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Results for "

μopioid receptors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (5) Aminopeptidase (1) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (4) Autophagy (4) Cholinesterase (ChE) (2) Dopamine Receptor (1) Drug Metabolite (2) Endogenous Metabolite (3) Enterovirus (2) iGluR (5) Isotope-Labeled Compounds (10) MMP (5) Neprilysin (1) NF-κB (9) Opioid Receptor (87) PI3K (5) Reference Standards (8) Sigma Receptor (2) TRP Channel (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (2) Endocrinology (1) Infection (3) Inflammation/Immunology (13) Metabolic Disease (3) Neurological Disease (81)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100122

Bevenopran 1 Publications Verification CB-5945; ADL-5945	Opioid Receptor	Neurological Disease
Bevenopran is a peripheral **μ-opioid receptor** antagonist .

HY-P1087

Adrenorphin Metorphamide	Opioid Receptor	Cancer
Adrenorphin is a opioid octapeptide, acting as a potent agonist of **μ-opioid receptor, with K_i** of 12 nM.

HY-13243

Alvimopan ADL 8-2698; LY 246736	Opioid Receptor	Neurological Disease
Alvimopan (ADL 8-2698) is a potent, selective, orally active and reversible **μ-opioid receptor antagonist, with an IC₅₀** of 1.7 nM. Alvimopan has selectivity for μ-opioid receptor (K_i=0.47 nM) over κ- and δ-opioid receptors (K_is=100, 12 nM, respectively). Alvimopan can be used for the research of postoperative ileus .

HY-128038

N-Desmethyl-loperamide	Opioid Receptor	Neurological Disease
N-Desmethyl-loperamide is a major metabolite of loperamide, a drug that selectively activates peripheral μopioid receptors with a K_i value of 0.16 nM. N-Desmethyl-loperamide is a substrate of the ATP-dependent efflux transporter P-glycoprotein .

HY-130367

U-48520	Opioid Receptor	Neurological Disease
U-48520 is an agonist for **μ-opioid receptor with EC₅₀** of 1561 nM .

HY-123689A

Samidorphan hydrochloride ALKS-33 hydrochloride; RDC-0313 hydrochloride	Opioid Receptor	Neurological Disease
Samidorphan hydrochloride is an orally active *opioid* system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan hydrochloride acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan hydrochloride primarily acts as an opioid receptor antagonist in vivo. Samidorphan can improve the behavior of depressed animals .

HY-76657

Alvimopan monohydrate ADL 8-2698 monohydrate; LY 246736 monohydrate	Opioid Receptor	Neurological Disease Cancer
Alvimopan monohydrate (ADL 8-2698 monohydrate) is a potent, selective, orally active and reversible **μ-opioid receptor antagonist, with an IC₅₀** of 1.7 nM. Alvimopan monohydrate has selectivity for μ-opioid receptor (K_i=0.47 nM) over κ- and δ-opioid receptors (K_is=100, 12 nM, respectively). Alvimopan monohydrate can be used for the research of postoperative ileus .

HY-P1577

Dermorphin Analog	Opioid Receptor	Inflammation/Immunology
Dermorphin Analog is an analog of Dermorphin. Dermorphin is a natural heptapeptide **μ-opioid receptor** agonist found in amphibian skin.

HY-123689S

Samidorphan-d4 ALKS-33-d₄; RDC-0313-d₄	Isotope-Labeled Compounds Opioid Receptor	Neurological Disease
Samidorphan-d4 is the deuterium labeled Samidorphan(HY-123689).Samidorphan (ALKS-33) is an orally active *opioid* system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo .

HY-123689S1

Samidorphan-d5 ALKS-33-d₅; RDC-0313-d₅	Isotope-Labeled Compounds Opioid Receptor	Neurological Disease
Samidorphan-d5 (ALKS-33-d5) is is a deuterated compound of Samidorphan. Samidorphan is an orally active *opioid* system modulator that binds with high affinity to *μ-opioid, κ-opioid, and δ-opioid* receptors. Samidorphan is a *μ-opioid* receptor antagonist and a partial agonist at *k-opioid* and *δ-opioid* receptors. Samidorphan acts primarily as an *opioid* receptor antagonist in vivo .

