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  3. NO Synthase
  4. S-Isopropylisothiourea hydrobromide

S-Isopropylisothiourea hydrobromide  (Synonyms: S-isopropyl ITU; IPTU)

Cat. No.: HY-101304 Purity: 98.0%
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S-Isopropylisothiourea hydrobromide (S-isopropyl ITU; IPTU) is a blood-brain barrier (BBB) penetrant NOS inhibitor with IC50 values of 0.66, 0.75 and 0.29 μM against mouse spinal cord, cerebellar, bovine aortic and porcine endothelial cell NOS. S-Isopropylisothiourea exhibits a significant blood pressure-raising effect without damaging the perfusion of vital organs and can also inhibit the late-phase pain response induced by formalin. S-Isopropylisothiourea hydrobromide is used in the researchs for hemorrhagic shock and pain response based on NOS.

For research use only. We do not sell to patients.

S-Isopropylisothiourea hydrobromide

S-Isopropylisothiourea hydrobromide Chemical Structure

CAS No. : 4269-97-0

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S-Isopropylisothiourea hydrobromide Related Antibodies

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Description

S-Isopropylisothiourea hydrobromide (S-isopropyl ITU; IPTU) is a blood-brain barrier (BBB) penetrant NOS inhibitor with IC50 values of 0.66, 0.75 and 0.29 μM against mouse spinal cord, cerebellar, bovine aortic and porcine endothelial cell NOS. S-Isopropylisothiourea exhibits a significant blood pressure-raising effect without damaging the perfusion of vital organs and can also inhibit the late-phase pain response induced by formalin. S-Isopropylisothiourea hydrobromide is used in the researchs for hemorrhagic shock and pain response based on NOS[1][2].

IC50 & Target[1][2]

eNOS

0.5 μM (IC50)

nNOS

0.66 μM (IC50)

nNOS

0.75 μM (IC50)

eNOS

0.29 μM (IC50)

In Vivo

S-Isopropylisothiourea hydrobromide (50 mg/kg, i.p., single dose) can pass through the blood-brain barrier and reach an effective concentration in the central nervous system, and achieves a potent and sustained blood-pressure-raising effect by inhibiting vascular eNOS in mice[1].
S-Isopropylisothiourea hydrobromide (10-50 mg/kg, i.p., single dose) exhibits selective analgesic effects at a dose of 50 mg/kg, specifically inhibiting pain in the late phase (15-30 min)[1].
S-Isopropylisothiourea hydrobromide (0.1 mg/kg, i.v., 3 doses) significantly increases mean arterial pressure (MAP) and achieve a 100% survival rate in a rat model of severe hemorrhagic shock[2].
S-Isopropylisothiourea hydrobromide (0.3 mg/kg plus 1 mg/kg·h, i.v., maintain infusion for 120 min) significantly increases MAP to a normal level, without reducing cardiac output, and maintain perfusion of vital organs[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Formalin-induced hindpaw licking behaviour established in mice (male, LACA, 25-35 g)[1]
Dosage: 10, 20 and 30 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose
Result: Reduced the movement and grooming behaviors of mice.
Did not affect the paw edema induced by formalin.
Animal Model: Pylorus-ligated model established in male Wistar rats[2]
Dosage: 0.1 mg/kg
Administration: Intravenous injection (i.v.), 10 min, 20 min, and 40 min, administered in three doses
Result: Increased MAP to 65-70 mmHg, and the survival rate was 100%.
Animal Model: Porcine hemorrhagic shock model established in York shire pigs (6-10 weeks, 10-15.5 kg)[2]
Dosage: 0.3 mg/kg plus 1 mg/kg·h
Administration: Intravenous injection (i.v.), maintain infusion for 120 min
Result: Increased MAP to 90 mmHg.
Maintained a stable heart rate and do not affect the cardiac output.
Increased the vascular resistance of the system.
Molecular Weight

199.11

Formula

C4H11BrN2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(SC(C)C)=N.Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.0%

SDS (393 KB)

COA (245 KB)

Handling Instructions (2659 KB)
References
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S-Isopropylisothiourea hydrobromide Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-Isopropylisothiourea4269-97-0S-isopropyl ITU IPTUNO SynthaseNitric oxide synthasesNOSIsothioureaMethylisothioureaIsopropylisothioureaNitric oxide synthaseBlood pressureAntinociceptionInhibitorinhibitorinhibit

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