ABCC1

By Targets:	Amyloid-β (2) Bacterial (2) Dopamine Receptor (2) Fluorescent Dye (1) Histamine Receptor (2) Leukotriene Receptor (2) LPL Receptor (2) P-glycoprotein (7) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (5) Infection (2) Inflammation/Immunology (2) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113805

MC70	P-glycoprotein	Cancer
MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC₅₀ of 0.69 µM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1 ^[1] .

HY-19989A

MK-571 sodium Maximum Cited Publications 27 Publications Verification L-660711 sodium	P-glycoprotein LPL Receptor Leukotriene Receptor	Inflammation/Immunology
MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D₄ (LTD₄) receptor antagonist, with K_i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and **ABCC1 (MRP1)*. MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1*-phosphate) release ^[1] .

HY-17013A

Dofequidar fumarate 2 Publications Verification MS-209	P-glycoprotein	Cancer
Dofequidar fumarate (MS-209) is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar fumarate has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar fumarate competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect ^[1] .

HY-17013

Dofequidar 2 Publications Verification MS-209 free base	P-glycoprotein	Cancer
Dofequidar (MS-209 free base) is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect ^[1] .

HY-19989

MK-571 Maximum Cited Publications 27 Publications Verification L-660711	P-glycoprotein LPL Receptor Leukotriene Receptor	Inflammation/Immunology
MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D₄ (LTD₄) receptor antagonist, with K_i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and **ABCC1 (MRP1)** inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release ^[1] .

HY-RS16913

Abcc1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Abcc1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Abcc1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Abcc1 Mouse Pre-designed siRNA Set A Abcc1 Mouse Pre-designed siRNA Set A

HY-RS23355

Abcc1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Abcc1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Abcc1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Abcc1 Rat Pre-designed siRNA Set A Abcc1 Rat Pre-designed siRNA Set A

HY-RS00057

ABCC1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ABCC1 Human Pre-designed siRNA Set A contains three designed siRNAs for ABCC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ABCC1 Human Pre-designed siRNA Set A ABCC1 Human Pre-designed siRNA Set A

HY-D1609

BODIPY FL Verapamil hydrochloride	Fluorescent Dye	Others
BODIPY FL Verapamil hydrochloride is a fluorescent dye, it can be used as a molecular probe to label tissues and cells. BODIPY FL Verapamil hydrochloride is a substrate for both ABCB1 and ABCC1 ^[1] .

HY-17013D

Dofequidar sesquifumarate MS-209 sesquifumarate	P-glycoprotein	Cancer
Dofequidar (MS-209) sesquifumarate is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar sesquifumarate has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar sesquifumarate competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect ^[1] .

HY-B1794

Thiethylperazine 1 Publications Verification	Dopamine Receptor Histamine Receptor Bacterial Amyloid-β	Infection Neurological Disease
Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective *ABCC1*activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects ^[1] .

HY-B1794A

Thiethylperazine dimaleate 1 Publications Verification	Dopamine Receptor Histamine Receptor Bacterial Amyloid-β	Infection Neurological Disease
Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a selective *ABCC1*activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects ^[1] .

HY-101453

Ceefourin 1	P-glycoprotein	Cancer
Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma ^[1] .

Cat. No.	Product Name	Type

HY-D1609

BODIPY FL Verapamil hydrochloride	Dyes
BODIPY FL Verapamil hydrochloride is a fluorescent dye, it can be used as a molecular probe to label tissues and cells. BODIPY FL Verapamil hydrochloride is a substrate for both ABCB1 and ABCC1 ^[1] .

Species:	Human (1) Bovine (1)
Tag:	GFP (1) His (2) Strep (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P701355

	ABCC1 Protein, Bovine (HEK293, GFP, StrepⅡ, His) ABCC1; Multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; Leukotriene C(4) transporter; LTC4 transporter	Bovine	HEK293
	The ABCC1 protein plays a key role in cellular physiology, mediating the ATP-dependent export of a variety of substrates, including drugs and organic anions. Notably, it confers resistance to anticancer drugs, actively reducing their intracellular accumulation. ABCC1 Protein, Bovine (HEK293, GFP, Strep, His) is the recombinant bovine-derived ABCC1 protein, expressed by HEK293 , with C-10*His, C-GFP, C-StrepII labeled tag.

HY-P72069

	ABCC1 Protein, Human (His) ABC 29; ABC29; ABCC 1; ABCC; ABCC1; ATP binding cassette sub family C CFTR/MRP; member 1; ATP binding cassette sub-family C member 1; ATP binding cassette subfamily C member 1; ATP binding cassette transporter variant ABCC1delta ex13; ATP binding cassette transporter variant ABCC1delta ex13&14; ATP binding cassette transporter variant ABCC1delta ex25; ATP binding cassette transporter variant ABCC1delta ex25&26; ATP binding cassette, sub-family C CFTR/MRP; , member 1; ATP-binding cassette sub-family C member 1; DKFZp686N04233; DKFZp781G125; GS X; GSX; Leukotriene C4; transporter; LTC4 transporter; MRP 1; MRP; MRP1; MRP1_HUMAN; Multidrug resistance associated protein 1; Multidrug resistance protein; Multidrug resistance-associated protein 1; Multiple drug resistance associated protein; Multiple drug resistance protein 1	Human	E. coli
	ABCC1, Human (His) is a multitasking ATP-binding cassette (ABC) transporter. ABCC1, Human plays a part in inflammatory and other immunological diseases, age-related macular degeneration, cardiovascular disease, and certain neurological disorders as well as tumor progression.

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HY-P81838

	MRP1 Antibody (YA1583) ABC29; ABCC1; GSX; Leukotriene C(4) transporter; LTC4 transporter; MRP1	WB, FC	Human
	MRP1 Antibody (YA1583) is a non-conjugated IgG antibody, targeting MRP1, with a predicted molecular weight of 172 kDa. MRP1 Antibody (YA1583) can be used for WB, FC experiment in human background.

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Cat. No.	Product Name		Classification

HY-RS16913

Abcc1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Abcc1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Abcc1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23355

Abcc1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Abcc1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Abcc1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00057

ABCC1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ABCC1 Human Pre-designed siRNA Set A contains three designed siRNAs for ABCC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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