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<i>Escherichia coli</i> (<i>E. coli</i>)、<i>Klebsiella pneumoniae</i>

" in MedChemExpress (MCE) Product Catalog:

19

Inhibitors & Agonists

1

Peptides

5

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-124679A
    (R)-DS86760016

    		Bacterial Others
    (R)-DS86760016 is the R-enantiomer of DS86760016 (HY-124679). DS86760016 is a potent leucyl-tRNA synthetase (LeuRS) inhibitor with activity against multidrug-resistant (MDR) Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa .
    (R)-DS86760016
  • HY-109008
    Nacubactam
    2 Publications Verification

    OP0595 free acid

    		 Beta-lactamase Bacterial Infection
    Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and C β-lactamases. Nacubactam acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs. Nacubactam potentiates the antimicrobial activities of Piperacillin (HY-B1923), Cefepime (HY-B0692), and Meropenem (HY-13678) against CTX-M-15-positive Escherichia coli and KPC-positive Klebsiella pneumoniae .
    Nacubactam
  • HY-124679
    DS86760016

    		Bacterial Infection
    DS86760016 is a potent leucyl-tRNA synthetase (LeuRS) inhibitor with activity against multidrug-resistant (MDR) Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. DS86760016 inhibits LeuRS enzymes from Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, with IC50s of 0.38, 0.62, and 0.16 μM, respectively .
    DS86760016
  • HY-W012444
    Glyceryl 1-monooctanoate

    		Antibiotic Fungal Infection
    Glyceryl 1-monooctanoate is a glycerol monolaurate derivative. Glyceryl 1-monooctanoate is a broad-spectrum antimicrobial, suppresses the growth of pathogenic yeast (Candida albicans and Candida parapsilosis), as well as Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumoniae) bacteria .
    Glyceryl 1-monooctanoate
  • HY-129331
    Neothramycin A

    		Antibiotic Bacterial Fungal Infection Cancer
    Neothramycin A is an antibiotic, which can be isolated from Streptomyces. Neothramycin A exhibits board spectrum antimicrobial activity, inhibits Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli W677, and Saccharomyces cerevisia with MIC of 25-50 μg/mL. Neothramycin A exhibits antitumor efficacy against leukemia in mouse models .
    Neothramycin A
  • HY-N14871
    Pyrronamycin A

    		Bacterial Infection
    Pyrronamycin A has antibacterial activity against Gram-positive and negative bacteria such as Staphylococcus aureus, enterococcus, Escherichia coli, Klebsiella pneumoniae, Proteus, Shigella and Salmonella .
    Pyrronamycin A
  • HY-N14115
    γ-Chloronorvaline

    		Bacterial Infection
    γ-Chloronorvaline has the activity of resistance to Pseudomonas aeruginosa, Serrata, Klebsiella pneumoniae and Bacillus subtilis in the synthetic medium, but has no effect on Escherichia coli .
    γ-Chloronorvaline
  • HY-P5734
    Bactenecin 5

    		Bacterial Infection
    Bactenecin 5 is a bovine antibacterial peptide. Bactenecin 5 is active against Escherichia coli, Salmonella typhimurium, and Klebsiella pneumoniae. T, with MIC values of 12-25 μg/mL .
    Bactenecin 5
  • HY-N14872
    Pyrronamycin B

    		Bacterial Infection Cancer
    Pyrronamycin B has antibacterial activity against Gram-positive and negative bacteria such as Staphylococcus aureus, enterococcus, Escherichia coli, Klebsiella pneumoniae, Proteus, Shigella and Salmonella. Pyrronamycin B also has anti-tumor activity .
    Pyrronamycin B
  • HY-114860
    LY 215891

    		Bacterial Inflammation/Immunology
    LY 215891 (compound 6a) exhibits potent Gram-positive and Gram-negative antibacterial activity with MICs of 0.015 μg/mL and 0.06 μg/mL for Klebsiella pneumoniae X26 and Escherichia coli EC14, respectively .
    LY 215891
  • HY-107064
    Cefroxadine