HY-123689

Samidorphan ALKS-33; RDC-0313	Opioid Receptor	Neurological Disease
Samidorphan (ALKS-33) is an orally active *opioid* system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo. Samidorphan can improve the behavior of depressed animals .

HY-76657A

Alvimopan dihydrate ADL 8-2698 dihydrate; LY 246736 dihydrate	Opioid Receptor	Neurological Disease Cancer
Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible **μ-opioid receptor antagonist, with an IC₅₀** of 1.7 nM. Alvimopan dihydrate has selectivity for μ-opioid receptor (K_i=0.47 nM) over κ- and δ-opioid receptors (K_is=100, 12 nM, respectively). Alvimopan dihydrate can be used for the research of postoperative ileus .

HY-P2018

FK 33-824	Opioid Receptor	Cardiovascular Disease
FK 33-824, a synthetic analogue of Met-enkephalin, is a selective agonist of the μ-opioid receptor (μ-OR) .

HY-P0244

Dermorphin	Opioid Receptor	Neurological Disease
Dermorphin is a natural heptapeptide **μ-opioid receptor (MOR**) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-170033

3-Carboxamidonaltrexone	Opioid Receptor	Neurological Disease
3-Carboxamidonaltrexone (example 32) is a **opioid receptor binding compound with K_i** values of 1.9 nM, 110 nM, and 22 nM for μ-opioid receptor, δ-opioid receptor, and K-opioid receptor, respectively .

HY-P0244A

Dermorphin TFA	Opioid Receptor	Neurological Disease
Dermorphin TFA is a natural heptapeptide **μ-opioid receptor (MOR**) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-P3870

DALDA	Opioid Receptor	Neurological Disease
DALDA is a potent and highly selective **μ-opioid receptor agonist with a K_i** of 1.69 nM. DALDA shows antinociceptive and respiratory effects .

HY-P3870A

DALDA acetate	Opioid Receptor	Neurological Disease
DALDA acetate is a potent and highly selective **μ-opioid receptor agonist with a K_i** of 1.69 nM. DALDA acetate shows antinociceptive and respiratory effects .

HY-P0210

DAMGO 5+ Cited Publications	Opioid Receptor	Cancer
DAMGO is a **μ-opioid receptor (μ-OPR ) selective agonist with a K_d** of 3.46 nM for native μ-OPR .

HY-162669

*Mu opioid* receptor antagonist 8**	Opioid Receptor	Neurological Disease
Mu opioid receptor antagonist 8 (368) is a **μ-opioid receptor** antagonist. Mu opioid receptor antagonist 8 (368) significantly inhibits met-enkephalin-induced µOR activation of G_i .

HY-123689R

Samidorphan (Standard)	Opioid Receptor Reference Standards	Neurological Disease
Samidorphan (Standard) is the analytical standard of Samidorphan. This product is intended for research and analytical applications. Samidorphan (ALKS-33) is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo. Samidorphan can improve the behavior of depressed animals.

HY-13243R

Alvimopan (Standard)	Opioid Receptor	Neurological Disease Cancer
Alvimopan (Standard) is the analytical standard of Alvimopan. This product is intended for research and analytical applications. Alvimopan (ADL 8-2698) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan can be used for the research of postoperative ileus .

HY-P0210B

DAMGO TFA 5+ Cited Publications	Opioid Receptor	Cancer
DAMGO TFA is a **μ-opioid receptor (μ-OPR ) selective agonist with a K_d** of 3.46 nM for native μ-OPR .

HY-15122

Sinomenine Maximum Cited Publications 14 Publications Verification	NF-κB Opioid Receptor Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of **μ-opioid receptor** .

HY-N0398

Sec-O-Glucosylhamaudol	Opioid Receptor	Neurological Disease
Sec-O-Glucosylhamaudol is a natural compound extracted from Peucedanum japonicum Thunb, decreases levels of **μ-opioid receptor**, with analgesic effect .

HY-101011

Naloxonazine dihydrochloride	Opioid Receptor	Infection Neurological Disease
Naloxonazine dihydrochloride is a specific **μ-opioid receptor antagonist with an IC₅₀** of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity .

HY-P3870B

DALDA TFA	Opioid Receptor	Neurological Disease
DALDA TFA is a potent and highly selective **μ-opioid receptor agonist with a K_i** of 1.69 nM. DALDA TFA shows antinociceptive and respiratory effects .

