTase (Rab geranylgeranyl transferase) inhibitor with an IC50 value of 1.3 µM. Psoromic acid is an antioxidative agent. Psoromic acid exhibits a competitive type of HMGR inhibition and mixed type of ACE (angiotensin converting enzyme) inhibition .
    Psoromic acid
  • HY-126404
    Casein hydrolysate

    		Angiotensin-converting Enzyme (ACE) Cardiovascular Disease
    Casein hydrolysate is the hydrolysis product of Casein (HY-125865). Casein hydrolysate reduces the blood pressure, through inhibition of angiotensin-converting enzyme (ACE) and reduction of bradykinin breakdown .
    Casein hydrolysate
  • HY-P99590
    Sotatercept

    ACE-011; MK-7962

    		 TGF-β Receptor Cardiovascular Disease Inflammation/Immunology Cancer
    Sotatercept (ACE-011) is a soluble activin receptor 2A (ACVR2A) type IgG Fc fusion protein. Sotatercept combines activin and growth differentiation factor to try to restore the balance between growth promotion and growth inhibition signal pathways. Sotatercept has potential application in pulmonary arterial hypertension, anemia, bone loss, erythropoiesis, multiple myeloma (MM) osteolytic lesions .
    Sotatercept
  • HY-116439
    Diisononyl phthalate

    DINP

    		 Angiotensin Receptor Cardiovascular Disease
    Diisononyl phthalate (DINP) is a phthalate used as a plasticizer. Diisononyl phthalate induces an increase in blood pressure through activation of the ACE/AT1R axis and inhibition of NO production in mice. Diisononyl phthalate can also be used in resin solvents, building materials, lubricants, adhesives, cosmetics and printing inks .
    Diisononyl phthalate
  • HY-B0690
    Fosinopril

    SQ28555 free acid

    		 Angiotensin-converting Enzyme (ACE) Apoptosis Cardiovascular Disease
    Fosinopril (SQ28555 free acid) is the ester proagent of angiotensin-converting enzyme (ACE) inhibitor with an IC50 value of 0.18 μM. Fosinopril demonstrates a non-competitive inhibition effect on ACE activity with an Ki value of 1.675 μM .
    Fosinopril
  • HY-B0690S
    Fosinopril-d5

    SQ28555-d5 free acid

    		 Isotope-Labeled Compounds Apoptosis Angiotensin-converting Enzyme (ACE) Cardiovascular Disease
    Fosinopril-d5 (SQ28555-d5 (free acid)) is deuterium labeled Fosinopril. Fosinopril (SQ28555 free acid) is the ester proagent of angiotensin-converting enzyme (ACE) inhibitor with an IC50 value of 0.18 μM. Fosinopril demonstrates a non-competitive inhibition effect on ACE activity with an Ki value of 1.675 μM .
    Fosinopril-d5
  • HY-162550
    Jobosic acid

    		SARS-CoV Infection
    Jobosic acid, a saturated fatty acid, is a selective SARS-CoV-2 inhibitor. Jobosic acid inhibits Mpro and spike-RBD/ACE-2 interaction with IC50 values of 7.5 μg/mL and 3 μg/mL, respectively. Jobosic acid shows viral entry inhibition for the omicron SARS-CoV-2 variant .
    Jobosic acid
  • HY-175724
    MBL-IN-6

    		Beta-lactamase Bacterial Infection
    MBL-IN-6 (Compound 6d) is a Metallo-β-lactamase (MBL) inhibitor with Kis of 2.6 and 0.08 μM for NDM-1 and VIM-2, respectively. MBL-IN-6 has a synergistic activities with Imipenem (HY-B1369A) on MBL-producing clinical isolates (such as E. coli SI-M001, K. pneumonia T2301 and S. marcescens SI-1591) with MICs of 2-64 μg/mL. MBL-IN-6 does not have off-target effects without ACE-1 inhibition activity. MBL-IN-6 can be used for antimicrobial resistance research .
    MBL-IN-6
  • HY-W011258
    H-Tyr-Phe-OH

    L-Tyrosyl-L-phenylalanine

    		 Xanthine Oxidase Angiotensin-converting Enzyme (ACE) Inflammation/Immunology Cancer
    H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells .
    H-Tyr-Phe-OH
  • HY-175697
    Glycosyltransferase-IN-2

    		Glycosyltransferase SARS-CoV Angiotensin-converting Enzyme (ACE) DNA/RNA Synthesis Infection
    Glycosyltransferase-IN-2 (Compound 20) is a Glycosyltransferase inhibitor. Glycosyltransferase-IN-2 has a broad-spectrum anticoronavirus activity with IC50s of 11.3, 5.5 and ~16.2 μM for MHV, HCoV-NL63 and SARS-CoV-2, respectively. Glycosyltransferase-IN-2 interferes with the coronavirus infectivity, alters viral protein glycosylation with inhibition of interaction with the ACE2 receptor or SC-VLP secretion, and inhibits RNA replication. Glycosyltransferase-IN-2 can be used for coronavirus infections research .
    Glycosyltransferase-IN-2

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