PSMG3 Protein, Human

The PSMG3 protein acts as a chaperone and actively promotes the assembly of the 20S proteasome. It involves potential cooperation with the PSMG1-PSMG2 heterodimer to ensure precise assembly of the proteasome. PSMG3 Protein, Human is the recombinant human-derived PSMG3 protein, expressed by E. coli , with tag free.

PSMG3 (Proteasome assembly chaperone 3) is a chaperone protein crucial for the assembly of the 20S proteasome, an essential component of the cellular protein degradation machinery. PSMG3 may cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes. Existing as a homodimer, PSMG3 interacts with PSMG4 and directly engages with both alpha and beta subunits of the 20S proteasome. Notably, it dissociates before the formation of half-proteasomes, likely occurring upon the recruitment of POMP. This highlights PSMG3's role in facilitating the precise assembly of the 20S proteasome, a critical process for maintaining cellular homeostasis through effective protein degradation.

Human

E. coli

Tag Free

Q9BT73 (M1-W122)

84262

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.