HY-13243S1

Alvimopan-d7 ADL 8-2698-d₇; LY 246736-d₇	Isotope-Labeled Compounds Opioid Receptor	Neurological Disease Cancer
Alvimopan-d₇ (ADL 8-2698-d₇) is deuterium labeled Alvimopan. Alvimopan (ADL 8-2698) is a potent, selective, orally active and reversible **μ-opioid receptor antagonist, with an IC₅₀** of 1.7 nM. Alvimopan has selectivity for μ-opioid receptor (K_i=0.47 nM) over κ- and δ-opioid receptors (K_is=100, 12 nM, respectively). Alvimopan can be used for the research of postoperative ileus .

HY-15122A

Sinomenine hydrochloride Maximum Cited Publications 14 Publications Verification Cucoline hydrochloride	NF-κB Opioid Receptor Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of **μ-opioid receptor** .

HY-P3043

Bilaid A	Opioid Receptor	Neurological Disease
Bilaid A is a **μ-opioid receptor agonist that can be extracted from Penicillium. The K_i** value is 3.1 μM. Bilaid A can be used in pain research .

HY-P1502

β-Endorphin, human 1 Publications Verification	Opioid Receptor	Neurological Disease
β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of **opioid receptor, with preferred affinity for μ-opioid receptor** and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity.

HY-19902

GSK1521498	Opioid Receptor	Neurological Disease
GSK1521498 is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 has the potential for disorders of compulsive consumption of food, alcohol, and agents .

HY-A0115R

Ramiprilat (Standard) HOE 498 diacid (Standard); Ramipril diacid (Standard)	Drug Metabolite Reference Standards Angiotensin-converting Enzyme (ACE) Endogenous Metabolite	Cardiovascular Disease
Alvimopan (dihydrate) (Standard) is the analytical standard of Alvimopan (dihydrate). This product is intended for research and analytical applications. Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan dihydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan dihydrate can be used for the research of postoperative ileus .

HY-76657AR

Alvimopan dihydrate (Standard) ADL 8-2698 dihydrate (Standard); LY 246736 dihydrate (Standard)	Reference Standards Opioid Receptor	Neurological Disease Cancer
Alvimopan (dihydrate) (Standard) is the analytical standard of Alvimopan (dihydrate). This product is intended for research and analytical applications. Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan dihydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan dihydrate can be used for the research of postoperative ileus .

HY-172637

Phenethyl 4-ANPP	Opioid Receptor	Neurological Disease
Phenethyl 4-ANPP is a MOR (μ-opioid receptor) agonist. Phenethyl 4-ANPP is an analytical reference standard that is structurally similar to known opioids .

HY-A0118

Naloxegol NKTR-118; AZ-13337019	Opioid Receptor	Neurological Disease Cancer
Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .

HY-107750A

Cyprodime hydrochloride	Opioid Receptor	Neurological Disease
Cyprodime hydrochloride is a highly selective **μ-opioid receptor antagonist with K_i** values of 5.4 nM, 244.6 nM and 2187 nM for μ-, δ- and κ-opioid receptors, respectively. Cyprodime hydrochloride has anti-depressant-like effect .

HY-P0186

Endomorphin 2	Opioid Receptor	Neurological Disease
Endomorphin 2, a high affinity, highly selective agonist of the **μ-opioid receptor, displays reasonable affinities for kappa₃ binding sites, with K_i** value between 20 and 30 nM.

HY-104006

CYM51010	Opioid Receptor	Neurological Disease
CYM51010 is a biased ligand of μ-opioid receptor – δ-opioid receptor heterodimers with an EC₅₀ of 403 nM. CYM51010 exhibits anti-nociceptive activity similar to morphine but with a decreased levels of tolerance development and withdrawal symptoms .

HY-170310

AP-238	Opioid Receptor	Neurological Disease
AP-238 is a a new synthetic opioid (NSO), and acts as an agonist for **μ-opioid receptor (MOR) with an EC₅₀** of 248 nM. AP-238 exhibits analgesic activity .

HY-122681

SR-16435	Opioid Receptor	Neurological Disease
SR-16435 is a nociceptin/orphanin FQ (NOP)/μ-opioid receptor partial agonist, with high binding affinity (NOP receptor K_i=7.49; μ-Opioid receptor K_i=2.70). SR-16435 can relieve pain .

