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α1A receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (5) Adenosine Receptor (2) Adrenergic Receptor (29) Apoptosis (2) Bacterial (2) Drug Metabolite (1) Endogenous Metabolite (6) Isotope-Labeled Compounds (3) mAChR (1) MCHR1 (GPR24) (2) PROTACs (1) Reference Standards (3)
By Research Areas:	Cancer (6) Cardiovascular Disease (15) Endocrinology (16) Inflammation/Immunology (1) Neurological Disease (8)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147100

α1A-AR Degrader 9c	PROTACs Adrenergic Receptor	Cancer
α1A-AR Degrader 9c (compound 9c) is a potent, selective and reversible *α1A-AR* (Adrenergic receptor) PROTAC degrader, with a DC₅₀ of 2.86 μM. α1A-AR Degrader 9c induces *α1A-AR* degradation can be attributed to proteasomal degradation. α1A-AR Degrader 9c inhibits the proliferation of PC-3 cells, with an IC₅₀ of 6.12 μM. α1A-AR Degrader 9c shows antitumor activity, and can be used for prostate cancer research .

HY-101300

Cirazoline hydrochloride LD 3098 hydrochloride	Adenosine Receptor	Neurological Disease
Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (K_i=120 nM) and only a partial agonist at α1B-AR (K_i= 960 nM) and α1D-AR (K_i=660 nM) .

HY-10122

Silodosin 5 Publications Verification KAD 3213; KMD 3213	Adrenergic Receptor Bacterial	Endocrinology Cancer
Silodosin (KAD 3213; KMD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (K_i=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH .

HY-100169

KRG-3332 hydrochloride	Adrenergic Receptor	Neurological Disease
KRG-3332 (hydrochloride) is a selective **α1A receptor** antagonist. KRG-3332 (hydrochloride) can be used in Glaucoma .

HY-10122A

(Rac)-Silodosin (Rac)-KAD 3213; (Rac)-KMD 3213	Adrenergic Receptor	Endocrinology
(Rac)-Silodosin ((Rac)-KAD 3213) is the racemate of Silodosin (HY-10122). Silodosin is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker .

HY-145480

Silodosin Glucuronide sodium Silodosin β-D-glucuronide sodium	Drug Metabolite	Others
Silodosin Glucuronide sodium (Silodosin β-D-glucuronide sodium) is the metabolite of Silodosin (HY-10122). Silodosin is a selective and orally active antagonist for α1A-adrenergic receptor (α1A-AR) with K_i of 0.036 nM .

HY-103202A

SNAP5089	Adrenergic Receptor	Cardiovascular Disease
SNAP5089 is a selective α1A-adrenoceptor antagonist with over 1700-fold selectivity for the α1A subtype, which may have implications for the treatment of hypertension and benign prostatic hypertrophy. SNAP5089 demonstrates significant receptor affinity compared to other clinical drugs, emphasizing its potential therapeutic advantages. SNAP5089's high affinity aligns with its suitability for conditions where precise α1A modulation is desirable.

HY-137055

PF-3774076	Others	Others
PF-3774076 is a highly central nervous system (CNS) penetrant, potent, and selective human α1A-adrenoceptor partial agonist. It exhibits good potency and selectivity in multiple binding and functional assays. PF-3774076 increases peak urethral pressure in anesthetized female dogs in a dose-dependent manner via a central mechanism. PF-3774076 affects both the proximal and distal portions of the urethra in vivo. These properties suggest that PF-3774076 may have significant benefit in the treatment of stress urinary incontinence (SUI) as a CNS-penetrant α1A receptor partial agonist. However, despite its partial agonism and selectivity for α1A receptors, PF-3774076 failed to provide adequate safety differences in in vivo models of cardiovascular function. This may be due to the simultaneous activation of both peripheral and central α1A receptors. These data suggest that while central α1A partial agonists may have significant benefit in the treatment of SUI, this class of agents may have difficulty achieving the desired urethral selectivity without affecting cardiovascular function.

HY-116623

A-123189	Adrenergic Receptor	Endocrinology
A-123189 is a selective and potent α_1D antagonist with K_is of 0.312 and 0.17 for human α_1D and rat α_1D, respectively. A-123189 displays selectivities between 10- to 20-fold for the α_1D receptor over the human α_1A and rat α_1A receptors .

HY-103202

SNAP5089 hydrochloride	Adrenergic Receptor	Cardiovascular Disease
SNAP5089 (hydrochloride) is a selective **α1A adrenergic receptor** antagonist. SNAP5089 (hydrochloride) can be used in the research of hypertension and benign prostatic hyperplasia .

HY-10122S

Silodosin-d4	Isotope-Labeled Compounds Adrenergic Receptor	Endocrinology Cancer
Silodosin-d₄ is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH .

HY-101300R

Cirazoline hydrochloride (Standard) LD 3098 hydrochloride (Standard)	Reference Standards Adenosine Receptor	Neurological Disease
Cirazoline (hydrochloride) (Standard) is the analytical standard of Cirazoline (hydrochloride). This product is intended for research and analytical applications. Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full?α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM) .

