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25-Hydroxycholesterol

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) ATF6 (1) Biochemical Assay Reagents (1) Calcium Channel (1) DNA/RNA Synthesis (1) Endogenous Metabolite (3) Isotope-Labeled Compounds (1) Parasite (1) Phospholipase (1) SARS-CoV (1) Smo (1) Somatostatin Receptor (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Endocrinology (1) Infection (2) Inflammation/Immunology (5) Metabolic Disease (1)

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Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113134

*25-Hydroxycholesterol* 20+ Cited Publications 25-OHC	Endogenous Metabolite	Inflammation/Immunology
25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC₅₀≈65 nM) and selective suppressor of IgA production by B cells.

HY-113134S

25-Hydroxycholesterol-d6 25-OHC-d₆	Isotope-Labeled Compounds Endogenous Metabolite	Inflammation/Immunology
25-Hydroxycholesterol-d₆ (25-OHC-d₆) is the deuterium labeled 25-Hydroxycholesterol. 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC₅₀≈65 nM) and selective suppressor of IgA production by B cells .

HY-125586

β-Amanitin	DNA/RNA Synthesis ADC Payload	Cancer
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .

HY-113134R

25-Hydroxycholesterol (Standard)	Endogenous Metabolite	Inflammation/Immunology
25-Hydroxycholesterol (Standard) is the analytical standard of 25-Hydroxycholesterol. This product is intended for research and analytical applications. 25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

HY-133974

7-keto-25-Hydroxycholesterol 7-keto-25-OHC	Smo	Cancer
7-keto-25-Hydroxycholesterol (7-keto-25-OHC), a oxysterol, is a Smoothened (Smo) activator. 7-keto-25-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo .

HY-P10906

Talovirtide	Biochemical Assay Reagents	Others
Talovirtide is a peptide containing L-valyl .

HY-P10872

P315V3	SARS-CoV	Infection
P315V3 is an pan inhibitor for coronavirus, that inhibits SARS-CoV-2 prototypePT, Delta, BA.1 and BA.4 strain with IC₅₀s of 10.9, 8.9, 8.6, and 2.7 nM. P315V3 exhibits cytotoxicity in Vero cell with CC₅₀ of 4.3 μM. P315V3 exhibits anti-infectious efficacy in mouse models .

HY-158104

LPPM-8	ATF6	Others
LPPM-8 is a ligand of *Med25* and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology .

HY-P3100

Orfamide A	Parasite	Infection
Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC₅₀ value of 34.5 μg/mL .

HY-P2424

Cholecystokinin-J CCK-J	Calcium Channel	Others
Cholecystokinin-J (CCK-J), a cholecystokinin, stimulates Ca ²⁺ release .

HY-P10447

Plipastatin A1 Fengycin IX; SNA-60-367-3	Phospholipase	Inflammation/Immunology
Plipastatin A1 is a lipopeptide with enzyme inhibitory and immunosuppressive activities. Plipastatin A1 is found in Bacillus cereus and inhibits phospholipase A2 (PLA2), PLC, and PLD .

HY-17365

Octreotide acetate 10+ Cited Publications SMS 201-995 acetate	Somatostatin Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.

Cat. No.	Product Name	Target	Research Area

HY-125586

β-Amanitin	DNA/RNA Synthesis ADC Payload	Cancer
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .

HY-105055

Didemnin B	Peptides	Cancer
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .

HY-17365

Octreotide acetate 10+ Cited Publications SMS 201-995 acetate	Somatostatin Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.

HY-P10906

Talovirtide	Biochemical Assay Reagents	Others
Talovirtide is a peptide containing L-valyl .

HY-P10872

P315V3	SARS-CoV	Infection
P315V3 is an pan inhibitor for coronavirus, that inhibits SARS-CoV-2 prototypePT, Delta, BA.1 and BA.4 strain with IC₅₀s of 10.9, 8.9, 8.6, and 2.7 nM. P315V3 exhibits cytotoxicity in Vero cell with CC₅₀ of 4.3 μM. P315V3 exhibits anti-infectious efficacy in mouse models .

HY-P4755

*N-((RS)-2-Hydroxy-propyl)-Val-Leu-anilide*	Peptides	Others
N-((RS)-2-Hydroxy-propyl)-Val-Leu-anilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-158104

LPPM-8	ATF6	Others
LPPM-8 is a ligand of *Med25* and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology .

HY-P3100

Orfamide A	Parasite	Infection
Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC₅₀ value of 34.5 μg/mL .

HY-P2424

Cholecystokinin-J CCK-J	Calcium Channel	Others
Cholecystokinin-J (CCK-J), a cholecystokinin, stimulates Ca ²⁺ release .

HY-P10447

Plipastatin A1 Fengycin IX; SNA-60-367-3	Phospholipase	Inflammation/Immunology
Plipastatin A1 is a lipopeptide with enzyme inhibitory and immunosuppressive activities. Plipastatin A1 is found in Bacillus cereus and inhibits phospholipase A2 (PLA2), PLC, and PLD .

HY-125357

Ternatin	Peptides	Metabolic Disease
Ternatin (compound 2) is a cyclic heptapeptides that can be isolated from mushroom Coliorus versicolor. Ternatin inhibits fat-accumulation with an IC₅₀ of 0.027 μM in 3T3-L1 adipocytes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113134

*25-Hydroxycholesterol* 20+ Cited Publications 25-OHC	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Endogenous Metabolite
25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC₅₀≈65 nM) and selective suppressor of IgA production by B cells.

HY-105055

Didemnin B	Structural Classification Natural Products Animals Classification of Application Fields Marine natural products Source classification Other marine organisms Disease Research Fields Cancer	Others
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .

HY-113134R

25-Hydroxycholesterol (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Endogenous Metabolite
25-Hydroxycholesterol (Standard) is the analytical standard of 25-Hydroxycholesterol. This product is intended for research and analytical applications. 25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

Cat. No.	Product Name	Chemical Structure

HY-113134S

25-Hydroxycholesterol-d6
25-Hydroxycholesterol-d₆ (25-OHC-d₆) is the deuterium labeled 25-Hydroxycholesterol. 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC₅₀≈65 nM) and selective suppressor of IgA production by B cells .

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25-Hydroxycholesterol

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products