HY-P0186A

Endomorphin 2 TFA	Opioid Receptor	Neurological Disease
Endomorphin 2 TFA, a high affinity, highly selective agonist of the **μ-opioid receptor, displays reasonable affinities for kappa₃ binding sites, with K_i** value between 20 and 30 nM .

HY-115066

GSK1521498 free base	Opioid Receptor	Neurological Disease
GSK1521498 free base is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 free base has the potential for disorders of compulsive consumption of food, alcohol, and agents .

HY-A0118A

Naloxegol oxalate 2 Publications Verification NKTR-118 oxalate; AZ-13337019 oxalate	Opioid Receptor	Neurological Disease Cancer
Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is a *μ-opioid-receptor* antagonist. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .

HY-115066A

GSK1521498 free base (hydrochloride)	Opioid Receptor	Neurological Disease
GSK1521498 free base (hydrochloride) is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 free base (hydrochloride) is being used for the treatment of disorders of compulsive consumption of food, alcohol, and agents .

HY-118416

BMS-986124	Opioid Receptor	Neurological Disease
BMS-986124 is a **μ-opioid receptor** silent allosteric modulator (μ-SAMs). BMS-986124 antagonizes positive allosteric modulator effect of BMS-986122 (µ-OR PAM) .

HY-121854A

Bromadoline maleate	Opioid Receptor	Inflammation/Immunology
Bromadoline maleate is an opioid analgesic selective for the μ-opioid receptor, exhibiting analgesic activity in various biological fluids. Bromadoline maleate has been successfully quantified alongside its N-demethylated metabolites in human and canine samples.

HY-15122R

Sinomenine (Standard)	Reference Standards NF-κB Opioid Receptor Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Sinomenine (Standard) is the analytical standard of Sinomenine. This product is intended for research and analytical applications. Sinomenine, an alkaloid extracted from?Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of μ-opioid receptor .

HY-15122AR

Sinomenine hydrochloride (Standard) Cucoline hydrochloride (Standard)	Reference Standards NF-κB Opioid Receptor Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Sinomenine hydrochloride (Standard) is the analytical standard of Sinomenine hydrochloride. This product is intended for research and analytical applications. Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of μ-opioid receptor .

HY-153471

MOR agonist-1	Opioid Receptor	Infection Inflammation/Immunology
MOR agonist-1 is a MOR (μ-opioid receptor) agonist. MOR agonist-1 has good analgesic effect. MOR agonist-1 can be used for the research of pain and pain-related disorders .

Cat. No.	Product Name	Target	Research Area

HY-P1087

Adrenorphin Metorphamide	Opioid Receptor	Cancer
Adrenorphin is a opioid octapeptide, acting as a potent agonist of **μ-opioid receptor, with K_i** of 12 nM.

HY-P0244

Dermorphin	Opioid Receptor	Neurological Disease
Dermorphin is a natural heptapeptide **μ-opioid receptor (MOR**) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-P3870A

DALDA acetate	Opioid Receptor	Neurological Disease
DALDA acetate is a potent and highly selective **μ-opioid receptor agonist with a K_i** of 1.69 nM. DALDA acetate shows antinociceptive and respiratory effects .

HY-P0210

DAMGO Maximum Cited Publications 8 Publications Verification	Opioid Receptor	Cancer
DAMGO is a **μ-opioid receptor (μ-OPR ) selective agonist with a K_d** of 3.46 nM for native μ-OPR .

HY-P0210B

DAMGO TFA Maximum Cited Publications 8 Publications Verification	Opioid Receptor	Cancer
DAMGO TFA is a **μ-opioid receptor (μ-OPR ) selective agonist with a K_d** of 3.46 nM for native μ-OPR .

HY-P1577

Dermorphin Analog	Opioid Receptor	Inflammation/Immunology
Dermorphin Analog is an analog of Dermorphin. Dermorphin is a natural heptapeptide **μ-opioid receptor** agonist found in amphibian skin.

HY-P2018

FK 33-824	Opioid Receptor	Cardiovascular Disease
FK 33-824, a synthetic analogue of Met-enkephalin, is a selective agonist of the μ-opioid receptor (μ-OR) .

