PD-1 Protein, Cynomolgus (143a.a, HEK293, Fc)

PD-1 is a cell surface receptor on T and B cells that binds to PD-L1 and PD-L2. PD-1 is an immune checkpoint that protects autoimmunity by promoting apoptosis of antigen-specific T cells in lymph nodes (programmed cell death) and reducing apoptosis of regulatory T cells (anti-inflammatory, inhibitory T cells). The expression of PD-L1 on tumor cells inhibits anti-tumor activity through the binding of PD-1 to effector T cells. PD-1 Protein, Cynomolgus (143a.a, HEK293, Fc) is the recombinant cynomolgus-derived PD-1 protein, expressed by HEK293 , with C-hFc labeled tag.

PD-1 is a protein encoded by the PDCD1 gene in the human body. PD-1 is a cell surface receptor on T cells and B cells, which regulates the immune system's response to human cells by inhibiting the inflammatory activity of T cells, downregulating the immune system and promoting self-tolerance. PD-1 is an immune checkpoint that protects autoimmunity by promoting apoptosis of antigen-specific T cells in lymph nodes (programmed cell death) and reducing apoptosis of regulatory T cells (anti-inflammatory, inhibitory T cells). PD-1 can bind to two ligands, PD-L1 and PD-L2. The expression of PD-L1 on tumor cells inhibits anti-tumor activity through the binding of PD-1 to effector T cells. PD-1 knockout mice showed lupus-like glomerulonephritis and dilated cardiomyopathy in the C57BL/6 and BALB/c gene backgrounds, respectively. In the mouse thymus, the gene was induced to express in the thymus when anti-CD3 antibodies were injected and a large number of thymocytes underwent apoptosis. Mice bred in the BALB/c context lacking the gene developed dilated cardiomyopathy and died of congestive heart failure^{[1][2][3][4][5]}.

Cynomolgus

HEK293

C-hFc

B0LAJ3 (L25-Q167)

102123659  [NCBI]

LESPDRPWNAPTFSPALLLVTEGDNATFTCSFSNASESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTRLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQ

60-75 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.