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Results for "

4E-BP1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (2) ATM/ATR (2) Autophagy (2) Bacterial (2) Casein Kinase (1) CDK (2) Hedgehog (2) mTOR (8) PI3K (1) Pim (5) Reference Standards (2) Small Interfering RNA (siRNA) (2) STAT (2)
By Research Areas:	Cancer (18) Infection (1) Inflammation/Immunology (3)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W412264

Pim-1/2 kinase inhibitor 1	Pim	Cancer
Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of *4E-BP1* and p27 ^Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer .

HY-N6954

Garcinone C 2 Publications Verification	ATM/ATR STAT CDK Hedgehog	Inflammation/Immunology Cancer
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and *4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog* signaling pathway. Garcinone C is orally active .

HY-143510

RMC-4627	mTOR	Cancer
RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.

HY-130723A

AMPK activator 2 hydrochloride	AMPK	Cancer
AMPK activator 2 (compound 7a) hydrochloride, a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 hydrochloride inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) .

HY-149292

SR-4133	Casein Kinase	Cancer
SR-4133 is a potent and highly CK1ε selective inhibitor with an IC₅₀ of 58 nM. SR-4133 binds to the ATP-binding site of CK1ε. SR-4133 displays nanomolar growth inhibition of bladder cancer cells, and inhibits the phosphorylation of 4E-BP1 .

HY-N6954R

Garcinone C (Standard)	Reference Standards ATM/ATR STAT CDK Hedgehog	Inflammation/Immunology Cancer
Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and *4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog* signaling pathway. Garcinone C is orally active .

HY-115869

RMC-4529	mTOR	Cancer
RMC-4529 has an IC₅₀ value of 1.0 nM against p-4E-BP1-(T37/46) in mTOR kinase cellular assay.

HY-114267

Cbz-B3A	mTOR	Others
Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).

HY-RS04277

EIF4EBP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EIF4EBP1 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF4EBP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EIF4EBP1 Human Pre-designed siRNA Set A EIF4EBP1 Human Pre-designed siRNA Set A

HY-130723

AMPK activator 2	AMPK	Cancer
AMPK activator 2 (compound 7a), a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) .

HY-111370

mTOR inhibitor-2	mTOR	Cancer
mTOR inhibitor-2 is a highlt potent, selective and oral mTOR inhibitor with an IC₅₀ of 7 nM. mTOR inhibitor-2 inhibits cellular phosphorylation of mTORC1 (pS6 and p4E-BP1) and mTORC2 (pAKT (S473)) substrates .

HY-N0656A

(+)-Usnic acid 2 Publications Verification	mTOR Bacterial Autophagy	Infection Inflammation/Immunology Cancer
(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer and anti-inflammatory activity. (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .

HY-RS20227

Eif4ebp1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Eif4ebp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Eif4ebp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Eif4ebp1 Mouse Pre-designed siRNA Set A Eif4ebp1 Mouse Pre-designed siRNA Set A

HY-18095A

CX-6258 hydrochloride hydrate 1 Publications Verification	Pim	Cancer
CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC₅₀s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively .

HY-18095

CX-6258 1 Publications Verification	Pim	Cancer
CX-6258 is a potent and kinase selective pan-Pim kinases inhibitor, with IC₅₀s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively .

HY-18095B

CX-6258 hydrochloride 1 Publications Verification	Pim	Cancer
CX-6258 hydrochloride is a potent and kinase selective pan-Pim kinases inhibitor, with IC₅₀s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively .

HY-N0656AR

(+)-Usnic acid (Standard)	Reference Standards mTOR Bacterial Autophagy	Cancer
(+)-Usnic acid (Standard) is the analytical standard of (+)-Usnic acid. This product is intended for research and analytical applications. (+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity . (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .

HY-W348485

WRX606	mTOR	Cancer
WRX606 is an orally active nonrapalog inhibitor for mTOR complex 1 (mTORC1M). WRX606 inhibits the phosphorylation of mTORC1 substrate S6 kinase 1 (S6K1) (IC₅₀ = 10 nM) and eukaryotic translation initiation factor 4E binding protein (p-4E-BP1) (IC₅₀ = 0.27 μM) in MCF-7 cells. WRX606 suppresses tumor growth in mice without promotion of metastasis. WRX606 can be studied in research as an antitumor agent .