HY-P0244A

Dermorphin TFA	Opioid Receptor	Neurological Disease
Dermorphin TFA is a natural heptapeptide **μ-opioid receptor (MOR**) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-P3870

DALDA	Opioid Receptor	Neurological Disease
DALDA is a potent and highly selective **μ-opioid receptor agonist with a K_i** of 1.69 nM. DALDA shows antinociceptive and respiratory effects .

HY-P3870B

DALDA TFA	Opioid Receptor	Neurological Disease
DALDA TFA is a potent and highly selective **μ-opioid receptor agonist with a K_i** of 1.69 nM. DALDA TFA shows antinociceptive and respiratory effects .

HY-P3043

Bilaid A	Opioid Receptor	Neurological Disease
Bilaid A is a **μ-opioid receptor agonist that can be extracted from Penicillium. The K_i** value is 3.1 μM. Bilaid A can be used in pain research .

HY-P1502

β-Endorphin, human 1 Publications Verification	Opioid Receptor	Neurological Disease
β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of **opioid receptor, with preferred affinity for μ-opioid receptor** and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity.

HY-P0186

Endomorphin 2	Opioid Receptor	Neurological Disease
Endomorphin 2, a high affinity, highly selective agonist of the **μ-opioid receptor, displays reasonable affinities for kappa₃ binding sites, with K_i** value between 20 and 30 nM.

HY-P0186A

Endomorphin 2 TFA	Opioid Receptor	Neurological Disease
Endomorphin 2 TFA, a high affinity, highly selective agonist of the **μ-opioid receptor, displays reasonable affinities for kappa₃ binding sites, with K_i** value between 20 and 30 nM .

HY-P1502F

Biocytin-β-endorphin, human	Opioid Receptor	Neurological Disease
Biocytin-β-endorphin, human is abiotinylated β-Endorphin, human (HY-P1502). β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of **opioid receptor, with preferred affinity for μ-opioid receptor** and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity.

HY-P4107

Bilaid C	Opioid Receptor	Neurological Disease
Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective **μ-Opioid Receptor (MOPr**) agonist (K_i=210 nM, hMOPr) .

HY-P1329

CTOP	Opioid Receptor	Neurological Disease
CTOP is a potent and highly selective **μ-opioid receptor** antagonist. CTOP antagonizes the acute morphine-induced analgesic effect and hypermotility. CTOP enhances extracellular dopamine levels in the nucleus accumbens. CTOP dose-dependently enhances locomotor activity .

HY-P1626

Acetyl tetrapeptide-15	Opioid Receptor	Neurological Disease
Acetyl tetrapeptide-15 is a synthetic peptide. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway. Acetyl tetrapeptide-15 is used in the cosmetics for sensitive skin .

HY-P0185A

Endomorphin 1 acetate 3 Publications Verification	Opioid Receptor	Neurological Disease
Endomorphin 1 acetate, a high affinity, highly selective agonist of the **μ-opioid receptor (K_i: 1.11 nM), displays reasonable affinities for kappa₃ binding sites, with K_i** value between 20 and 30 nM. Endomorphin 1 acetate has antinociceptive properties .

HY-P0185

Endomorphin 1 3 Publications Verification	Opioid Receptor	Neurological Disease
Endomorphin 1, a high affinity, highly selective agonist of the **μ-opioid receptor (K_i: 1.11 nM), displays reasonable affinities for kappa₃ binding sites, with K_i** value between 20 and 30 nM. Endomorphin 1 has antinociceptive properties .

HY-P1329A

CTOP TFA 1 Publications Verification	Opioid Receptor	Neurological Disease
CTOP TFA is a potent and highly selective **μ-opioid receptor** antagonist. CTOP TFA antagonizes the acute analgesic effect and hypermotility. CTOP TFA enhances extracellular dopamine levels in the nucleus accumbens. CTOP TFA dose-dependently enhances locomotor activity .

HY-P1253

α-Endorphin (human)	Opioid Receptor	Neurological Disease
α-Endorphin (human) is a neuropeptide, that acts on the central nervous system (CNS) and peripheral nervous system (PNS). α-Endorphin (human) binds **μ-opioid receptor**, and exhibits analgesic efficacy. α-Endorphin (human) regulates sexual behaviors and pleasure felling .

