AITRL/TNFSF18 Protein, Human (Biotinylated, HEK293, Fc-Avi)

AITRL/TNFSF18 protein binds to TNFRSF18/AITR/GITR and regulates T cell responses. AITRL/TNFSF18 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived AITRL/TNFSF18 protein, expressed by HEK293 , with N-hFc, N-Avi labeled tag. The total length of AITRL/TNFSF18 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 128 a.a., with molecular weight of 45-53 kDa.

AITRL/TNFSF18 protein, a cytokine, binds to TNFRSF18/AITR/GITR, playing a pivotal role in the regulation of T-cell responses. Functioning as a costimulator, it effectively lowers the threshold for T-cell activation and proliferation, contributing to the modulation of immune processes. AITRL/TNFSF18 is particularly significant for interactions between activated T-lymphocytes and endothelial cells, mediating the activation of NF-kappa-B and triggering increased phosphorylation of STAT1. Furthermore, it up-regulates the expression of adhesion molecules VCAM1 and ICAM1, thereby promoting leukocyte adhesion to endothelial cells. Additionally, AITRL/TNFSF18 is involved in the regulation of monocyte migration from the splenic reservoir to sites of inflammation. Existing as both a homodimer and homotrimer, AITRL/TNFSF18 showcases its versatile structural arrangements, highlighting its ability to engage in distinct molecular configurations for effective immune regulation.

Human

HEK293

N-hFc;N-Avi

Q9UNG2 (Q50-S177)

8995  [NCBI]

45-53 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.