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Isoforms Recommended: Wnt3
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Wnt3

" in MedChemExpress (MCE) Product Catalog:
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  • HY-P70453C
    Wnt3a Surrogate Protein, Human (HEK293, C-hFc)
    2 Publications Verification

    Wnt-3a; Wnt 3a; Wnt3A protein; Wnt3a

    		 Human HEK293
    Wnt3a Surrogate protein is a Wnt recombination protein that plays an important role in embryonic development, adult tissue homeostasis and injury repair. Wnt3a Surrogate protein, consisting of the domain and Fc portion of Wnt3a, helps organoids expand and maintain a source of Wnt. Organoids are a rapidly evolving model system for tissue development, and Wnt3a is considered as the essential protein for organoid growth. Wnt3a or the small molecule glycogen synthase kinase 3 (GSK3) inhibitor CHIR are commonly used as Wnt sources in experiments. However, the application of Wnt3a is hampered by Wnt lipidation, and cross-reactivity with Wnt frizzled (Fzd). Therefore, Wnt3a Surrogate protein was used instead of Wnt3a, as a water-soluble and Fzd-specific alternative Wnt agonist. And the Wnt3a Surrogate protein exhibits tissue selectivity consistent with Fzd isoform specificity. Wnt3a Surrogate Protein, Human (HEK293, C-hFc) is the recombinant human-derived Wnt3a Surrogate, expressed by HEK293, with C-hFc labeled tag.
  • HY-P70453A
    Wnt3a Protein, Human (His)
    Maximum Cited Publications
    6 Publications Verification

    MGC119418; MGC119419; MGC119420; protein Wnt-3a; wingless-type MMTV integration site family, member 3A; Wnt3a; Wnt-3a

    		 Human E. coli
    Wnt3a Protein, Human is an activator of the Wnt/β-catenin pathway that inhibits GSK-3β, stabilizes β-catenin and promotes its nuclear translocation to activate FOXM1. Wnt3a Protein is mainly used in studies on neuroprotection in ischemic stroke (such as reducing cerebral infarction volume in MCAO models). Wnt3a Protein, Human (His) is a recombinant human Wnt3a protein expressed in E. coli with a 6His tag at the N-terminus.
  • HY-P70453B
    Wnt3a Surrogate Protein, Human (HEK293, Fc)
    2 Publications Verification

    Wnt3a Surrogate, Human (HEK293, Fc)

    		 Human HEK293
    Wnt3a Surrogate protein is a Wnt recombination protein that plays an important role in embryonic development, adult tissue homeostasis and injury repair. Wnt3a Surrogate protein, consisting of the domain and Fc portion of Wnt3a, helps organoids expand and maintain a source of Wnt. Organoids are a rapidly evolving model system for tissue development, and Wnt3a is considered as the essential protein for organoid growth. Wnt3a or the small molecule glycogen synthase kinase 3 (GSK3) inhibitor CHIR are commonly used as Wnt sources in experiments. However, the application of Wnt3a is hampered by Wnt lipidation, and cross-reactivity with Wnt frizzled (Fzd). Therefore, Wnt3a Surrogate protein was used instead of Wnt3a, as a water-soluble and Fzd-specific alternative Wnt agonist. And the Wnt3a Surrogate protein exhibits tissue selectivity consistent with Fzd isoform specificity. Wnt3a Surrogate Protein, Human (HEK293, Fc) is a recombinant Wnt3a protein of human origin, expressed by HEK293 cells with an Fc tag.
  • HY-P70453D
    Wnt3a Surrogate Protein, Human (HEK293, N-hFc)

    Wnt3a Surrogate, Human (HEK293, N-hFc)

    		 Human HEK293
    Wnt3a Surrogate protein is a Wnt recombination protein that plays an important role in embryonic development, adult tissue homeostasis and injury repair. Wnt3a Surrogate protein, consisting of the domain and Fc portion of Wnt3a, helps organoids expand and maintain a source of Wnt. Organoids are a rapidly evolving model system for tissue development, and Wnt3a is considered as the essential protein for organoid growth. Wnt3a or the small molecule glycogen synthase kinase 3 (GSK3) inhibitor CHIR are commonly used as Wnt sources in experiments. However, the application of Wnt3a is hampered by Wnt lipidation, and cross-reactivity with Wnt frizzled (Fzd). Therefore, Wnt3a Surrogate protein was used instead of Wnt3a, as a water-soluble and Fzd-specific alternative Wnt agonist. And the Wnt3a Surrogate protein exhibits tissue selectivity consistent with Fzd isoform specificity. Wnt3a Surrogate Protein, Human (HEK293, N-hFc) is the recombinant human-derived Wnt3a Surrogate, expressed by HEK293, with N-hFc labeled tag.

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