HY-P3517

β-Endorphin (6-31), human β-EP (6-31), human	Opioid Receptor	Neurological Disease Endocrinology
β-Endorphin, an endogenous opioid neuropeptide, is an **opioid receptor** agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation .

HY-P10555

(D-Arg2, Sar 4)-Dermorphin (1-4)	Opioid Receptor	Neurological Disease
(D-Arg2, Sar 4)-Dermorphin (1-4) is a tetrapeptide derivative of the peptide Dermorphin (HY-P0244) found in amphibian skin. (D-Arg2, Sar 4)-Dermorphin (1-4) has significant analgesic effects by binding to the μ-opioid receptor (MOR) in the body. (D-Arg2, Sar 4)-Dermorphin (1-4) can be used in the development of analgesic drugs .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P0244

Dermorphin	Natural Products Animals Source classification Phenols Polyphenols	Opioid Receptor
Dermorphin is a natural heptapeptide **μ-opioid receptor (MOR**) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-15122

Sinomenine Maximum Cited Publications 14 Publications Verification	Alkaloids Piperidine Alkaloids Monophenols Neurological Disease Classification of Application Fields Sinomenium acutum(Thunb．)Rehd．Et Wils． Source classification Phenols Plants Menispermaceae Inflammation/Immunology Disease Research Fields	NF-κB Opioid Receptor Autophagy Apoptosis
Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of **μ-opioid receptor** .

HY-N0398

Sec-O-Glucosylhamaudol	Flavonoids Flavones Carpesium cernuum L. Umbelliferae Plants	Opioid Receptor
Sec-O-Glucosylhamaudol is a natural compound extracted from Peucedanum japonicum Thunb, decreases levels of **μ-opioid receptor**, with analgesic effect .

HY-15122A

Sinomenine hydrochloride Maximum Cited Publications 14 Publications Verification Cucoline hydrochloride	Alkaloids Piperidine Alkaloids Monophenols Neurological Disease Classification of Application Fields Sinomenium acutum(Thunb．)Rehd．Et Wils． Source classification Phenols Plants Menispermaceae Inflammation/Immunology Disease Research Fields	NF-κB Opioid Receptor Autophagy Apoptosis
Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of **μ-opioid receptor** .

HY-15122R

Sinomenine (Standard)	Alkaloids Piperidine Alkaloids Monophenols Sinomenium acutum(Thunb．)Rehd．Et Wils． Source classification Phenols Plants Menispermaceae	Reference Standards NF-κB Opioid Receptor Autophagy Apoptosis
Sinomenine (Standard) is the analytical standard of Sinomenine. This product is intended for research and analytical applications. Sinomenine, an alkaloid extracted from?Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of μ-opioid receptor .

HY-P0185

Endomorphin 1 3 Publications Verification	Natural Products Monophenols Pyrrole Alkaloids Neurological Disease Source classification Phenols Endogenous metabolite Disease Research Fields Indole Alkaloids	Opioid Receptor
Endomorphin 1, a high affinity, highly selective agonist of the **μ-opioid receptor (K_i: 1.11 nM), displays reasonable affinities for kappa₃ binding sites, with K_i** value between 20 and 30 nM. Endomorphin 1 has antinociceptive properties .

HY-P0244A

Dermorphin TFA	Animals Source classification Phenols Polyphenols	Opioid Receptor
Dermorphin TFA is a natural heptapeptide **μ-opioid receptor (MOR**) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-A0115R

Ramiprilat (Standard) HOE 498 diacid (Standard); Ramipril diacid (Standard)	Alkaloids Pyrrole Alkaloids Source classification Endogenous metabolite	Drug Metabolite Reference Standards Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Alvimopan (dihydrate) (Standard) is the analytical standard of Alvimopan (dihydrate). This product is intended for research and analytical applications. Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan dihydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan dihydrate can be used for the research of postoperative ileus .

HY-15122AR

Sinomenine hydrochloride (Standard) Cucoline hydrochloride (Standard)	Alkaloids Piperidine Alkaloids Monophenols Sinomenium acutum(Thunb．)Rehd．Et Wils． Source classification Phenols Plants Menispermaceae	Reference Standards NF-κB Opioid Receptor Autophagy Apoptosis
Sinomenine hydrochloride (Standard) is the analytical standard of Sinomenine hydrochloride. This product is intended for research and analytical applications. Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of μ-opioid receptor .