    CGP 9000; Oraspor

    		 Bacterial Antibiotic Infection
    Cefroxadine (CGP 9000) is an orally active cephalosporin antibiotic. Cefroxadine is more effective than cephalexin against Escherichia coli and Klebsiella pneumoniae with MIC values of 3.13 and 1.56 μg/mL respectively with a concentration of 10 6 μg/mL. Cefroxadine can be used for the research of infection .
    Cefroxadine
  • HY-170308
    IspE kinase-IN-1

    		Bacterial Infection
    IspE kinase-IN-1 (compound 4) is a potent IspE kinase inhibitor with IC50 values of 6.2, 5.2 µM for EclspE, KplspE, respectively .
    IspE kinase-IN-1
  • HY-150767
    KPC-2-IN-2

    		Bacterial Infection
    KPC-2-IN-2 (Compound 6c) is a potent Klebsiella pneumoniae carbapenemase (KPC-2) inhibitor (Ki=0.038 μM). KPC-2-IN-2 can enhance the activity of cefotaxime in KPC-2 expressing Escherichia coli .
    KPC-2-IN-2
  • HY-144284
    MsbA-IN-5

    		Bacterial Infection
    MsbA-IN-5 (compound 40) is a potent and highly selective MsbA inhibitor with an IC50 value of 2 nM. MsbA-IN-5 has inhibitory activity against Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae with MICs of 12 μM, 12 μM and 25 μM, respectively. MsbA-IN-5 can be used for researching anti-Gram-negative bacteria .
    MsbA-IN-5
  • HY-159969
    MLEB-22043

    		Bacterial Antibiotic Infection
    MLEB-22043 is a synthetic siderophore-monobactam conjugate that is taken up into bacteria via its synthetic siderophore component by TonB-dependent transporters. Once inside the bacteria, it exerts antibacterial activity through its β-lactam component. MLEB-22043 is a broad-spectrum antibiotic with significant inhibitory activity against Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa .
    MLEB-22043
  • HY-168674
    Antibacterial agent 255

    		Bacterial Infection
    Antibacterial agent 255 (compound (±)-1) is a potent antibacterial agent. Antibacterial agent 255 is a potent and selective 4-diphosphocytidyl-2-C-methyl-D-erythritol (IspE) inhibitor with IC50 values of 13.0, 8.0, 20 µM for EclspE, KplspE, AblspE, respectively .
    Antibacterial agent 255
  • HY-164036
    Lolamicin

    		Antibiotic Bacterial Infection
    Lolamicin is an orally effective inhibitor that specifically targets the Gram-negative bacteria lipoprotein transport system LolCDE complex. It selectively inhibits the transmembrane transport of outer membrane lipoproteins by competitively binding to lipoprotein binding sites. Lolamicin destroys the integrity of the bacterial outer membrane, leading to cell death, and has both bactericidal and antibacterial activity. It has significant effects on multidrug-resistant Enterobacteriaceae pathogens (such as Escherichia coli and Klebsiella pneumoniae). Lolamicin can be used to inhibit the study of acute pneumonia, sepsis and other infections caused by Gram-negative bacteria .
    Lolamicin
  • HY-161404
    Antibacterial agent 202

    		Bacterial Infection
    Antibacterial agent 202 (compound 45c) is a low cytotoxicity bacterial inhibitor with good activity against Gram-negative bacteria, including Escherichia coli, Klebsiella pneumonia, especially Pseudomonas aeruginosa, (MIC (minimum inhibitory concentration)=7.8-31.25 μM). Antibacterial agent 202 can exert antibacterial activity by destroying the integrity of cell membranes and can be used in the research of bacterial infections .
    Antibacterial agent 202
  • HY-B0147
    Pefloxacin
    2 Publications Verification

    Pefloxacinium

    		 Antibiotic Bacterial Parasite DNA/RNA Synthesis Topoisomerase Infection Inflammation/Immunology
    Pefloxacin is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC50 of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC90s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies .
    Pefloxacin

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