TRPM7 Protein, Human (HEK293, Flag)

TRPM7 Protein, Human (HEK293, Flag) is the recombinant human-derived TRPM7, expressed by HEK293 , with Flag labeled tag. ,

TRPM7 is a bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically Ca2+, Mg2+, and Zn2+, mediating their influx. TRPM7 controls a wide range of biological processes, including Ca2+, Mg2+, and Zn2+ homeostasis, vesicular Zn2+ release, intracellular Ca2+ signaling, embryonic development, immune responses, cell motility, proliferation, and differentiation (by similarity). Its C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7. In vivo, TRPM7 phosphorylates SMAD2, suggesting its kinase may activate SMAD signaling pathways. In vitro, the TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms, and various proteins with diverse cellular functions.

Human

HEK293

Flag

Q96QT4 (S2-L1865)

54822

Partial

Greater than 80% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.