HY-N0398R

Sec-O-Glucosylhamaudol (Standard)	Flavonoids Flavones Carpesium cernuum L. Umbelliferae Plants	Reference Standards Opioid Receptor
Sec-O-Glucosylhamaudol (Standard) is the analytical standard of Sec-O-Glucosylhamaudol. This product is intended for research and analytical applications. Sec-O-Glucosylhamaudol is a natural compound extracted from Peucedanum japonicum Thunb, decreases levels of μ-opioid receptor, with analgesic effect .

HY-N0923

Corydaline (+)-Corydaline; Corydalin	Alkaloids Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Cholinesterase (ChE) Enterovirus Opioid Receptor
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC₅₀ of 226 μM. Corydaline is a **μ-opioid receptor (K_i of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC₅₀** of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities .

HY-N0923R

Corydaline (Standard) (+)-Corydaline (Standard); Corydalin (Standard)	Alkaloids Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Reference Standards Cholinesterase (ChE) Enterovirus Opioid Receptor
Corydaline (Standard) is the analytical standard of Corydaline. This product is intended for research and analytical applications. Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC₅₀ of 226 μM. Corydaline is a μ-opioid receptor (Ki of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC₅₀ of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities .

Cat. No.	Product Name	Chemical Structure

HY-123689S

Samidorphan-d4

Samidorphan-d4 is the deuterium labeled Samidorphan(HY-123689).Samidorphan (ALKS-33) is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo .

HY-123689S1

Samidorphan-d5

Samidorphan-d5 (ALKS-33-d5) is is a deuterated compound of Samidorphan. Samidorphan is an orally active opioid system modulator that binds with high affinity to μ-opioid, κ-opioid, and δ-opioid receptors. Samidorphan is a μ-opioid receptor antagonist and a partial agonist at k-opioid and δ-opioid receptors. Samidorphan acts primarily as an opioid receptor antagonist in vivo .

HY-13243S1

Alvimopan-d7

Alvimopan-d₇ (ADL 8-2698-d₇) is deuterium labeled Alvimopan. Alvimopan (ADL 8-2698) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC₅₀ of 1.7 nM. Alvimopan has selectivity for μ-opioid receptor (K_i=0.47 nM) over κ- and δ-opioid receptors (K_is=100, 12 nM, respectively). Alvimopan can be used for the research of postoperative ileus .

HY-A0118AS

Naloxegol-d5 oxalate
Naloxegol-d₅ (oxalate) is deuterium labeled Naloxegol (oxalate). Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is a μ-opioid-receptor antagonist. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .

HY-A0118S1

Naloxegol-13C,d2
Naloxegol- ¹³C,d₂ (NKTR-118- ¹³C,d₂) is ¹³C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .

HY-A0118S

Naloxegol-13C,d3
Naloxegol- ¹³C,d₃ (NKTR-118- ¹³C,d₃) is ¹³C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .

HY-109054AS

O-Desmethyltramadol-d6 hydrochloride
O-Desmethyltramadol-d6 (hydrochloride) is a deuterated labeled O-Desmethyltramadol (hydrochloride) . O-Desmethyltramadol (hydrochloride) is a primary active metabolite of Tramadol. O-Demethyltramadol is mainly responsible for its μ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme .

HY-132428S

O-Desmethyl Tramadol-d6
O-Desmethyl Tramadol-d₆ is the deuterium labeled O-Desmethyl Tramadol.?O-Desmethyl Tramadol is a primary active metabolite of Tramadol. O-Desmethyl Tramadol is mainly responsible for its μ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme .

HY-144224S

Tianeptine-d6 hydrochloride

Tianeptine-d₆ hydrochloride is the deuterium labeled Tianeptine hydrochloride. Tianeptine hydrochloride is an atypical antidepressant. Tianeptine hydrochloride is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR). Tianeptine hydrochloride is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. Tianeptine hydrochloride increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine hydrochloride exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine hydrochloride inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine hydrochloride can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects.

HY-90003S

Tianeptine-d12

Tianeptine-d₁₂ is a deuterated analog of Tianeptine (HY-90003).Tianeptine is an atypical antidepressant. Tianeptine is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR). Tianeptine is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. Tianeptine increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects.

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