HY-16576A

SMI-4a 1 Publications Verification TCS-PIM-1-4a	Pim	Cancer
SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC₅₀ of 24 μM and a K_i of 0.6 μM. SMI-4a also inhibits Pim-2 (IC₅₀ of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity .

HY-134903

(32-Carbonyl)-RMC-5552	mTOR	Cancer
(32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC₅₀s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2) .

HY-124348

DM-PIT-1 3,5-Dimethyl PIT-1	PI3K	Cancer
DM-PIT-1 is a PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction inhibitor. DM-PIT-1 decreases he expression of P-Akt, P-GSK-3-β, P-p70S6K, P-S6, P-4E-BP1. DM-PIT-1 induces apoptosis and shows anticancer activity. DM-PIT-1 has the potential for the research of ovarian cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6954

Garcinone C 2 Publications Verification	Structural Classification other families Xanthones Classification of Application Fields Garcinia oblongifolia Champ. ex Benth. Guttiferae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	ATM/ATR STAT CDK Hedgehog
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and *4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog* signaling pathway. Garcinone C is orally active .

HY-N0656A

(+)-Usnic acid 2 Publications Verification	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Plants Lichen Disease Research Fields Cancer	mTOR Bacterial Autophagy
(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer and anti-inflammatory activity. (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .

HY-N6954R

Garcinone C (Standard)	Structural Classification other families Xanthones Garcinia oblongifolia Champ. ex Benth. Guttiferae Source classification Phenols Polyphenols Plants	Reference Standards ATM/ATR STAT CDK Hedgehog
Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and *4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog* signaling pathway. Garcinone C is orally active .

HY-N0656AR

(+)-Usnic acid (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Plants Lichen	Reference Standards mTOR Bacterial Autophagy
(+)-Usnic acid (Standard) is the analytical standard of (+)-Usnic acid. This product is intended for research and analytical applications. (+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity . (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .

Cat. No.	Compare	Product Name	Species	Source

HY-P70415

	EIF4EBP1 Protein, Human (His) rHuEukaryotic translation initiation factor 4E-binding protein 1/EIF4EBP1, His; Eukaryotic Translation Initiation Factor 4E-Binding Protein 1; 4E-BP1; eIF4E-Binding Protein 1; Phosphorylated Heat- and Acid-Stable Protein Regulated by Insulin 1; PHAS-I; EIF4EBP1	Human	E. coli
	EIF4EBP1 is a translation initiation repressor protein that complexly regulates EIF4E activity. In the hypophosphorylated state, EIF4EBP1 competes with EIF4G1/EIF4G3 to inhibit translation by binding to EIF4E. EIF4EBP1 Protein, Human (His) is the recombinant human-derived EIF4EBP1 protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80526

	4E BP1 Antibody (YA650) EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, IHC-P, IP	Human, Mouse, Rat, Hamster
	4E BP1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 13 kDa, targeting to 4E BP1. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat, Hamster.

HY-P80786

	*Phospho-4E BP1* (Thr46) Antibody (YA230)** EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, IHC-P, IP	Human, Mouse, Rat
	Phospho-4E BP1 (Thr46) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 13 kDa, targeting to Phospho-4E BP1 (Thr46). It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P86332

	4E-BP1 Antibody (YA6024) EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	4E-BP1 Antibody (YA6024) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 4E-BP1. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

HY-P84548

	*Phospho-4E-BP1* (Ser65) Antibody (YA4245)** EIF4EBP1; BP-1; 4EBP1; 4E-BP1; PHAS-I	IHC-P, ICC/IF, FC, ELISA	Human
	Phospho-4E-BP1 (Ser65) Antibody (YA4245) is a mouse-derived and non-conjugated IgG1 antibody, targeting to 4E-BP1 (Ser65). It can be applicated for IHC-P, ICC/IF, FC, ELISA assays, in the background of human.

HY-P86088

	*Phospho-4E-BP1(Thr37/46) Antibody (YA5780)* EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-4E-BP1(Thr37/46) Antibody (YA5780) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to phosphorylated 4E-BP1 (Thr37/46). It can be applicated for WB, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.