HY-10122R

Silodosin (Standard) KAD 3213 (Standard); KMD 3213 (Standard)	Reference Standards Adrenergic Receptor Bacterial	Endocrinology Cancer
Silodosin (Standard) is the analytical standard of Silodosin. This product is intended for research and analytical applications. Silodosin (KAD 3213; KMD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (K_i=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH .

HY-117071A

Dabuzalgron hydrochloride Ro 115-1240 hydrochloride	Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology
Dabuzalgron (Ro 115-1240) hydrochloride is an orally active and selective α-1A adrenergic receptor agonist for the treatment of urinary incontinence. Dabuzalgron hydrochloride protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function .

HY-101366

A-61603	Adrenergic Receptor	Cardiovascular Disease
A-61603 is a selective **α_1A-adrenergic receptor** agonist . A-61603 increases the frequency of spontaneous Ca ²⁺ transients in rat ventricular myocytes in vitro .

HY-117071

Dabuzalgron Ro 115-1240	Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology
Dabuzalgron (Ro 115-1240) is an orally active and selective α-1A adrenergic receptor agonist for the treatment of urinary incontinence. Dabuzalgron protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function .

HY-B0471

Phenylephrine hydrochloride Maximum Cited Publications 31 Publications Verification (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
(R)-(-)-Phenylephrine hydrochloride is a selective α₁-adrenoceptor agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-106954

Upidosin Rec 15/2739; Recordati 15/2739; SB 216469	Adrenergic Receptor	Inflammation/Immunology
Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a K_b value of 2-3 nM higher than in ear artery and aorta with a K_b value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction .

HY-U00237B

L-771688 hydrochloride	Adrenergic Receptor	Others
L-771688 hydrochloride is a potent and highly selective α1A-adrenoceptor antagonist (Kd=43-90 pM). L-771688 hydrochloride is effective against cloned human, rat and dog α1A-adrenergic receptors. L-771688 exhibits high affinity (Ki ≤ 1 nM) and over 500-fold selectivity over the α1B and α1D isoforms. L-771688 potently antagonizes norepinephrine-induced responses at these receptors. Inhibits contractions induced by phenylephrine or A-61603 in rat, dog, human and monkey models .

HY-W103372

Vasorelaxant agent-2	Adrenergic Receptor	Cardiovascular Disease
Vasorelaxant agent-2 (Compound 8h) targets α1A-adrenergic receptor with an affinity of pD2=5.4. Vasorelaxant agent-2 exhibits vasodilator activity in rats aortic rings with an EC₅₀ of 0.79 μM .

HY-B0471S

Phenylephrine-d3 hydrochloride (R)-(-)-Phenylephrine-d₃ (hydrochloride); L-Phenylephrine-d₃ (hydrochloride)	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Phenylephrine-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0471S3

Phenylephrine-d6 hydrochloride (R)-(-)-Phenylephrine-d₆ hydrochloride; L-Phenylephrine-d₆ hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0471S2

(S)-Phenylephrine-d6 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
(S)-Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0471R

Phenylephrine hydrochloride (Standard) (R)-(-)-Phenylephrine hydrochloride (Standard); L-Phenylephrine hydrochloride (Standard)	Reference Standards Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Phenylephrine (hydrochloride) (Standard) is the analytical standard of Phenylephrine (hydrochloride). This product is intended for research and analytical applications. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-123044

Tedatioxetine Lu AA24530	5-HT Receptor Adrenergic Receptor	Neurological Disease
Tedatioxetine (Lu AA24530) acts as a serotonin and norepinephrine (NE)-preferring triple reuptake inhibitor (TRI) and 5-HT_2A, 5-HT_2C, 5-HT₃ and **α_1A-adrenergic receptor** antagonist .

HY-101514

β3-AR agonist 1	Adrenergic Receptor	Cardiovascular Disease Endocrinology
β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available *β3-adrenergic receptor* (β3-AR) agonist (EC₅₀**=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold) .

HY-B0471S1

Phenylephrine-2,4,6-d3 hydrochloride (R)-(-)-Phenylephrine-2,4,6-d₃ (hydrochloride); L-Phenylephrine-2,4,6-d₃ (hydrochloride)	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Phenylephrine-2,4,6-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-101755

Tedatioxetine hydrobromide Lu AA24530 hydrobromide	5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
Tedatioxetine (Lu AA24530) hydrobromide acts as a serotonin and norepinephrine (NE)-preferring triple reuptake inhibitor (TRI) and 5-HT_2A, 5-HT_2C, 5-HT₃ and **α_1A-adrenergic receptor** antagonist . ,

HY-107625A

SNAP 94847 hydrochloride 2 Publications Verification	MCHR1 (GPR24)	Neurological Disease
SNAP 94847 hydrochloride is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (K_i= 2.2 nM, K_d=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 hydrochloride binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters .

HY-107625

SNAP 94847	MCHR1 (GPR24)	Neurological Disease Endocrinology
SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (K_i= 2.2 nM, K_d=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters .

HY-P5158

Conopeptide rho-TIA	Adrenergic Receptor	Others
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α_1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human **α_1A-Adrenergic Receptor and α_1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α₁-Adrenergic Receptor subtype-selective drugs** .

HY-P5846

Muscarinic toxin 3 MT3	mAChR Adrenergic Receptor	Neurological Disease
Muscarinic toxin 3 (MT3) is a potent and non-competitive mAChR and adrenoceptors antagonist with pIC₅₀s of 6.71, 8.79, 8.86, 7.57, 8.13, 8.49, <6.5, 7.29 against M₁, M₄, α_1A, α_1B, α_1D,α_2A,α_2B and α_2C receptors, respectively. Muscarinic toxin 3 displays prominent adrenoceptor activity .

HY-162677

MT-1207	Adrenergic Receptor 5-HT Receptor	Cardiovascular Disease
MT-1207 is an orally active and selective adrenergic α₁ and 5-HT_2A receptor antagonist. MT-1207 shows IC₅₀<0.1 nM, 0.15 nM, 1.40 nM and 0.27 nM for α_1A, α_1B, α_1D and 5-HT_2A, respectively. MT-1207 achieves an effective blood pressure (BP) reduction in the 2K2C rat model without damaging renal function. MT-1207 is a potent multitarget inhibitor with the potential for vasodilatation research .

HY-100554

BMY 7378 2 Publications Verification	Adrenergic Receptor 5-HT Receptor	Cardiovascular Disease
BMY 7378 is a selective antagonist of α_1D-adrenoceptor (α_1D-AR). BMY 7378 binds to membranes expressing the cloned rat α_1D-AR with a >100-fold higher affinity (K_i=2 nM) than binding to either the cloned rat α_1A-AR (K_i=800 nM) or the hamster α_1B-AR (K_i=600 nM). BMY 7378 is a 5-HT_1A receptor partial agonist .

HY-116982

BMY 7378 free base	Adrenergic Receptor 5-HT Receptor
BMY 7378 (free base) is a selective antagonist of α_1D-adrenoceptor (α_1D-AR). BMY 7378 (free base) binds to membranes expressing the cloned rat α_1D-AR with a >100-fold higher affinity (K_i=2 nM) than binding to either the cloned rat α_1A-AR (K_i=800 nM) or the hamster α_1B-AR (K_i=600 nM). BMY 7378 (free base) is a 5-HT_1A receptor partial agonist .

Cat. No.	Product Name	Target	Research Area

HY-P5158

Conopeptide rho-TIA	Adrenergic Receptor	Others
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α_1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human **α_1A-Adrenergic Receptor and α_1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α₁-Adrenergic Receptor subtype-selective drugs** .

HY-P5846

Muscarinic toxin 3 MT3	mAChR Adrenergic Receptor	Neurological Disease
Muscarinic toxin 3 (MT3) is a potent and non-competitive mAChR and adrenoceptors antagonist with pIC₅₀s of 6.71, 8.79, 8.86, 7.57, 8.13, 8.49, <6.5, 7.29 against M₁, M₄, α_1A, α_1B, α_1D,α_2A,α_2B and α_2C receptors, respectively. Muscarinic toxin 3 displays prominent adrenoceptor activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0471

Phenylephrine hydrochloride 30+ Cited Publications (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride	Cardiovascular Disease Alkaloids Monophenols Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
(R)-(-)-Phenylephrine hydrochloride is a selective α₁-adrenoceptor agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-B0471R

Phenylephrine hydrochloride (Standard) (R)-(-)-Phenylephrine hydrochloride (Standard); L-Phenylephrine hydrochloride (Standard)	Alkaloids Monophenols Other Alkaloids Source classification Phenols Endogenous metabolite	Reference Standards Adrenergic Receptor Endogenous Metabolite
Phenylephrine (hydrochloride) (Standard) is the analytical standard of Phenylephrine (hydrochloride). This product is intended for research and analytical applications. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

Cat. No.	Product Name	Chemical Structure

HY-B0471S1

Phenylephrine-2,4,6-d3 hydrochloride
Phenylephrine-2,4,6-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-10122S

Silodosin-d4
Silodosin-d₄ is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH .

Silodosin-d4

Silodosin-d₄ is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH .

HY-B0471S

Phenylephrine-d3 hydrochloride
Phenylephrine-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0471S3

Phenylephrine-d6 hydrochloride
Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0471S2

(S)-Phenylephrine-d6 hydrochloride
(S)-Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82314

	alpha 1a Adrenergic Receptor Antibody (YA2059) ADRA1A; ADRA1C; Alpha-1A adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c	WB, IHC-P	Rat
	alpha 1a Adrenergic Receptor Antibody (YA2059) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to alpha 1a Adrenergic Receptor.

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